M Kuwana

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. pmc Complications of Evans' syndrome in an infant with hereditary spherocytosis: a case report
    Hideki Yoshida
    Department of Pediatrics, Matsushita Memorial Hospital, Moriguchi, Japan
    J Hematol Oncol 2:40. 2009
  2. pmc Enhanced angiogenic potency of monocytic endothelial progenitor cells in patients with systemic sclerosis
    Yukie Yamaguchi
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arthritis Res Ther 12:R205. 2010
  3. pmc Natural killer cells control a T-helper 1 response in patients with Behçet's disease
    Yukie Yamaguchi
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arthritis Res Ther 12:R80. 2010
  4. ncbi request reprint Human circulating CD14+ monocytes as a source of progenitors that exhibit mesenchymal cell differentiation
    Masataka Kuwana
    Instiute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    J Leukoc Biol 74:833-45. 2003
  5. ncbi request reprint Autoreactive CD4(+) T cells to beta(2)-glycoprotein I in patients with antiphospholipid syndrome
    Masataka Kuwana
    Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, 160 8582 Tokyo, Japan
    Autoimmun Rev 2:192-8. 2003
  6. ncbi request reprint Endothelial differentiation potential of human monocyte-derived multipotential cells
    Masataka Kuwana
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Stem Cells 24:2733-43. 2006
  7. ncbi request reprint Evaluation of functional disability using the health assessment questionnaire in Japanese patients with systemic sclerosis
    Masataka Kuwana
    Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    J Rheumatol 30:1253-8. 2003
  8. ncbi request reprint Preliminary laboratory based diagnostic criteria for immune thrombocytopenic purpura: evaluation by multi-center prospective study
    M Kuwana
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Thromb Haemost 4:1936-43. 2006
  9. ncbi request reprint Potential benefit of statins for vascular disease in systemic sclerosis
    Masataka Kuwana
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Curr Opin Rheumatol 18:594-600. 2006
  10. ncbi request reprint The role of autoantibody-producing plasma cells in immune thrombocytopenic purpura refractory to rituximab
    M Kuwana
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Hematol 82:846-8. 2007

Collaborators

Detail Information

Publications113 found, 100 shown here

  1. pmc Complications of Evans' syndrome in an infant with hereditary spherocytosis: a case report
    Hideki Yoshida
    Department of Pediatrics, Matsushita Memorial Hospital, Moriguchi, Japan
    J Hematol Oncol 2:40. 2009
    ..HS and Evans' syndrome have different mechanisms of pathophysiology one another. We reported the quite rare case of an infant who had these diseases concurrently. Possible explanations of the unexpected complication are discussed...
  2. pmc Enhanced angiogenic potency of monocytic endothelial progenitor cells in patients with systemic sclerosis
    Yukie Yamaguchi
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arthritis Res Ther 12:R205. 2010
    ....
  3. pmc Natural killer cells control a T-helper 1 response in patients with Behçet's disease
    Yukie Yamaguchi
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arthritis Res Ther 12:R80. 2010
    ..We evaluated the regulatory role of natural killer (NK) cells in Th1-biased immune responses in patients with BD...
  4. ncbi request reprint Human circulating CD14+ monocytes as a source of progenitors that exhibit mesenchymal cell differentiation
    Masataka Kuwana
    Instiute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    J Leukoc Biol 74:833-45. 2003
    ..Our findings represent the first evidence that human circulating CD14+ monocytes are a source of progenitors that exhibit mesenchymal cell differentiation...
  5. ncbi request reprint Autoreactive CD4(+) T cells to beta(2)-glycoprotein I in patients with antiphospholipid syndrome
    Masataka Kuwana
    Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, 160 8582 Tokyo, Japan
    Autoimmun Rev 2:192-8. 2003
    ..Finally, beta(2)GPI-specific T cell is a reasonable target of potential therapeutic strategies that selectively suppress pathogenic aPL production in APS patients...
  6. ncbi request reprint Endothelial differentiation potential of human monocyte-derived multipotential cells
    Masataka Kuwana
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Stem Cells 24:2733-43. 2006
    ..These findings indicate that human MOMCs can proliferate and differentiate along the endothelial lineage in a specific permissive environment and thus represent an autologous transplantable cell source for therapeutic neovasculogenesis...
  7. ncbi request reprint Evaluation of functional disability using the health assessment questionnaire in Japanese patients with systemic sclerosis
    Masataka Kuwana
    Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    J Rheumatol 30:1253-8. 2003
    ..To assess whether the functional disability in Japanese patients with systemic sclerosis (SSc) can be adequately evaluated by the Health Assessment Questionnaire (HAQ) developed in the United States...
  8. ncbi request reprint Preliminary laboratory based diagnostic criteria for immune thrombocytopenic purpura: evaluation by multi-center prospective study
    M Kuwana
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Thromb Haemost 4:1936-43. 2006
    ....
  9. ncbi request reprint Potential benefit of statins for vascular disease in systemic sclerosis
    Masataka Kuwana
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Curr Opin Rheumatol 18:594-600. 2006
    ..These 'pleiotropic' effects suggest that statins may be beneficial for treating SSc vasculopathy. This review focuses on the action of statins on endothelial functions and their potential use in treating SSc...
  10. ncbi request reprint The role of autoantibody-producing plasma cells in immune thrombocytopenic purpura refractory to rituximab
    M Kuwana
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Hematol 82:846-8. 2007
    ..In this patient, the appearance of plasma cells producing anti-platelet autoantibodies is likely to be one of the mechanisms for rituximab resistance...
  11. ncbi request reprint Effect of a single injection of humanized anti-CD154 monoclonal antibody on the platelet-specific autoimmune response in patients with immune thrombocytopenic purpura
    Masataka Kuwana
    Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Blood 103:1229-36. 2004
    ..These findings suggest that CD40/CD154 blockade therapy is potentially effective for refractory ITP, through selective suppression of autoreactive T and B cells to platelet antigens...
  12. ncbi request reprint Increase in circulating endothelial precursors by atorvastatin in patients with systemic sclerosis
    Masataka Kuwana
    Keio University School of Medicine, Tokyo, Japan
    Arthritis Rheum 54:1946-51. 2006
    ..To evaluate whether atorvastatin can increase bone marrow-derived circulating endothelial precursors (CEPs) and improve the vascular symptoms in patients with systemic sclerosis (SSc; scleroderma)...
  13. ncbi request reprint Binding of beta 2-glycoprotein I to anionic phospholipids facilitates processing and presentation of a cryptic epitope that activates pathogenic autoreactive T cells
    Masataka Kuwana
    Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Blood 105:1552-7. 2005
    ..Our finding is the first demonstration of an in vitro mechanism eliciting pathogenic autoreactive T-cell responses to beta(2)GPI and should be useful in clarifying the pathogenesis of APS...
  14. ncbi request reprint Defective vasculogenesis in systemic sclerosis
    Masataka Kuwana
    Institute for Advanced Medical Research Keio University School of Medicine, Tokyo, Japan
    Lancet 364:603-10. 2004
    ..We investigated whether vasculogenesis is impaired in patients with systemic sclerosis...
  15. ncbi request reprint The role of autoreactive T-cells in the pathogenesis of idiopathic thrombocytopenic purpura
    Masataka Kuwana
    Institute for Advanced Medical Research, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Int J Hematol 81:106-12. 2005
    ..Further studies examining the mechanisms that induce the processing and presentation of cryptic peptides derived from the platelet antigen at disease onset will clarify how the pathogenic autoantibody response in ITP is initiated...
  16. ncbi request reprint Enzyme-linked immunosorbent assay for detection of anti-RNA polymerase III antibody: analytical accuracy and clinical associations in systemic sclerosis
    Masataka Kuwana
    Keio University School of Medicine, Tokyo, Japan
    Arthritis Rheum 52:2425-32. 2005
    ..This study was conducted to assess the analytical accuracy and clinical associations of the anti-RNAP III ELISA in patients with systemic sclerosis (SSc)...
  17. ncbi request reprint Beta2-glycoprotein I: antiphospholipid syndrome and T-cell reactivity
    Masataka Kuwana
    Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Thromb Res 114:347-55. 2004
    ..Delineating the mechanisms that induce the efficient processing and presentation of cryptic determinants of beta2GPI as a consequence of antigen processing would clarify the etiology that initiates the autoantibody response in APS...
  18. ncbi request reprint Initial laboratory findings useful for predicting the diagnosis of idiopathic thrombocytopenic purpura
    Masataka Kuwana
    Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    Am J Med 118:1026-33. 2005
    ..To identify initial laboratory findings useful for the later diagnosis of idiopathic thrombocytopenic purpura (ITP) in adult patients with thrombocytopenia...
  19. ncbi request reprint HLA class II alleles in systemic sclerosis patients with anti-RNA polymerase I/III antibody: associations with subunit reactivities
    Masataka Kuwana
    Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Rheumatol 30:2392-7. 2003
    ..To examine HLA class II gene associations with anti-RNA polymerase (RNAP) I/III antibody responses in patients with systemic sclerosis (SSc)...
  20. ncbi request reprint Two types of autoantibody-mediated thrombocytopenia in patients with systemic lupus erythematosus
    M Kuwana
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Rheumatology (Oxford) 45:851-4. 2006
    ..To determine whether autoantibodies to two platelet-specific antigens, glycoprotein IIb/IIIa (GPIIb/IIIa) and thrombopoietin receptor (TPOR), contribute to thrombocytopenia in patients with systemic lupus erythematosus (SLE)...
  21. ncbi request reprint Detection of circulating B cells secreting platelet-specific autoantibody is useful in the diagnosis of autoimmune thrombocytopenia
    Masataka Kuwana
    Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Am J Med 114:322-5. 2003
  22. doi request reprint Splenic macrophages maintain the anti-platelet autoimmune response via uptake of opsonized platelets in patients with immune thrombocytopenic purpura
    M Kuwana
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Thromb Haemost 7:322-9. 2009
    ..Activation of autoreactive CD4(+) T cells upon recognition of cryptic GPIIb/IIIa peptides presented by antigen-presenting cells (APCs) is a critical step for triggering and maintaining the pathogenic anti-platelet autoantibody response...
  23. ncbi request reprint Spleen is a primary site for activation of platelet-reactive T and B cells in patients with immune thrombocytopenic purpura
    Masataka Kuwana
    Institute for Advanced Medical Research and Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Immunol 168:3675-82. 2002
    ....
  24. ncbi request reprint Induction of antigen-specific human CD4(+) T cell anergy by peripheral blood DC2 precursors
    M Kuwana
    Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    Eur J Immunol 31:2547-57. 2001
    ..These results suggest that pDC2 are involved in maintenance of peripheral T cell tolerance and have potential for use in the suppression of pathogenic T cell responses in autoimmune diseases and organ transplantation...
  25. ncbi request reprint Autoantibodies to the amino-terminal fragment of beta-fodrin expressed in glandular epithelial cells in patients with Sjögren's syndrome
    M Kuwana
    Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Immunol 167:5449-56. 2001
    ....
  26. ncbi request reprint Immunodominant epitopes on glycoprotein IIb-IIIa recognized by autoreactive T cells in patients with immune thrombocytopenic purpura
    M Kuwana
    Institute for Advanced Medical Research and the Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Blood 98:130-9. 2001
    ..These results indicate that the immunodominant epitopes recognized by pathogenic CD4(+) T cells in patients with ITP are located within the amino-terminal portions of both GPIIbalpha and GPIIIa...
  27. doi request reprint Long-term beneficial effects of statins on vascular manifestations in patients with systemic sclerosis
    Masataka Kuwana
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Mod Rheumatol 19:530-5. 2009
    ..This pilot study suggests that statins may be beneficial in treating vascular manifestations of SSc, through their pleiotropic effects. However, this treatment did not correct the defect in EPC recruitment...
  28. pmc Differences in autoantibody response to Th/To between systemic sclerosis and other autoimmune diseases
    M Kuwana
    Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Ann Rheum Dis 61:842-6. 2002
    ..To examine differences in autoantibody response and immunogenetic background between patients with systemic sclerosis (SSc) and those with other autoimmune diseases who had serum anti-Th/To antibodies...
  29. ncbi request reprint Autoantibody to c-Mpl (thrombopoietin receptor) in systemic lupus erythematosus: relationship to thrombocytopenia with megakaryocytic hypoplasia
    Masataka Kuwana
    Keio University School of Medicine, Tokyo, Japan
    Arthritis Rheum 46:2148-59. 2002
    ..To examine the prevalence, clinical associations, and pathogenic role of autoantibodies to c-Mpl, the thrombopoietin (TPO) receptor, in patients with systemic lupus erythematosus (SLE)...
  30. ncbi request reprint Induction of anergic and regulatory T cells by plasmacytoid dendritic cells and other dendritic cell subsets
    Masataka Kuwana
    Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    Hum Immunol 63:1156-63. 2002
    ..These "tolerogenic" DCs may be relevant to therapeutic applications for autoimmune and allergic diseases as well as organ transplant rejection...
  31. ncbi request reprint Suppression of autoreactive T-cell response to glycoprotein IIb/IIIa by blockade of CD40/CD154 interaction: implications for treatment of immune thrombocytopenic purpura
    Masataka Kuwana
    Institute for Advanced Medical Research and Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Blood 101:621-3. 2003
    ....
  32. ncbi request reprint Identification of an immunodominant epitope on RNA polymerase III recognized by systemic sclerosis sera: application to enzyme-linked immunosorbent assay
    Masataka Kuwana
    Institute for Advanced Medical Research, Keio University School of Medicine, 55 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arthritis Rheum 46:2742-7. 2002
    ..To characterize an immunodominant epitope on RNA polymerase III (RNAP III) recognized by systemic sclerosis (SSc) sera and to develop an enzyme-linked immunosorbent assay (ELISA) for the detection of serum anti-RNAP I/III antibodies...
  33. ncbi request reprint A significant role of stromal fibroblasts in rapidly progressive dry eye in patients with chronic GVHD
    Y Ogawa
    Departments of Ophthalmology and. Diagnostic Pathology, Institute for Advanced Medical Research, Tokyo, Japan
    Invest Ophthalmol Vis Sci 42:111-9. 2001
    ..In addition, it is likely that stromal fibroblasts are actively involved in the pathogenic process of chronic GVHD in the lacrimal gland by producing excessive extracellular matrix components...
  34. ncbi request reprint Autoreactive CD4(+) T-cell clones to beta2-glycoprotein I in patients with antiphospholipid syndrome: preferential recognition of the major phospholipid-binding site
    T Arai
    Institute for Advanced Medical Research and Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Blood 98:1889-96. 2001
    ..These findings are potentially useful for clarifying the pathogenesis of APS and for developing therapeutic strategies that suppress pathogenic antiphospholipid antibody production in these patients...
  35. ncbi request reprint Successful treatment of dry eye in two patients with chronic graft-versus-host disease with systemic administration of FK506 and corticosteroids
    Y Ogawa
    Department of Ophthalmology, Division of Hematology, The Department of Medicine, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    Cornea 20:430-4. 2001
    ..We present two cases of severe dry eye in patients with chronic graft-versus-host disease (CGVHD) after hematopoietic stem cell transplantation (SCT) who were successfully treated by the systemic administration of FK506 and corticosteroids...
  36. ncbi request reprint Heterogeneous immunogenetic background in Japanese adults with myasthenia gravis
    S Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160-8582, Japan
    J Neurol Sci 189:59-64. 2001
    ..045). These findings indicate that immunogenetic backgrounds in Japanese adult MG patients are heterogeneous and are apparently different from those in Caucasian patients...
  37. ncbi request reprint Prolonged thrombocytopenia after allogeneic hematopoietic stem cell transplantation: associations with impaired platelet production and increased platelet turnover
    R Yamazaki
    Division of Hematology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Bone Marrow Transplant 38:377-84. 2006
    ..In summary, post transplant prolonged thrombocytopenia is associated with complex mechanisms, including impaired thrombopoiesis and increased platelet turnover...
  38. ncbi request reprint Autoantibody to CD40 ligand in systemic lupus erythematosus: association with thrombocytopenia but not thromboembolism
    M Nakamura
    Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Rheumatology (Oxford) 45:150-6. 2006
    ..To examine the prevalence, clinical associations and pathogenic roles of autoantibodies to CD40 ligand (CD40L) in patients with systemic lupus erythematosus (SLE)...
  39. doi request reprint Association study of a polymorphism of the CTGF gene and susceptibility to systemic sclerosis in the Japanese population
    Y Kawaguchi
    Institute of Rheumatology, Tokyo Women s Medical University, Shinjuku ku, Tokyo 162 0054, Japan
    Ann Rheum Dis 68:1921-4. 2009
    ..To validate the association of a single nucleotide polymorphism (SNP) of the connective tissue growth factor gene (CTGF) with susceptibility to systemic sclerosis (SSc) in the Japanese population...
  40. ncbi request reprint Antibodies to Th/To ribonucleoprotein in patients with localized scleroderma
    K Yamane
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Rheumatology (Oxford) 40:683-6. 2001
    ..CONCLUSION: Anti-Th/To is one of the serological abnormalities in localized scleroderma, and the presence of anti-Th/To may be a serological indicator of a mild form of cutaneous involvement...
  41. ncbi request reprint Cytokine and immunogenetic profiles in Japanese patients with adult Still's disease. Association with chronic articular disease
    T Fujii
    Section of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo 160-8582, Japan
    Rheumatology (Oxford) 40:1398-404. 2001
    ..CONCLUSION: The present study suggests that ASD with chronic articular disease has distinct clinical, cytokine and immunogenetic profiles...
  42. doi request reprint Clinical utility of anti-signal recognition particle antibody in the differential diagnosis of myopathies
    S Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Rheumatology (Oxford) 47:1539-42. 2008
    ..The aim of the present study was to elucidate whether detection of anti-SRP antibody can discriminate of PM from muscular dystrophy (MD)...
  43. pmc Autoreactive T cells to platelet GPIIb-IIIa in immune thrombocytopenic purpura. Role in production of anti-platelet autoantibody
    M Kuwana
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Invest 102:1393-402. 1998
    ..In summary, CD4(+) and HLA-DR-restricted T cells to GPIIb-IIIa are involved in production of anti-platelet autoantibody in ITP patients and are related to the pathogenic process in chronic ITP...
  44. ncbi request reprint Excessive exposure to anionic surfaces maintains autoantibody response to beta(2)-glycoprotein I in patients with antiphospholipid syndrome
    Yukie Yamaguchi
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Blood 110:4312-8. 2007
    ..Continuous exposure to these anionic surfaces may play a critical role in maintaining the pathogenic anti-beta(2)GPI antibody response in patients with APS...
  45. ncbi request reprint Circulating anti-double-stranded DNA antibody-secreting cells in patients with systemic lupus erythematosus: a novel biomarker for disease activity
    H Hanaoka
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Japan
    Lupus 21:1284-93. 2012
    ..001). Circulating anti-dsDNA antibody-secreting cells are a useful biomarker for assessing disease activity in SLE patients...
  46. ncbi request reprint HLA class II alleles in Japanese patients with immune thrombocytopenic purpura. Associations with anti-platelet glycoprotein autoantibodies and responses to splenectomy
    M Kuwana
    Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    Tissue Antigens 56:337-43. 2000
    ..In addition, HLA class II genotyping could be useful in predicting therapeutic responses to splenectomy in Japanese patients with ITP...
  47. ncbi request reprint Clinical characteristics of Japanese patients with anti-OJ (anti-isoleucyl-tRNA synthetase) autoantibodies
    S Sato
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Rheumatology (Oxford) 46:842-5. 2007
    ..The clinical and laboratory characteristics of seven patients with anti-aminoacyl-tRNA synthetase (ARS) autoantibodies, specifically anti-OJ (anti-isoleucyl-tRNA synthetase), were examined and compared with previously published findings...
  48. ncbi request reprint Autologous serum eye drops for the treatment of severe dry eye in patients with chronic graft-versus-host disease
    Y Ogawa
    Department of Ophthalmology, School of Medicine, Keio University, Tokyo, Japan
    Bone Marrow Transplant 31:579-83. 2003
    ....
  49. pmc The tetraspanin CD9 is preferentially expressed on the human CD4(+)CD45RA+ naive T cell population and is involved in T cell activation
    H Kobayashi
    Division of Clinical Immunology, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
    Clin Exp Immunol 137:101-8. 2004
    ..Furthermore, anti5H9 inhibits both the recombinant beta2-glycoprotein I- and the recall antigen tetanus toxoid-specific T cell proliferation. These results suggest that the tetraspanin CD9 plays an important role in T cell activation...
  50. ncbi request reprint Preferential activation of circulating CD8+ and gammadelta T cells in patients with active Behçet's disease and HLA-B51
    H Yasuoka
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Clin Exp Rheumatol 26:S59-63. 2008
    ..To evaluate the activation status of circulating CD4+, CD8+, and gammadelta T cells in patients with active and inactive Behçet's disease (BD)...
  51. ncbi request reprint Estrogen receptor gene polymorphisms in Japanese patients with systemic sclerosis
    M Hoshi
    Department of Internal Medicine, Den en Chofu Central Hospital, Tokyo, Japan
    Clin Exp Rheumatol 26:914-7. 2008
    ..To investigate whether single-nucleotide polymorphisms (SNPs) within the estrogen receptor (ER) alpha and Beta genes are associated with disease susceptibility and clinical presentation in Japanese patients with systemic sclerosis (SSc)...
  52. doi request reprint Clinical associations with autoantibody reactivities to individual components of U1 small nuclear ribonucleoprotein
    Y Kaneko
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Lupus 19:307-12. 2010
    ..The detection of autoantibody reactivities to individual components of the U1 snRNP particle is potentially useful for predicting the clinical course in patients with connective tissue disease and anti-U1 snRNP antibodies...
  53. ncbi request reprint Anti-c-Mpl (thrombopoietin receptor) autoantibody-induced amegakaryocytic thrombocytopenia in a patient with systemic sclerosis
    Yasuhiro Katsumata
    Department of Internal Medicine, Kawasaki Municipal Hospital, Kanagawa, Japan
    Arthritis Rheum 48:1647-51. 2003
    ..Our case report suggests that AMT in patients with SSc could be mediated by the anti-c-Mpl antibody, which functionally blocks an interaction between thrombopoietin and c-Mpl...
  54. doi request reprint Muscarinic-3 acetylcholine receptor autoantibody in patients with systemic sclerosis: contribution to severe gastrointestinal tract dysmotility
    Y Kawaguchi
    Institute of Rheumatology, Tokyo Women s Medical University, Tokyo, Japan
    Ann Rheum Dis 68:710-4. 2009
    ..To clarify the pathogenesis of GIT involvement, the occurrence of autoantibody was investigated for muscarinic-3 acetylcholine receptor (M3R) in patients with SSc...
  55. ncbi request reprint Clinical characteristics of Japanese patients with anti-PL-7 (anti-threonyl-tRNA synthetase) autoantibodies
    S Sato
    Department of Internal Medicine, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Clin Exp Rheumatol 23:609-15. 2005
    ..The clinical and laboratory features of seven Japanese patients with anti-aminoacyl-tRNA synthetase (ARS) autoantibodies against PL-7 (anti-threonyl-tRNA synthetase) were analyzed and compared with previously published findings...
  56. doi request reprint Successful treatment of amegakaryocytic thrombocytopenia with anti-CD20 antibody (rituximab) in a patient with systemic lupus erythematosus
    T Fukushima
    Division of Hematology and Immunology, Department of Internal Medicine, Kanazawa Medical University, Kahoku gun, Ishikawa, Japan
    Lupus 17:210-4. 2008
    ....
  57. ncbi request reprint A role of autoantibody-mediated platelet destruction in thrombocytopenia in patients with cirrhosis
    Mikio Kajihara
    Division of Gastroenterology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hepatology 37:1267-76. 2003
    ..In conclusion, the similar profile of the anti-GPIIb-IIIa autoantibody response in patients with LC and ITP suggests that autoantibody-mediated platelet destruction may contribute at least in part to cirrhotic thrombocytopenia...
  58. ncbi request reprint Autoreactive T cells to the P3A+ isoform of AChR alpha subunit in myasthenia gravis
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Neuroimmunol 137:177-86. 2003
    ..These autoreactive T cells may be involved in the pathogenic process in a subset of MG patients...
  59. ncbi request reprint Donor fibroblast chimerism in the pathogenic fibrotic lesion of human chronic graft-versus-host disease
    Yoko Ogawa
    Institute for Advanced Medical Research, Keio University School of Medicine, Shinanomachi, Tokyo, Japan
    Invest Ophthalmol Vis Sci 46:4519-27. 2005
    ..The current study was undertaken to investigate whether the increase in fibroblasts at the site of pathogenic fibrosis originated from transplanted donor cells in patients with chronic GVHD...
  60. ncbi request reprint Novel autoantibodies to a voltage-gated potassium channel Kv1.4 in a severe form of myasthenia gravis
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160 8582, Japan
    J Neuroimmunol 170:141-9. 2005
    ..These findings suggest that anti-Kv1.4 antibody is a novel autoantibody associated with a severe MG subset and thymoma...
  61. doi request reprint Clinical usefulness of anti-RNA polymerase III antibody measurement by enzyme-linked immunosorbent assay
    Takashi Satoh
    Department of Internal Medicine, Division of Rheumatology, Keio University School of Medicine, Tokyo 160 8582, Japan
    Rheumatology (Oxford) 48:1570-4. 2009
    ..To evaluate the clinical usefulness of measuring anti-RNA polymerase (RNAP) III antibody with a commercially available ELISA in Japanese patients with SSc...
  62. ncbi request reprint Single nucleotide polymorphisms of the inflammatory cytokine genes in adults with chronic immune thrombocytopenic purpura
    Takashi Satoh
    Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    Br J Haematol 124:796-801. 2004
    ..02 and P < 0.001, respectively). These findings suggest that the SNP located at TNF-beta (+252) contributes to susceptibility to chronic ITP by controlling the autoreactive B-cell responses to platelet membrane glycoproteins...
  63. doi request reprint Single nucleotide polymorphism of interleukin-1beta associated with Helicobacter pylori infection in immune thrombocytopenic purpura
    T Satoh
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Tissue Antigens 73:353-7. 2009
    ..01, odds ratio = 0.31) ITP patients diagnosed before age 50. These findings suggest that a single nucleotide polymorphism within the IL-1beta (-511) may affect susceptibility to early-onset ITP associated with H. pylori infection...
  64. doi request reprint Successful treatment of refractory polymyositis with the immunosuppressant mizoribine: case report
    A Suwa
    Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara, Kanagawa 259 1193, Japan
    Clin Rheumatol 28:227-9. 2009
    ..Mizoribine is a purine antimetabolite that inhibits T cell activation/proliferation and B cell proliferation. The potential efficacy of mizoribine for polymyositis was suggested by this case...
  65. ncbi request reprint Characterization of autoreactive T-cell clones to myeloperoxidase in patients with microscopic polyangiitis and healthy individuals
    N Seta
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Clin Exp Rheumatol 27:826-9. 2009
    ..To characterize autoreactive T cells against myeloperoxidase (MPO) by generating antigen-specific T-cell clones from patients with microscopic polyangiitis (MPA) and healthy individuals...
  66. ncbi request reprint Lack of circulating autoantibodies to bone morphogenetic protein receptor-II or activin receptor-like kinase 1 in mixed connective tissue disease patients with pulmonary arterial hypertension
    T Satoh
    Institute for Advanced Medical Research, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Rheumatology (Oxford) 44:192-6. 2005
    ....
  67. ncbi request reprint [Recent topics on basic research for idiopathic thrombocytopenic purpura]
    M Kuwana
    Institute for Advanced Medical Research, Keio University School of Medicine, Shinjuku-ku, Tokyo 160-8582
    Rinsho Byori 49:992-5. 2001
    ..Suppression of GPIIb-IIIa-reactive CD4+ T cells may be of therapeutic use in treating refractory patients...
  68. pmc Helicobacter pylori eradication shifts monocyte Fcgamma receptor balance toward inhibitory FcgammaRIIB in immune thrombocytopenic purpura patients
    Atsuko Asahi
    Division of Rheumatology, Department of Internal Medicine, and Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    J Clin Invest 118:2939-49. 2008
    ..Our findings strongly suggest that the recovery in platelet numbers observed in ITP patients after H. pylori eradication is mediated through a change in FcgammaR balance toward the inhibitory FcgammaRIIB...
  69. ncbi request reprint Periductal area as the primary site for T-cell activation in lacrimal gland chronic graft-versus-host disease
    Yoko Ogawa
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 44:1888-96. 2003
    ..To examine immune processes in the lacrimal gland of patients with chronic graft-versus-host disease (cGVHD) by evaluating the expression of surface molecules associated with T-cell activation...
  70. doi request reprint RNA helicase encoded by melanoma differentiation-associated gene 5 is a major autoantigen in patients with clinically amyopathic dermatomyositis: Association with rapidly progressive interstitial lung disease
    Shinji Sato
    Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Arthritis Rheum 60:2193-200. 2009
    ..To identify the autoantigen recognized by the autoantibody that is associated with clinically amyopathic dermatomyositis (C-ADM) and rapidly progressive interstitial lung disease (ILD)...
  71. ncbi request reprint Restricted T-cell receptor beta-chain usage by T cells autoreactive to beta(2)-glycoprotein I in patients with antiphospholipid syndrome
    Kazue Yoshida
    Institute for Advanced Medical Research, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Blood 99:2499-504. 2002
    ..Our results indicate preferential usage of TCRbeta chains by beta(2)GPI-reactive T cells. These TCRbeta chains can be reasonable targets for TCR-based immunotherapy for patients with APS...
  72. doi request reprint Autoreactive T-cell responses to myeloperoxidase in patients with antineutrophil cytoplasmic antibody-associated vasculitis and in healthy individuals
    Noriyuki Seta
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Mod Rheumatol 18:593-600. 2008
    ..In summary, we successfully used recombinant MPO fragments to detect autoreactive CD4+ T cells to multiple MPO epitopes in blood samples from patients with MPO-ANCA-associated vasculitis and healthy individuals...
  73. ncbi request reprint Acute inflammatory sensorimotor polyradiculoneuropathy associated with immune thrombocytopenic purpura
    N Sato
    Department of Internal Medicine, Tokyo Metropolitan Bokutoh Hospital, Tokyo, Japan
    J Intern Med 257:473-7. 2005
    ..By reviewing past similar reports, we noticed that AIP associated with ITP tends to manifest severe sensory impairment and is often preceded by upper respiratory tract infection, but not by gastrointestinal infection...
  74. pmc Prevalence in myositis of antibodies recognizing anti-U3 RNA probably in a novel complex with 22/25 kD protein and not fibrillarin
    M Kubo
    Department of Dermatology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
    Clin Exp Immunol 126:339-44. 2001
    ..There may be a subgroup of PM/DM patients whose sera are positive for anti-Myo 22/25 antibodies...
  75. ncbi request reprint Longterm effect of intermittent cyclical etidronate therapy on corticosteroid-induced osteoporosis in Japanese patients with connective tissue disease: 7-year followup
    Shinji Sato
    Department of Internal Medicine, Keio University, School of Medicine, Tokyo, Japan
    J Rheumatol 35:142-6. 2008
    ..To determine the efficacy and safety of intermittent cyclical etidronate therapy of up to 7 years for corticosteroid-induced osteoporosis...
  76. ncbi request reprint Classification of myasthenia gravis based on autoantibody status
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160 8582, Japan
    Arch Neurol 64:1121-4. 2007
    ..To investigate the autoantibody status of patients with myasthenia gravis (MG) and to evaluate its usefulness for disease classification...
  77. ncbi request reprint Novel system evaluating in vivo pathogenicity of desmoglein 3-reactive T cell clones using murine pemphigus vulgaris
    Hayato Takahashi
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Immunol 181:1526-35. 2008
    ..This strategy is useful for evaluating the effector function of autoreactive T cells involved in the pathogenesis of various autoimmune diseases...
  78. doi request reprint Autoimmune targets of heart and skeletal muscles in myasthenia gravis
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arch Neurol 66:1334-8. 2009
    ..To investigate the clinical, histological, and immunological features of patients with myasthenia gravis (MG) who also developed myocarditis and/or myositis...
  79. ncbi request reprint A novel protein highly expressed in testis is overexpressed in systemic sclerosis fibroblasts and targeted by autoantibodies
    Hidekata Yasuoka
    Department of Internal Medicine and Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    J Immunol 171:6883-90. 2003
    ..These findings suggest that the autoantibody response to PHET can be induced by ectopic overexpression of PHET in dermal fibroblasts in SSc patients...
  80. ncbi request reprint Cardiomyogenic potential of mesenchymal progenitors derived from human circulating CD14+ monocytes
    Hiroaki Kodama
    Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo 160 8582, Japan
    Stem Cells Dev 14:676-86. 2005
    ..Our results demonstrate for the first time that human circulating CD14+ monocytes include progenitors capable of proliferating and differentiating along the cardiomyogenic lineage via their differentiation into MOMPs...
  81. ncbi request reprint Initial predictors of development of pure red cell aplasia in myasthenia gravis after thymectomy
    Shigeaki Suzuki
    Department of Neurology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Clin Neurol Neurosurg 106:16-8. 2003
    ..Japanese MG patients with these characteristics at presentation were at significant risk for the development of PRCA after thymectomy...
  82. ncbi request reprint Altered peptide ligands control type II collagen-reactive T cells from rheumatoid arthritis patients
    Yasuyuki Ohnishi
    Division of Rheumatology, Department of Internal Medicine, Institute of Clinical Medicine, University of Tsukuba, 1 1 1 Tenodai, Tsukuba, 305 8575, Japan
    Mod Rheumatol 16:226-8. 2006
    ..Results showed that 262 (G-->A) APL of CII 256-271 exhibited antagonistic activity in all T-cell lines and it was suggested that the application of CII APL might be a new therapeutic strategy in the regulation of RA...
  83. ncbi request reprint Dry eye as a major complication associated with chronic graft-versus-host disease after hematopoietic stem cell transplantation
    Yoko Ogawa
    Institute for Advanced Medical Research, and Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Cornea 22:S19-27. 2003
    ..To review the condition of dry eye associated with chronic graft-versus-host disease (GVHD)...
  84. ncbi request reprint [Idiopathic thrombocytopenic purpura]
    Masataka Kuwana
    Institute for Advanced Medical Research, Keio University School of Medicine
    Nihon Rinsho 63:443-9. 2005
  85. ncbi request reprint Autoantibodies to a 140-kd polypeptide, CADM-140, in Japanese patients with clinically amyopathic dermatomyositis
    Shinji Sato
    Keio University School of Medicine, Tokyo, Japan
    Arthritis Rheum 52:1571-6. 2005
    ..To identify novel autoantibodies specific for dermatomyositis (DM), especially those specific for clinically amyopathic DM (C-ADM)...
  86. ncbi request reprint Immune responses to DNA mismatch repair enzymes hMSH2 and hPMS1 in patients with pancreatic cancer, dermatomyositis and polymyositis
    Takaho Okada
    Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    Int J Cancer 116:925-33. 2005
    ....
  87. ncbi request reprint Helicobacter pylori and immune thrombocytopenic purpura: unsolved questions and controversies
    Masataka Kuwana
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Int J Hematol 84:309-15. 2006
    ....
  88. ncbi request reprint Evaluation of platelet kinetics in patients with liver cirrhosis: similarity to idiopathic thrombocytopenic purpura
    Mikio Kajihara
    Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    J Gastroenterol Hepatol 22:112-8. 2007
    ..The purpose of the present paper was to evaluate the platelet kinetics in LC patients by examining several non-invasive convenient markers...
  89. ncbi request reprint Effect of intermittent cyclical etidronate therapy on corticosteroid induced osteoporosis in Japanese patients with connective tissue disease: 3 year followup
    Shinji Sato
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Rheumatol 30:2673-9. 2003
    ..A 3 year prospective randomized study was conducted to clarify the efficacy of intermittent cyclical etidronate therapy on corticosteroid induced osteoporosis...
  90. ncbi request reprint Dry eye associated with chronic graft-versus-host disease
    Y Ogawa
    Department of Ophthalmology, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    Adv Exp Med Biol 506:1041-5. 2002
  91. doi request reprint A CD40-CD154 interaction in tissue fibrosis
    Masataka Kawai
    Keio University School of Medicine, Tokyo, Japan
    Arthritis Rheum 58:3562-73. 2008
    ..To examine the role of an interaction between fibroblasts and mononuclear infiltrates through CD40-CD154 engagement in the development of tissue fibrosis...
  92. ncbi request reprint Characteristics of patients with early systemic sclerosis and severe gastrointestinal tract involvement
    Emi Nishimagi
    Institute of Rheumatology, Tokyo Women s Medical University School of Medicine, Tokyo, Japan
    J Rheumatol 34:2050-5. 2007
    ..To clarify the clinical features of patients with systemic sclerosis (SSc) who developed severe gastrointestinal tract (GIT) involvement in the early stage of the disease...
  93. ncbi request reprint Neurogenic potential of progenitors derived from human circulating CD14+ monocytes
    Hiroaki Kodama
    Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    Immunol Cell Biol 84:209-17. 2006
    ..The capacity of MOMC to differentiate into both mesodermal and neuroectodermal lineages suggests that circulating CD14+ monocytes are more multipotential than previously thought...
  94. ncbi request reprint [Immunologic tests: Anti-Scl-70 antibody (anti-topoisomerase I antibody)]
    Masataka Kuwana
    Institute for Advanced Medical Research, Keio University School of Medicine
    Nihon Rinsho 63:499-501. 2005
  95. ncbi request reprint [Blockade of CD40/CD154 signal as a therapeutic strategy for autoimmune diseases]
    Masataka Kuwana
    Institute for Advanced Medical Research, Keio University School of Medicine
    Nihon Rinsho Meneki Gakkai Kaishi 26:259-66. 2003
  96. ncbi request reprint [Immunologic tests: Anti-rNA polymerase antibody]
    Masataka Kuwana
    Institute for Advanced Medical Research, Keio University School of Medicine
    Nihon Rinsho 63:491-4. 2005
  97. doi request reprint Human circulating monocytes can express receptor activator of nuclear factor-kappaB ligand and differentiate into functional osteoclasts without exogenous stimulation
    Noriyuki Seta
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Immunol Cell Biol 86:453-9. 2008
    ..These results indicate that human MOMCs derived from circulating monocytes can express RANKL and differentiate into functional osteoclasts without RANKL-expressing accessory cells...
  98. ncbi request reprint Human circulating monocytes as multipotential progenitors
    Noriyuki Seta
    Division of Rheumatology, Department of Internal Medicine, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    Keio J Med 56:41-7. 2007
    ..These observations together indicate that circulating monocytes are more multipotential than previously thought. In addition, cell transplantation therapies using circulating monocytes are a potential approach for tissue regeneration...
  99. doi request reprint Derivation of multipotent progenitors from human circulating CD14+ monocytes
    Noriyuki Seta
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Exp Hematol 38:557-63. 2010
    ....
  100. doi request reprint Clinical and histopathological features of myopathies in Japanese patients with anti-SRP autoantibodies
    Tetsuya Takada
    Division of Rheumatology, Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Mod Rheumatol 19:156-64. 2009
    ..These studies suggest that anti-SRP autoantibodies are most likely to be related to myopathies that are resistant to corticosteroid therapy and without inflammation histopathologically...
  101. doi request reprint Cardiac involvements in myasthenia gravis associated with anti-Kv1.4 antibodies
    S Suzuki
    Department of Neurology, Keio University School of Medicine, Tokyo, Japan
    Eur J Neurol 21:223-30. 2014
    ..4 antibodies. The purpose of this study was to disclose the association between anti-Kv1.4 antibodies and cardiac involvements in MG patients...