Takeshi Kawauchi

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. ncbi request reprint Molecular pathways regulating cytoskeletal organization and morphological changes in migrating neurons
    Takeshi Kawauchi
    Department of Anatomy, Keio University School of Medicine, Tokyo, Japan
    Dev Neurosci 30:36-46. 2008
  2. doi request reprint Rab GTPases-dependent endocytic pathways regulate neuronal migration and maturation through N-cadherin trafficking
    Takeshi Kawauchi
    Department of Anatomy, Keio University School of Medicine, Tokyo 160 8582, Japan
    Neuron 67:588-602. 2010
  3. pmc Reelin controls neuronal positioning by promoting cell-matrix adhesion via inside-out activation of integrin α5β1
    Katsutoshi Sekine
    Department of Anatomy, Keio University School of Medicine, Tokyo 160 8582, Japan
    Neuron 76:353-69. 2012
  4. doi request reprint The outermost region of the developing cortical plate is crucial for both the switch of the radial migration mode and the Dab1-dependent "inside-out" lamination in the neocortex
    Katsutoshi Sekine
    Department of Anatomy, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Neurosci 31:9426-39. 2011
  5. doi request reprint Role of dual leucine zipper-bearing kinase (DLK/MUK/ZPK) in axonal growth
    Kaoru Eto
    Department of Anatomy, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Neurosci Res 66:37-45. 2010
  6. pmc Dissecting the factors involved in the locomotion mode of neuronal migration in the developing cerebral cortex
    Yoshiaki V Nishimura
    Department of Anatomy, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Biol Chem 285:5878-87. 2010
  7. ncbi request reprint Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration
    Takeshi Kawauchi
    Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Nat Cell Biol 8:17-26. 2006
  8. ncbi request reprint Involvement of a Rac activator,P-Rex1, in neurotrophin-derived signaling and neuronal migration
    Masato Yoshizawa
    Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    J Neurosci 25:4406-19. 2005
  9. pmc The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration
    Takeshi Kawauchi
    Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    EMBO J 22:4190-201. 2003
  10. ncbi request reprint Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum
    Mikio Hoshino
    Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Neuron 47:201-13. 2005

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Molecular pathways regulating cytoskeletal organization and morphological changes in migrating neurons
    Takeshi Kawauchi
    Department of Anatomy, Keio University School of Medicine, Tokyo, Japan
    Dev Neurosci 30:36-46. 2008
    ..In this review, we introduce the molecular pathways underlying cortical neuronal migration and morphological changes, with particular focus on recent findings for the regulatory mechanisms of actin cytoskeleton and microtubules...
  2. doi request reprint Rab GTPases-dependent endocytic pathways regulate neuronal migration and maturation through N-cadherin trafficking
    Takeshi Kawauchi
    Department of Anatomy, Keio University School of Medicine, Tokyo 160 8582, Japan
    Neuron 67:588-602. 2010
    ..Taken together, our findings reveal physiological roles of endocytic pathways, each of which has specific functions in distinct steps of neuronal migration and maturation during mammalian brain formation...
  3. pmc Reelin controls neuronal positioning by promoting cell-matrix adhesion via inside-out activation of integrin α5β1
    Katsutoshi Sekine
    Department of Anatomy, Keio University School of Medicine, Tokyo 160 8582, Japan
    Neuron 76:353-69. 2012
    ..These data indicate that Reelin-dependent activation of neuronal adhesion to the extracellular matrix is crucial for the eventual birth-date-dependent layering of the neocortex...
  4. doi request reprint The outermost region of the developing cortical plate is crucial for both the switch of the radial migration mode and the Dab1-dependent "inside-out" lamination in the neocortex
    Katsutoshi Sekine
    Department of Anatomy, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Neurosci 31:9426-39. 2011
    ....
  5. doi request reprint Role of dual leucine zipper-bearing kinase (DLK/MUK/ZPK) in axonal growth
    Kaoru Eto
    Department of Anatomy, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Neurosci Res 66:37-45. 2010
    ..These results suggest that the DLK/MUK/ZPK-JNK pathway directly regulates axonal growth through phosphorylation of MAP1B...
  6. pmc Dissecting the factors involved in the locomotion mode of neuronal migration in the developing cerebral cortex
    Yoshiaki V Nishimura
    Department of Anatomy, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Biol Chem 285:5878-87. 2010
    ..It also uncovered roles for Fyn and PKCdelta in the early and final phases of migration, respectively...
  7. ncbi request reprint Cdk5 phosphorylates and stabilizes p27kip1 contributing to actin organization and cortical neuronal migration
    Takeshi Kawauchi
    Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Nat Cell Biol 8:17-26. 2006
    ..Our findings shed light on a previously unknown new relationship between CDK and CKI in G0-arrested cells that regulates cytoskeletal reorganization and neuronal migration during corticogenesis...
  8. ncbi request reprint Involvement of a Rac activator,P-Rex1, in neurotrophin-derived signaling and neuronal migration
    Masato Yoshizawa
    Department of Pathology and Tumor Biology, Kyoto University Graduate School of Medicine, Kyoto 606 8501, Japan
    J Neurosci 25:4406-19. 2005
    ..These findings suggest that P-Rex1, which is expressed in a variety of cell types, is activated by extracellular cues such as neurotrophins and contributes to neuronal migration in the developing nervous system...
  9. pmc The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration
    Takeshi Kawauchi
    Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    EMBO J 22:4190-201. 2003
    ..Our data thus provide important clues for understanding the intracellullar signaling machinery for cortical neuronal migration...
  10. ncbi request reprint Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum
    Mikio Hoshino
    Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Neuron 47:201-13. 2005
    ..Our results suggest that Ptf1a is involved in driving neural precursors to differentiate into GABAergic neurons in the cerebellum...