Masaya Nakamura

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. pmc Novel concept of motor functional analysis for spinal cord injury in adult mice
    Munehisa Shinozaki
    Department of Physiology, Keio University School of Medicine, Shinjuku, Tokyo 160 8582, Japan
    J Biomed Biotechnol 2011:157458. 2011
  2. doi request reprint Clinical significance of diffusion tensor tractography as a predictor of functional recovery after laminoplasty in patients with cervical compressive myelopathy
    Masaya Nakamura
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    J Neurosurg Spine 17:147-52. 2012
  3. pmc Blockade of interleukin-6 signaling inhibits the classic pathway and promotes an alternative pathway of macrophage activation after spinal cord injury in mice
    Alexander Rodriguez Guerrero
    Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui, Matsuoka Shimoaizuki 23, Eiheiji, Fukui 910 1193, Japan
    J Neuroinflammation 9:40. 2012
  4. doi request reprint Long-term surgical outcomes of spinal meningiomas
    Masaya Nakamura
    Department of Orthopaedic Surgery, Keio University, Tokyo, Japan
    Spine (Phila Pa 1976) 37:E617-23. 2012
  5. pmc Severe progressive scoliosis due to huge subcutaneous cavernous hemangioma: A case report
    Yoji Ogura
    Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan
    Scoliosis 6:3. 2011
  6. pmc Long-term surgical outcomes of idiopathic spinal cord herniation
    Masaya Nakamura
    Department of Orthopedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160 8582, Japan
    J Orthop Sci 16:347-51. 2011
  7. ncbi request reprint Pleomorphic xanthoastrocytoma of the spinal cord. Case report
    Masaya Nakamura
    Department of Orthopedic Surgery, Keio University, Tokyo, Japan
    J Neurosurg Spine 5:72-5. 2006
  8. doi request reprint Cordotomy for patients with thoracic malignant astrocytoma
    Masaya Nakamura
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Shinjuku, Tokyo, Japan
    J Neurosurg Spine 13:418-23. 2010
  9. ncbi request reprint Retrospective study of surgery-related outcomes in patients with syringomyelia associated with Chiari I malformation: clinical significance of changes in the size and localization of syrinx on pain relief
    Masaya Nakamura
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    J Neurosurg 100:241-4. 2004
  10. doi request reprint Long-term surgical outcomes for myxopapillary ependymomas of the cauda equina
    Masaya Nakamura
    Department of Orthopedic Surgery, School of Medicine, Keio University, Shinjuku, Tokyo, Japan
    Spine (Phila Pa 1976) 34:E756-60. 2009

Detail Information

Publications96

  1. pmc Novel concept of motor functional analysis for spinal cord injury in adult mice
    Munehisa Shinozaki
    Department of Physiology, Keio University School of Medicine, Shinjuku, Tokyo 160 8582, Japan
    J Biomed Biotechnol 2011:157458. 2011
    ..Moreover, these values were significantly correlated with open-field scores. The maximum speed and acceleration of SCI model mice using a SCANET system are objective, easy to obtain, and reproducible for evaluating locomotive function...
  2. doi request reprint Clinical significance of diffusion tensor tractography as a predictor of functional recovery after laminoplasty in patients with cervical compressive myelopathy
    Masaya Nakamura
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    J Neurosurg Spine 17:147-52. 2012
    ....
  3. pmc Blockade of interleukin-6 signaling inhibits the classic pathway and promotes an alternative pathway of macrophage activation after spinal cord injury in mice
    Alexander Rodriguez Guerrero
    Department of Orthopaedics and Rehabilitation Medicine, Faculty of Medical Sciences, University of Fukui, Matsuoka Shimoaizuki 23, Eiheiji, Fukui 910 1193, Japan
    J Neuroinflammation 9:40. 2012
    ....
  4. doi request reprint Long-term surgical outcomes of spinal meningiomas
    Masaya Nakamura
    Department of Orthopaedic Surgery, Keio University, Tokyo, Japan
    Spine (Phila Pa 1976) 37:E617-23. 2012
    ..Retrospective case series...
  5. pmc Severe progressive scoliosis due to huge subcutaneous cavernous hemangioma: A case report
    Yoji Ogura
    Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan
    Scoliosis 6:3. 2011
    ....
  6. pmc Long-term surgical outcomes of idiopathic spinal cord herniation
    Masaya Nakamura
    Department of Orthopedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160 8582, Japan
    J Orthop Sci 16:347-51. 2011
    ..The purpose of this study is to determine the long-term effectiveness of this procedure...
  7. ncbi request reprint Pleomorphic xanthoastrocytoma of the spinal cord. Case report
    Masaya Nakamura
    Department of Orthopedic Surgery, Keio University, Tokyo, Japan
    J Neurosurg Spine 5:72-5. 2006
    ..To their knowledge, this is only the second report of a spinal cord PXA. In addition they provide a review of the literature on these tumors...
  8. doi request reprint Cordotomy for patients with thoracic malignant astrocytoma
    Masaya Nakamura
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Shinjuku, Tokyo, Japan
    J Neurosurg Spine 13:418-23. 2010
    ..In this study the authors investigated the surgical outcomes of cordotomy in patients with thoracic malignant astrocytomas to determine the effectiveness of this procedure...
  9. ncbi request reprint Retrospective study of surgery-related outcomes in patients with syringomyelia associated with Chiari I malformation: clinical significance of changes in the size and localization of syrinx on pain relief
    Masaya Nakamura
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    J Neurosurg 100:241-4. 2004
    ....
  10. doi request reprint Long-term surgical outcomes for myxopapillary ependymomas of the cauda equina
    Masaya Nakamura
    Department of Orthopedic Surgery, School of Medicine, Keio University, Shinjuku, Tokyo, Japan
    Spine (Phila Pa 1976) 34:E756-60. 2009
    ..Retrospective case series...
  11. ncbi request reprint Surgical treatment of intramedullary spinal cord tumors: prognosis and complications
    M Nakamura
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    Spinal Cord 46:282-6. 2008
    ..Retrospective case series...
  12. doi request reprint Clinical significance and prognosis of idiopathic syringomyelia
    Masaya Nakamura
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Shinjuku, Tokyo, Japan
    J Spinal Disord Tech 22:372-5. 2009
    ..Retrospective case series...
  13. pmc Prevalence and characteristics of chronic musculoskeletal pain in Japan
    Masaya Nakamura
    Department of Orthopaedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo, 160 8582, Japan
    J Orthop Sci 16:424-32. 2011
    ..This cross-sectional study was conducted to obtain epidemiologic data on chronic musculoskeletal pain in the Japanese people, and with it a better understanding of the actual conditions and problems involved...
  14. pmc Mimicking the neurotrophic factor profile of embryonic spinal cord controls the differentiation potential of spinal progenitors into neuronal cells
    Masaya Nakamura
    Department of Orthopaedic Surgery, Keio University, Tokyo, Japan
    PLoS ONE 6:e20717. 2011
    ..These findings suggest that endogenous CNTF and exogenous BDNF and NT-3 play roles in the differentiation of embryonic spinal cord derived progenitor cells into astrocytes, neurons and oligodendrocytes, respectively...
  15. doi request reprint Transplantation of galectin-1-expressing human neural stem cells into the injured spinal cord of adult common marmosets
    Junichi Yamane
    Department of Physiology, Keio University School of Medicine, Shinjuku, Tokyo, Japan
    J Neurosci Res 88:1394-405. 2010
    ..These findings suggest that Gal-NS/PCs have better therapeutic potential than NS/PCs for SCI in nonhuman primates and that human Gal-NS/PC transplantation might be a feasible treatment for human SCI...
  16. pmc Time-dependent changes in the microenvironment of injured spinal cord affects the therapeutic potential of neural stem cell transplantation for spinal cord injury
    Soraya Nishimura
    Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160 8582, Japan
    Mol Brain 6:3. 2013
    ..To address this question, NS/PC transplantation was performed after contusive spinal cord injury in adult mice at the sub-acute and chronic phases...
  17. pmc Pre-evaluated safe human iPSC-derived neural stem cells promote functional recovery after spinal cord injury in common marmoset without tumorigenicity
    Yoshiomi Kobayashi
    Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    PLoS ONE 7:e52787. 2012
    ..Taken together, these results indicate that pre-evaluated safe hiPSC-NS/PCs are a potential source of cells for the treatment of SCI in the clinic...
  18. ncbi request reprint Chondroitinase ABC combined with neural stem/progenitor cell transplantation enhances graft cell migration and outgrowth of growth-associated protein-43-positive fibers after rat spinal cord injury
    Takeshi Ikegami
    Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan
    Eur J Neurosci 22:3036-46. 2005
    ....
  19. pmc Therapeutic potential of appropriately evaluated safe-induced pluripotent stem cells for spinal cord injury
    Osahiko Tsuji
    Department of Physiology, School of Medicine, Keio University, Shinjuku, Tokyo 160 8582, Japan
    Proc Natl Acad Sci U S A 107:12704-9. 2010
    ..These findings suggest that pre-evaluated safe iPS clone-derived neural stem/progenitor cells may be a promising cell source for transplantation therapy for SCI...
  20. pmc Human hepatocyte growth factor promotes functional recovery in primates after spinal cord injury
    Kazuya Kitamura
    Department of Orthopedic Surgery, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    PLoS ONE 6:e27706. 2011
    ..In addition, this is the first presentation of a novel scale for assessing neurological motor performance in non-human primates after contusive cervical SCI...
  21. doi request reprint In vivo tracing of neural tracts in tiptoe walking Yoshimura mice by diffusion tensor tractography
    Morito Takano
    Department of Orthopaedic Surgery, Keio University, Shinanomachi 35, Shinjuku ku, Tokyo, Japan
    Spine (Phila Pa 1976) 38:E66-72. 2013
    ..Basic imaging experiment...
  22. doi request reprint Significance of remyelination by neural stem/progenitor cells transplanted into the injured spinal cord
    Akimasa Yasuda
    Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan
    Stem Cells 29:1983-94. 2011
    ..These findings establish the biological importance of remyelination by graft-derived cells for functional recovery after the transplantation of NS/PCs into the injured spinal cord...
  23. doi request reprint Posterior decompression surgery for extraforaminal entrapment of the fifth lumbar spinal nerve at the lumbosacral junction
    Morio Matsumoto
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    J Neurosurg Spine 12:72-81. 2010
    ..In this paper, the authors' goal was to elucidate the clinical features and results of decompression surgery for extraforaminal stenosis at the lumbosacral junction...
  24. pmc Roles of ES cell-derived gliogenic neural stem/progenitor cells in functional recovery after spinal cord injury
    Gentaro Kumagai
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 4:e7706. 2009
    ..These findings suggest that gliogenic NS/PCs are effective for promoting the recovery from SCI, and provide essential insight into the mechanisms through which cellular transplantation leads to functional improvement after SCI...
  25. doi request reprint Risk factors for closure of lamina after open-door laminoplasty
    Morio Matsumoto
    Department of Advanced Therapy for Spine and Spinal Cord Disorders, School of Medicine, Keio University, Tokyo, Japan
    J Neurosurg Spine 9:530-7. 2008
    ..This retrospective study was conducted to evaluate the prevalence and clinical consequences of postoperative lamina closure after open-door laminoplasty and to identify the risk factors...
  26. pmc Schwann-spheres derived from injured peripheral nerves in adult mice--their in vitro characterization and therapeutic potential
    Takehiko Takagi
    Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 6:e21497. 2011
    ....
  27. doi request reprint Steps toward safe cell therapy using induced pluripotent stem cells
    Hideyuki Okano
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Circ Res 112:523-33. 2013
    ..Insights on safety and preclinical use of iPSCs in cardiovascular repair model are also discussed...
  28. ncbi request reprint In vivo imaging of engrafted neural stem cells: its application in evaluating the optimal timing of transplantation for spinal cord injury
    Seiji Okada
    Department of Physiology, Keio University School of Medicine, Shinjuku, Tokyo, Japan
    FASEB J 19:1839-41. 2005
    ..Optimization of cell therapies can be greatly accelerated and refined by imaging, and the methods in the present study can be widely applied to various research fields of regeneration medicine, including transplantation study...
  29. pmc Vertebral derotation in adolescent idiopathic scoliosis causes hypokyphosis of the thoracic spine
    Kota Watanabe
    Department of Advanced Therapy for Spine and Spinal Cord Disorders, KeioUniversity, Tokyo, Japan
    BMC Musculoskelet Disord 13:99. 2012
    ..The purpose of this study was to test the hypothesis that direct vertebral derotation by pedicle screws (PS) causes hypokyphosis of the thoracic spine in adolescent idiopathic scoliosis (AIS) patients, using computer simulation...
  30. doi request reprint Morphologic evaluation of the thoracic vertebrae for safe free-hand pedicle screw placement in adolescent idiopathic scoliosis: a CT-based anatomical study
    Guanyu Cui
    Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160 8582, Japan
    Surg Radiol Anat 34:209-16. 2012
    ..To evaluate the morphologic characteristics of the thoracic pedicle with regard to safe free-hand thoracic pedicle screw placement, based on multi-planar reconstruction CT images...
  31. pmc Grafted human-induced pluripotent stem-cell-derived neurospheres promote motor functional recovery after spinal cord injury in mice
    Satoshi Nori
    Department of Physiology, School of Medicine, Keio University, Shinjuku, Tokyo 160 8582, Japan
    Proc Natl Acad Sci U S A 108:16825-30. 2011
    ..No tumor formation was observed in the hiPSC-NS-grafted mice. These findings suggest that hiPSCs give rise to neural stem/progenitor cells that support improved function post-SCI and are a promising cell source for its treatment...
  32. ncbi request reprint Postoperative factors affecting neurological recovery after surgery for cervical spondylotic myelopathy
    Yuto Ogawa
    Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan
    J Neurosurg Spine 5:483-7. 2006
    ..The purpose of this study was to elucidate such postoperative factors affecting neurological recovery...
  33. ncbi request reprint Hepatocyte growth factor promotes endogenous repair and functional recovery after spinal cord injury
    Kazuya Kitamura
    Department of Orthopaedic Surgery, Keio University School of Medicine, Shinjuku, Tokyo, Japan
    J Neurosci Res 85:2332-42. 2007
    ..These results suggest that HGF gene delivery to the injured spinal cord exerts multiple beneficial effects and enhances endogenous repair after SCI. This is the first study to demonstrate the efficacy of HGF for SCI...
  34. doi request reprint Progressive kyphoscoliosis associated with tethered cord treated by posterior vertebral column resection: a case report
    Morio Matsumoto
    Departments of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    Spine (Phila Pa 1976) 34:E965-8. 2009
    ..0%). CONCLUSION.: Correction of progressive kyphoscoliosis associated with a tethered cord can be achieved successfully by posterior vertebral column resection even after complicated untethering surgery...
  35. doi request reprint Late instrumentation failure after total en bloc spondylectomy
    Morio Matsumoto
    Department of Orthopaedic Surgery, Keio University, Tokyo, Japan
    J Neurosurg Spine 15:320-7. 2011
    ..The object of this study was to investigate failures after spinal reconstruction following total en bloc spondylectomy (TES), related factors, and sequelae arising from such failures in patients with malignant spinal tumors...
  36. doi request reprint Nocturnal leg cramps: a common complaint in patients with lumbar spinal canal stenosis
    Morio Matsumoto
    Department of Advanced Therapy for Spine and Spinal Cord Disease, School of Medicine, Keio University, Tokyo, Japan
    Spine (Phila Pa 1976) 34:E189-94. 2009
    ..Questionnaire survey on leg cramps for patients with lumbar spinal canal stenosis (LCS)...
  37. ncbi request reprint Implantation of dendritic cells in injured adult spinal cord results in activation of endogenous neural stem/progenitor cells leading to de novo neurogenesis and functional recovery
    Yuji Mikami
    Neuroimmunology Research Group, Keio University School of Medicine, Tokyo, Japan
    J Neurosci Res 76:453-65. 2004
    ..Our results suggest that DC-implantation exerts trophic effects, including activation of endogenous NSPCs, leading to repair of the injured adult spinal cord...
  38. doi request reprint Risk factors for development of subaxial subluxations following atlantoaxial arthrodesis for atlantoaxial subluxations in rheumatoid arthritis
    Ken Ishii
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Shinjuku, Tokyo, Japan
    Spine (Phila Pa 1976) 35:1551-5. 2010
    ..Retrospective radiographic/imaging study...
  39. doi request reprint Recurrence of lumbar disc herniation after microendoscopic discectomy
    Morio Matsumoto
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    J Neurol Surg A Cent Eur Neurosurg 74:222-7. 2013
    ..The purpose of the present study was to retrospectively investigate the recurrence rate after MED for LDH and to determine the risk factors for recurrence in patients treated by a single surgeon...
  40. doi request reprint Transplantation of dendritic cells promotes functional recovery from spinal cord injury in common marmoset
    Masae Yaguchi
    Neuroimmunology Research Group, Keio University School of Medicine, Tokyo 160 8582, Japan
    Neurosci Res 65:384-92. 2009
    ..These results suggest DC therapy to possibly be beneficial in primates with SCI and that this treatment has potential for clinical application...
  41. doi request reprint Long-term surgical outcomes of cervical dumbbell neurinomas
    Masaya Nakamura
    Department of Orthopaedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    J Orthop Sci 18:8-13. 2013
    ..Retrospective case series...
  42. doi request reprint Conditions for quantitative evaluation of injured spinal cord by in vivo diffusion tensor imaging and tractography: preclinical longitudinal study in common marmosets
    Tsunehiko Konomi
    Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Neuroimage 63:1841-53. 2012
    ..FA-value-oriented color DTT was used to represent axonal sparing or regeneration of the different tracts. These findings indicated that DTT analysis might be a versatile non-invasive tool for evaluating the axonal disruption after SCI...
  43. doi request reprint Central neuropathic pain after surgical resection in patients with spinal intramedullary tumor
    Masaya Nakamura
    Department of Orthopaedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    J Orthop Sci 17:352-7. 2012
    ..Retrospective case series...
  44. pmc Loss of apical vertebral derotation in adolescent idiopathic scoliosis: 2-year follow-up using multi-planar reconstruction computed tomography
    Guanyu Cui
    Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan
    Eur Spine J 21:1111-20. 2012
    ..The objective of this study was to evaluate 2 years post-surgical loss of three-dimensional correction in adolescent idiopathic scoliosis (AIS) patients using multi-planar reconstruction computed tomography (CT)...
  45. doi request reprint Evaluation of human fetal neural stem/progenitor cells as a source for cell replacement therapy for neurological disorders: properties and tumorigenicity after long-term in vitro maintenance
    Daisuke Ogawa
    Department of Physiology, School of Medicine, Keio University, Tokyo, Japan
    J Neurosci Res 87:307-17. 2009
    ..These findings support the idea that hNS/PCs may represent a nontumorigenic, safe, and appropriate cell source for regenerative therapies for neurological disorders...
  46. ncbi request reprint Establishment of three-dimensional culture of neural stem/progenitor cells in collagen Type-1 Gel
    Kota Watanabe
    Department of Orthopaedic Surgery, Keio University 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Restor Neurol Neurosci 25:109-17. 2007
    ..We, then, evaluated the ability of NSPCs to differentiate under the optimal condition...
  47. ncbi request reprint Comparison between fetal spinal-cord- and forebrain-derived neural stem/progenitor cells as a source of transplantation for spinal cord injury
    Kota Watanabe
    Department of Orthopaedic Surgery, Keio University, Tokyo, Japan
    Dev Neurosci 26:275-87. 2004
    ..In conclusion, forebrain-derived NSPCs could be used as an alternative to spinal-cord-derived NSPCs as a potential therapeutic agent for spinal cord injuries...
  48. doi request reprint Schwann cell plasticity after spinal cord injury shown by neural crest lineage tracing
    Narihito Nagoshi
    Department of Physiology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Glia 59:771-84. 2011
    ..This process, involving Schwann cell plasticity, is a novel repair mechanism for the lesioned mammalian spinal cord...
  49. ncbi request reprint Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury
    Seiji Okada
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nat Med 12:829-34. 2006
    ..These results suggest that Stat3 is a key regulator of reactive astrocytes in the healing process after SCI, providing a potential target for intervention in the treatment of CNS injury...
  50. doi request reprint Diffusion tensor imaging and tractography of the spinal cord: from experimental studies to clinical application
    Kanehiro Fujiyoshi
    Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Exp Neurol 242:74-82. 2013
    ..In this review we outline the basic principles of DTT, and describe the characteristics, limitations, and future uses of DTT to examine the spinal cord...
  51. doi request reprint Impact of lamina closure on long-term outcomes of open-door laminoplasty in patients with cervical myelopathy: minimum 5-year follow-up study
    Morio Matsumoto
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    Spine (Phila Pa 1976) 37:1288-91. 2012
    ..A prospective follow-up study...
  52. ncbi request reprint Long-term results after expansive open-door laminoplasty for the segmental-type of ossification of the posterior longitudinal ligament of the cervical spine: a comparison with nonsegmental-type lesions
    Yuto Ogawa
    Department of Orthopedic Surgery, School of Medicine Keio University, Shinjuku, Tokyo, Japan
    J Neurosurg Spine 3:198-204. 2005
    ..To clarify this issue, the long-term results after surgical treatment of segmental-type OPLL were compared with those of other types...
  53. pmc Beneficial compaction of spinal cord lesion by migrating astrocytes through glycogen synthase kinase-3 inhibition
    Francois Renault-Mihara
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    EMBO Mol Med 3:682-96. 2011
    ..Our results reveal a novel benefit of GSK-3 inhibition for SCI and suggest that the stimulation of astrocyte migration is a feasible therapeutic strategy for traumatic injury in the central nervous system...
  54. doi request reprint Ball tip technique for thoracic pedicle screw placement in patients with adolescent idiopathic scoliosis
    Kota Watanabe
    Department of Advanced Treatment for Spine and Spinal Cord Disorders, Keio University School of Medicine, Tokyo, Japan
    J Neurosurg Spine 13:246-52. 2010
    ..To further enhance the accuracy and safety of TPS placement, the authors developed the ball tip technique...
  55. doi request reprint Surgical treatment for scoliosis in patients with Shprintzen-Goldberg syndrome
    Kota Watanabe
    Department of Advanced Therapy for Spine and Spinal Cord Disorders, Keio University School of Medicine, Tokyo, Japan
    J Pediatr Orthop 31:186-93. 2011
    ..Among these skeletal findings, developmental scoliosis is recognized in half of all patients with SGS. However, no earlier reports have described the surgical treatment of scoliosis associated with SGS...
  56. doi request reprint Remodeling of C2 facet deformity prevents recurrent subluxation in patients with chronic atlantoaxial rotatory fixation: a novel strategy for treatment of chronic atlantoaxial rotatory fixation
    Ken Ishii
    Departments of Orthopaedic Surgery, School of Medicine, Keio University, Shinjuku, Tokyo, Japan
    Spine (Phila Pa 1976) 36:E256-62. 2011
    ..A retrospective case series...
  57. doi request reprint Complicated surgical resection of malignant tumors in the upper cervical spine after failed ion-beam radiation therapy
    Morio Matsumoto
    Departments of Orthopaedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Spine (Phila Pa 1976) 35:E505-9. 2010
    ..Case report...
  58. doi request reprint Anti-IL-6-receptor antibody promotes repair of spinal cord injury by inducing microglia-dominant inflammation
    Masahiko Mukaino
    Department of Rehabilitation Medicine, Keio University School of Medicine, Shinjuku, Tokyo 160 8582, Japan
    Exp Neurol 224:403-14. 2010
    ..Our findings indicate that the functional improvement elicited by MR16-1 involves microglial functions, and provide new insights into the role of IL-6 signaling in the pathology of SCI...
  59. ncbi request reprint A selective Sema3A inhibitor enhances regenerative responses and functional recovery of the injured spinal cord
    Shinjiro Kaneko
    Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjyuku ku, Tokyo 160 8582, Japan
    Nat Med 12:1380-9. 2006
    ..Thus, Sema3A is essential for the inhibition of axonal regeneration and other regenerative responses after spinal cord injury (SCI). These results support the possibility of using Sema3A inhibitors in the treatment of human SCI...
  60. doi request reprint Serum cartilage metabolites as biomarkers of degenerative lumbar scoliosis
    Naobumi Hosogane
    Orthopedic Surgery, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo 160 8582, Japan
    J Orthop Res 30:1249-53. 2012
    ..As type II collagen is a major component of collagens in the nucleus pulposus and facet joint cartilages, its enhanced turnover may be related to the development and progression of DLS...
  61. pmc Sox10-Venus mice: a new tool for real-time labeling of neural crest lineage cells and oligodendrocytes
    Shinsuke Shibata
    Department of Physiology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Mol Brain 3:31. 2010
    ..We generated Sox10-Venus BAC transgenic mice to monitor Sox10 expression in both normal development and in pathological processes...
  62. doi request reprint Visualization of peripheral nerve degeneration and regeneration: monitoring with diffusion tensor tractography
    Takehiko Takagi
    Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan
    Neuroimage 44:884-92. 2009
    ....
  63. doi request reprint Total en bloc spondylectomy for spinal metastasis of differentiated thyroid cancers: a long-term follow-up
    Morio Matsumoto
    Department of Orthopaedic Surgery, Keio University, Tokyo, Japan
    J Spinal Disord Tech 26:E137-42. 2013
    ..A retrospective case series...
  64. doi request reprint Surgical treatment of spinal extradural arachnoid cysts in the thoracolumbar spine
    Haruki Funao
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    Neurosurgery 71:278-84; discussion 284. 2012
    ..Because an idiopathic spinal extradural arachnoid cyst (SEAC) is rare, its optimal surgical treatment remains controversial...
  65. ncbi request reprint Long-term results of expansive open-door laminoplasty for cervical myelopathy--average 14-year follow-up study
    Kazuhiro Chiba
    Department of Orthopaedic Surgery, Keio University, Tokyo, Japan
    Spine (Phila Pa 1976) 31:2998-3005. 2006
    ..Retrospective case series on long-term follow-up results of original expansive open-door laminoplasty for cervical myelopathy due to cervical spondylosis (CSM) and ossification of posterior longitudinal ligament (OPLL)...
  66. pmc Efficient derivation of multipotent neural stem/progenitor cells from non-human primate embryonic stem cells
    Hiroko Shimada
    Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    PLoS ONE 7:e49469. 2012
    ....
  67. pmc MRI characterization of paranodal junction failure and related spinal cord changes in mice
    Morito Takano
    Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 7:e52904. 2012
    ..These findings demonstrate the potential of using MRI and DTI to evaluate white matter disorders that involve paranodal junction failure...
  68. ncbi request reprint Sustained bFGF-release tubes for peripheral nerve regeneration: comparison with autograft
    Takehiko Takagi
    Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo, Japan
    Plast Reconstr Surg 130:866-76. 2012
    ..To improve this technique, the authors examined conduits containing gelatin hydrogel as a carrier enabling the sustained release of basic fibroblast growth factor (bFGF)...
  69. ncbi request reprint In vivo tracing of neural tracts in the intact and injured spinal cord of marmosets by diffusion tensor tractography
    Kanehiro Fujiyoshi
    Department of Orthopaedic Surgery, Keio University School of Medicine, Shinjuku, Tokyo 160 8582, Japan
    J Neurosci 27:11991-8. 2007
    ..Taken together, these findings demonstrate the feasibility of applying DTT to preclinical and clinical studies of spinal cord injury...
  70. pmc The dual origin of the peripheral olfactory system: placode and neural crest
    Hiroyuki Katoh
    Department of Orthopaedic Surgery, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Mol Brain 4:34. 2011
    ....
  71. doi request reprint Comparative study of methods for administering neural stem/progenitor cells to treat spinal cord injury in mice
    Yuichiro Takahashi
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    Cell Transplant 20:727-39. 2011
    ..In terms of grafted cell survival and safety, we conclude that the IL application of NS/PCs is the most effective and feasible method for transplanting NS/PCs into the SCI site...
  72. ncbi request reprint Usefulness of neurological examination for diagnosis of the affected level in patients with cervical compressive myelopathy: prospective comparative study with radiological evaluation
    Morio Matsumoto
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    J Neurosurg Spine 2:535-9. 2005
    ..Although neurological examination is the key step to reaching a correct diagnosis of cervical compressive myelopathy (CCM), the accuracy of diagnosis of the affected spinal level for CCM has not yet been tested...
  73. ncbi request reprint Pathognomonic radiological signs for predicting prognosis in patients with chronic atlantoaxial rotatory fixation
    Ken Ishii
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    J Neurosurg Spine 5:385-91. 2006
    ..The authors conducted a study to assess the correlation between radiological features and clinical courses in patients with chronic atlantoaxial rotatory fixation (AARF) and to determine diagnostic imaging signs for predicting prognosis...
  74. ncbi request reprint Extensive total spondylectomy for recurrent giant cell tumor in the thoracic spine. Case report
    Morio Matsumoto
    Department of Musculoskeletal Reconstruction and Regeneration Surgery, School of Medicine, Keio University, Tokyo, Japan
    J Neurosurg Spine 6:600-5. 2007
    ..This surgical technique can be an effective option for this pathological condition, which is difficult to manage using other conventional treatment options including repeated curettage and radiotherapy...
  75. doi request reprint Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad
    Narihito Nagoshi
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Cell Stem Cell 2:392-403. 2008
    ..The identification of NCSCs in accessible adult tissue provides a new potential source for autologous cell therapy after nerve injury or disease...
  76. ncbi request reprint Spinal kyphosis causes demyelination and neuronal loss in the spinal cord: a new model of kyphotic deformity using juvenile Japanese small game fowls
    Kentaro Shimizu
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    Spine (Phila Pa 1976) 30:2388-92. 2005
    ..Histologic changes in the spinal cord caused by progressive spinal kyphosis were assessed using a new animal model...
  77. ncbi request reprint Long-term results of expansive open-door laminoplasty for ossification of the posterior longitudinal ligament of the cervical spine
    Yuto Ogawa
    Department of Orthopedic Surgery, Keio University School of Medicine, Shinjuku, Tokyo, Japan
    J Neurosurg Spine 1:168-74. 2004
    ..To address this issue, the authors assessed the benefits and limitations of expansive open-door laminoplasty for OPLL-related myelopathy by evaluating mid- and long-term clinical results...
  78. ncbi request reprint Disease progression of human SOD1 (G93A) transgenic ALS model rats
    Arifumi Matsumoto
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    J Neurosci Res 83:119-33. 2006
    ..In particular, the onset of muscle weakness coincided with the loss of approximately 50% of spinal motor neurons. This study should provide a valuable tool for future experiments to test potential ALS therapies...
  79. doi request reprint Sterility of posterior elements of the spine in posterior correction surgery
    Yuta Shiono
    Department of Orthopaedic Surgery, Keio University, Tokyo, Japan
    Spine (Phila Pa 1976) 37:523-6. 2012
    ..Prospective clinical series...
  80. doi request reprint A rare case of spinal dumbbell tanycytic ependymoma
    Hiroko Ishihama
    Department of Orthopedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    Spine (Phila Pa 1976) 36:E612-4. 2011
    ..Case report...
  81. ncbi request reprint Targeted expression of anti-apoptotic protein p35 in oligodendrocytes reduces delayed demyelination and functional impairment after spinal cord injury
    Mutsuhiro Tamura
    Department of Orthopaedic Surgery, Keio University School of Medicine, Tokyo, Japan
    Glia 51:312-21. 2005
    ..Thus, the inhibition of OLG apoptosis decreased the extent of functional impairment after SCI. These findings suggest that the inhibition of OLG apoptosis may be a potential treatment for SCI...
  82. pmc Comparative study of spinopelvic sagittal alignment between patients with and without degenerative spondylolisthesis
    Haruki Funao
    Department of Orthopeadic Surgery, School of Medicine, Keio University, 35 Shinjuku, 160 8582, Tokyo, Japan
    Eur Spine J 21:2181-7. 2012
    ..The objectives of this study were to compare differences in spinopelvic sagittal alignment between patients with or without DS and to elucidate factors related to spinopelvic sagittal alignment...
  83. doi request reprint Spatiotemporal and anatomical analyses of P2X receptor-mediated neuronal and glial processing of sensory signals in the rat dorsal horn
    Ryoma Aoyama
    Department of Orthopaedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Pain 152:2085-97. 2011
    ..Astrocytes are involved in sensitization of sensory network activity more importantly in the superficial than in the deep layer...
  84. doi request reprint Matrix metalloproteinase 13 in the ligamentum flavum from lumbar spinal canal stenosis patients with and without diabetes mellitus
    Guanyu Cui
    Department of Orthopedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, 160 8582, Japan
    J Orthop Sci 16:785-90. 2011
    ....
  85. pmc Transplantation of human neural stem/progenitor cells overexpressing galectin-1 improves functional recovery from focal brain ischemia in the Mongolian gerbil
    Junichi Yamane
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    Mol Brain 4:35. 2011
    ..This study provides evidence for a potential application of hGal1 with hNSPCs-transplantation in the treatment of brain ischemia...
  86. pmc Cell therapy for spinal cord injury by neural stem/progenitor cells derived from iPS/ES cells
    Osahiko Tsuji
    Department of Orthopaedic Surgery, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Neurotherapeutics 8:668-76. 2011
    ..In this review, we outline the neural induction of mouse embryonic stem cells and induced pluripotent stem cells, their therapeutic efficacy in spinal cord injury, and their safety in vivo...
  87. ncbi request reprint Microendoscopic partial resection of the sacral ala to relieve extraforaminal entrapment of the L-5 spinal nerve at the lumbosacral tunnel. Technical note
    Morio Matsumoto
    Department of Musculoskeletal Reconstruction and Regeneration Surgery, School of Medicine, Keio University, Tokyo, Japan
    J Neurosurg Spine 4:342-6. 2006
    ..Microendoscopic partial resection of the sacral ala is an effective and minimally invasive surgical option for patients with extraforaminal entrapment of the L-5 spinal nerve...
  88. ncbi request reprint Role of IL-6 in spinal cord injury in a mouse model
    Masaya Nakamura
    Department of Orthopedic Surgery, Keio University School of Medicine, Tokyo 160 8582, Japan
    Clin Rev Allergy Immunol 28:197-204. 2005
    ..This article presents the data from this investigation and discusses the relationship between IL-6 signals and spinal cord injury...
  89. ncbi request reprint Regeneration-based therapies for spinal cord injuries
    Hideyuki Okano
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Neurochem Int 51:68-73. 2007
    ....
  90. doi request reprint Spinal cord injury: emerging beneficial role of reactive astrocytes' migration
    Francois Renault-Mihara
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Int J Biochem Cell Biol 40:1649-53. 2008
    ..Stimulation of reactive astrocytes migration in the sub-acute phase of SCI might thus represent a new approach to improve the functional outcome of patients...
  91. doi request reprint Neural crest-derived stem cells display a wide variety of characteristics
    Narihito Nagoshi
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Cell Biochem 107:1046-52. 2009
    ..In this review, we discuss the origin, migration, and lineage potential of NCSCs from various mammalian tissue sources...
  92. ncbi request reprint [Transplantation of neural stem cells for spinal cord injury]
    Masaya Nakamura
    Department of Orthopedic Surgery, Keio University, School of Medicine
    Rinsho Shinkeigaku 45:874-6. 2005
    ..These results indicate that in vitro expanded NSCs derived from human fetal spinal cord are useful sources for the therapeutics of spinal cord injury in primates...
  93. ncbi request reprint Neural stem cells and regeneration of injured spinal cord
    Hideyuki Okano
    Department of Physiology, Keio University School of Medicine, Tokyo, Japan
    Kidney Int 68:1927-31. 2005
    ....
  94. doi request reprint Diffusion-tensor neuronal fiber tractography and manganese-enhanced MR imaging of primate visual pathway in the common marmoset: preliminary results
    Masayuki Yamada
    Central Institute for Experimental Animals, Collaborating Institute for Graduate School of Medicine, Keio University, Tokyo, Japan
    Radiology 249:855-64. 2008
    ....
  95. doi request reprint Radiographic predictors of residual low back pain after laminectomy for lumbar spinal canal stenosis: minimum 5-year follow-up
    Yingpeng Xia
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    J Spinal Disord Tech 21:153-8. 2008
    ..Retrospective study of patients who underwent laminectomy for unification...
  96. ncbi request reprint Posterior osteotomy and instrumentation for thoracolumbar kyphosis in patients with achondroplasia
    Xin Qi
    Department of Musculoskeletal Reconstruction and Regeneration Surgery, School of Medicine, Keio University, Tokyo, Japan
    Spine (Phila Pa 1976) 31:E606-10. 2006
    ..A retrospective case series of surgically treated achondroplastic patients with severe thoracolumbar kyphosis...