M Nishizawa

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. ncbi The Pho85 kinase, a member of the yeast cyclin-dependent kinase (Cdk) family, has a regulation mechanism different from Cdks functioning throughout the cell cycle
    M Nishizawa
    Department of Microbiology, Keio University School of Medicine, Shinjuku, Tokyo 160 8582, Japan
    Genes Cells 4:627-42. 1999
  2. ncbi Mouse cyclin-dependent kinase (Cdk) 5 is a functional homologue of a yeast Cdk, pho85 kinase
    M Nishizawa
    Department of Microbiology, Keio University School of Medicine, Shinjuku, Tokyo 160 8582, Japan
    J Biol Chem 274:33859-62. 1999
  3. ncbi Negative regulation of transcription by the yeast global transcription factors, Gal11 and Sin4
    M Nishizawa
    Department of Microbiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Yeast 18:1099-110. 2001
  4. ncbi Pho85 kinase, a yeast cyclin-dependent kinase, regulates the expression of UGP1 encoding UDP-glucose pyrophosphorylase
    M Nishizawa
    Department of Microbiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Yeast 18:239-49. 2001
  5. pmc Phosphorylation of sic1, a cyclin-dependent kinase (Cdk) inhibitor, by Cdk including Pho85 kinase is required for its prompt degradation
    M Nishizawa
    Department of Microbiology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Mol Biol Cell 9:2393-405. 1998
  6. pmc Yeast Gal11 protein mediates the transcriptional activation signal of two different transacting factors, Gal4 and general regulatory factor I/repressor/activator site binding protein 1/translation upstream factor
    M Nishizawa
    Department of Microbiology, Keio University School of Medicine, Tokyo, Japan
    Proc Natl Acad Sci U S A 87:5373-7. 1990
  7. pmc Isolation and characterization of SGE1: a yeast gene that partially suppresses the gal11 mutation in multiple copies
    H Amakasu
    Department of Microbiology, Keio University School of Medicine, Tokyo, Japan
    Genetics 134:675-83. 1993
  8. pmc The yeast GAL11 protein is involved in regulation of the structure and the position effect of telomeres
    Y Suzuki
    Department of Microbiology, Keio University School of Medicine, Tokyo, Japan
    Mol Cell Biol 14:3791-9. 1994
  9. ncbi Purification and characterization of the yeast negative regulatory protein GAL80
    S J Yun
    Laboratory of Molecular Genetics, Keio University School of Medicine, Tokyo, Japan
    J Biol Chem 266:693-7. 1991
  10. pmc Toward a protein-protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins
    T Ito
    Human Genome Center, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 97:1143-7. 2000

Collaborators

Detail Information

Publications36

  1. ncbi The Pho85 kinase, a member of the yeast cyclin-dependent kinase (Cdk) family, has a regulation mechanism different from Cdks functioning throughout the cell cycle
    M Nishizawa
    Department of Microbiology, Keio University School of Medicine, Shinjuku, Tokyo 160 8582, Japan
    Genes Cells 4:627-42. 1999
    ..By analysing the genetic and biochemical properties of Pho85p, we studied whether the regulation of Pho85p activity is similar to other cyclin-dependent kinases (Cdks) directly involved in cell cycle regulation...
  2. ncbi Mouse cyclin-dependent kinase (Cdk) 5 is a functional homologue of a yeast Cdk, pho85 kinase
    M Nishizawa
    Department of Microbiology, Keio University School of Medicine, Shinjuku, Tokyo 160 8582, Japan
    J Biol Chem 274:33859-62. 1999
    ..Thus mouse Cdk5 is a functional homologue of yeast Pho85 kinase...
  3. ncbi Negative regulation of transcription by the yeast global transcription factors, Gal11 and Sin4
    M Nishizawa
    Department of Microbiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Yeast 18:1099-110. 2001
    ..Based on these results, possible mechanisms by which a mediator subcomplex regulates transcription is discussed...
  4. ncbi Pho85 kinase, a yeast cyclin-dependent kinase, regulates the expression of UGP1 encoding UDP-glucose pyrophosphorylase
    M Nishizawa
    Department of Microbiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Yeast 18:239-49. 2001
    ..We also found that expression of several Pho85-cyclin genes were altered by the carbon source, the growth phase and Pho85 kinase itself...
  5. pmc Phosphorylation of sic1, a cyclin-dependent kinase (Cdk) inhibitor, by Cdk including Pho85 kinase is required for its prompt degradation
    M Nishizawa
    Department of Microbiology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Mol Biol Cell 9:2393-405. 1998
    ..Pho85 and other G1 Cdks appear to phosphorylate Sic1 at different sites in vivo. Thus at least two distinct Cdks can participate in phosphorylation of Sic1 and may therefore regulate progression through G1...
  6. pmc Yeast Gal11 protein mediates the transcriptional activation signal of two different transacting factors, Gal4 and general regulatory factor I/repressor/activator site binding protein 1/translation upstream factor
    M Nishizawa
    Department of Microbiology, Keio University School of Medicine, Tokyo, Japan
    Proc Natl Acad Sci U S A 87:5373-7. 1990
    ....
  7. pmc Isolation and characterization of SGE1: a yeast gene that partially suppresses the gal11 mutation in multiple copies
    H Amakasu
    Department of Microbiology, Keio University School of Medicine, Tokyo, Japan
    Genetics 134:675-83. 1993
    ..SGE1-specific mRNA of 1.8 kilonucleotides was detected by Northern analysis along the direction of the open reading frame. The gene mapped near RAD56, at the right end of chromosome 16...
  8. pmc The yeast GAL11 protein is involved in regulation of the structure and the position effect of telomeres
    Y Suzuki
    Department of Microbiology, Keio University School of Medicine, Tokyo, Japan
    Mol Cell Biol 14:3791-9. 1994
    ....
  9. ncbi Purification and characterization of the yeast negative regulatory protein GAL80
    S J Yun
    Laboratory of Molecular Genetics, Keio University School of Medicine, Tokyo, Japan
    J Biol Chem 266:693-7. 1991
    ..We have also purified mutant GAL80 proteins encoded by two different alleles of gal80 known to be incapable of inhibiting the function of GAL4. These proteins were, in fact, unable to bind GAL4...
  10. pmc Toward a protein-protein interaction map of the budding yeast: A comprehensive system to examine two-hybrid interactions in all possible combinations between the yeast proteins
    T Ito
    Human Genome Center, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 97:1143-7. 2000
    ..The approach described here thus will provide many leads for integration of various cellular functions and serve as a major driving force in the completion of the protein-protein interaction map...
  11. ncbi A set of Hox proteins interact with the Maf oncoprotein to inhibit its DNA binding, transactivation, and transforming activities
    K Kataoka
    Department of Virology, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokanedai, Minato ku 108 8639, Tokyo, Japan
    J Biol Chem 276:819-26. 2001
    ..These results suggested that the interaction of a set of Hox proteins with Maf family members may interfere not only with their oncogenicity but also with their physiological roles...
  12. pmc Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site
    T Oyake
    Department of Biochemistry, Tohoku University School of Medicine, Sendai, Japan
    Mol Cell Biol 16:6083-95. 1996
    ..The results suggest that members of the Bach family play important roles in coordinating transcription activation and repression by MafK...
  13. ncbi Regulation of transcription by dimerization of erythroid factor NF-E2 p45 with small Maf proteins
    K Igarashi
    Department of Biochemistry, Tohoku University School of Medicine, Sendai, Japan
    Nature 367:568-72. 1994
    ....
  14. ncbi Activity and expression of murine small Maf family protein MafK
    K Igarashi
    Department of Biochemistry, Tohoku University School of Medicine, Sendai, Japan
    J Biol Chem 270:7615-24. 1995
    ..mRNA for MafK is expressed in fractions enriched for hematopoietic stem cells as well as erythroid cells, suggesting that MafK plays an important regulatory role in hematopoiesis...
  15. pmc Cloning and characterization of a novel erythroid cell-derived CNC family transcription factor heterodimerizing with the small Maf family proteins
    K Itoh
    Department of Biochemistry, Tohoku University School of Medicine, Sendai, Japan
    Mol Cell Biol 15:4184-93. 1995
    ..In a transfection assay, ECH transactivates transcription depending on the presence of NF-E2 sites on the reporter gene plasmid. These results indicate that ECH is likely a key regulator of avian erythropoiesis...
  16. ncbi Identification of a gene conferring resistance to zinc and cadmium ions in the yeast Saccharomyces cerevisiae
    A Kamizono
    Biosciences Laboratory, Mitsubishi Kasei Corporation, Yokohama, Japan
    Mol Gen Genet 219:161-7. 1989
    ....
  17. pmc Clinical, molecular and histopathological features of short stature syndrome with novel CUL7 mutation in Yakuts: new population isolate in Asia
    N Maksimova
    Yakut Scientific Centre of Russian Academy of Medical Sciences and Government of Republic of Sakha Yakutia, Yakutsk, Russia
    J Med Genet 44:772-8. 2007
    ..In total, 43 patients having short stature syndrome in 37 Yakut families with autosomal recessive prenatal and postnatal nonprogressive growth failure and facial dysmorphism but with normal intelligence have been identified...
  18. ncbi cDNA cloning, expression and characterization of human prostaglandin F synthase
    T Suzuki-Yamamoto
    Department of Anatomy and Cell Biology, School of Medicine, The University of Tokushima, Kuramoto, Japan
    FEBS Lett 462:335-40. 1999
    ..These results support the notion that human PGFS plays an important role in the pathogenesis of allergic diseases such as asthma...
  19. ncbi Dysferlin mutations in Japanese Miyoshi myopathy: relationship to phenotype
    T Takahashi
    Department of Neurology, Tohoku University School of Medicine, Sendai, Japan
    Neurology 60:1799-804. 2003
    ..To study dysferlin gene mutations and genotype-phenotype correlations in Japanese patients with Miyoshi myopathy (MM)...
  20. ncbi Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes
    M Nishizawa
    Department of Medical Chemistry Department of Obstetrics and Gynecology, Kansai Medical University, 10 15 Fumizono, Moriguchi, Osaka 570 8506, Japan
    Genes Cells 5:111-25. 2000
    ..High homology between human 20alpha-HSD [AKR 1C1] cDNA with other AKRs had caused difficulty in gene isolation and expression analysis. Thus, the metabolism of progesterone in the human reproductive system remained unclear...
  21. pmc Keratin attenuates tumor necrosis factor-induced cytotoxicity through association with TRADD
    H Inada
    Division of Biochemistry, Aichi Cancer Center Research Institute, Aichi 464 8681, Japan
    J Cell Biol 155:415-26. 2001
    ..These results indicate that K18 may sequester TRADD to attenuate interactions between TRADD and activated TNFR1 and moderate TNF-induced apoptosis in simple epithelial cells...
  22. ncbi A large Japanese SPG4 family with a novel insertion mutation of the SPG4 gene: a clinical and genetic study
    M Namekawa
    Department of Neurology, Jichi Medical School, Tochigi 329-0498, Japan
    J Neurol Sci 185:63-8. 2001
    ..Clinically, it is noteworthy that the disease progression in the patients of this family was slow in spite of the late onset, and more than half of the patients showed severe constipation in addition to pure spastic paraplegia...
  23. ncbi Molecular cloning and sequencing of cDNA encoding the phosphatidylinositol kinase from rat brain
    A Yamakawa
    Department of Pharmacology, Tokyo Metropolitan Institute of Gerontology, Japan
    J Biol Chem 266:17580-3. 1991
    ..The messenger RNA for PI 4-kinase was found predominantly in brain and rat neural cell lines. This PI kinase may play a specific role in neural signal transduction...
  24. ncbi Analysis of all exons of TSC1 and TSC2 genes for germline mutations in Japanese patients with tuberous sclerosis: report of 10 mutations
    Y Yamashita
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Am J Med Genet 90:123-6. 2000
    ..e., (1) TSC1 mutations are rarer in sporadic cases than in familial cases, (2) substantial numbers of sporadic cases arise from mutations in the TSC2 gene, and (3) mutations of the TSC1 gene may cause premature truncation of hamartin...
  25. ncbi Regulation of lens fiber cell differentiation by transcription factor c-Maf
    S Kawauchi
    Center for Tsukuba Advanced Research Alliance and Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba 305 8577, Japan
    J Biol Chem 274:19254-60. 1999
    ..The expression of crystallin genes was severely impaired in the c-maf-null mutant mouse lens. These results demonstrate that c-Maf is an indispensable regulator of lens differentiation during murine development...
  26. ncbi Molecular cloning of cDNA and a chromosomal gene encoding GPE1-BP, a nuclear protein which binds to granulocyte colony-stimulating factor promoter element 1
    M Nishizawa
    Osaka Bioscience Institute, Japan
    FEBS Lett 282:95-7. 1991
    ..The nuclear extract from COS cells transfected with the cDNA showed GPE1-binding activity. Transcripts were ubiquitously detected, and may be spliced from two exons of a single gene...
  27. pmc Structure, expression, and chromosomal location of the human c-fgr gene
    M Nishizawa
    Mol Cell Biol 6:511-7. 1986
    ..Furthermore, karyotype analysis of several human-mouse hybrid cells and Southern blot analyses of DNAs of the hybrids with a human c-fgr locus-specific probe showed that this gene is located on chromosome 1...
  28. pmc cDNA structure, alternative splicing and exon-intron organization of the predisposing tuberous sclerosis (Tsc2) gene of the Eker rat model
    T Kobayashi
    Department of Experimental Pathology, Cancer Institute, Tokyo, Japan
    Nucleic Acids Res 23:2608-13. 1995
    ....
  29. pmc Small Maf proteins heterodimerize with Fos and may act as competitive repressors of the NF-E2 transcription factor
    K Kataoka
    Department of Viral Oncology, Cancer Institute, Tokyo, Japan
    Mol Cell Biol 15:2180-90. 1995
    ..These results raise the possibility that tissue-specific gene expression and differentiation of erythroid cells are regulated by competition among Fos, NF-E2 p45, and Ech for small Maf proteins and for binding sites...
  30. pmc MafB, a new Maf family transcription activator that can associate with Maf and Fos but not with Jun
    K Kataoka
    Department of Viral Oncology, Cancer Institute, Tokyo, Japan
    Mol Cell Biol 14:7581-91. 1994
    ..Through formation of numerous bZip dimers, the Maf family proteins along with the AP-1 components should provide great diversity in transcriptional regulation for a wide variety of genes...
  31. ncbi Molecular cloning of the aminopeptidase Y gene of Saccharomyces cerevisiae. Sequence analysis and gene disruption of a new aminopeptidase
    M Nishizawa
    Meiji Institute of Health Science, Odawara, Japan
    J Biol Chem 269:13651-5. 1994
    ..2 and 2.8%, respectively. Mutant cells showed no ability to hydrolyze Lys-Ala-MCA to Lys and Ala-MCA, although vacuolar carboxypeptidase Y activity was similar to that in wild-type cells...
  32. ncbi Gilbert's syndrome is caused by a heterozygous missense mutation in the gene for bilirubin UDP-glucuronosyltransferase
    O Koiwai
    Laboratories of Biochemistry, Aichi Cancer Center Research Institute, Nagoya, Japan
    Hum Mol Genet 4:1183-6. 1995
    ..However, the UGT activity of the patient with Gilbert's syndrome was unexpectedly < 50% of the normal, perhaps as the result of the dominant negative nature of the mutation...
  33. ncbi A novel two-base mutation in the Cu/Zn superoxide dismutase gene associated with familial amyotrophic lateral sclerosis in Japan
    M Morita
    Department of Neurology, Tohoku University School of Medicine, Japan
    Neurosci Lett 205:79-82. 1996
    ..These findings suggest that clinical courses are variable with each mutation, even in the same exon...
  34. pmc Small Maf proteins interact with the human transcription factor TCF11/Nrf1/LCR-F1
    O Johnsen
    Biotechnology Centre of Oslo, University of Oslo, Norway
    Nucleic Acids Res 24:4289-97. 1996
    ..These findings place TCF11 as a good candidate for the proposed widely expressed factor(s) known to interact with small Maf proteins and bind NF-E2 sites in a sequence-specific manner resembling NF-E2...
  35. ncbi Single sperm analysis of the CAG repeats in the gene for dentatorubral-pallidoluysian atrophy (DRPLA): the instability of the CAG repeats in the DRPLA gene is prominent among the CAG repeat diseases
    Y Takiyama
    Department of Neurology, Jichi Medical School, 3311 1 Minamikawachi, Kawachi, Tochigi 329 0498, Japan
    Hum Mol Genet 8:453-7. 1999
    ..161) from the expected 1:1 segregation ratio, and thus segregation distortion of expanded alleles in meiosis in male patients with DRPLA was not demonstrated...
  36. doi Total deletion and a missense mutation of ITPR1 in Japanese SCA15 families
    K Hara
    Department of Molecular Neuroscience, Center for Bioresource based Researches, Brain Research Institute, Niigata University, 1 757, Asahi machi dori, Niigata City 951 8585, Japan
    Neurology 71:547-51. 2008
    ..Recently, partial deletions involving both the type 1 inositol 1,4,5-triphosphate receptor (ITPR1) and sulfatase modifying factor 1 (SUMF1) genes have been identified in Australian and British families with SCA15...