Research Topics
Genomes and Genes
| Koichi MatsuoSummaryAffiliation: Keio University Country: Japan Publications
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Detail Information
Publications
Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-FosKoichi Matsuo
Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo 160 8582, Japan
J Biol Chem 279:26475-80. 2004..These data indicate that lack of Nfatc1 expression is the cause of the differentiation block in Fos(-/-) osteoclast precursors and that transcriptional induction of Nfatc1 is a major function of c-Fos in osteoclast differentiation...
Cross-talk among bone cellsKoichi Matsuo
Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
Curr Opin Nephrol Hypertens 18:292-7. 2009..Bone cells such as osteoclasts, osteoblasts, and osteocytes 'talk' to each other throughout adult life to maintain bone integrity. This review highlights frontier areas of research on intercellular communication among bone cells...- Osteoclast-osteoblast communicationKoichi Matsuo
Department of Microbiology and Immunology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, 160 8582 Tokyo, Japan
Arch Biochem Biophys 473:201-9. 2008..At the termination phase, bone remodeling is completed by osteoblastic bone formation and mineralization of bone matrix. Here, we describe molecular communication between osteoclasts and osteoblasts at distinct phases of bone remodeling... - Eph and ephrin interactions in boneKoichi Matsuo
Collaborative Research Resources, School of Medicine, Keio University, 160 8582 Tokyo, Japan
Adv Exp Med Biol 658:95-103. 2010..Other groups have reported the regulation of ephrinB2 by PTH or PTHrP and the possible involvement of EphB4 in osteoarthritis. It is likely that various ephrins and Ephs mediate interaction among bone cells... - Osteoclasts, mononuclear phagocytes, and c-Fos: new insight into osteoimmunologyKoichi Matsuo
Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
Keio J Med 53:78-84. 2004..Yet, c-Fos/AP-1 plays a positive role in osteoclasts but a negative role in macrophages and dendritic cells. Further study is necessary to clarify this dual role of c-Fos... - Receptor activator of NF-kappa B ligand and osteoprotegerin regulate proinflammatory cytokine production in miceKenta Maruyama
Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
J Immunol 177:3799-805. 2006..Strikingly, prior administration of RANKL protected mice from LPS-induced death. These data reveal prophylactic potential of RANKL in acute inflammatory diseases... - Fos proteins suppress dextran sulfate sodium-induced colitis through inhibition of NF-kappaBYasunari Takada
Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
J Immunol 184:1014-21. 2010..In this paper, we propose that AP-1 transcription factors containing c-Fos or Fra-1 are negative regulators of NF-kappaB-mediated stress responses... - Fra-1/AP-1 impairs inflammatory responses and chondrogenesis in fracture healingToru Yamaguchi
Department of Orthopedic Surgery, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
J Bone Miner Res 24:2056-65. 2009..These data suggest that the Fra-1-containing transcription factor AP-1 inhibits fracture-induced endochondral ossification and bony bridge formation presumably through suppression of inflammation-induced chondrogenesis... - Bidirectional ephrinB2-EphB4 signaling controls bone homeostasisChen Zhao
Department of Microbiology and Immunology, School of Medicine, Keio University, Shinjuku ku, Tokyo, 160 8582, Japan
Cell Metab 4:111-21. 2006..These data demonstrate that ephrin-Eph bidirectional signaling links two major molecular mechanisms for cell differentiation--one in osteoclasts and the other in osteoblasts--thereby maintaining bone homeostasis... - Induction of DC-STAMP by alternative activation and downstream signaling mechanismsMitsuru Yagi
Department of Cell Differentiation, The Sakaguchi Laboratory, Keio University School of Medicine, Tokyo, Japan
J Bone Miner Res 22:992-1001. 2007..Here, we show that dc-stamp expression and cell-cell fusion are regulated in a cell type-specific manner... 
Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesisNaoko Irie
Department of Microbiology and Immunology, Keio University, Tokyo 160 8582, Japan
J Biol Chem 284:14637-44. 2009..Therefore, ephrinA2-EphA2 interaction facilitates the initiation phase of bone remodeling by enhancing osteoclast differentiation and suppressing osteoblast differentiation...- c-Fos-deficient mice are susceptible to Salmonella enterica serovar Typhimurium infectionKenta Maruyama
Department of Microbiology and Immunology, School of Medicine, Keio University, 160 8582 Tokyo, Japan
Infect Immun 75:1520-3. 2007..Furthermore, mice lacking c-Fos are highly susceptible to infection, suggesting that c-Fos confers resistance to Salmonella infection in mice... - c-Fos suppresses systemic inflammatory response to endotoxinNeelanjan Ray
Department of Microbiology and Immunology, School of Medicine, Keio University, 35 Shinanomachi, 160 8582 Tokyo, Japan
Int Immunol 18:671-7. 2006..Such shock responses in Fos-/- mice were significantly reversed by neutralizing TNF-alpha. These data reveal a novel in vivo role for c-Fos as an anti-inflammatory transcription factor acting through suppression of NF-kappaB activity... - Impaired vibration of auditory ossicles in osteopetrotic miceSho Kanzaki
Department of Otolaryngology, School of Medicine, Keio University, Tokyo, Japan
Am J Pathol 178:1270-8. 2011..These data suggest that osteoclastic bone resorption is required for thinning of auditory ossicles and enlargement of the tympanic cavity so that auditory ossicles vibrate freely... - Cot kinase promotes Ca2+ oscillation/calcineurin-independent osteoclastogenesis by stabilizing NFATc1 proteinYukiko Kuroda
Laboratory of Cell and Tissue Biology, School of Medicine, Keio University, Tokyo, Japan
Mol Cell Biol 32:2954-63. 2012..We propose that NFAT activation in vivo occurs via phosphorylation-induced protein stabilization, even in the absence of Ca(2+) oscillation and calcineurin activity... - Bisphosphonate therapy ameliorates hearing loss in mice lacking osteoprotegerinSho Kanzaki
Department of Otolaryngology, School of Medicine, Keio University, Tokyo, Japan
J Bone Miner Res 24:43-9. 2009..These data suggest that hearing loss in pathologies characterized by excessive resorption of the auditory ossicles may be prevented by bisphosphonates... - Flagella facilitate escape of Salmonella from oncotic macrophagesGen ichiro Sano
Department of Microbiology and Immunology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
J Bacteriol 189:8224-32. 2007..These results suggest that induction of macrophage oncosis and intracellular accumulation of flagellated bacilli constitute a strategy whereby Salmonella escapes from host macrophages... - [Regulation of bone metabolism by Eph-ephrin family members]Koichi Matsuo
School of Medicine, Keio University, Japan
Clin Calcium 22:1669-75. 2012..Here we review similarities and differences between downstream events of Eph-ephrin signaling in bone cells compared to other cell types... - Bone cell interactions through Eph/ephrin: bone modeling, remodeling and associated diseasesKoichi Matsuo
Laboratory of Cell and Tissue Biology, School of Medicine, Keio University, Tokyo, Japan
Cell Adh Migr 6:148-56. 2012..Furthermore, ephrins and Ephs likely modulate pathological conditions such as osteoarthritis, rheumatoid arthritis, multiple myeloma and osteosarcoma. This review focuses on ephrin/Eph-mediated cell-cell interactions in bone biology... - Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell-cell fusionTsukasa Oikawa
Laboratory of Cell and Tissue Biology, Institute for Advanced Medical Research, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
J Cell Biol 197:553-68. 2012..Our results thus reveal an unexpected link between circumferential podosome/invadopodium formation and cell-cell fusion in and beyond osteoclasts... - [Osteocytic osteolysis : measurements of the volume of osteocytic lacunae]Koichi Matsuo
Laboratory of Cell and Tissue Biology, School of Medicine, Keio University, Japan
Clin Calcium 22:677-83. 2012..This review discusses published literature relevant to osteocytic osteolysis and compares 2D and 3D measurements of the volume of osteocytic lacunae, which serve as anatomical evidence for "periosteocytic osteolysis" ... - IL-27 abrogates receptor activator of NF-kappa B ligand-mediated osteoclastogenesis of human granulocyte-macrophage colony-forming unit cells through STAT1-dependent inhibition of c-FosMitsuru Furukawa
Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
J Immunol 183:2397-406. 2009..Our results suggest that hIL-27 may prove useful as a therapeutic target for inflammatory bone destruction... - [Transcription factors in osteoclast differentiation]Koichi Matsuo
Department of Microbiology and Immunology, School of Medicine, Keio University
Nippon Rinsho 63:1541-6. 2005..Surprisingly, recent studies have begun to uncover a linear relationship among these transcription factors, including the c-Fos-NFATc1 transcriptional activation cascade... - Resorption of auditory ossicles and hearing loss in mice lacking osteoprotegerinSho Kanzaki
Department of Otolaryngology, School of Medicine, Keio University, 35 Shinanomachi, Tokyo 160 8582, Japan
Bone 39:414-9. 2006..These data suggest that osteoprotegerin plays a crucial role in hearing by protecting the auditory ossicles and otic capsule from osteoclastic bone resorption... - Reduced expression of thrombospondins and craniofacial dysmorphism in mice overexpressing Fra1Toru Nishiwaki
Department of Orthopaedics, School of Medicine, Keio University, Tokyo, Japan
J Bone Miner Res 21:596-604. 2006..Fra1 Tg and non-osteosclerotic Thbs1-/-Thbs2-/- mice share an edge-to-edge bite. Therefore, reduced expression of thrombospondins may contribute to craniofacial dysmorphism independently of osteosclerosis... - Murine osteoblasts respond to LPS and IFN-gamma similarly to macrophagesKenta Maruyama
Department of Microbiology and Immunology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan
J Bone Miner Metab 24:454-60. 2006..Taken together, these observations indicate that osteoblasts can exhibit a subset of phenotypes reminiscent of macrophages in the course of bacterial infection... - Osteosclerosis and inhibition of human hematopoiesis in NOG mice expressing human Delta-like 1 in osteoblastsRyoji Ito
Central Institute for Experimental Animals, Kawasaki, Japan Department of Anatomy, Keio University School of Medicine, Tokyo, Japan
Exp Hematol 40:953-963.e3. 2012..These unique humanized mice with sclerotic bone reconstituted by human HSCs are useful models of hematopoiesis in patients with osteosclerosis, such as osteopetrosis, and for investigation of osteogenesis via Notch signaling... - Signaling flux redistribution at toll-like receptor pathway junctionsKumar Selvarajoo
Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan
PLoS ONE 3:e3430. 2008..Our data suggest that SFR may enlighten hitherto unexplainable intracellular signaling alterations in genetic diseases where gain or loss-of-function mutations are observed... - Gefitinib, but not erlotinib, is a possible inducer of Fra-1-mediated interstitial lung diseaseYasunari Takada
Laboratory of Cell and Tissue Biology, School of Medicine, Keio University, Tokyo, Japan
Keio J Med 61:120-7. 2012.... - Molecular mechanisms of triggering, amplifying and targeting RANK signaling in osteoclastsYukiko Kuroda
Yukiko Kuroda, Koichi Matsuo, Laboratory of Cell and Tissue Biology, School of Medicine, Keio University, Tokyo 160 8582, Japan
World J Orthop 3:167-74. 2012..This review focuses on molecular mechanisms for each of the three phases of RANK signaling during osteoclast differentiation... - Role of heterodimerization of c-Fos and Fra1 proteins in osteoclast differentiationLatifa Bakiri
Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
Bone 40:867-75. 2007..We propose that Fra1 together with a dimerization partner different from Jun proteins can rescue osteoclast differentiation in c-Fos-deficient precursors... - Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesisYukiko Kuroda
Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokane dai, Minato ku, Tokyo 108 8639, Japan
Proc Natl Acad Sci U S A 105:8643-8. 2008..Taken together, we conclude that both Ca(2+) oscillation/calcineurin-dependent and -independent signaling pathways contribute to NFATc1 activation, leading to efficient osteoclastogenesis in vivo... - Promoter specificity and biological activity of tethered AP-1 dimersLatifa Bakiri
Unité Expression Génétique et Maladies, CNRS URA 1644, Institut Pasteur, 75724 Paris Cedex 15, France
Mol Cell Biol 22:4952-64. 2002.... - NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1Teruhito Yamashita
Department of Pathology and Laboratory Medicine and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
J Biol Chem 282:18245-53. 2007..Inhibition of NF-kappaB should prevent RANKL- and TNF-induced bone resorption... - ATF3 and Fra1 have opposite functions in JNK- and ERK-dependent DNA damage responsesMohamed Hamdi
Department of Molecular Cell Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
DNA Repair (Amst) 7:487-96. 2008..Thus, we identify novel reciprocal functions of ATF3 and Fra1 in JNK- and ERK-dependent DNA damage responses... - [Assessment of bone quality. Bone remodeling and bone quality]Gen ichiro Sano
Keio University School of Medicine, Department of Microbiology and Immunology
Clin Calcium 18:315-20. 2008..Therefore understanding the relationship between bone remodeling and bone quality is essential to design interventions to effectively treat osteoporosis... - Detection of osteoclastic cell-cell fusion through retroviral vector packagingTakako Kondo
Department of Geriatric Research, National Institute for Longevity Sciences (NILS, Aichi 474-8522, Japan
Bone 35:1120-6. 2004..These data suggest that retrovirus production can occur as a result of cell-cell fusion. This provides a novel approach for isolating and characterizing fusogenic genes using retroviral expression vectors... - RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-betaHiroshi Takayanagi
Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
Nature 416:744-9. 2002..Our study places the IFN-beta system in a new context, and may offer a molecular basis for the treatment of bone diseases... - Suppression of VEGFR-3 signaling inhibits lymph node metastasis in gastric cancerKenji Shimizu
Department of Gastroenterological Surgery, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
Cancer Sci 95:328-33. 2004..Antilymphangiogenesis by inhibiting VEGFR-3 signaling could provide a potential strategy for the prevention of lymph node metastasis in gastric cancer... - SIAH1 inactivation correlates with tumor progression in hepatocellular carcinomasKoichi Matsuo
Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
Genes Chromosomes Cancer 36:283-91. 2003..SIAH1 was significantly downregulated in advanced HCCs, including poorly differentiated tumors, larger tumors, and tumors in advanced stages. These findings suggest that inactivation of SIAH1 plays an important role in HCC progression... - Absence of PERV infection in baboons after transgenic porcine liver perfusionRyuta Nishitai
Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, 54 Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, Japan
J Surg Res 124:45-51. 2005..CONCLUSIONS: ECLP did not result in PERV infection or pig-cell microchimerism in baboons... - The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulatorYu Hikosaka
Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima 770 8503, Japan
Immunity 29:438-50. 2008..These results indicate that RANKL produced by positively selected thymocytes is responsible for fostering thymic medulla formation, thereby establishing central tolerance... - Suppressed complement activation in human decay accelerating factor transgenic porcine liver cross-circulated with nonhuman primatesTakakazu Matsushita
Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Shogoin, Sakyo-ku, Kyoto, Japan
Transplantation 75:1807-12. 2003..CONCLUSION: The hDAF transgenic porcine liver reduced complement activation in xenoperfusion with healthy nonhuman primate blood and led to extended duration of cross-circulation...