Kaoru Ogawa

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. ncbi Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea
    Kenichiro Wakabayashi
    Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinju ku, Tokyo 160 8582, Japan
    Neurosci Res 66:345-52. 2010
  2. ncbi Unusual computed tomography findings of radionecrosis after chemoradiation of stage IV hypopharyngeal cancer: a case report
    Yuh Baba
    Department of Otorhinolaryngology, Ohtawara Red Cross Hospital, 2 7 3 Sumiyoshi cho, Ohtawara City, Tochigi 324 8686, Japan
    J Med Case Reports 5:25. 2011
  3. ncbi Hyperplasia of lymphoid structures in the hypopharynx: a case report
    Yuh Baba
    Department of Otorhinolaryngology, Ohtawara Red Cross Hospital, 2 7 3 Sumiyoshi cho Ohtawara City, Tochigi 324 8686, Japan
    J Med Case Reports 4:388. 2010
  4. ncbi Phobic postural vertigo treated with autogenic training: a case report
    Fumiyuki Goto
    Department of Otorhinolaryngology, Hino Municipal Hospital, Tamadaira 4 3 1, Hino shi, Tokyo 191 0062, Japan
    Cases J 1:189. 2008
  5. ncbi Effect of prostaglandin E1 on idiopathic sudden sensorineural hearing loss: a double-blinded clinical study
    Kaoru Ogawa
    Department of Otolaryngology, School of Medicine, Keio University, Tokyo, Japan
    Otol Neurotol 23:665-8. 2002
  6. ncbi Influence of depressive symptoms, state anxiety, and pure-tone thresholds on the tinnitus handicap inventory in Japan
    Naoki Oishi
    Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan
    Int J Audiol 50:491-5. 2011
  7. ncbi Balance dysfunction resulting from acute inner ear energy failure is caused primarily by vestibular hair cell damage
    Kunio Mizutari
    Laboratory of Auditory Disorders, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    J Neurosci Res 88:1262-72. 2010
  8. ncbi [Thyroglobulin concentration measurement in fine-needle aspiration fluid from cystic cervical lymph node metastases of papillary thyroid carcinoma]
    Yozo Inagaki
    Department of Otorhinolaryngology, Head and Neck Surgery, Keio University, Tokyo
    Nihon Jibiinkoka Gakkai Kaiho 114:912-6. 2011
  9. ncbi Neuroprotective effects of T-817MA against noise-induced hearing loss
    Daisuke Yamashita
    Department of Otolaryngology, Keio University Hospital, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Neurosci Res 61:38-42. 2008
  10. ncbi GFAP aggregates in the cochlear nerve increase the noise vulnerability of sensory cells in the organ of Corti in the murine model of Alexander disease
    Masatsugu Masuda
    Department of Otolaryngology, Keio University, School of Medicine, Tokyo, Japan
    Neurosci Res 62:15-24. 2008

Detail Information

Publications92

  1. ncbi Blockade of interleukin-6 signaling suppressed cochlear inflammatory response and improved hearing impairment in noise-damaged mice cochlea
    Kenichiro Wakabayashi
    Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinju ku, Tokyo 160 8582, Japan
    Neurosci Res 66:345-52. 2010
    ..Anti-inflammatory cytokine therapy including IL-6 blockade would be a feasible novel therapeutic strategy for acute sensory neural hearing loss...
  2. ncbi Unusual computed tomography findings of radionecrosis after chemoradiation of stage IV hypopharyngeal cancer: a case report
    Yuh Baba
    Department of Otorhinolaryngology, Ohtawara Red Cross Hospital, 2 7 3 Sumiyoshi cho, Ohtawara City, Tochigi 324 8686, Japan
    J Med Case Reports 5:25. 2011
    ..abstract:..
  3. ncbi Hyperplasia of lymphoid structures in the hypopharynx: a case report
    Yuh Baba
    Department of Otorhinolaryngology, Ohtawara Red Cross Hospital, 2 7 3 Sumiyoshi cho Ohtawara City, Tochigi 324 8686, Japan
    J Med Case Reports 4:388. 2010
    ..Ectopic tonsillar tissue simulating a benign tumor of the hypopharynx is described in this report...
  4. ncbi Phobic postural vertigo treated with autogenic training: a case report
    Fumiyuki Goto
    Department of Otorhinolaryngology, Hino Municipal Hospital, Tamadaira 4 3 1, Hino shi, Tokyo 191 0062, Japan
    Cases J 1:189. 2008
    ..abstract:..
  5. ncbi Effect of prostaglandin E1 on idiopathic sudden sensorineural hearing loss: a double-blinded clinical study
    Kaoru Ogawa
    Department of Otolaryngology, School of Medicine, Keio University, Tokyo, Japan
    Otol Neurotol 23:665-8. 2002
    ..The authors conducted a prospective, randomized, double-blinded clinical trial for the purpose of elucidating the effects of prostaglandin E1 (PGE1) on idiopathic sudden sensorineural hearing loss...
  6. ncbi Influence of depressive symptoms, state anxiety, and pure-tone thresholds on the tinnitus handicap inventory in Japan
    Naoki Oishi
    Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan
    Int J Audiol 50:491-5. 2011
    ..To assess factors that contribute to Tinnitus Handicap Inventory (THI) scores in Japan...
  7. ncbi Balance dysfunction resulting from acute inner ear energy failure is caused primarily by vestibular hair cell damage
    Kunio Mizutari
    Laboratory of Auditory Disorders, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    J Neurosci Res 88:1262-72. 2010
    ..These results indicate that acute inner ear energy failure causes balance dysfunction mainly by damaging hair cells in the vestibule, which is distinct from the mechanism underlying auditory disorders...
  8. ncbi [Thyroglobulin concentration measurement in fine-needle aspiration fluid from cystic cervical lymph node metastases of papillary thyroid carcinoma]
    Yozo Inagaki
    Department of Otorhinolaryngology, Head and Neck Surgery, Keio University, Tokyo
    Nihon Jibiinkoka Gakkai Kaiho 114:912-6. 2011
    ..We assessed the role of thyroglobulin measurement in FNA fluid (FNATg) in differentially diagnosing cystic cervical mass lesions, including PTC cystic lymph node metastasis...
  9. ncbi Neuroprotective effects of T-817MA against noise-induced hearing loss
    Daisuke Yamashita
    Department of Otolaryngology, Keio University Hospital, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Neurosci Res 61:38-42. 2008
    ..T-817MA significantly reduced threshold deficits and hair cell death. These results suggest T-817MA reduces noise-induced hearing loss and cochlear damage, suggesting functional and morphological protection...
  10. ncbi GFAP aggregates in the cochlear nerve increase the noise vulnerability of sensory cells in the organ of Corti in the murine model of Alexander disease
    Masatsugu Masuda
    Department of Otolaryngology, Keio University, School of Medicine, Tokyo, Japan
    Neurosci Res 62:15-24. 2008
    ..Thus, we should focus more on the roles of cochlear nerve glial cells in SNHL...
  11. ncbi Repetitive transcranial magnetic stimulation (rTMS) for treatment of chronic tinnitus
    Shujiro B Minami
    National Institute of Sensory Organs, National Tokyo Medical Center, 2 5 1 Higashigaoka, Tokyo, Japan
    Auris Nasus Larynx 38:301-6. 2011
    ..We aimed to investigate the effects of low-frequency rTMS in patients and determine the factors that predict a beneficial outcome with rTMS treatment...
  12. ncbi Mucoepidermoid carcinoma of the head and neck: clinical analysis of 43 patients
    Hiroyuki Ozawa
    Department of Otolaryngology, School of Medicine Keio University, Tokyo, Japan
    Jpn J Clin Oncol 38:414-8. 2008
    ..While the high-grade type is a highly aggressive tumor, its low-grade counterpart usually demonstrates a more benign nature and several systems have, therefore, been proposed to grade this neoplasm...
  13. ncbi Overexpression of SIP1 and downregulation of E-cadherin predict delayed neck metastasis in stage I/II oral tongue squamous cell carcinoma after partial glossectomy
    Koji Sakamoto
    Department of Otorhinolaryngology Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan
    Ann Surg Oncol 19:612-9. 2012
    ..The present study aimed to examine the associations of EMT-involved molecular factors and clinicopathological factors with DNM in stage I/II TSCC...
  14. ncbi Laryngeal function after supracricoid laryngectomy
    Koichiro Saito
    Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan
    Otolaryngol Head Neck Surg 140:487-92. 2009
    ..The purpose of this study was to assess laryngeal function after supracricoid laryngectomy...
  15. ncbi Long-term prognosis of low-frequency hearing loss and predictive factors for the 10-year outcome
    Naoki Oishi
    Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan
    Otolaryngol Head Neck Surg 142:565-9. 2010
    ..To determine the long-term prognosis of low-frequency hearing loss and predictive factors for the 10-year outcome of low-frequency hearing loss...
  16. ncbi Bisphosphonate therapy ameliorates hearing loss in mice lacking osteoprotegerin
    Sho Kanzaki
    Department of Otolaryngology, School of Medicine, Keio University, Tokyo, Japan
    J Bone Miner Res 24:43-9. 2009
    ..These data suggest that hearing loss in pathologies characterized by excessive resorption of the auditory ossicles may be prevented by bisphosphonates...
  17. ncbi Caspase inhibitor facilitates recovery of hearing by protecting the cochlear lateral wall from acute cochlear mitochondrial dysfunction
    Kunio Mizutari
    Laboratory of Auditory Disorders, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    J Neurosci Res 86:215-22. 2008
    ..Moreover, the results of the present study suggest that systemic administration of a caspase inhibitor may be an effective therapy for sensorineural hearing loss caused by acute energy failure such as that observed in cochlear ischemia...
  18. ncbi Late-phase recovery in the cochlear lateral wall following severe degeneration by acute energy failure
    Kunio Mizutari
    Laboratory of Auditory Disorders, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo, Japan
    Brain Res 1419:1-11. 2011
    ..These results indicate that ABR recovery is caused by regeneration of the cochlear lateral wall. Our findings demonstrate the recoverable capacity of the cochlear lateral wall that leads to functional recovery after severe damage...
  19. ncbi Acoustic overstimulation-induced apoptosis in fibrocytes of the cochlear spiral limbus of mice
    Yong Cui
    Department of Otolaryngology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Eur Arch Otorhinolaryngol 268:973-8. 2011
    ..These results suggest that noise exposure might result in apoptosis of fibrocytes in spiral limbus, which suggest a mechanism for noise-induced hearing loss...
  20. ncbi Diagnosis and management of cervical sympathetic chain schwannoma: a review of 9 cases
    Toshiki Tomita
    Department of Otolaryngology, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, Japan
    Acta Otolaryngol 129:324-9. 2009
    ..Surgical resection of CSCS is relatively effortless, and Horner's syndrome is an expected but acceptable postoperative complication. Intratumoral hemorrhage and vasodilation may be the main reasons for significant enhancement on MRI...
  21. ncbi Cholesterol granuloma surrounding the endolymphatic sac
    Sho Kanzaki
    Department of Otorhinolaryngology, School of Medicine, Keio University, Shinjuku, Tokyo 160 8582, Japan
    Auris Nasus Larynx 34:95-100. 2007
    ..At his 12-month postoperative follow-up, there was no evidence of recurrence. We discuss the radiology, pathology, and surgical removal of CGs surrounding ES...
  22. ncbi Effects of selective serotonin reuptake inhibitor on treating tinnitus in patients stratified for presence of depression or anxiety
    Naoki Oishi
    Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan
    Audiol Neurootol 15:187-93. 2010
    ..These results suggest that paroxetine is effective in treating distressed tinnitus patients with depression and anxiety by reducing their tinnitus severity as well as their depression and anxiety...
  23. ncbi Application of the endoscopic transsphenoidal approach to true type transsellar transsphenoidal meningoencephalocele in an adult: a case report and literature review
    Katsuya Saito
    Department of Neurosurgery, Keio University School of Medicine, 35 Shinano machi, Shinjnku ku, Tokyo, 160 8582, Japan
    Acta Neurochir (Wien) 154:1511-5. 2012
    ..We believe that the endoscopic transsphenoidal approach allows less invasive surgery and provides an acceptable operative outcome in comparison with other microsurgical approaches...
  24. ncbi Various levels of plasma brain-derived neurotrophic factor in patients with tinnitus
    Fumiyuki Goto
    Department of Otolaryngology, Hino Municipal Hospital, Japan
    Neurosci Lett 510:73-7. 2012
    ..To determine whether BDNF levels could be used to evaluate tinnitus severity, we evaluated plasma BDNF levels in patients with tinnitus...
  25. ncbi Experimental evaluation of relapse-risks in operated zygoma fractures
    Maki Nagasao
    Department of Otolaryngology, Keio University, Tokyo, Japan
    Auris Nasus Larynx 36:168-75. 2009
    ....
  26. ncbi Nuclear factor-kappa B nuclear translocation in the cochlea of mice following acoustic overstimulation
    Masatsugu Masuda
    Department of Otolaryngology, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    Brain Res 1068:237-47. 2006
    ..These results suggest that NF-kappaB may have a detrimental role in the response to acoustic overstimulation in the cochlea of mice...
  27. ncbi Burow's solution-induced acute sensorineural hearing loss: report of two cases
    Naoki Oishi
    Department of Otolaryngology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan
    Auris Nasus Larynx 37:369-72. 2010
    ..These two case reports demonstrate that the ototoxicity of Burow's solution should be considered when it is used to treat otitis media accompanied by tympanic membrane perforation...
  28. ncbi Sendai virus vector-mediated transgene expression in the cochlea in vivo
    Sho Kanzaki
    Department of Otolaryngology, Keio University, Tokyo, Japan
    Audiol Neurootol 12:119-26. 2007
    ..Because SeV vectors can potentially deliver stimuli to the cochlea to induce hair cell regeneration, it may be a powerful tool for repairing the organ of Corti...
  29. ncbi Novel in vivo imaging analysis of an inner ear drug delivery system in mice: comparison of inner ear drug concentrations over time after transtympanic and systemic injections
    Sho Kanzaki
    Department of Otolaryngology Head and Neck Surgery, Keio University, Shinjuku ku, Tokyo, Japan
    PLoS ONE 7:e48480. 2012
    ..Here, we used a new in vivo imaging system to monitor drug delivery in live mice and to compare drug concentrations over time after TT and systemic injections...
  30. ncbi Neurally mediated syncope presenting with paroxysmal positional vertigo and tinnitus
    Fumiyuki Goto
    Department of Otorhinolaryngology, Hino Municipal Hospital, 4 3 1 Tamadaira Hino shi, Tokyo, Japan
    Auris Nasus Larynx 39:531-3. 2012
    ..We should carefully rule out cardiovascular disorders, especially when we see the patients with suspected BPPV without the characteristic positional nystagmus...
  31. ncbi Surgical results of an endoscopic endonasal approach for clival chordomas
    Katsuya Saito
    Department of Neurosurgery, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Acta Neurochir (Wien) 154:879-86. 2012
    ..We describe our experience with the endoscopic endonasal approach and provide a review of the literature...
  32. ncbi Thirteen-month-old boy with malignant lymphoma having symptoms mimicking acute otitis media and mastoiditis with facial palsy
    Sho Kanzaki
    Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan
    ORL J Otorhinolaryngol Relat Spec 73:266-70. 2011
    ..As this case illustrates, physicians should consider a diagnosis of malignant lymphoma if a patient presents with otitis media and mastoiditis accompanied by facial palsy...
  33. ncbi Hearing handicap predicts the development of depressive symptoms after 3 years in older community-dwelling Japanese
    Hideyuki Saito
    Department of Otorhinolaryngology, Head and Neck Surgery, School of Medicine, Keio University, Tokyo, Japan
    J Am Geriatr Soc 58:93-7. 2010
    ..To examine the association between hearing handicap and depressive symptoms in older community-dwelling Japanese...
  34. ncbi Pure tone auditory thresholds can change according to duration of interrupted tones in patients with psychogenic hearing loss
    Naoki Oishi
    Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan
    Acta Otolaryngol 131:628-32. 2011
    ..Pure tone auditory thresholds can change according to duration of interrupted tones in patients with mild to severe psychogenic hearing loss (PHL)...
  35. ncbi Vestibular dysfunction in a Japanese patient with a mutation in the gene OPA1
    Kunio Mizutari
    Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan
    J Neurol Sci 293:23-8. 2010
    ..Based on this case, we suggest that vestibular evaluation should be performed in auditory neuropathy patients carrying an OPA1 mutation, even if the patients are free of symptoms of vestibular dysfunction...
  36. ncbi Impaired vibration of auditory ossicles in osteopetrotic mice
    Sho Kanzaki
    Department of Otolaryngology, School of Medicine, Keio University, Tokyo, Japan
    Am J Pathol 178:1270-8. 2011
    ..These data suggest that osteoclastic bone resorption is required for thinning of auditory ossicles and enlargement of the tympanic cavity so that auditory ossicles vibrate freely...
  37. ncbi [Evaluation of the quality of life in sudden deafness patients by HHIA (hearing Hatidicap Inventory) and questionnaire]
    Minako Sato
    Department of Otorhinolaryngology, School of Medicine, Keio University, Tokyo
    Nippon Jibiinkoka Gakkai Kaiho 108:1158-64. 2005
    ..Even though hearing may not improve after initial treatment in ears affected by SD, informed consent about the clinical course and audiological follow-up should be done...
  38. ncbi The possible contribution of angiitis to the onset of benign paroxysmal positional vertigo (BPPV)
    Fumiyuki Goto
    Department of Otorhinolaryngology, Hino Municipal Hospital, Tokyo, Japan
    Int Tinnitus J 16:25-8. 2010
    ....
  39. ncbi Liposarcoma of the retropharyngeal space: report of a case and review of literature
    Hiroyuki Ozawa
    Department of Otolaryngology, School of Medicine Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Auris Nasus Larynx 34:417-21. 2007
    ..In the present case, functional resection and radiotherapy were performed and proved to be efficacious in that no recurrence was observed for 2 years...
  40. ncbi Surgical strategy for tumors located in or extending from the intracranial space to the infratemporal fossa-Advantages of the transcranial approach (zygomatic infratemporal fossa approach) and the indications for a combined transcranial and transcervical
    Kazunari Yoshida
    Department of Neurosurgery, Keio University School of Medicine, Shinjuki ku, Tokyo, Japan
    Neurol Med Chir (Tokyo) 49:580-6. 2009
    ....
  41. ncbi Traditional Chinese Medicine for treatment of laryngeal papillomatosis
    Keisuke Okubo
    Department of Otolaryngology Head and Neck Surgery, Keio University School of Medicine, Shinjuku, Tokyo, Japan
    J Altern Complement Med 16:427-33. 2010
    ..The objective of this study was to assess the clinical effectiveness of Traditional Chinese Medicine (TCM) as an adjuvant therapy for recurrent respiratory papillomatosis...
  42. ncbi Application of autogenic training in patients with Ménière disease
    Fumiyuki Goto
    Department of Otorhinolaryngology, Hino Municipal Hospital, Hino, Tokyo, Japan
    Eur Arch Otorhinolaryngol 268:1431-5. 2011
    ..97, P < 0.05). In conclusion, autogenic training may enhance the mental well-being of patients with Ménière disease and improve clinical outcome...
  43. ncbi Proinflammatory cytokines expression in noise-induced damaged cochlea
    Masato Fujioka
    Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan
    J Neurosci Res 83:575-83. 2006
    ..These cytokines, produced by the cochlear structure itself in response to noise exposure, may initiate an inflammatory response and have some role in the mechanism of noise-induced cochlear damage...
  44. ncbi Long-term prognosis of steroid-dependent sensorineural hearing loss
    Jin Kanzaki
    Department of Otolaryngology, Keio University, School of Medicine, Shinjuku, Tokyo, Japan
    Audiol Neurootol 14:26-34. 2009
    ....
  45. ncbi Physical and physiological effects on otoacoustic emissions in hypobaric hypoxia
    Rika Ide
    Department of Otorhinolaryngology, Keio University School of Medicine, Tokyo, Japan
    ORL J Otorhinolaryngol Relat Spec 72:225-32. 2010
    ..We conclude that the impact of hypobaric hypoxia on cochlear function was negligible up to pressures of 540 hPa...
  46. ncbi Acute-onset unilateral psychogenic hearing loss in adults: report of six cases and diagnostic pitfalls
    Naoki Oishi
    Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan
    ORL J Otorhinolaryngol Relat Spec 71:279-83. 2009
    ..Compared to the existing reports of similar cases, our cases had a poorer prognosis (only 2 cases were cured)...
  47. ncbi Resorption of auditory ossicles and hearing loss in mice lacking osteoprotegerin
    Sho Kanzaki
    Department of Otolaryngology, School of Medicine, Keio University, 35 Shinanomachi, Tokyo 160 8582, Japan
    Bone 39:414-9. 2006
    ..These data suggest that osteoprotegerin plays a crucial role in hearing by protecting the auditory ossicles and otic capsule from osteoclastic bone resorption...
  48. ncbi Effect of single-drug treatment on idiopathic sudden sensorineural hearing loss
    Jin Kanzaki
    Department of Otolaryngology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
    Auris Nasus Larynx 30:123-7. 2003
    ..CONCLUSION: From these results, we could not find any specific drugs recommended for ISSNHL. In evaluating the effect of the drugs, however, several problems in the clinical trial for ISSHL should be considered...
  49. ncbi Hypothyroidism after radiotherapy for patients with head and neck cancer
    Hiroyuki Ozawa
    Department of Otolaryngology, Keio University School of Medicine, Tokyo, Japan
    Am J Otolaryngol 28:46-9. 2007
    ..We believe that thyroid function should be evaluated periodically in patients who have undergone neck radiation because it is often difficult to diagnose hypothyroidism only from clinical symptoms...
  50. ncbi Expression and function of Sox21 during mouse cochlea development
    Makoto Hosoya
    Department of Physiology, School of Medicine, Keio University, Tokyo, Japan
    Neurochem Res 36:1261-9. 2011
    ..Also, the characteristic expression pattern may be useful for labelling a particular subset of supporting cells...
  51. ncbi Appropriate diameter for screws to fix the maxilla following Le Fort I osteotomy: an investigation utilizing finite element analysis
    Tomohisa Nagasao
    Department of Plastic and Reconstructive Surgery, School of Medicine, Keio University, Tokyo, Japan
    J Craniomaxillofac Surg 35:227-33. 2007
    ..The present study aims to elucidate the relationship between the diameters of the screws and the structural stability of the maxilla after Le Fort I osteotomy...
  52. ncbi Tracheoesophageal diversion versus total laryngectomy for intractable aspiration
    Toshiki Tomita
    Department of Otolaryngology, Yokohama Municipal Citizen s Hospital, Yokohama, Japan
    J Laryngol Otol 118:15-8. 2004
    ..Tracheoesophageal diversion was thus found to be a simple, safe, and reliable therapeutic modality for the control of intractable aspiration. Moreover, it induced less surgical stress than total laryngectomy...
  53. ncbi Analysis of the orbital floor morphology
    Tomohisa Nagasao
    Department of Plastic and Reconstructive Surgery, School of Medicine, Keio University, Tokyo, Japan
    J Craniomaxillofac Surg 35:112-9. 2007
    ..The purpose of the present study was to elucidate how age and gender affect its three-dimensional morphology...
  54. ncbi Correlations of inflammatory biomarkers with the onset and prognosis of idiopathic sudden sensorineural hearing loss
    Masatsugu Masuda
    Department of Otolaryngology, School of Medicine, Keio University, Tokyo, Japan
    Otol Neurotol 33:1142-50. 2012
    ..We investigated whether inflammatory biomarkers and stress are involved in the pathophysiology of idiopathic sensorineural hearing loss (ISHL)...
  55. ncbi A new device for delivering drugs into the inner ear: otoendoscope with microcatheter
    Sho Kanzaki
    Department of Otolaryngology, Head and Neck Surgery, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan
    Auris Nasus Larynx 39:208-11. 2012
    ..We developed and tested a novel otoendoscopy device that allows visualization of the RWM for the purpose of ITI...
  56. ncbi Development of solitary plasmacytoma in the internal auditory canal and inner ear after allogeneic hematopoietic stem cell transplantation for plasma cell leukemia
    Masatsugu Masuda
    Department of Otolaryngology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Jpn J Clin Oncol 37:701-3. 2007
    ..This case elucidates the biology of PCL and stresses the need for an individual approach to the clinical management of patients with plasma cell neoplasm undergoing allo-SCT...
  57. ncbi The Japanese version of the Dizziness Handicap Inventory as an index of treatment success: exploratory factor analysis
    Fumiyuki Goto
    Department of Otolaryngology, Hino Municipal Hospital, 4 3 1 Tamadahira Hinoshi, Tokyo, Japan
    Acta Otolaryngol 131:817-25. 2011
    ..The Japanese version of the Dizziness Handicap Inventory (DHI) is a reliable, comprehensively validated, and clinically useful tool to measure self-perceived handicap associated with dizziness...
  58. ncbi [Adaptation of Japanese version of the Hearing Handicap Inventory for Adults (HHIA)]
    Minako Sato
    Department of Otolaryngology, School of Medicine, Keio University, Tokyo
    Nippon Jibiinkoka Gakkai Kaiho 107:489-93. 2004
    ..The HHIA Japanese version is thus useful for following up patients with hearing disorders...
  59. ncbi A novel model for prognosis of Meniere's disease using oxidative stress susceptibility of lymphoblastoid cell lines
    Ken Hayashi
    Department of Otolaryngology, Shinkawa Clinic, Hadano, Kanagawa, Japan
    Biosci Trends 4:72-8. 2010
    ..Also, the difference of the sensitivity of H(2)O(2)-treated LCLs to ATP might relate to prognosis and treatment of MD. This system may form the basis of tailor-made therapy for MD...
  60. ncbi Hypertrophic chronic pachymeningitis associated with chronic otitis media and mastoiditis
    Sho Kanzaki
    Department of Otolaryngology, Head and Neck Surgery, Keio University Hospital, 35 Shinanomachi, Shinjuku, Tokyo 160 0082, Japan
    Auris Nasus Larynx 31:155-9. 2004
    ..We speculate that removal of the infectious granulation within the middle ears and mastoids ameliorated the acute inflammation. The etiology remains unknown in this case...
  61. ncbi [A multidisciplinary approach to carotid body tumors. Report of five cases]
    Toshiki Tomita
    Department of Otolaryngology, Keio University School of Medicine, Tokyo
    Nihon Jibiinkoka Gakkai Kaiho 110:743-51. 2007
    ..A multidisciplinary approach should be used, involving the fields of otolaryngology, radiology, neurosurgery and vascular surgery to treat these patients...
  62. ncbi [Clinical experience with silicon pharyngeal tube for pharyngocutaneous fistula and cervical esophagus stenosis]
    Masayuki Tomifuji
    Department of Otolaryngology, Keio University School of Medicine, Tokyo
    Nippon Jibiinkoka Gakkai Kaiho 109:530-4. 2006
    ..Silicon pharyngeal tubes are useful for the treatment of pharyngocutaneous fistula and cervical esophageal stenosis...
  63. ncbi A novel drug therapy for recurrent laryngeal nerve injury using T-588
    Yuko Mori
    Department of Otolaryngology Head and Neck Surgery, Keio University School of Medicine, Shinjuku, Tokyo, Japan
    Laryngoscope 117:1313-8. 2007
    ..In the present study, the possibility of new drug treatments using T-588 for RLN injury was assessed using rat models...
  64. ncbi Laryngeal carcinoma presenting as a large anterior neck abscess
    Hideki Nakagawa
    Department of Otolaryngology, Seibo International Catholic Hospital, 2 5 1 Nakaochiai, Shinjuku ku, Tokyo 161 8521, Japan
    Auris Nasus Larynx 34:249-51. 2007
    ..Precise observation and biopsy under directscopic vestibulectomy played an important role in diagnosis of malignancy inherent in severe inflammatory tissues...
  65. ncbi Inostamycin prevents malignant phenotype of cancer: inhibition of phosphatidylinositol synthesis provides a therapeutic advantage for head and neck squamous cell carcinoma
    Yuh Baba
    Department of Otolaryngology, Tochigi National Hospital, Tochigi 320 8580, Japan
    Cell Biol Int 34:171-5. 2010
    ..e. a therapeutic concept to prolong 'time to treatment failure' or 'time to progression'...
  66. ncbi Role of salivary gland scintigraphy with Tc-99m pertechnetate in determining treatment of solitary parotid gland tumors: a retrospective study
    Tadaki Nakahara
    Department of Radiology, Keio University School of Medicine, Tokyo, Japan
    Clin Nucl Med 32:363-6. 2007
    ..Although salivary gland scintigraphy has been useful for the diagnosis of Warthin's tumor (WT), there are no reports concerning the clinical impact of this scintigraphy...
  67. ncbi Inferior meatal antrostomy impairs dynamic stability of the orbital walls
    Tomohisa Nagasao
    Department of Plastic and Reconstructive Surgery, School of Medicine, Keio University, Tokyo, Japan
    Auris Nasus Larynx 36:431-7. 2009
    ..We conducted the present study to elucidate the effect of the IMA on the vulnerability of the orbital floor...
  68. ncbi Two cases of pulmonary embolism after head and neck surgery
    Sho Kanzaki
    Department of Otolaryngology, Head and Neck Surgery, Keio University Hospital, 35 Shinanomachi Shinjuku, Tokyo 160 0082, Japan
    Auris Nasus Larynx 31:313-7. 2004
    ....
  69. ncbi Quality of life of Japanese seasonal allergic rhinitis patients is related to timing of pollen dispersal - multicenter analysis
    Sho Kanzaki
    Department of Otolaryngology, Head and Neck Surgery, Keio University Medical School, Tokyo, Japan
    Acta Otolaryngol 131:290-7. 2011
    ....
  70. ncbi Expression of c-Fos after noise-induced temporary threshold shift in the guinea pig cochlea
    Ken Shizuki
    Department of Otolaryngology, National Tokyo Medical Center, 2 5 1 Higashigaoka, Meguro ku, Tokyo 152 8902, Japan
    Neurosci Lett 320:73-6. 2002
    ..Since the threshold shift was temporary, the expression of c-Fos is therefore considered to contribute to the survival or protective function of the organ of Corti...
  71. ncbi Pulse-oximetery is useful in determining the indications for adeno-tonsillectomy in pediatric sleep-disordered breathing
    Hideyuki Saito
    Department of Otorhinolaryngology, Keio University School of Medicine, 160 8582, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Int J Pediatr Otorhinolaryngol 71:1-6. 2007
    ..We investigated whether pulse-oximetry is useful for determining the optional treatment modality for pediatric SDB...
  72. ncbi An anatomical study of the three-dimensional structure of the nasal septum in patients with alveolar clefts and alveolar-palatal clefts
    Tomohisa Nagasao
    Department of Plastic and Reconstructive Surgery, School of Medicine, Keio University, Tokyo, Japan
    Plast Reconstr Surg 121:2074-83. 2008
    ..The present study was performed to quantitatively analyze the three-dimensional morphology of the nasal septa of patients with alveolar and alveolopalatal clefts...
  73. ncbi [Surgical management of parapharyngeal space tumors]
    Toshiki Tomita
    Department of Otolaryngology, Keio University School of Medicine, Tokyo
    Nippon Jibiinkoka Gakkai Kaiho 109:88-95. 2006
    ..In poststyloid parapharyngeal space tumors, however, it appears necessary to judge indication for surgery more carefully while considering the social background, age, and occupation of prospective surgical candidates...
  74. ncbi CCND1 amplification predicts sensitivity to chemotherapy and chemoradiotherapy in head and neck squamous cell carcinoma
    Ryuichiro Ishiguro
    Department of Otolaryngology, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku ku, Tokyo 160 8582, Japan
    Anticancer Res 23:5213-20. 2003
    ..Cyclin D1 has been reported to be associated with poor prognosis in head and neck squamous cell carcinoma (HNSCC)...
  75. ncbi Suitability of calcium phosphate cement for injection laryngoplasty in rabbits
    Asako Ikeda
    Department of Otolaryngology, Head and Neck Surgery, Keio University School of Medicine, Tokyo, Japan
    ORL J Otorhinolaryngol Relat Spec 68:103-9. 2006
    ..These results indicated that CPC appears to be biocompatible, nonabsorbable, nonmigratory, and suitable for injection laryngoplasty...
  76. ncbi Noninvasive in vivo delivery of transgene via adeno-associated virus into supporting cells of the neonatal mouse cochlea
    Takashi Iizuka
    Department of Otorhinolaryngology, Juntendo University School of Medicine, Tokyo 113 8421, Japan
    Hum Gene Ther 19:384-90. 2008
    ....
  77. ncbi Creatine and tempol attenuate noise-induced hearing loss
    Shujiro B Minami
    Kresge Hearing Research Institute, University of Michigan, 1301 E Ann Street, Ann Arbor, MI 48109 0506, USA
    Brain Res 1148:83-9. 2007
    ..Our results indicate that the maintenance of ATP levels is important in attenuating both temporary and permanent NIHL, while the scavenging of free radicals provides protection from permanent NIHL...
  78. ncbi Infantile congenital petrosal cholesteatoma: a case report and literature review
    Kazuharu Yamazaki
    Department of Otorhinolaryngology, Iwate Medical University, Uchimaru 19-1, Morioka, Iwate 020-8505, Japan
    Int J Pediatr Otorhinolaryngol 69:1703-7. 2005
    ..To our knowledge, the present case seems to be the youngest case of congenital petrosal cholesteatoma reported, and also demonstrates congenital petrosal cholesteatoma could exhibit facial nerve paralysis in early childhood...
  79. ncbi Transgene expression in neonatal mouse inner ear explants mediated by first and advanced generation adenovirus vectors
    Sho Kanzaki
    Kresge Hearing Research Institute, The University of Michigan, MSRB 3, Room 9303, Ann Arbor, MI 48109-0648, USA
    Hear Res 169:112-20. 2002
    ..The data demonstrate that differentiating HCs and SCs in mouse explants can be transduced by adenovirus vectors, suggesting that cultures of mouse ears are a valuable model for developing inner ear gene therapy protocols...
  80. ncbi Adenoviral gene transfer of BDNF and GDNF synergistically prevent motoneuron loss in the nucleus ambiguus
    Kazuhisa Moro
    Department of Otolaryngology-Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 1608582, Japan
    Brain Res 1076:1-8. 2006
    ..These results indicate that adenovirus-mediated BDNF and GDNF gene transfer may prevent the degeneration of motoneurons in humans after either vagal nerve injury or recurrent laryngeal nerve injury...
  81. ncbi Identification of highly expressed genes in peripheral blood T cells from patients with atopic dermatitis
    Yoshiko Matsumoto
    Genox Research, Inc, Teikyo University Biotech Center, Kawasaki, Kanagawa, Japan
    Int Arch Allergy Immunol 129:327-40. 2002
    ..Further functional characterization will provide a better understanding of the pathophysiology of circulating T cells in AD...
  82. ncbi Percutaneous transhepatic small-caliber choledochoscopic lithotomy: a safe and effective technique for percutaneous transhepatic common bile duct exploration in high-risk elderly patients
    Kaoru Ogawa
    Department of Internal Medicine, Juntendo University Izunagaoka Hospital, 1129 Izunagaoka, Tagata, Shizuoka 410-2295, Japan
    J Hepatobiliary Pancreat Surg 9:213-7. 2002
    ..CONCLUSIONS: Percutaneous transhepatic choledochoscopic lithotomy, using electrohydraulic lithotripsy, is an attractive alternative for patients with common bile duct stones when surgery or retrograde methods are not suitable...
  83. ncbi Sentinel node concept in clinically n0 laryngeal and hypopharyngeal cancer
    Masayuki Tomifuji
    Department of Otolaryngology Head and Neck Surgery, National Defense Medical College, 3 2 Namiki, Tokorozawa, Saitama, 3598513, Japan
    Ann Surg Oncol 15:2568-75. 2008
    ..In this study, we investigated whether the SN concept is applicable for laryngeal and hypopharyngeal cancer...
  84. ncbi Adenoviral GDNF gene transfer prevents motoneuron loss in the nucleus ambiguus
    Koichiro Saito
    Department of Otolaryngology-Head and Neck Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 1608582, Japan
    Brain Res 962:61-7. 2003
    ..These results indicate that adenovirus-mediated GDNF gene transfer may prevent the degeneration of motoneurons in humans after either vagal nerve injury or recurrent laryngeal nerve injury...
  85. ncbi [Treatment of recurred HCV infection after liver transplantation]
    Takafumi Ichida
    Department of Gastroenterology, Juntendo University, School of Medicine, Shizuoka Hospital
    Nippon Rinsho 63:2012-21. 2005
    ..On the contrary, some of Japanese investigator reported with 40-50% SVR with same drug management. It is still controversy whether HCV recipients are poor prognosis after transplantation and treatment resistance...
  86. ncbi Analysis of gene expression in peripheral blood eosinophils from patients with atopic dermatitis by differential display
    Ryoichi Hashida
    Genox Research Inc, Teikyo University Biotechnology Center, 907 Nogawa, Kawasaki, Japan
    Int Arch Allergy Immunol 131:26-33. 2003
    ..The mouse counterpart of one of these genes, intersectin 2, was expressed dramatically, as measured by ear edema, in 1-fluoro-2,4-dinitrobenzene-induced mouse contact dermatitis and in NC/Nga mouse dermatitis...
  87. ncbi Permanent threshold shift caused by acute cochlear mitochondrial dysfunction is primarily mediated by degeneration of the lateral wall of the cochlea
    Yasuhide Okamoto
    Laboratory of Auditory Disorders, National Institute of Sensory Organs, National Tokyo Medical Center, Tokyo 152-8902, Japan
    Audiol Neurootol 10:220-33. 2005
    ....
  88. ncbi Expression of a human SOCS protein, HSOCP-1, in peripheral blood eosinophils from patients with atopic dermatitis
    Kaoru Ogawa
    Genox Research Inc, Kawasaki, Kanagawa, Japan
    Int Arch Allergy Immunol 134:2-6. 2004
    ..It is a protein that also interacts with the cyclin-dependent kinase inhibitor p16(INK4), suggesting that HSOCP-1 is involved in cell cycle control and apoptosis...
  89. ncbi Bcl-2 genes regulate noise-induced hearing loss
    Daisuke Yamashita
    Kresge Hearing Research Institute, University of Michigan, Ann Arbor, Michigan 48109 0506, USA
    J Neurosci Res 86:920-8. 2008
    ..Bcl-xL plays an essential role in prevention of sensory cell death following TTS levels of noise, and PTS exposure provokes the expression of Bak and, with that, cell death...
  90. ncbi [Two cases of Meniere's disease with drop attacks]
    Fumiyuki Goto
    Department of Otorhinolaryngology, Hino Municipal Hospital, Tokyo
    Nippon Jibiinkoka Gakkai Kaiho 108:222-5. 2005
    ..To correctly diagnose drop attacks, the patient must exhibit sudden falls, and transient ischemic attack should be carefully ruled out...
  91. ncbi [Clinical significance of recurrence of hepatitis C virus after liver transplantation--Japanese experience--]
    Takafumi Ichida
    Department of Gastroenterology, Juntendo University Shizuoka Hospital
    Nippon Shokakibyo Gakkai Zasshi 103:615-25. 2006
  92. ncbi Brl1p -- a novel nuclear envelope protein required for nuclear transport
    Yoh Hei Saitoh
    Department of Molecular Biology, Graduate School of Medical Science, Kyushu University, 3 1 1 Maidashi, Higashi ku, Fukuoka 812 8582, Japan
    Traffic 6:502-17. 2005
    ..The genetic analysis suggested that Brl1p functionally interacts with Brr6p. An interaction of Brl1p with Brr6p was shown by the two-hybrid method. We hypothesize that Brl1p functions for nuclear export as a complex with Brr6p...