T Mitsudomi

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. ncbi request reprint Prognostic significance of p53 alterations in patients with non-small cell lung cancer: a meta-analysis
    T Mitsudomi
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    Clin Cancer Res 6:4055-63. 2000
  2. ncbi request reprint Molecular lesions as targets for diagnosis and therapy of lung cancer
    Tetsuya Mitsudomi
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Gan To Kagaku Ryoho 29:112-6. 2002
  3. pmc p53 mutations in non-small-cell lung cancers occurring in individuals without a past history of active smoking
    Y Takagi
    Laboratory of Ultrastructure Research, Aichi Cancer Center Research Institute, Nagoya, Japan
    Br J Cancer 77:1568-72. 1998
  4. pmc Topographical distributions of allelic loss in individual non-small-cell lung cancers
    Y Yatabe
    Department of Pathology and Clinical Laboratorie, Aichi Cancer Center Hospital, Nagoya, Japan
    Am J Pathol 157:985-93. 2000
  5. pmc Dietary factors and lung cancer risk in Japanese: with special reference to fish consumption and adenocarcinomas
    T Takezaki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, 464 8681, Nagoya, Japan
    Br J Cancer 84:1199-206. 2001
  6. ncbi request reprint Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas
    H Sakamoto
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan
    J Pathol 212:287-94. 2007
  7. pmc Persistent increase in chromosome instability in lung cancer: possible indirect involvement of p53 inactivation
    N Haruki
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Am J Pathol 159:1345-52. 2001
  8. ncbi request reprint Time to first cigarette and lung cancer risk in Japan
    H Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Ann Oncol 24:2870-5. 2013
  9. doi request reprint Identifying patients with peripheral-type early non-small cell lung cancer (T1N0M0) for whom irradiation of the primary focus alone could lead to successful treatment
    N Fuwa
    Department of Radiation Oncology, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya, Japan
    Br J Radiol 81:815-20. 2008
  10. ncbi request reprint Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach
    S Tomida
    Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Oncogene 26:4600-8. 2007

Collaborators

Detail Information

Publications72

  1. ncbi request reprint Prognostic significance of p53 alterations in patients with non-small cell lung cancer: a meta-analysis
    T Mitsudomi
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    Clin Cancer Res 6:4055-63. 2000
    ..Whether p53 alteration also provides information that can alter treatment decisions should be asked in clinical trials...
  2. ncbi request reprint Molecular lesions as targets for diagnosis and therapy of lung cancer
    Tetsuya Mitsudomi
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Gan To Kagaku Ryoho 29:112-6. 2002
    ..Here, we would like to discuss p53 alterations as a prognostic factor for lung cancer patients or as a predictor of chemosensitivity...
  3. pmc p53 mutations in non-small-cell lung cancers occurring in individuals without a past history of active smoking
    Y Takagi
    Laboratory of Ultrastructure Research, Aichi Cancer Center Research Institute, Nagoya, Japan
    Br J Cancer 77:1568-72. 1998
    ..This study is, to our knowledge, the largest so far analysing a well-defined cohort of non-smokers in a single laboratory...
  4. pmc Topographical distributions of allelic loss in individual non-small-cell lung cancers
    Y Yatabe
    Department of Pathology and Clinical Laboratorie, Aichi Cancer Center Hospital, Nagoya, Japan
    Am J Pathol 157:985-93. 2000
    ..Furthermore, the present study indicated that cross-sectional examination of individual tumors is also important for better understanding of molecular pathogenesis of lung cancers...
  5. pmc Dietary factors and lung cancer risk in Japanese: with special reference to fish consumption and adenocarcinomas
    T Takezaki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, 464 8681, Nagoya, Japan
    Br J Cancer 84:1199-206. 2001
    ..This study suggests cooked/raw fish consumption lowers the risk of adenocarcinoma of the lung in Japanese...
  6. ncbi request reprint Disproportionate representation of KRAS gene mutation in atypical adenomatous hyperplasia, but even distribution of EGFR gene mutation from preinvasive to invasive adenocarcinomas
    H Sakamoto
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan
    J Pathol 212:287-94. 2007
    ..Taking these factors together, it is suggested that AAH could develop by either KRAS or EGFR gene mutation, but AAH harbouring a KRAS gene mutation might not progress further to an invasive cancer...
  7. pmc Persistent increase in chromosome instability in lung cancer: possible indirect involvement of p53 inactivation
    N Haruki
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Am J Pathol 159:1345-52. 2001
    ....
  8. ncbi request reprint Time to first cigarette and lung cancer risk in Japan
    H Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Ann Oncol 24:2870-5. 2013
    ..Cigarette smoking is the major cause of lung cancer (LC). Although the time to first cigarette (TTFC) of the day is a distinct indicator of nicotine dependence, little information is available on its possible relation to LC...
  9. doi request reprint Identifying patients with peripheral-type early non-small cell lung cancer (T1N0M0) for whom irradiation of the primary focus alone could lead to successful treatment
    N Fuwa
    Department of Radiation Oncology, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya, Japan
    Br J Radiol 81:815-20. 2008
    ..5 cm in diameter. The proportion of our patients fitting these criteria was approximately 30%. For these patients, stereotactic body radiotherapy and particle therapy may be indicated...
  10. ncbi request reprint Identification of a metastasis signature and the DLX4 homeobox protein as a regulator of metastasis by combined transcriptome approach
    S Tomida
    Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Oncogene 26:4600-8. 2007
    ....
  11. ncbi request reprint Identification of an epitope from the epithelial cell adhesion molecule eliciting HLA-A*2402-restricted cytotoxic T-lymphocyte responses
    K Tajima
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Tissue Antigens 64:650-9. 2004
    ..All these data suggest that the peptide-specific CTL responses may play some roles both in anti-cancer and autoimmune reactions. The peptide should prove useful to study anti-Ep-CAM CTL responses among population possessing HLA-A*2402...
  12. doi request reprint Subcategorization of resectable non-small cell lung cancer involving neighboring structures
    Noriaki Sakakura
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    Ann Thorac Surg 86:1076-83; discussion 1083. 2008
    ..Although the prognoses of patients with resectable lung cancer involving neighboring structures vary, the current tumor-nodes-metastasis (TNM) classification system does not elucidate criteria for tumor subcategorization...
  13. ncbi request reprint Epidermal growth factor receptor mutations in lung cancers
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya, Japan
    Pathol Int 57:233-44. 2007
    ..In the present study the current knowledge of EGFR mutations is reviewed, insights from which raise many further questions, and thus suggest new directions for future research...
  14. ncbi request reprint Impact of one-carbon metabolism-related gene polymorphisms on risk of lung cancer in Japan: a case control study
    Takeshi Suzuki
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Carcinogenesis 28:1718-25. 2007
    ..Further evaluation is warranted...
  15. ncbi request reprint MET amplification leads to gefitinib resistance in lung cancer by activating ERBB3 signaling
    Jeffrey A Engelman
    Massachusetts General Hospital Cancer Center, Boston, MA 02114, USA
    Science 316:1039-43. 2007
    ..Thus, we propose that MET amplification may promote drug resistance in other ERBB-driven cancers as well...
  16. ncbi request reprint Prospective validation for prediction of gefitinib sensitivity by epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer
    Kimihide Yoshida
    Department of Thoracic Oncology, Aichi Cancer Center Hospital, Nagoya, Japan
    J Thorac Oncol 2:22-8. 2007
    ..We evaluated the efficacy of gefitinib monotherapy prospectively in patients with advanced or pretreated non-small cell lung cancer (NSCLC) harboring epidermal growth factor receptor (EGFR) mutations...
  17. ncbi request reprint PTEN and PIK3CA expression is associated with prolonged survival after gefitinib treatment in EGFR-mutated lung cancer patients
    Hideki Endoh
    Department of Thoracic Surgery, Aichi Cancer Center Central Hospital, Nagoya, Japan
    J Thorac Oncol 1:629-34. 2006
    ..In this study, we searched for mutations or changes in the expression of genes downstream to EGFR and evaluated their relationship with the effectiveness of gefitinib...
  18. ncbi request reprint Significance of the number of positive lymph nodes in resected non-small cell lung cancer
    Takayuki Fukui
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    J Thorac Oncol 1:120-5. 2006
    ..In this study, we evaluated the prognostic significance of the number of positive lymph nodes in resected non-small cell lung cancer...
  19. ncbi request reprint The effect of gefitinib on B-RAF mutant non-small cell lung cancer and transfectants
    Shinichi Toyooka
    Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Okayama University, Okayama, Japan
    J Thorac Oncol 2:321-4. 2007
    ..However, our in vitro investigation did not explain the response observed in this particular patient. Further investigation is necessary to elucidate the mechanism of tumor sensitivity to EGFR tyrosine kinase inhibitors...
  20. ncbi request reprint Neuroendocrine tumor metastasis to the thyroid gland
    Hiroko Yamada
    Department of Otorhinolaryngology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Int J Clin Oncol 12:63-7. 2007
    ..Head and neck surgeons should be aware that a particular subset of lung cancers may develop a metastatic solitary nodule in the thyroid, as presented. An effective therapeutic strategy is largely dependent on the differential diagnosis...
  21. ncbi request reprint Risk factors differ for non-small-cell lung cancers with and without EGFR mutation: assessment of smoking and sex by a case-control study in Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 98:96-101. 2007
    ..In conclusion, our case-control study clearly demonstrated that the impacts of smoking and sex on the risk of EGFRmut NSCLC are different from those for EGFRwt NSCLC. Further epidemiological evaluation is warranted...
  22. ncbi request reprint Analysis of epidermal growth factor receptor gene mutation in patients with non-small cell lung cancer and acquired resistance to gefitinib
    Takayuki Kosaka
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Clin Cancer Res 12:5764-9. 2006
    ..Part of this "acquired resistance" is attributable to a secondary mutation resulting in threonine to methionine at codon 790 (T790M) of EGFR...
  23. ncbi request reprint Clinical aspects of multimodality therapy for resectable locoregional esophageal cancer
    Masayuki Shinoda
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    Ann Thorac Cardiovasc Surg 12:234-41. 2006
    ..More sophisticated trials should be conducted as treatment modalities used in these trials are far from routine...
  24. ncbi request reprint [Molecular biology in diagnosis and treatment of lung cancer]
    Tetsuya Mitsudomi
    Aichi Cancer Center Hospital, Nagoya, Japan
    Kyobu Geka 60:349-54. 2007
    ..In the next 10 years, individualization of cancer treatment especially by targeted drugs based on molecular characteristics of each tumor using patients' tissue will be increasingly more important...
  25. ncbi request reprint Controversy about small peripheral lung adenocarcinomas: how should we manage them?
    Takayuki Fukui
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    J Thorac Oncol 2:546-52. 2007
    ....
  26. ncbi request reprint Factors involved in lymph node metastasis in clinical stage I non-small cell lung cancer--from studies of 604 surgical cases
    Nobukazu Fuwa
    Department of Radiation Oncology, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusaku, Nagoya 464 0021, Japan
    Lung Cancer 57:311-6. 2007
    ..To identify the factors involved in lymph node metastasis, 604 clinical stage I non-small cell lung cancer cases were studied...
  27. doi request reprint Subcategorization of lung cancer based on tumor size and degree of visceral pleural invasion
    Noriaki Sakakura
    Department of Thoracic Surgery, Division of Epidemiology and Prevention, Aichi Cancer Center Hospital, Nagoya, Japan
    Ann Thorac Surg 86:1084-90. 2008
    ..Lung cancer staging system proposed in 2007 adopts detailed tumor size cut-off values. Alternatively, visceral pleural invasion is deemed an important prognosticator, but has not been easily incorporated into the staging system...
  28. doi request reprint Soy consumption reduces the risk of non-small-cell lung cancers with epidermal growth factor receptor mutations among Japanese
    Keitaro Matsuo
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 99:1202-8. 2008
    ..023). In conclusion, soy consumption may exert a protective association against the development of NSCLCs with EGFR mutations, providing possible insights into mechanisms of their genesis...
  29. doi request reprint Epidermal growth factor receptor gene amplification is acquired in association with tumor progression of EGFR-mutated lung cancer
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center, Nagoya 464 8681, Japan
    Cancer Res 68:2106-11. 2008
    ..Taken together, our results show that mutation occurs early in the development of lung adenocarcinoma, and that amplification may be acquired in association with tumor progression...
  30. doi request reprint Epidermal growth factor receptor mutation, but not sex and smoking, is independently associated with favorable prognosis of gefitinib-treated patients with lung adenocarcinoma
    Shinichi Toyooka
    Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, 2 5 1 Shikata cho, Okayama 700 8558, Japan
    Cancer Sci 99:303-8. 2008
    ....
  31. doi request reprint Phase II trial of preoperative chemoradiotherapy followed by surgical resection in patients with superior sulcus non-small-cell lung cancers: report of Japan Clinical Oncology Group trial 9806
    Hideo Kunitoh
    Department of Medical Oncology, National Cancer Center Hospital, 5 1 1 Tsukiji, Chuo Ku, Tokyo 104 0045, Japan
    J Clin Oncol 26:644-9. 2008
    ..To evaluate the safety and efficacy of preoperative chemoradiotherapy followed by surgical resection for superior sulcus tumors (SSTs)...
  32. pmc Predictors of survival in patients with bone metastasis of lung cancer
    Hideshi Sugiura
    Department of Orthopaedic Surgery, Aichi Cancer Center, 1 1 Kanokoden, Chikusa ku, Nagoya, Japan
    Clin Orthop Relat Res 466:729-36. 2008
    ..The data preliminarily suggest treatment with an epithelial growth factor receptor inhibitor may improve survival after bone metastasis...
  33. ncbi request reprint The impact of sex and smoking status on the mutational spectrum of epidermal growth factor receptor gene in non small cell lung cancer
    Shinichi Toyooka
    Department of Cancer and Thoracic Surgery, Okayama University, Okayama, Japan
    Clin Cancer Res 13:5763-8. 2007
    ..In this study, we extensively investigated the impact of sex and smoking on the EGFR mutation...
  34. ncbi request reprint Mutations of the epidermal growth factor receptor gene and related genes as determinants of epidermal growth factor receptor tyrosine kinase inhibitors sensitivity in lung cancer
    Tetsuya Mitsudomi
    Department of Thoracic Surgery, Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Cancer Sci 98:1817-24. 2007
    ..The door for genotype-based treatment of lung cancer is beginning to open, and through these efforts, it will be possible to slow the progression of lung cancer and eventually, to decrease mortality from lung cancer...
  35. ncbi request reprint LKB1 gene mutations in Japanese lung cancer patients
    Ryoichi Onozato
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya, Japan
    Cancer Sci 98:1747-51. 2007
    ..LKB1 gene mutations appear to be frequent in male, smoking patients of Caucasian origin, in contrast to EGFR or HER2 mutations that are frequent in non-smoking, female patients of Asian origin...
  36. ncbi request reprint [Gefitinib and epidermal growth factor receptor gene mutation]
    Takayuki Fukui
    Dept of Thoracic Surgery, Aichi Cancer Center Hospital, Japan
    Gan To Kagaku Ryoho 34:1168-72. 2007
    ..Based on this concept, phaseIII clinical trials comparing gefitinib monotherapy with standard platinum-based chemotherapy in lung cancer patients with EGFR mutations are ongoing...
  37. ncbi request reprint Lineage-specific dependency of lung adenocarcinomas on the lung development regulator TTF-1
    Hisaaki Tanaka
    Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Cancer Res 67:6007-11. 2007
    ....
  38. ncbi request reprint A 25-signal proteomic signature and outcome for patients with resected non-small-cell lung cancer
    Kiyoshi Yanagisawa
    Institute for Advanced Research, Nagoya University, Furo cho, Chikusa ku, Nagoya, Aichi 464 8601, Japan
    J Natl Cancer Inst 99:858-67. 2007
    ..Among patients with non-small-cell lung cancer (NSCLC), those with poor prognosis cannot be distinguished from those with good prognosis...
  39. ncbi request reprint Biological and clinical implications of EGFR mutations in lung cancer
    Tetsuya Mitsudomi
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, 464 8681, Japan
    Int J Clin Oncol 11:190-8. 2006
    ..These populations precisely coincide with those populations with higher response rates to TKIs. We and others subsequently confirmed and extended these findings...
  40. pmc A rapid, sensitive assay to detect EGFR mutation in small biopsy specimens from lung cancer
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Kanokoden, Nagoya 464 8681, Japan
    J Mol Diagn 8:335-41. 2006
    ..In conclusion, the assay is a rapid, sensitive method using paraffin sections of biopsy specimens without a tumor cell-enrichment procedure and is quite useful to select a treatment of choice in clinical practice...
  41. ncbi request reprint Expression profile-defined classification of lung adenocarcinoma shows close relationship with underlying major genetic changes and clinicopathologic behaviors
    Toshiyuki Takeuchi
    Division of Molecular Carcinogenesis, Center for Neurological Diseases and Cancer, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Clin Oncol 24:1679-88. 2006
    ..This study was conducted to gain insight into the relationship between expression profiles and underlying genetic changes, which are known to be important for the pathogenesis of lung cancers...
  42. ncbi request reprint Maspin expression in normal lung and non-small-cell lung cancers: cellular property-associated expression under the control of promoter DNA methylation
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan
    Oncogene 23:4041-9. 2004
    ..Separate analysis of methylation status in positive and negative portions of individual tumors provided an instance of intratumor diversity associated with promoter DNA methylation...
  43. ncbi request reprint Gene-environment interactions between the smoking habit and polymorphisms in the DNA repair genes, APE1 Asp148Glu and XRCC1 Arg399Gln, in Japanese lung cancer risk
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya Aichi, Japan
    Carcinogenesis 25:1395-401. 2004
    ..936) and that with light smoking was 2.67 (95% CI 1.00-7.68, P = 0.049). These results suggest that APE1 Asp148Glu and XRCC1 Arg399Gln polymorphisms might modify the risk of lung cancer attributable to cigarette smoking exposure...
  44. ncbi request reprint Prognostic model of pulmonary adenocarcinoma by expression profiling of eight genes as determined by quantitative real-time reverse transcriptase polymerase chain reaction
    Hideki Endoh
    Department of Thoracic Surgery, Aichi Cancer Center, Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    J Clin Oncol 22:811-9. 2004
    ....
  45. ncbi request reprint Analysis of beta-tubulin gene alteration in human lung cancer cell lines
    Hiroyuki Achiwa
    Department of Internal Medicine and Molecular Science, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho cho, Mizuho ku, Nagoya 467 8601, Japan
    Cancer Lett 201:211-6. 2003
    ..In addition, the presence of a closely related family of beta-tubulins or pseudogenes was thought to hinder accurate evaluation of the beta-tubulin gene...
  46. ncbi request reprint The sensitivity of lung cancer cell lines to the EGFR-selective tyrosine kinase inhibitor ZD1839 ('Iressa') is not related to the expression of EGFR or HER-2 or to K-ras gene status
    Takeshi Suzuki
    Department of Pulmonary Medicine, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Lung Cancer 42:35-41. 2003
    ..These findings warrant future study to clarify how ZD1839 inhibits lung cancer cell growth and to find a useful marker for prediction of sensitivity to this novel and promising agent for the treatment of lung cancers...
  47. ncbi request reprint Different risk relations with smoking for non-small-cell lung cancer: comparison of TP53 and TP73 genotypes
    Akio Hiraki
    Department of Respiratory Medicine, National Sanyo Hospital, Yamaguchi, Japan
    Asian Pac J Cancer Prev 4:107-12. 2003
    ..The association between TP53/TP73 gene polymorphisms and tobacco smoking was evaluated with regard to risk of non-small cell lung cancer (NSCLC)...
  48. ncbi request reprint Prognostic models in patients with non-small-cell lung cancer using artificial neural networks in comparison with logistic regression
    Taizo Hanai
    Department of Biotechnology, Graduate School of Engineering, Nagoya University, Chikusa ku, Nagoya 469 8603, Japan
    Cancer Sci 94:473-7. 2003
    ....
  49. ncbi request reprint RASSF1A gene inactivation in non-small cell lung cancer and its clinical implication
    Hideki Endoh
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    Int J Cancer 106:45-51. 2003
    ..0247). Epigenetic silencing of RASSF1A is a frequent event in non-small lung cancer and will provide novel opportunities to develop diagnosis and therapy of NSCLC...
  50. ncbi request reprint Decreased expression of 14-3-3sigma in neuroendocrine tumors is independent of origin and malignant potential
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan
    Oncogene 21:8310-9. 2002
    ....
  51. ncbi request reprint A limited association of OGG1 Ser326Cys polymorphism for adenocarcinoma of the lung
    Hidemi Ito
    Division of Epidemiology and Prevention, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Epidemiol 12:258-65. 2002
    ..This study supported the first study by Sugimura et al (Cancer Epidemiol Biomarkers Prev, 1999; 8: 669-674), that the association of OGG1 Ser326Cys polymorphism was limited for the risk of lung adenocarcinoma...
  52. ncbi request reprint [Molecular abnormalities in lung cancer]
    Shigeki Shimizu
    Department of Thoracic Surgery, Aichi Cancer Center Hospital
    Nihon Rinsho 60:73-7. 2002
  53. ncbi request reprint [Molecular diagnosis in lung cancer]
    Tetsuya Mitsudomi
    Department of Thoracic Surgery, Aichi Cancer Center Hospital
    Nihon Rinsho 60:233-7. 2002
  54. ncbi request reprint TTF-1 expression in pulmonary adenocarcinomas
    Yasushi Yatabe
    Department of Anatomic and Molecular Diagnostic Pathology, Aichi Cancer Center Hospital, Aichi Cancer Center Research Institute, Nagoya, Japan
    Am J Surg Pathol 26:767-73. 2002
    ..01), less frequent RB loss (p <0.05), and preserved expression of p27 (p <0.01). The results supported the TTF-1 lineage marker and suggested that molecular pathogenesis may in part be characterized by cellular lineage...
  55. ncbi request reprint Significant up-regulation of a novel gene, CLCP1, in a highly metastatic lung cancer subline as well as in lung cancers in vivo
    Katsumi Koshikawa
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Oncogene 21:2822-8. 2002
    ....
  56. ncbi request reprint Gene expression-based, individualized outcome prediction for surgically treated lung cancer patients
    Shuta Tomida
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya 464 8681, Japan
    Oncogene 23:5360-70. 2004
    ..Overall, these findings should advance not only our understanding of the biology of lung cancer but also our ability to individualize postoperative therapies based on the predicted outcome...
  57. ncbi request reprint Interferon-gamma differentially regulates susceptibility of lung cancer cells to telomerase-specific cytotoxic T lymphocytes
    Kouhei Tajima
    Division of Immunology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 110:403-12. 2004
    ....
  58. pmc EGFR mutations in patients with brain metastases from lung cancer: association with the efficacy of gefitinib
    Shinji Shimato
    Department of Neurosurgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neuro Oncol 8:137-44. 2006
    ..Gefitinib appears to be effective in treating brain metastases in a subgroup of patients. Our data suggested a possible association between the efficacy of gefitinib in the treatment of brain metastases and EGFR mutations...
  59. ncbi request reprint [Molecular targeted therapy--non-small-cell lung cancer and gefitinib]
    Junichi Shimizu
    Dept of Thoracic Oncology, Aichi Cancer Center Central Hospital
    Gan To Kagaku Ryoho 32:1879-85. 2005
    ....
  60. ncbi request reprint Mutations of epidermal growth factor receptor and K-ras genes in adenosquamous carcinoma of the lung
    Shinichi Toyooka
    Int J Cancer 118:1588-90. 2006
  61. ncbi request reprint [Translational research on lung cancer--EGFR gene mutation]
    Takayuki Kosaka
    Dept of Thoracic Surgery, Aichi Cancer Center Hospital, Nagoya, Japan
    Gan To Kagaku Ryoho 32:750-8. 2005
    ..It is ultimately necessary to identify non-tobacco-related carcinogens that cause EGFR mutations for effective prevention of lung cancer...
  62. ncbi request reprint EGFR mutation and response of lung cancer to gefitinib
    Shinichi Toyooka
    N Engl J Med 352:2136; author reply 2136. 2005
  63. ncbi request reprint EGFR mutation is specific for terminal respiratory unit type adenocarcinoma
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan
    Am J Surg Pathol 29:633-9. 2005
    ..These findings further confirm that TRU-type-adenocarcinoma is a distinct adenocarcinoma subset in which a particular molecular pathway is involved...
  64. ncbi request reprint Mutations of the epidermal growth factor receptor gene predict prolonged survival after gefitinib treatment in patients with non-small-cell lung cancer with postoperative recurrence
    Tetsuya Mitsudomi
    Department of Thoracic Surgery, Aichi Cancer Center Hospital, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    J Clin Oncol 23:2513-20. 2005
    ..To evaluate the relationship between mutations of the epidermal growth factor receptor (EGFR) gene and the effectiveness of gefitinib treatment in patients with recurrent lung cancer after pulmonary resection...
  65. ncbi request reprint Reduced expression of Dicer associated with poor prognosis in lung cancer patients
    Yoko Karube
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Sci 96:111-5. 2005
    ....
  66. ncbi request reprint Throwing new light on lung cancer pathogenesis: updates on three recent topics
    Shuta Tomida
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Aichi, Japan
    Cancer Sci 96:63-8. 2005
    ..Second, we deal with EGFR mutations, which shows revealing specificities in various aspects. Finally, advances in the expression profiling analysis of both transcriptomes and proteomes of lung cancers are summarized...
  67. ncbi request reprint Mutations of the epidermal growth factor receptor gene in lung cancer: biological and clinical implications
    Takayuki Kosaka
    Departments of Thoracic Surgery and Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan
    Cancer Res 64:8919-23. 2004
    ..EGFR mutations define a distinct subset of pulmonary adenocarcinoma without KRAS mutations, which is not caused by tobacco carcinogens...
  68. ncbi request reprint Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients
    Hirotaka Osada
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Int J Cancer 112:26-32. 2004
    ..Results of clustering analyses imply that class II HDAC genes may be regulated by a similar mechanism and deregulated during cancer development...
  69. ncbi request reprint Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survival
    Junichi Takamizawa
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, Nagoya, Japan
    Cancer Res 64:3753-6. 2004
    ..This study represents the first report of reduced expression of let-7 and the potential clinical and biological effects of such a microRNA alteration...
  70. ncbi request reprint CK20 expression, CDX2 expression, K-ras mutation, and goblet cell morphology in a subset of lung adenocarcinomas
    Yasushi Yatabe
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Hospital, Nagoya, Japan
    J Pathol 203:645-52. 2004
    ..However, some lung adenocarcinomas may express CDX2 strongly: in this case, CK20 also tends to be positive...
  71. pmc Identification of MGB1 as a marker in the differential diagnosis of lung tumors in patients with a history of breast cancer by analysis of publicly available SAGE data
    Takaomi Koga
    Department of Pathology and Molecular Diagnostics, Aichi Cancer Center Research Institute, Nagoya, Japan
    J Mol Diagn 6:90-5. 2004
    ..This suggests that MGB1 can serve as a differential molecular marker. In practice, prospective examination, using the nine cases with a history of breast cancer, confirmed the usefulness of MGB1 in differential diagnosis...
  72. ncbi request reprint Aberrant hypermethylation of the CHFR prophase checkpoint gene in human lung cancers
    Kotaro Mizuno
    Division of Molecular Oncology, Aichi Cancer Center Research Institute, 1 1 Kanokoden, Chikusa ku, Nagoya 464 8681, Japan
    Oncogene 21:2328-33. 2002
    ..This is the first description of aberrant hypermethylation of the CHFR gene in any type of human cancer, and provides further evidence of the involvement of multiple checkpoint alterations in lung cancer...