Koichi Matsuo

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. ncbi request reprint Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos
    Koichi Matsuo
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo 160 8582, Japan
    J Biol Chem 279:26475-80. 2004
  2. doi request reprint Osteoclast-osteoblast communication
    Koichi Matsuo
    Department of Microbiology and Immunology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, 160 8582 Tokyo, Japan
    Arch Biochem Biophys 473:201-9. 2008
  3. doi request reprint Cross-talk among bone cells
    Koichi Matsuo
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
    Curr Opin Nephrol Hypertens 18:292-7. 2009
  4. doi request reprint Eph and ephrin interactions in bone
    Koichi Matsuo
    Collaborative Research Resources, School of Medicine, Keio University, 160 8582 Tokyo, Japan
    Adv Exp Med Biol 658:95-103. 2010
  5. ncbi request reprint Osteoclasts, mononuclear phagocytes, and c-Fos: new insight into osteoimmunology
    Koichi Matsuo
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
    Keio J Med 53:78-84. 2004
  6. ncbi request reprint Receptor activator of NF-kappa B ligand and osteoprotegerin regulate proinflammatory cytokine production in mice
    Kenta Maruyama
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
    J Immunol 177:3799-805. 2006
  7. doi request reprint Fra-1/AP-1 impairs inflammatory responses and chondrogenesis in fracture healing
    Toru Yamaguchi
    Department of Orthopedic Surgery, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    J Bone Miner Res 24:2056-65. 2009
  8. doi request reprint Fos proteins suppress dextran sulfate sodium-induced colitis through inhibition of NF-kappaB
    Yasunari Takada
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
    J Immunol 184:1014-21. 2010
  9. ncbi request reprint Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis
    Chen Zhao
    Department of Microbiology and Immunology, School of Medicine, Keio University, Shinjuku ku, Tokyo, 160 8582, Japan
    Cell Metab 4:111-21. 2006
  10. ncbi request reprint Induction of DC-STAMP by alternative activation and downstream signaling mechanisms
    Mitsuru Yagi
    Department of Cell Differentiation, The Sakaguchi Laboratory, Keio University School of Medicine, Tokyo, Japan
    J Bone Miner Res 22:992-1001. 2007

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Nuclear factor of activated T-cells (NFAT) rescues osteoclastogenesis in precursors lacking c-Fos
    Koichi Matsuo
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo 160 8582, Japan
    J Biol Chem 279:26475-80. 2004
    ..These data indicate that lack of Nfatc1 expression is the cause of the differentiation block in Fos(-/-) osteoclast precursors and that transcriptional induction of Nfatc1 is a major function of c-Fos in osteoclast differentiation...
  2. doi request reprint Osteoclast-osteoblast communication
    Koichi Matsuo
    Department of Microbiology and Immunology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, 160 8582 Tokyo, Japan
    Arch Biochem Biophys 473:201-9. 2008
    ..At the termination phase, bone remodeling is completed by osteoblastic bone formation and mineralization of bone matrix. Here, we describe molecular communication between osteoclasts and osteoblasts at distinct phases of bone remodeling...
  3. doi request reprint Cross-talk among bone cells
    Koichi Matsuo
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
    Curr Opin Nephrol Hypertens 18:292-7. 2009
    ..Bone cells such as osteoclasts, osteoblasts, and osteocytes 'talk' to each other throughout adult life to maintain bone integrity. This review highlights frontier areas of research on intercellular communication among bone cells...
  4. doi request reprint Eph and ephrin interactions in bone
    Koichi Matsuo
    Collaborative Research Resources, School of Medicine, Keio University, 160 8582 Tokyo, Japan
    Adv Exp Med Biol 658:95-103. 2010
    ..Other groups have reported the regulation of ephrinB2 by PTH or PTHrP and the possible involvement of EphB4 in osteoarthritis. It is likely that various ephrins and Ephs mediate interaction among bone cells...
  5. ncbi request reprint Osteoclasts, mononuclear phagocytes, and c-Fos: new insight into osteoimmunology
    Koichi Matsuo
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
    Keio J Med 53:78-84. 2004
    ..Yet, c-Fos/AP-1 plays a positive role in osteoclasts but a negative role in macrophages and dendritic cells. Further study is necessary to clarify this dual role of c-Fos...
  6. ncbi request reprint Receptor activator of NF-kappa B ligand and osteoprotegerin regulate proinflammatory cytokine production in mice
    Kenta Maruyama
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
    J Immunol 177:3799-805. 2006
    ..Strikingly, prior administration of RANKL protected mice from LPS-induced death. These data reveal prophylactic potential of RANKL in acute inflammatory diseases...
  7. doi request reprint Fra-1/AP-1 impairs inflammatory responses and chondrogenesis in fracture healing
    Toru Yamaguchi
    Department of Orthopedic Surgery, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    J Bone Miner Res 24:2056-65. 2009
    ..These data suggest that the Fra-1-containing transcription factor AP-1 inhibits fracture-induced endochondral ossification and bony bridge formation presumably through suppression of inflammation-induced chondrogenesis...
  8. doi request reprint Fos proteins suppress dextran sulfate sodium-induced colitis through inhibition of NF-kappaB
    Yasunari Takada
    Department of Microbiology and Immunology, School of Medicine, Keio University, Tokyo, Japan
    J Immunol 184:1014-21. 2010
    ..In this paper, we propose that AP-1 transcription factors containing c-Fos or Fra-1 are negative regulators of NF-kappaB-mediated stress responses...
  9. ncbi request reprint Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis
    Chen Zhao
    Department of Microbiology and Immunology, School of Medicine, Keio University, Shinjuku ku, Tokyo, 160 8582, Japan
    Cell Metab 4:111-21. 2006
    ..These data demonstrate that ephrin-Eph bidirectional signaling links two major molecular mechanisms for cell differentiation--one in osteoclasts and the other in osteoblasts--thereby maintaining bone homeostasis...
  10. ncbi request reprint Induction of DC-STAMP by alternative activation and downstream signaling mechanisms
    Mitsuru Yagi
    Department of Cell Differentiation, The Sakaguchi Laboratory, Keio University School of Medicine, Tokyo, Japan
    J Bone Miner Res 22:992-1001. 2007
    ..Here, we show that dc-stamp expression and cell-cell fusion are regulated in a cell type-specific manner...
  11. pmc Bidirectional signaling through ephrinA2-EphA2 enhances osteoclastogenesis and suppresses osteoblastogenesis
    Naoko Irie
    Department of Microbiology and Immunology, Keio University, Tokyo 160 8582, Japan
    J Biol Chem 284:14637-44. 2009
    ..Therefore, ephrinA2-EphA2 interaction facilitates the initiation phase of bone remodeling by enhancing osteoclast differentiation and suppressing osteoblast differentiation...
  12. pmc Impaired vibration of auditory ossicles in osteopetrotic mice
    Sho Kanzaki
    Department of Otolaryngology, School of Medicine, Keio University, Tokyo, Japan
    Am J Pathol 178:1270-8. 2011
    ..These data suggest that osteoclastic bone resorption is required for thinning of auditory ossicles and enlargement of the tympanic cavity so that auditory ossicles vibrate freely...
  13. ncbi request reprint c-Fos suppresses systemic inflammatory response to endotoxin
    Neelanjan Ray
    Department of Microbiology and Immunology, School of Medicine, Keio University, 35 Shinanomachi, 160 8582 Tokyo, Japan
    Int Immunol 18:671-7. 2006
    ..Such shock responses in Fos-/- mice were significantly reversed by neutralizing TNF-alpha. These data reveal a novel in vivo role for c-Fos as an anti-inflammatory transcription factor acting through suppression of NF-kappaB activity...
  14. pmc c-Fos-deficient mice are susceptible to Salmonella enterica serovar Typhimurium infection
    Kenta Maruyama
    Department of Microbiology and Immunology, School of Medicine, Keio University, 160 8582 Tokyo, Japan
    Infect Immun 75:1520-3. 2007
    ..Furthermore, mice lacking c-Fos are highly susceptible to infection, suggesting that c-Fos confers resistance to Salmonella infection in mice...
  15. pmc Cot kinase promotes Ca2+ oscillation/calcineurin-independent osteoclastogenesis by stabilizing NFATc1 protein
    Yukiko Kuroda
    Laboratory of Cell and Tissue Biology, School of Medicine, Keio University, Tokyo, Japan
    Mol Cell Biol 32:2954-63. 2012
    ..We propose that NFAT activation in vivo occurs via phosphorylation-induced protein stabilization, even in the absence of Ca(2+) oscillation and calcineurin activity...
  16. pmc Flagella facilitate escape of Salmonella from oncotic macrophages
    Gen ichiro Sano
    Department of Microbiology and Immunology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Bacteriol 189:8224-32. 2007
    ..These results suggest that induction of macrophage oncosis and intracellular accumulation of flagellated bacilli constitute a strategy whereby Salmonella escapes from host macrophages...
  17. doi request reprint Bisphosphonate therapy ameliorates hearing loss in mice lacking osteoprotegerin
    Sho Kanzaki
    Department of Otolaryngology, School of Medicine, Keio University, Tokyo, Japan
    J Bone Miner Res 24:43-9. 2009
    ..These data suggest that hearing loss in pathologies characterized by excessive resorption of the auditory ossicles may be prevented by bisphosphonates...
  18. doi request reprint [Regulation of bone metabolism by Eph-ephrin family members]
    Koichi Matsuo
    School of Medicine, Keio University, Japan
    Clin Calcium 22:1669-75. 2012
    ..Here we review similarities and differences between downstream events of Eph-ephrin signaling in bone cells compared to other cell types...
  19. pmc Bone cell interactions through Eph/ephrin: bone modeling, remodeling and associated diseases
    Koichi Matsuo
    Laboratory of Cell and Tissue Biology, School of Medicine, Keio University, Tokyo, Japan
    Cell Adh Migr 6:148-56. 2012
    ..Furthermore, ephrins and Ephs likely modulate pathological conditions such as osteoarthritis, rheumatoid arthritis, multiple myeloma and osteosarcoma. This review focuses on ephrin/Eph-mediated cell-cell interactions in bone biology...
  20. pmc Tks5-dependent formation of circumferential podosomes/invadopodia mediates cell-cell fusion
    Tsukasa Oikawa
    Laboratory of Cell and Tissue Biology, Institute for Advanced Medical Research, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    J Cell Biol 197:553-68. 2012
    ..Our results thus reveal an unexpected link between circumferential podosome/invadopodium formation and cell-cell fusion in and beyond osteoclasts...
  21. doi request reprint [Osteocytic osteolysis : measurements of the volume of osteocytic lacunae]
    Koichi Matsuo
    Laboratory of Cell and Tissue Biology, School of Medicine, Keio University, Japan
    Clin Calcium 22:677-83. 2012
    ..This review discusses published literature relevant to osteocytic osteolysis and compares 2D and 3D measurements of the volume of osteocytic lacunae, which serve as anatomical evidence for "periosteocytic osteolysis" ...
  22. doi request reprint IL-27 abrogates receptor activator of NF-kappa B ligand-mediated osteoclastogenesis of human granulocyte-macrophage colony-forming unit cells through STAT1-dependent inhibition of c-Fos
    Mitsuru Furukawa
    Department of Orthopaedic Surgery, School of Medicine, Keio University, Tokyo, Japan
    J Immunol 183:2397-406. 2009
    ..Our results suggest that hIL-27 may prove useful as a therapeutic target for inflammatory bone destruction...
  23. ncbi request reprint Murine osteoblasts respond to LPS and IFN-gamma similarly to macrophages
    Kenta Maruyama
    Department of Microbiology and Immunology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Bone Miner Metab 24:454-60. 2006
    ..Taken together, these observations indicate that osteoblasts can exhibit a subset of phenotypes reminiscent of macrophages in the course of bacterial infection...
  24. ncbi request reprint Resorption of auditory ossicles and hearing loss in mice lacking osteoprotegerin
    Sho Kanzaki
    Department of Otolaryngology, School of Medicine, Keio University, 35 Shinanomachi, Tokyo 160 8582, Japan
    Bone 39:414-9. 2006
    ..These data suggest that osteoprotegerin plays a crucial role in hearing by protecting the auditory ossicles and otic capsule from osteoclastic bone resorption...
  25. ncbi request reprint Reduced expression of thrombospondins and craniofacial dysmorphism in mice overexpressing Fra1
    Toru Nishiwaki
    Department of Orthopaedics, School of Medicine, Keio University, Tokyo, Japan
    J Bone Miner Res 21:596-604. 2006
    ..Fra1 Tg and non-osteosclerotic Thbs1-/-Thbs2-/- mice share an edge-to-edge bite. Therefore, reduced expression of thrombospondins may contribute to craniofacial dysmorphism independently of osteosclerosis...
  26. ncbi request reprint [Transcription factors in osteoclast differentiation]
    Koichi Matsuo
    Department of Microbiology and Immunology, School of Medicine, Keio University
    Nihon Rinsho 63:1541-6. 2005
    ..Surprisingly, recent studies have begun to uncover a linear relationship among these transcription factors, including the c-Fos-NFATc1 transcriptional activation cascade...
  27. doi request reprint Osteosclerosis and inhibition of human hematopoiesis in NOG mice expressing human Delta-like 1 in osteoblasts
    Ryoji Ito
    Central Institute for Experimental Animals, Kawasaki, Japan Department of Anatomy, Keio University School of Medicine, Tokyo, Japan
    Exp Hematol 40:953-963.e3. 2012
    ..These unique humanized mice with sclerotic bone reconstituted by human HSCs are useful models of hematopoiesis in patients with osteosclerosis, such as osteopetrosis, and for investigation of osteogenesis via Notch signaling...
  28. doi request reprint Acquired Expression of NFATc1 Downregulates E-Cadherin and Promotes Cancer Cell Invasion
    Tsukasa Oikawa
    Authors Affiliations Laboratory of Cell and Tissue Biology Division of Gene Regulation, Institute for Advanced Medical Research Department of Pathology, School of Medicine, Keio University and CREST, Japan Science and Technology Agency, Tokyo, Japan
    Cancer Res 73:5100-9. 2013
    ..Our results thus suggest that the acquisition of NFATc1 expression contributes to tumor progression. Cancer Res; 73(16); 5100-9. ©2013 AACR. ..
  29. pmc Regulation of osteoclasts by membrane-derived lipid mediators
    Tsukasa Oikawa
    Laboratory of Cell and Tissue Biology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Cell Mol Life Sci 70:3341-53. 2013
    ..We examine the critical roles of phosphoinositides in the signaling cascades that regulate osteoclast functions. ..
  30. pmc Signaling flux redistribution at toll-like receptor pathway junctions
    Kumar Selvarajoo
    Institute for Advanced Biosciences, Keio University, Tsuruoka, Japan
    PLoS ONE 3:e3430. 2008
    ..Our data suggest that SFR may enlighten hitherto unexplainable intracellular signaling alterations in genetic diseases where gain or loss-of-function mutations are observed...
  31. pmc Molecular mechanisms of triggering, amplifying and targeting RANK signaling in osteoclasts
    Yukiko Kuroda
    Yukiko Kuroda, Koichi Matsuo, Laboratory of Cell and Tissue Biology, School of Medicine, Keio University, Tokyo 160 8582, Japan
    World J Orthop 3:167-74. 2012
    ..This review focuses on molecular mechanisms for each of the three phases of RANK signaling during osteoclast differentiation...
  32. ncbi request reprint Gefitinib, but not erlotinib, is a possible inducer of Fra-1-mediated interstitial lung disease
    Yasunari Takada
    Laboratory of Cell and Tissue Biology, School of Medicine, Keio University, Tokyo, Japan
    Keio J Med 61:120-7. 2012
    ....
  33. pmc Promoter specificity and biological activity of tethered AP-1 dimers
    Latifa Bakiri
    Unité Expression Génétique et Maladies, CNRS URA 1644, Institut Pasteur, 75724 Paris Cedex 15, France
    Mol Cell Biol 22:4952-64. 2002
    ....
  34. doi request reprint [Assessment of bone quality. Bone remodeling and bone quality]
    Gen ichiro Sano
    Keio University School of Medicine, Department of Microbiology and Immunology
    Clin Calcium 18:315-20. 2008
    ..Therefore understanding the relationship between bone remodeling and bone quality is essential to design interventions to effectively treat osteoporosis...
  35. ncbi request reprint Detection of osteoclastic cell-cell fusion through retroviral vector packaging
    Takako Kondo
    Department of Geriatric Research, National Institute for Longevity Sciences NILS, Aichi 474 8522, Japan
    Bone 35:1120-6. 2004
    ..These data suggest that retrovirus production can occur as a result of cell-cell fusion. This provides a novel approach for isolating and characterizing fusogenic genes using retroviral expression vectors...
  36. ncbi request reprint NF-kappaB p50 and p52 regulate receptor activator of NF-kappaB ligand (RANKL) and tumor necrosis factor-induced osteoclast precursor differentiation by activating c-Fos and NFATc1
    Teruhito Yamashita
    Department of Pathology and Laboratory Medicine and Center for Musculoskeletal Research, University of Rochester Medical Center, Rochester, New York 14642, USA
    J Biol Chem 282:18245-53. 2007
    ..Inhibition of NF-kappaB should prevent RANKL- and TNF-induced bone resorption...
  37. ncbi request reprint Role of heterodimerization of c-Fos and Fra1 proteins in osteoclast differentiation
    Latifa Bakiri
    Research Institute of Molecular Pathology IMP, A 1030 Vienna, Austria
    Bone 40:867-75. 2007
    ..We propose that Fra1 together with a dimerization partner different from Jun proteins can rescue osteoclast differentiation in c-Fos-deficient precursors...
  38. pmc Osteoblasts induce Ca2+ oscillation-independent NFATc1 activation during osteoclastogenesis
    Yukiko Kuroda
    Division of Molecular Neurobiology, Institute of Medical Science, University of Tokyo, 4 6 1, Shirokane dai, Minato ku, Tokyo 108 8639, Japan
    Proc Natl Acad Sci U S A 105:8643-8. 2008
    ..Taken together, we conclude that both Ca(2+) oscillation/calcineurin-dependent and -independent signaling pathways contribute to NFATc1 activation, leading to efficient osteoclastogenesis in vivo...
  39. doi request reprint ATF3 and Fra1 have opposite functions in JNK- and ERK-dependent DNA damage responses
    Mohamed Hamdi
    Department of Molecular Cell Biology, Leiden University Medical Center, 2300 RC Leiden, The Netherlands
    DNA Repair (Amst) 7:487-96. 2008
    ..Thus, we identify novel reciprocal functions of ATF3 and Fra1 in JNK- and ERK-dependent DNA damage responses...
  40. ncbi request reprint RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta
    Hiroshi Takayanagi
    Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo, Hongo 7 3 1, Bunkyo ku, Tokyo 113 0033, Japan
    Nature 416:744-9. 2002
    ..Our study places the IFN-beta system in a new context, and may offer a molecular basis for the treatment of bone diseases...
  41. ncbi request reprint Absence of PERV infection in baboons after transgenic porcine liver perfusion
    Ryuta Nishitai
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, Japan
    J Surg Res 124:45-51. 2005
    ..We evaluated whether PERV is capable of infecting nonhuman primates in vivo after extracorporeal porcine liver perfusion (ECLP)...
  42. ncbi request reprint SIAH1 inactivation correlates with tumor progression in hepatocellular carcinomas
    Koichi Matsuo
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Genes Chromosomes Cancer 36:283-91. 2003
    ..SIAH1 was significantly downregulated in advanced HCCs, including poorly differentiated tumors, larger tumors, and tumors in advanced stages. These findings suggest that inactivation of SIAH1 plays an important role in HCC progression...
  43. ncbi request reprint Suppressed complement activation in human decay accelerating factor transgenic porcine liver cross-circulated with nonhuman primates
    Takakazu Matsushita
    Department of Gastroenterological Surgery, Kyoto University Graduate School of Medicine, Shogoin, Sakyo ku, Kyoto, Japan
    Transplantation 75:1807-12. 2003
    ..We developed an extracorporeal liver perfusion (ECLP) system as a liver-assist device. In this study, we evaluated the safety of the ECLP using human decay accelerating factor (hDAF) transgenic porcine livers in healthy baboons...
  44. ncbi request reprint Suppression of VEGFR-3 signaling inhibits lymph node metastasis in gastric cancer
    Kenji Shimizu
    Department of Gastroenterological Surgery, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8507, Japan
    Cancer Sci 95:328-33. 2004
    ..Antilymphangiogenesis by inhibiting VEGFR-3 signaling could provide a potential strategy for the prevention of lymph node metastasis in gastric cancer...
  45. doi request reprint The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator
    Yu Hikosaka
    Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, Tokushima 770 8503, Japan
    Immunity 29:438-50. 2008
    ..These results indicate that RANKL produced by positively selected thymocytes is responsible for fostering thymic medulla formation, thereby establishing central tolerance...