Shinichiro Nakada

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. doi Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1
    Shinichiro Nakada
    Center of Integrated Medical Research, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo, 160 8582, Japan
    Nature 466:941-6. 2010
  2. doi Abnormalities in DNA double-strand break response beyond primary immunodeficiency
    Shinichiro Nakada
    Center of Integrated Medical Research, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Int J Hematol 93:425-33. 2011
  3. ncbi Identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (ATM) gene in childhood Hodgkin disease
    Masatoshi Takagi
    Department of Pediatrics and Developmental Biology, Postgraduate Medical School, Tokyo Medical and Dental University, Tokyo, Japan
    Blood 103:283-90. 2004
  4. doi Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism
    Eriko Nitta
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Tokyo, Japan
    Blood 117:4169-80. 2011
  5. pmc Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations
    Shinichiro Nakada
    Department of Pediatrics and Developmental Biology, Graduate Medical School, and Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Clin Invest 116:80-9. 2006

Collaborators

Detail Information

Publications5

  1. doi Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1
    Shinichiro Nakada
    Center of Integrated Medical Research, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo, 160 8582, Japan
    Nature 466:941-6. 2010
    ..Finally, OTUB1 depletion mitigates the DSB repair defect associated with defective ATM signalling, indicating that pharmacological targeting of the OTUB1-UBC13 interaction might enhance the DNA damage response...
  2. doi Abnormalities in DNA double-strand break response beyond primary immunodeficiency
    Shinichiro Nakada
    Center of Integrated Medical Research, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Int J Hematol 93:425-33. 2011
    ..Recent studies have begun to clarify the mechanisms underlying the molecular pathogenesis of such DNA DSB-related primary immunodeficiency...
  3. ncbi Identification and characterization of polymorphic variations of the ataxia telangiectasia mutated (ATM) gene in childhood Hodgkin disease
    Masatoshi Takagi
    Department of Pediatrics and Developmental Biology, Postgraduate Medical School, Tokyo Medical and Dental University, Tokyo, Japan
    Blood 103:283-90. 2004
    ..We conclude that the rare polymorphic variants of the ATM gene that we identified in children with HD encode functionally abnormal proteins, and we discuss the possible genetic risk factors for childhood HD...
  4. doi Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism
    Eriko Nitta
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Tokyo, Japan
    Blood 117:4169-80. 2011
    ..The current study demonstrates that TERT mitigates aging by protecting HSCs under stressful conditions through telomere length-independent mechanisms...
  5. pmc Early G2/M checkpoint failure as a molecular mechanism underlying etoposide-induced chromosomal aberrations
    Shinichiro Nakada
    Department of Pediatrics and Developmental Biology, Graduate Medical School, and Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan
    J Clin Invest 116:80-9. 2006
    ....