Jun Iwamoto

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. ncbi request reprint Effect of combined teriparatide and monthly minodronic acid therapy on cancellous bone mass in ovariectomized rats: a bone histomorphometry study
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan Electronic address
    Bone 64:88-94. 2014
  2. ncbi request reprint Vitamin K nutritional status and undercarboxylated osteocalcin in postmenopausal osteoporotic women treated with bisphosphonates
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Asia Pac J Clin Nutr 23:256-62. 2014
  3. ncbi request reprint Vitamin K₂ therapy for postmenopausal osteoporosis
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nutrients 6:1971-80. 2014
  4. pmc Seven years' experience with etidronate in a woman with anorexia nervosa and vertebral fractures
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Ther Clin Risk Manag 7:275-81. 2011
  5. pmc Five-year follow-up of a woman with pregnancy and lactation-associated osteoporosis and vertebral fractures
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Fukuoka
    Ther Clin Risk Manag 8:195-9. 2012
  6. pmc Eleven years of experience with bisphosphonate plus alfacalcidol treatment in a man with osteogenesis imperfecta type I
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo
    Ther Clin Risk Manag 9:1-7. 2013
  7. pmc Influence of treatment with alendronate on the speed of sound, an ultrasound parameter, of the calcaneus in postmenopausal Japanese women with osteoporosis: a clinical practice-based observational study
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo
    Ther Clin Risk Manag 8:287-93. 2012
  8. ncbi request reprint Chair rising time is longer in postmenopausal women with history of nonvertebral fracture
    J Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    J Musculoskelet Neuronal Interact 13:265-72. 2013
  9. ncbi request reprint Menatetrenone for the treatment of osteoporosis
    Jun Iwamoto
    Keio University School of Medicine, Institute for Integrated Sports Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Expert Opin Pharmacother 14:449-58. 2013
  10. ncbi request reprint Whole body vibration exercise improves body balance and walking velocity in postmenopausal osteoporotic women treated with alendronate: Galileo and Alendronate Intervention Trail (GAIT)
    J Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Musculoskelet Neuronal Interact 12:136-43. 2012

Collaborators

Detail Information

Publications100

  1. ncbi request reprint Effect of combined teriparatide and monthly minodronic acid therapy on cancellous bone mass in ovariectomized rats: a bone histomorphometry study
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan Electronic address
    Bone 64:88-94. 2014
    ..These results suggest the differential effect of teriparatide and monthly minodronic acid on cancellous bone structure and the additive effect of the two drugs on cancellous bone mass in OVX rats...
  2. ncbi request reprint Vitamin K nutritional status and undercarboxylated osteocalcin in postmenopausal osteoporotic women treated with bisphosphonates
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Asia Pac J Clin Nutr 23:256-62. 2014
    ....
  3. ncbi request reprint Vitamin K₂ therapy for postmenopausal osteoporosis
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nutrients 6:1971-80. 2014
    ..Further studies are required to clarify the efficacy of menatetrenone in combination with bisphosphonates against fractures in postmenopausal women with osteoporosis. ..
  4. pmc Seven years' experience with etidronate in a woman with anorexia nervosa and vertebral fractures
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Ther Clin Risk Manag 7:275-81. 2011
    ..No gastrointestinal tract symptoms were observed. Thus, etidronate was effective for increasing the lumbar spine BMD and reducing back pain over a 7-year period without causing either osteoporotic fractures or adverse events...
  5. pmc Five-year follow-up of a woman with pregnancy and lactation-associated osteoporosis and vertebral fractures
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Fukuoka
    Ther Clin Risk Manag 8:195-9. 2012
    ....
  6. pmc Eleven years of experience with bisphosphonate plus alfacalcidol treatment in a man with osteogenesis imperfecta type I
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo
    Ther Clin Risk Manag 9:1-7. 2013
    ..Thus, the present case report shows the long-term outcome and safety of bisphosphonate plus alfacalcidol treatment in a man with osteogenesis imperfecta type I...
  7. pmc Influence of treatment with alendronate on the speed of sound, an ultrasound parameter, of the calcaneus in postmenopausal Japanese women with osteoporosis: a clinical practice-based observational study
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo
    Ther Clin Risk Manag 8:287-93. 2012
    ....
  8. ncbi request reprint Chair rising time is longer in postmenopausal women with history of nonvertebral fracture
    J Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    J Musculoskelet Neuronal Interact 13:265-72. 2013
    ..1 sec (mean value) was 4.28 (1.78, 10.30). Thus, a significant association was found between the impairment of muscle power and a history of nonvertebral fracture in postmenopausal women with osteoporosis. ..
  9. ncbi request reprint Menatetrenone for the treatment of osteoporosis
    Jun Iwamoto
    Keio University School of Medicine, Institute for Integrated Sports Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Expert Opin Pharmacother 14:449-58. 2013
    ..The objective of the present review study was to evaluate the effect of menatetrenone on the skeleton of postmenopausal women, men and glucocorticoid-treated patients...
  10. ncbi request reprint Whole body vibration exercise improves body balance and walking velocity in postmenopausal osteoporotic women treated with alendronate: Galileo and Alendronate Intervention Trail (GAIT)
    J Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Musculoskelet Neuronal Interact 12:136-43. 2012
    ..The present study showed the benefit and safety of WBV exercise for improving physical function in postmenopausal osteoporotic women treated with alendronate...
  11. doi request reprint Teriparatide therapy for bisphosphonate-associated osteonecrosis of the jaw in an elderly Japanese woman with severe osteoporosis
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Clin Drug Investig 32:547-53. 2012
    ..These results suggest the beneficial effects of teriparatide therapy in the severely osteoporotic elderly woman with ONJ...
  12. doi request reprint Sunlight exposure is important for preventing hip fractures in patients with Alzheimer's disease, Parkinson's disease, or stroke
    J Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Acta Neurol Scand 125:279-84. 2012
    ..The purpose of this study was to clarify the efficacy of sunlight exposure for reducing the risk of hip fractures in patients with such neurological diseases...
  13. doi request reprint Efficacy of antiresorptive agents for preventing fractures in Japanese patients with an increased fracture risk: review of the literature
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Drugs Aging 29:191-203. 2012
    ....
  14. doi request reprint Vitamin K(2) improves renal function and increases femoral bone strength in rats with renal insufficiency
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Calcif Tissue Int 90:50-9. 2012
    ..These findings suggest that administration of vitamin K(2) improves renal function and increases cortical bone strength without altering BMD in rats with renal insufficiency...
  15. ncbi request reprint Effects of treadmill exercise on bone mass, bone metabolism, and calciotropic hormones in young growing rats
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    J Bone Miner Metab 22:26-31. 2004
    ..Further studies with long-term exercise may be needed to obtain a positive effect on the lumbar BMC...
  16. ncbi request reprint Beneficial effect of pretreatment and treatment continuation with risedronate and vitamin K2 on cancellous bone loss after ovariectomy in rats: a bone histomorphometry study
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Nutr Sci Vitaminol (Tokyo) 52:307-15. 2006
    ..Moreover, even though the dosing frequency of the drugs was reduced after OVX, treatment continuation appeared to be more beneficial than pretreatment for increasing the cancellous bone mass...
  17. ncbi request reprint Effect of walking exercise on bone metabolism in postmenopausal women with osteopenia/osteoporosis
    Satoshi Yamazaki
    Department of Orthopaedic Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, 160 8582, Tokyo, Japan
    J Bone Miner Metab 22:500-8. 2004
    ....
  18. ncbi request reprint Determinants of one-year response of lumbar bone mineral density to alendronate treatment in elderly Japanese women with osteoporosis
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Yonsei Med J 45:676-82. 2004
    ....
  19. ncbi request reprint Comparative effects of risedronate and calcitriol on cancellous bone in rats with glucocorticoid-induced osteopenia
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    J Nutr Sci Vitaminol (Tokyo) 52:21-7. 2006
    ..To compared the effects of risedronate (Ris) and calcitriol (Cal) on cancellous bone in rats with glucocorticoid (GC)-induced osteopenia...
  20. ncbi request reprint Effect of risedronate on the cortical and cancellous bone mass and mechanical properties in ovariectomized rats: a comparison with the effects of alfacalcidol
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Nutr Sci Vitaminol (Tokyo) 52:393-401. 2006
    ..Thus, the present study clearly showed that RIS and ALF had differential effects on the cortical and cancellous bone mass and mechanical properties in ovariectomized rats...
  21. ncbi request reprint Effects of alendronate on metacarpal and lumbar bone mineral density, bone resorption, and chronic back pain in postmenopausal women with osteoporosis
    Jun Iwamoto
    Department of Sports Medicine, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku ku, 160 8582, Tokyo, Japan
    Clin Rheumatol 23:383-9. 2004
    ....
  22. ncbi request reprint Comparative therapeutic effects of alendronate and alfacalcidol on cancellous and cortical bone mass and mechanical properties in ovariectomized osteopenic rats
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    J Nutr Sci Vitaminol (Tokyo) 52:1-8. 2006
    ..Thus, the present study clearly showed that alendronate and alfacalcidol had differential therapeutic effects on the cancellous and cortical bone mass and mechanical properties in ovariectomized osteopenic rats...
  23. ncbi request reprint Effects of alfacalcidol on cancellous and cortical bone mass in rats treated with glucocorticoid: a bone histomorphometry study
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    J Nutr Sci Vitaminol (Tokyo) 53:191-7. 2007
    ..The effects of ALF on cancellous bone mass, bone formation, and bone resorption were all dose-dependent. The present study showed the beneficial effects of ALF on cancellous and cortical bone mass in GC-treated rats...
  24. ncbi request reprint Early response to alendronate after treatment with etidronate in postmenopausal women with osteoporosis
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Keio J Med 52:113-9. 2003
    ....
  25. ncbi request reprint Interventions to prevent bone loss in astronauts during space flight
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Keio J Med 54:55-9. 2005
    ....
  26. ncbi request reprint Additive effect of vitamin K2 and risedronate on long bone mass in hypophysectomized young rats
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Exp Anim 56:103-10. 2007
    ..Despite the lack of a significant effect of vitamin K(2) on bone mass parameters, it had an additive effect with risedronate on the BMC, BMD and cortical bone mass of long bones in HX rats...
  27. doi request reprint Vitamin K2 promotes bone healing in a rat femoral osteotomy model with or without glucocorticoid treatment
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Calcif Tissue Int 86:234-41. 2010
    ..Thus, vitamin K(2) appears to be effective for promoting bone healing in a rat femoral osteotomy model with or without GC treatment...
  28. ncbi request reprint Early changes in urinary cross-linked N-terminal telopeptides of type I collagen level correlate with 1-year response of lumbar bone mineral density to alendronate in postmenopausal Japanese women with osteoporosis
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Bone Miner Metab 23:238-42. 2005
    ..Among the remaining 30% poor responders, about 60% showed satisfactory reduction of the urinary NTX level, exceeding the MSC, at 6 months after the start of treatment with alendronate...
  29. ncbi request reprint Effect of whole-body vibration exercise on lumbar bone mineral density, bone turnover, and chronic back pain in post-menopausal osteoporotic women treated with alendronate
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Aging Clin Exp Res 17:157-63. 2005
    ..The aim of this study was to determine whether whole-body vibration exercise would enhance the effect of alendronate on lumbar BMD and bone turnover, and reduce chronic back pain in postmenopausal women with osteoporosis...
  30. ncbi request reprint Comparison of the effect of alendronate on lumbar bone mineral density and bone turnover in men and postmenopausal women with osteoporosis
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Clin Rheumatol 26:161-7. 2007
    ....
  31. doi request reprint Effects of vitamin K(2) and risedronate on bone formation and resorption, osteocyte lacunar system, and porosity in the cortical bone of glucocorticoid-treated rats
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Calcif Tissue Int 83:121-8. 2008
    ..The present study showed the efficacy of vitamin K(2) and risedronate for bone formation and resorption, the osteocyte lacunar system, and porosity in the cortical bone of GC-treated rats...
  32. doi request reprint Effects of vitamin K2 on cortical and cancellous bone mass, cortical osteocyte and lacunar system, and porosity in sciatic neurectomized rats
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Calcif Tissue Int 87:254-62. 2010
    ..The present study showed the efficacy of vitamin K2 for cancellous bone mass and cortical lacunar occupancy by viable osteocytes and porosity in sciatic NX rats...
  33. pmc Influence of ovariectomy on bone turnover and trabecular bone mass in mature cynomolgus monkeys
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Yonsei Med J 50:358-67. 2009
    ..To examine the influence of ovariectomy (OVX) on bone turnover and trabecular bone mass at the 3 clinically important skeletal sites in mature cynomolgus monkeys...
  34. pmc Effects of vitamin K2 on the development of osteopenia in rats as the models of osteoporosis
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Yonsei Med J 47:157-66. 2006
    ..Thus, vitamin K2 could regulate bone metabolism in rats, which represented the various models of osteoporosis. However, the effects of vitamin K2 on bone mass and bone metabolism seem to be modest...
  35. ncbi request reprint Therapeutic effect of risedronate on cancellous and cortical bone in ovariectomized osteopenic rats: a comparison with the effects of alfacalcidol
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Exp Anim 55:333-42. 2006
    ..Thus, the results of the present study show differential effects of RIS and ALF on cancellous and cortical bone in ovariectomized osteopenic rats...
  36. ncbi request reprint Beneficial effects of combined administration of alendronate and alfacalcidol on cancellous bone mass of the tibia in orchidectomized rats: a bone histomorphometry study
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Japan
    J Nutr Sci Vitaminol (Tokyo) 54:11-7. 2008
    ..The present study showed the beneficial effects of combined administration of ALN and ALF on the cancellous bone mass of the tibia in orchidectomized rats...
  37. ncbi request reprint Effects of combined administration of alfacalcidol and risedronate on cancellous and cortical bone mass of the tibia in glucocorticoid-treated young rats
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Chin J Physiol 51:121-8. 2008
    ..The present study showed the efficacy of combined administration of ALF and RIS for the geometry of cortical bone in GC-treated rats...
  38. ncbi request reprint Preventive effects of risedronate and calcitriol on cancellous osteopenia in rats treated with high-dose glucocorticoid
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Exp Anim 55:349-55. 2006
    ..This study showed the differential effects of Ris and Cal on cancellous osteopenia in rats treated with high-dose GC...
  39. ncbi request reprint Comparative effects of orchidectomy and sciatic neurectomy on cortical and cancellous bone in young growing rats
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Bone Miner Metab 21:211-6. 2003
    ..The importance of mechanical loading, with or without testosterone deficiency, is emphasized in cortical and cancellous bone growth...
  40. ncbi request reprint Prevention of hip fractures by exposure to sunlight and pharmacotherapy in patients with Alzheimer's disease
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Aging Clin Exp Res 21:277-81. 2009
    ..The purpose of the present study was to clarify the efficacy of interventions against hip fractures in patients with Alzheimer's disease...
  41. ncbi request reprint Effect of treadmill exercise on bone mass in female rats
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Exp Anim 54:1-6. 2005
    ..Treadmill exercise may have a positive effect on the skeleton in young, and adult, ovariectomized, and osteopenic female rats...
  42. ncbi request reprint Efficacy of risedronate against hip fracture in patients with neurological diseases: a meta-analysis of randomized controlled trials
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Curr Med Res Opin 24:1379-84. 2008
    ..The purpose of the present study was to clarify the efficacy of risedronate against hip fracture in patients with neurological diseases...
  43. doi request reprint Effect of alendronate on bone mineral density and bone turnover markers in post-gastrectomy osteoporotic patients
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Bone Miner Metab 28:202-8. 2010
    ..No severe adverse events were observed, and alendronate therapy was well tolerated. These results suggest that alendronate mildly increases lumbar spine BMD by mildly reducing bone turnover in osteoporotic patients after a gastrectomy...
  44. ncbi request reprint Effects of alendronate and alfacalcidol on the femoral bone mass and bone strength in orchidectomized rats
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Chin J Physiol 51:331-7. 2008
    ..These findings suggest differential effects of ALN and ALF on femoral bone mass and the beneficial effects of combined administration of ALN and ALF on the trabecular bone of the femur in ORX rats...
  45. ncbi request reprint Comparative effects of alendronate and alfacalcidol on cancellous and cortical bone mass and bone mechanical properties in ovariectomized rats
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Exp Anim 55:357-67. 2006
    ....
  46. doi request reprint Effect of vitamin K2 on cortical and cancellous bone mass and hepatic lipids in rats with combined methionine-choline deficiency
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Bone 48:1015-21. 2011
    ..These findings suggest a beneficial effect of vitamin K2 on cortical bone mass and hepatic lipid metabolism in rats with MCD. The loss of cancellous bone mass could possibly have been due to re-distribution of minerals to cortical bone...
  47. ncbi request reprint Insufficiency fracture of the femoral neck during osteoporosis treatment: a case report
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Orthop Sci 7:707-12. 2002
    ..A possibility of increased bone fragility should be kept in mind when oral cyclical etidronate is applied to elderly Japanese, small-physique women with osteoporosis at a daily dose of 400 mg (higher dose)...
  48. doi request reprint Urinary levels of cross-linked N-terminal telopeptide of type I collagen and nutritional status in Japanese professional baseball players
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Bone Miner Metab 28:540-6. 2010
    ..The present study raised an issue regarding the nutritional status from the point of view of bone metabolism in elite male athletes such as professional baseball players...
  49. doi request reprint Retrospective case evaluation of gender differences in sports injuries in a Japanese sports medicine clinic
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Gend Med 5:405-14. 2008
    ....
  50. ncbi request reprint Effects of cyclical etidronate with alfacalcidol on lumbar bone mineral density, bone resorption, and back pain in postmenopausal women with osteoporosis
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Orthop Sci 8:532-7. 2003
    ....
  51. ncbi request reprint Comparative effects of vitamin K and vitamin D supplementation on calcium balance in young rats fed normal or low calcium diets
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Nutr Sci Vitaminol (Tokyo) 51:211-5. 2005
    ..This study shows the differential effects of vitamin K and vitamin D supplementation on calcium balance in young rats fed a normal or low calcium diet...
  52. pmc Comparison of effect of treatment with etidronate and alendronate on lumbar bone mineral density in elderly women with osteoporosis
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Yonsei Med J 46:750-8. 2005
    ..This study confirmed that alendronate treatment had a greater efficacy than etidronate treatment in increasing the lumbar BMD through the reduction of bone resorption in elderly women with osteoporosis...
  53. ncbi request reprint Effects of 5-year treatment with elcatonin and alfacalcidol on lumbar bone mineral density and the incidence of vertebral fractures in postmenopausal women with osteoporosis: a retrospective study
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Orthop Sci 7:637-43. 2002
    ..Further study with prospective observations are needed to confirm the results of the present study...
  54. ncbi request reprint Effects of vitamin K2 on osteoporosis
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Curr Pharm Des 10:2557-76. 2004
    ..No randomized well-controlled prospective studies conducted on a sufficiently large number of patients have been reported yet, therefore, further studies are needed to confirm the efficacy of vitamin K2 in the treatment of osteoporosis...
  55. pmc Comparison of the effect of vitamin K(2) and risedronate on trabecular bone in glucocorticoid-treated rats: a bone histomorphometry study
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Yonsei Med J 50:189-94. 2009
    ..To compare the effect of vitamin K(2) and risedronate on trabecular bone in glucocorticoid (GC)-treated rats...
  56. doi request reprint Factors affecting discontinuation of alendronate treatment in postmenopausal Japanese women with osteoporosis
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    J Chin Med Assoc 72:619-24. 2009
    ....
  57. pmc Comparison of effects of alendronate and raloxifene on lumbar bone mineral density, bone turnover, and lipid metabolism in elderly women with osteoporosis
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinano machi, Tokyo 160 8582, Japan
    Yonsei Med J 49:119-28. 2008
    ..To compare the effects of alendronate and raloxifene on lumbar bone mineral density (BMD), bone turnover, and lipid metabolism in elderly women with osteoporosis...
  58. ncbi request reprint Transient relief of metastatic cancer bone pain by oral administration of etidronate
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Bone Miner Metab 20:228-34. 2002
    ..Although the present study had a small sample size, and had no placebo controls, the results may be useful, especially as they raise additional questions that could stimulate further research in Japan...
  59. ncbi request reprint Response of cortical and cancellous bones to mild calcium deficiency in young growing female rats: a bone histomorphometry study
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Exp Anim 53:347-54. 2004
    ....
  60. ncbi request reprint Effects of treatment with etidronate and alfacalcidol for osteogenesis imperfecta type I: a case report
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Orthop Sci 8:243-7. 2003
    ..This report provides evidence indicating that treatment with intermittent cyclical oral etidronate and alfacalcidol has potential use in adult patients with OI type I...
  61. doi request reprint Effectiveness of exercise in the treatment of lumbar spinal stenosis, knee osteoarthritis, and osteoporosis
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Aging Clin Exp Res 22:116-22. 2010
    ..Lumbar spinal stenosis (LSS), osteoarthritis (OA) of the knee, and osteoporosis are major locomotive diseases in the elderly population. The aim of this study was to examine the effectiveness of exercise in these three diseases...
  62. doi request reprint High-dose vitamin K supplementation reduces fracture incidence in postmenopausal women: a review of the literature
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Nutr Res 29:221-8. 2009
    ..The review of the reliable literature confirmed the effect of vitamin K(1) and vitamin K(2) supplementation on the skeleton of postmenopausal women mediated by mechanisms other than bone mineral density and bone turnover...
  63. pmc Comparison of the effects of alendronate and alfacalcidol on hip bone mineral density and bone turnover in Japanese men having osteoporosis or osteopenia with clinical risk factors for fractures
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Yonsei Med J 50:474-81. 2009
    ..An open-labeled prospective study was conducted to compare the treatment effects of alendronate and alfacalcidol on hip BMD and bone turnover in Japanese men with osteoporosis or osteopenia with clinical risk factors for fractures...
  64. ncbi request reprint Menatetrenone (vitamin K2) and bone quality in the treatment of postmenopausal osteoporosis
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nutr Rev 64:509-17. 2006
    ..Thus, available evidence supports an effect of menatetrenone on bone quality during osteoporosis treatment...
  65. ncbi request reprint Effects of risedronate on femoral bone mineral density and bone strength in sciatic neurectomized young rats
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Bone Miner Metab 23:456-62. 2005
    ..The results of the present preclinical study should be taken into consideration prior to the commencement of Ris treatment for disabled children...
  66. ncbi request reprint Combined treatment with vitamin k2 and bisphosphonate in postmenopausal women with osteoporosis
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Yonsei Med J 44:751-6. 2003
    ..It is proposed that the role of vitamin K2 should be emphasized, when used in combination with bisphosphonates, especially in patients with vitamin K deficiency...
  67. doi request reprint Three-year experience with alendronate treatment in postmenopausal osteoporotic Japanese women with or without renal dysfunction: a retrospective study
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Drugs Aging 29:133-42. 2012
    ..A retrospective study was conducted to compare outcomes after 3 years of alendronate treatment in postmenopausal osteoporotic Japanese women with or without renal dysfunction (RD)...
  68. ncbi request reprint Effect of vitamin K2 on cortical and cancellous bones in orchidectomized and/or sciatic neurectomized rats
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    J Bone Miner Res 18:776-83. 2003
    ..The present study provides evidence indicating that vitamin K2 has the potential to suppress bone resorption or bone turnover and/or stimulate bone formation in vivo in ORX and/or NX rats...
  69. ncbi request reprint Effect of surgical treatment on physical activity and bone resorption in patients with neurogenic intermittent claudication
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Orthop Sci 7:84-90. 2002
    ..Surgical treatment may contribute to the prevention of physical inactivity-induced osteoporosis in elderly patients with neurogenic intermittent claudication caused by degenerative lumbar disease...
  70. ncbi request reprint Short-term outcome of conservative treatment in athletes with symptomatic lumbar disc herniation
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Phys Med Rehabil 85:667-74; quiz 675-7. 2006
    ..The purpose of this study was to clarify the efficacy of conservative treatment in athletes with symptomatic lumbar disc herniation, especially in terms of their ability to return to their original sporting activities...
  71. ncbi request reprint Comparative effects of treatment with etidronate and alendronate on bone resorption, back pain, and activities of daily living in elderly women with vertebral fractures
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Keio J Med 52:230-5. 2003
    ..A double-blind placebo-controlled study is needed to confirm the therapeutic effects of these agents on back pain and deterioration of ADL...
  72. ncbi request reprint Role of vitamin K2 in the treatment of postmenopausal osteoporosis
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Curr Drug Saf 1:87-97. 2006
    ....
  73. doi request reprint Vitamin K₂ prevents hyperglycemia and cancellous osteopenia in rats with streptozotocin-induced type 1 diabetes
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Calcif Tissue Int 88:162-8. 2011
    ..These results suggest that vitamin K₂ has beneficial effects on glucose concentration and cancellous bone mass in rats with STZ-induced type 1 diabetes...
  74. ncbi request reprint Three-year experience with alendronate treatment in postmenopausal osteoporotic Japanese women with or without type 2 diabetes
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Diabetes Res Clin Pract 93:166-73. 2011
    ..A retrospective study was conducted to compare the outcome of alendronate (ALN) treatment for 3 years in postmenopausal osteoporotic Japanese women with or without type 2 diabetes...
  75. pmc Prevention and treatment of corticosteroid-induced osteoporosis
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Yonsei Med J 46:456-63. 2005
    ..Further RCTs of fracture prevention conducted on a large number of patients and their meta-analysis are needed to confirm the efficacy of bisphosphonates, PTH, or other agents in preventing vertebral and nonvertebral fractures...
  76. doi request reprint Role of sport and exercise in the maintenance of female bone health
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Bone Miner Metab 27:530-7. 2009
    ..However, sport activity and exercise across the life span of the average female should be encouraged in the maintenance of bone health...
  77. ncbi request reprint Effects of antifracture drugs in postmenopausal, male and glucocorticoid-induced osteoporosis--usefulness of alendronate and risedronate
    Jun Iwamoto
    Keio University School of Medicine, Department of Sports Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Expert Opin Pharmacother 8:2743-56. 2007
    ....
  78. doi request reprint The return to sports activity after conservative or surgical treatment in athletes with lumbar disc herniation
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Phys Med Rehabil 89:1030-5. 2010
    ..The purpose of this study was to clarify the efficacy of conservative or surgical treatment in athletes with lumbar disc herniation by reviewing the literature...
  79. pmc Hip fracture protection by alendronate treatment in postmenopausal women with osteoporosis: a review of the literature
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Clin Interv Aging 3:483-9. 2008
    ..Thus, the efficacy of alendronate against hip fractures has been confirmed in postmenopausal women with osteoporosis, especially with a once-weekly dosing regimen...
  80. ncbi request reprint Efficacy and safety of alendronate and risedronate for postmenopausal osteoporosis
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Curr Med Res Opin 22:919-28. 2006
    ..This paper discusses the efficacy and safety of alendronate and risedronate in the treatment of postmenopausal osteoporosis...
  81. doi request reprint Bone quality and vitamin K2 in type 2 diabetes: review of preclinical and clinical studies
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Nutr Rev 69:162-7. 2011
    ..These new findings suggesting a possible beneficial effect of vitamin K(2) supplementation on bone quality in type 2 diabetes warrant further investigation...
  82. ncbi request reprint Effect of vitamin K2 and growth hormone on the long bones in hypophysectomized young rats: a bone histomorphometry study
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Bone Miner Metab 25:46-53. 2007
    ..These results suggest that, despite the lack of an obvious effect on bone parameters, vitamin K(2) normalizes the size of the marrow cavity during development of the bone marrow in young HX rats treated with GH...
  83. doi request reprint [Anti-fracture efficacy of vitamin K]
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Japan
    Clin Calcium 19:1805-14. 2009
    ..The review of the reliable literature showed the effect of high-dose vitamin K supplementation on the skeleton of postmenopausal women mediated by mechanisms other than bone mineral density and bone turnover...
  84. pmc Effects of risedronate on osteoarthritis of the knee
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Yonsei Med J 51:164-70. 2010
    ....
  85. doi request reprint [Effects of SERMs on bone health. Discrimination of SERMs from bisphosphonates in the treatment of postmenopausal osteoporosis]
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine
    Clin Calcium 20:396-407. 2010
    ..Because the incidence of vertebral fractures is higher in Japanese patients, raloxifene plays an important role in the prevention of vertebral fractures in postmenopausal Japanese women with osteoporosis...
  86. doi request reprint Efficacy of oral bisphosphonates for preventing hip fracture in disabled patients with neurological diseases: a meta-analysis of randomized controlled trials among the Japanese population
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Curr Med Res Opin 27:1141-8. 2011
    ..The purpose of the present study was to clarify the efficacy of oral bisphosphonates for preventing hip fracture in disabled patients with such neurological diseases...
  87. doi request reprint Efficacy of menatetrenone (vitamin K2) against non-vertebral and hip fractures in patients with neurological diseases: meta-analysis of three randomized, controlled trials
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Clin Drug Investig 29:471-9. 2009
    ..The purpose of the present study was to clarify the efficacy of menatetrenone (vitamin K(2)) against non-vertebral and hip fractures in patients with neurological diseases...
  88. pmc Effects of short-term combined treatment with alendronate and elcatonin on bone mineral density and bone turnover in postmenopausal women with osteoporosis
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Ther Clin Risk Manag 5:499-505. 2009
    ....
  89. pmc A radiographic study on the associations of age and prevalence of vertebral fractures with abdominal aortic calcification in Japanese postmenopausal women and men
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Osteoporos 2010:748380. 2010
    ..The present study confirmed that age and the number of vertebral fractures were associated with the severity of abdominal aortic calcification in Japanese postmenopausal women and men...
  90. pmc Five-year alendronate treatment outcome in older postmenopausal Japanese women with osteoporosis or osteopenia and clinical risk factors for fractures
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Ther Clin Risk Manag 5:773-9. 2009
    ..ALN successfully suppressed bone turnover and sustained the metacarpal BMD over the 5-year period of treatment in postmenopausal Japanese women with an increased risk of fractures...
  91. pmc Seven years' experience with alendronate in postmenopausal Japanese women with osteoporosis
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Ther Clin Risk Manag 6:201-6. 2010
    ..ALN successfully suppressed bone turnover and increased lumbar spine BMD from the baseline value over the course of the seven-year treatment period without causing any severe adverse events...
  92. doi request reprint [Effect of exercise on developing bone mass and cortical bone geometry]
    Jun Iwamoto
    Integrated Sports Medicine, Keio University School of Medicine, Japan
    Clin Calcium 21:1323-8. 2011
    ..In girls, interventions must be initiated during the pre-menarcheal period to effectively maximize peak bone mass...
  93. pmc Experience with alendronate treatment for four years among Japanese men with osteoporosis or osteopenia and clinical risk factors for fractures
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo
    Ther Clin Risk Manag 6:593-600. 2010
    ..A retrospective study based on a conventional medical practice was performed to evaluate the outcome of alendronate treatment for four years in Japanese men with osteoporosis or osteopenia and clinical risk factors for fractures...
  94. ncbi request reprint Radiographic abnormalities of the inferior pole of the patella in juvenile athletes
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, Tokyo, Japan
    Keio J Med 58:50-3. 2009
    ....
  95. pmc Serum leptin concentration positively correlates with body weight and total fat mass in postmenopausal Japanese women with osteoarthritis of the knee
    Jun Iwamoto
    Institute for Integrated Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arthritis 2011:580632. 2011
    ..These results suggest that the serum leptin concentration might be related to increases in body weight and total fat mass, but not to BMD or bone turnover markers, in postmenopausal women with OA...
  96. ncbi request reprint Effect of muscle strengthening exercises on the muscle strength in patients with osteoarthritis of the knee
    Jun Iwamoto
    Department of Sports Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, and Department of Neurology, Mitate Hospital, Fukuoka, Japan
    Knee 14:224-30. 2007
    ....