Affiliation: Keio University
Tai Nagara I, Yoshikawa Y, Numata N, Ando T, Okabe K, Sugiura Y, et al
. Placental labyrinth formation in mice requires endothelial FLRT2/UNC5B signaling. Development. 2017;144:2392-2401 pubmed publisher
..Our results suggest that the proper organization of the placental labyrinth depends on coordinated inter-endothelial repulsion, which prevents uncontrolled layering of the endothelium. ..
Yoshikawa Y, Yamada T, Tai Nagara I, Okabe K, Kitagawa Y, Ema M, et al
. Developmental regression of hyaloid vasculature is triggered by neurons. J Exp Med. 2016;213:1175-83 pubmed publisher
..Collectively, our data indicate that neurons trigger transition from the fetal to the postnatal circulatory systems in the retina. ..
Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Okuno Y, et al
. Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero. J Exp Med. 2011;208:949-60 pubmed publisher
..Thus, in postnatal mice, although growing vessels are formed primarily by angiogenesis from preexisting vessels, a minor population of arterial endothelia may be derived from tissue-resident vascular precursor cells. ..
Kubota Y. Tumor angiogenesis and anti-angiogenic therapy. Keio J Med. 2012;61:47-56 pubmed
..These findings offer opportunities to greatly improve current anti-angiogenic treatment for cancer. ..
Okabe K, Kobayashi S, Yamada T, Kurihara T, Tai Nagara I, Miyamoto T, et al
. Neurons limit angiogenesis by titrating VEGF in retina. Cell. 2014;159:584-96 pubmed publisher
..Thus, this study revealed neurovascular crosstalk and unprecedented cellular regulation of VEGF: retinal neurons titrate VEGF to limit neuronal vascularization. PAPERFLICK: ..