Susumu Ishida

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. ncbi request reprint Selective suppression of pathologic, but not physiologic, retinal neovascularization by blocking the angiotensin II type 1 receptor
    Norihiro Nagai
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Invest Ophthalmol Vis Sci 46:1078-84. 2005
  2. ncbi request reprint [Lifestyle-related diseases and anti-aging ophthalmology: suppression of retinal and choroidal pathologies by inhibiting renin-angiotensin system and inflammation]
    Susumu Ishida
    Inaida Endowed Department of Anti Aging Ophthalmology, Laboratory of Retinal Cell Biology, Center for Integrated Medical Research, Keio University School of Medicine, Tokyo, Japan
    Nippon Ganka Gakkai Zasshi 113:403-22; discussion 423. 2009
  3. ncbi request reprint [The current state and issues of medical treatment for age-related macular degeneration]
    Susumu Ishida
    Nihon Yakurigaku Zasshi 131:47-9. 2008
  4. ncbi request reprint Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:422-9. 2007
  5. pmc Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina
    Toshihide Kurihara
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Diabetes 57:2191-8. 2008
  6. pmc (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Inaida Endowed Department of Anti Aging Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Pathol 173:1911-8. 2008
  7. doi request reprint Prevention of ocular inflammation in endotoxin-induced uveitis with resveratrol by inhibiting oxidative damage and nuclear factor-kappaB activation
    Shunsuke Kubota
    Department ofOphthalmology, Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:3512-9. 2009
  8. ncbi request reprint Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, Tokyo, and Department of Ophthalmology, Kobe City General Hospital, Japan
    Invest Ophthalmol Vis Sci 47:2686-92. 2006
  9. doi request reprint Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin
    Kanako Izumi-Nagai
    Laboratory of Retinal Cell Biology, Keio University of Medicne, Tokyo, Japan
    Invest Ophthalmol Vis Sci 49:1679-85. 2008
  10. ncbi request reprint Suppression of diabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappaB pathway
    Norihiro Nagai
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:4342-50. 2007

Detail Information

Publications112 found, 100 shown here

  1. ncbi request reprint Selective suppression of pathologic, but not physiologic, retinal neovascularization by blocking the angiotensin II type 1 receptor
    Norihiro Nagai
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Invest Ophthalmol Vis Sci 46:1078-84. 2005
    ..To investigate the anti-inflammatory and anti-angiogenic effects of telmisartan, an angiotensin II type 1 receptor (AT1-R) antagonist, on ischemia-induced retinal neovascularization...
  2. ncbi request reprint [Lifestyle-related diseases and anti-aging ophthalmology: suppression of retinal and choroidal pathologies by inhibiting renin-angiotensin system and inflammation]
    Susumu Ishida
    Inaida Endowed Department of Anti Aging Ophthalmology, Laboratory of Retinal Cell Biology, Center for Integrated Medical Research, Keio University School of Medicine, Tokyo, Japan
    Nippon Ganka Gakkai Zasshi 113:403-22; discussion 423. 2009
    ..In the present review, we provide biological evidence for RAS inhibition and food factor supplementation in the early intervention for retinal and choroidal pathologies as an 'anti-aging ophthalmology' approach...
  3. ncbi request reprint [The current state and issues of medical treatment for age-related macular degeneration]
    Susumu Ishida
    Nihon Yakurigaku Zasshi 131:47-9. 2008
  4. ncbi request reprint Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:422-9. 2007
    ..The purpose of the present study was to investigate whether nonproteolytically activated prorenin plays a role in ischemia-induced retinal neovascularization...
  5. pmc Angiotensin II type 1 receptor signaling contributes to synaptophysin degradation and neuronal dysfunction in the diabetic retina
    Toshihide Kurihara
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Diabetes 57:2191-8. 2008
    ..The aim of the present study was to show the relationship of the renin-angiotensin system (RAS) with the synaptic vesicle protein synaptophysin and neuronal activity in the diabetic retina...
  6. pmc (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Inaida Endowed Department of Anti Aging Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Pathol 173:1911-8. 2008
    ..These results indicate the significant contribution of RAPS to CNV pathogenesis...
  7. doi request reprint Prevention of ocular inflammation in endotoxin-induced uveitis with resveratrol by inhibiting oxidative damage and nuclear factor-kappaB activation
    Shunsuke Kubota
    Department ofOphthalmology, Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:3512-9. 2009
    ..Resveratrol is known as one of the antioxidant polyphenols contained in red wine and grape skin. The purpose of the present study was to investigate the role of resveratrol in ocular inflammation in endotoxin-induced uveitis (EIU)...
  8. ncbi request reprint Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, Tokyo, and Department of Ophthalmology, Kobe City General Hospital, Japan
    Invest Ophthalmol Vis Sci 47:2686-92. 2006
    ..The purpose of the present study was to elucidate the role of the receptor-dependent nonproteolytic activation of prorenin in ocular inflammation in endotoxin-induced uveitis (EIU)...
  9. doi request reprint Inhibition of choroidal neovascularization with an anti-inflammatory carotenoid astaxanthin
    Kanako Izumi-Nagai
    Laboratory of Retinal Cell Biology, Keio University of Medicne, Tokyo, Japan
    Invest Ophthalmol Vis Sci 49:1679-85. 2008
    ..The purpose of the present study was to investigate the effect of AST on the development of experimental choroidal neovascularization (CNV) with underlying cellular and molecular mechanisms...
  10. ncbi request reprint Suppression of diabetes-induced retinal inflammation by blocking the angiotensin II type 1 receptor or its downstream nuclear factor-kappaB pathway
    Norihiro Nagai
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:4342-50. 2007
    ..To investigate the involvement of the renin-angiotensin system (RAS) and the nuclear factor (NF)-kappaB pathway with diabetes-induced retinal inflammation...
  11. ncbi request reprint Eicosapentaenoic acid is anti-inflammatory in preventing choroidal neovascularization in mice
    Takashi Koto
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:4328-34. 2007
    ..To investigate the role of eicosapentaenoic acid (EPA), the major omega-3 polyunsaturated fatty acid (PUFA), in the development of choroidal neovascularization (CNV), together with underlying molecular mechanisms...
  12. doi request reprint Mechanism of visual sensations experienced during pars plana vitrectomy under retrobulbar anesthesia
    Eiko Sugisaka
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Ophthalmologica 224:103-8. 2010
    ..To investigate the visual sensations experienced by patients during vitrectomy under retrobulbar anesthesia...
  13. doi request reprint Neuroprotective effect of an antioxidant, lutein, during retinal inflammation
    Mariko Sasaki
    Department of Ophthalmology, Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:1433-9. 2009
    ..The aim of this study was to investigate, with the use of a mouse endotoxin-induced uveitis (EIU) model, the neuroprotective effects of lutein against retinal neural damage caused by inflammation...
  14. ncbi request reprint Suppression of ocular inflammation in endotoxin-induced uveitis by blocking the angiotensin II type 1 receptor
    Norihiro Nagai
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 46:2925-31. 2005
    ..To examine whether the angiotensin II type 1 receptor (AT1-R) signaling plays a role in ocular inflammation in endotoxin-induced uveitis (EIU)...
  15. doi request reprint Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model
    Miyuki Kubota
    Department of Ophthalmology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Invest Ophthalmol Vis Sci 52:427-33. 2011
    ..To investigate the role of reactive oxygen species (ROS) as the prime initiators of the angiogenic response after alkali injury of the cornea and observe the effects of antioxidants in preventing angiogenesis...
  16. ncbi request reprint Neuroprotective effects of angiotensin II type 1 receptor (AT1R) blocker, telmisartan, via modulating AT1R and AT2R signaling in retinal inflammation
    Toshihide Kurihara
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 47:5545-52. 2006
    ..To investigate the retinal neural damage that occurs during inflammation and the therapeutic effects of the angiotensin II type 1 receptor (AT1R) blocker, telmisartan, using a model of endotoxin-induced uveitis (EIU)...
  17. pmc (Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammation
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Diabetes 58:1625-33. 2009
    ..The aim of the present study was to define the association of the RAPS with diabetes-induced retinal inflammation...
  18. ncbi request reprint Macular pigment lutein is antiinflammatory in preventing choroidal neovascularization
    Kanako Izumi-Nagai
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arterioscler Thromb Vasc Biol 27:2555-62. 2007
    ..The aim of the current study was to investigate the effect of lutein supplementation on the development of the murine model of laser-induced CNV together with underlying molecular mechanisms...
  19. doi request reprint Suppression of alkali burn-induced corneal neovascularization by dendritic cell vaccination targeting VEGF receptor 2
    Hiroshi Mochimaru
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Invest Ophthalmol Vis Sci 49:2172-7. 2008
    ..To investigate whether the induction of cytotoxic T lymphocytes (CTLs) targeting VEGF receptor 2 inhibits corneal neovascularization caused by alkali injury...
  20. doi request reprint Inhibition of corneal neovascularization by blocking the angiotensin II type 1 receptor
    Tomohiko Usui
    Department of Ophthalmology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Invest Ophthalmol Vis Sci 49:4370-6. 2008
    ..To determine the role of angiotensin II type 1 receptor (AT1R) signaling in corneal neovascularization...
  21. ncbi request reprint Suppression of choroidal neovascularization by inhibiting angiotensin-converting enzyme: minimal role of bradykinin
    Norihiro Nagai
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:2321-6. 2007
    ..The purpose of the present study was to investigate the role of bradykinin in the development of choroidal neovascularization (CNV), with or without ACE inhibition...
  22. pmc Angiotensin II type 1 receptor antagonist attenuates lacrimal gland, lung, and liver fibrosis in a murine model of chronic graft-versus-host disease
    Saori Yaguchi
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 8:e64724. 2013
    ..Our findings point to AT1R antagonist as a possible target for therapeutic intervention in cGVHD...
  23. ncbi request reprint Hypoxia induces the expression of membrane-type 1 matrix metalloproteinase in retinal glial cells
    Kousuke Noda
    Department of Pathology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 46:3817-24. 2005
    ..However, little is known about the triggers for MT1-MMP induction in the diabetic retina. In the present study, the effect of tissue hypoxia on MT1-MMP expression in retinal glial cells was investigated...
  24. doi request reprint Suppression of experimental autoimmune uveitis by angiotensin II type 1 receptor blocker telmisartan
    Yoko Okunuki
    Department of Ophthalmology, Tokyo Medical University, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:2255-61. 2009
    ..The aim of this study was to examine whether blockade of AT1-R is effective in the suppression of murine experimental autoimmune uveoretinitis (EAU)...
  25. ncbi request reprint Angiotensin II type 1 receptor-mediated inflammation is required for choroidal neovascularization
    Norihiro Nagai
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Arterioscler Thromb Vasc Biol 26:2252-9. 2006
    ..The aim of the current study was to determine the involvement of the renin-angiotensin system (RAS) with the development of CNV, using human surgical samples and the murine model of laser-induced CNV...
  26. doi request reprint Serum vascular adhesion protein-1 correlates with vascular endothelial growth factor in patients with type II diabetes
    Nami Yoshikawa
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    J Diabetes Complications 27:162-6. 2013
    ..To study serum levels of soluble vascular adhesion protein (sVAP)-1 in type II diabetic patients with retinopathy...
  27. pmc Roles of STAT3/SOCS3 pathway in regulating the visual function and ubiquitin-proteasome-dependent degradation of rhodopsin during retinal inflammation
    Yoko Ozawa
    Department of Ophthalmology, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Biol Chem 283:24561-70. 2008
    ..These findings suggest SOCS3 as a potential therapeutic target molecule for protecting photoreceptor cell function during inflammation...
  28. pmc Resveratrol prevents light-induced retinal degeneration via suppressing activator protein-1 activation
    Shunsuke Kubota
    Laboratories of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Am J Pathol 177:1725-31. 2010
    ..Our data suggest the potential use of resveratrol as a therapeutic agent to prevent retinal degeneration related to light damage...
  29. doi request reprint Tissue kallikrein attenuates choroidal neovascularization via cleavage of vascular endothelial growth factor
    Junichi Fukuhara
    Laboratory of Ocular Cell Biology and Visual Science, Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Invest Ophthalmol Vis Sci 54:274-9. 2013
    ..To investigate the antiangiogenic properties of tissue kallikrein in a murine model of laser-induced choroidal neovascularization (CNV)...
  30. doi request reprint Alphab-crystallin expression in epiretinal membrane of human proliferative diabetic retinopathy
    Zhenyu Dong
    Laboratory of Ocular Cell Biology and Visual Science, Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
    Retina 32:1190-6. 2012
    ..To examine the expression of alphaB-crystallin and its colocalization with vascular endothelial growth factor in the epiretinal membrane of human proliferative diabetic retinopathy...
  31. pmc Hypoxia disrupts the barrier function of neural blood vessels through changes in the expression of claudin-5 in endothelial cells
    Takashi Koto
    Department of Pathology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Am J Pathol 170:1389-97. 2007
    ..These in vitro and in vivo data indicate that claudin-5 is a target molecule of hypoxia leading to the disruption of the barrier function of neural vasculature...
  32. ncbi request reprint Inhibition of diabetic leukostasis and blood-retinal barrier breakdown with a soluble form of a receptor for advanced glycation end products
    Yuichi Kaji
    Department of Ophthalmology, University of Tsukuba, Institute of Clinical Medicine, Ibaraki, Japan
    Invest Ophthalmol Vis Sci 48:858-65. 2007
    ..In the present study, the role of an AGE receptor, RAGE, was investigated in the development of diabetic retinopathy in vivo...
  33. doi request reprint Long-term efficacy and safety of ranibizumab administered pro re nata in Japanese patients with neovascular age-related macular degeneration in the EXTEND-I study
    Yasuo Tano
    Department of Ophthalmology, Osaka University Medical School, Osaka, Japan
    Acta Ophthalmol 89:208-17. 2011
    ....
  34. doi request reprint Retinal ganglion cell loss in superoxide dismutase 1 deficiency
    Kenya Yuki
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 52:4143-50. 2011
    ..To investigate the influence of deficiency in superoxide dismutase (SOD) 1, a major antioxidative enzyme, on retinal ganglion cells (RGCs)...
  35. doi request reprint Expression of vascular endothelial growth factor in human ocular adnexal lymphoma
    Satoshi Kinoshita
    Laboratory of Ocular Cell Biology and Visual Science, Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
    Invest Ophthalmol Vis Sci 55:3461-7. 2014
    ..To examine the expression of VEGF in extranodal marginal zone B-cell lymphoma (EMZL) and reactive lymphoid hyperplasia (RLH) of human ocular adnexa, and analyze the correlation with the intratumoral microvessel density (MVD)...
  36. doi request reprint Atp6ap2/(pro)renin receptor interacts with Par3 as a cell polarity determinant required for laminar formation during retinal development in mice
    Atsuhiro Kanda
    Laboratory of Ocular Cell Biology and Visual Science, Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060 8638, Japan, Department of Ophthalmology, Keio University School of Medicine, Tokyo 160 8582, Japan, Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, and JST, CREST, Suita, Osaka, 565 0871, Japan, and Department of Endocrinology and Hypertension, Tokyo Women s Medical University, Tokyo 162 8666, Japan
    J Neurosci 33:19341-51. 2013
    ..We propose that this cellular activity associated with the Par-aPKC system, in addition to the v-ATPase function and tissue RAS activation, is the third biological role of Atp6ap2/(P)RR. ..
  37. doi request reprint Clinical features of human T lymphotropic virus type 1-associated uveitis in Hokkaido, Japan
    Satoru Kase
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Jpn J Ophthalmol 57:379-84. 2013
    ..To clarify the clinical features of human lymphotropic virus type 1 (HTLV-1)-associated uveitis (HAU) in patients of Hokkaido University Hospital, Hokkaido, northern Japan...
  38. pmc Specific inhibition of serine/arginine-rich protein kinase attenuates choroidal neovascularization
    Zhenyu Dong
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Mol Vis 19:536-43. 2013
    ..To investigate the applicability of serine/arginine-rich protein kinase (SRPK)-specific inhibitor, SRPIN340, for attenuation of choroidal neovascularization (CNV) formation using a mouse model...
  39. doi request reprint Biological role of lutein in the light-induced retinal degeneration
    Mariko Sasaki
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Nutr Biochem 23:423-9. 2012
    ..Lutein reduced light-induced oxidative stress in the retina, which might contribute to promote DNA repair. The lutein-supplemented diet attenuated light-induced visual impairment by protecting the photoreceptor cells' DNA...
  40. pmc Amelioration of endotoxin-induced uveitis treated with an IκB kinase β inhibitor in rats
    Anton Lennikov
    Laboratory of Ocular Cell Biology and Visual Science, Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Mol Vis 18:2586-97. 2012
    ..In the present study, we examined whether IKKβ inhibition has therapeutic effects on EIU by using IMD-0354 and its prodrug IMD-1041...
  41. doi request reprint Roles of AMP-activated protein kinase in diabetes-induced retinal inflammation
    Shunsuke Kubota
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 52:9142-8. 2011
    ..The purpose of the present study was to elucidate the roles of AMPK in the pathogenesis of diabetic retinopathy using the known AMPK activators resveratrol and AICAR (5-aminoimidazole-4-carboxamide ribonucleoside) in a mouse model...
  42. ncbi request reprint Treatment of retinal detachment after macular translocation with scleral infolding: preservation of macular translocation
    Makoto Inoue
    Department of Ophthalmology, Keio University, Tokyo, Japan
    Retina 24:962-4. 2004
  43. doi request reprint Involvement of hyaluronan and its receptor CD44 with choroidal neovascularization
    Hiroshi Mochimaru
    Department of Ophthalmology, Laboratory of Retinal Cell Biology, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 50:4410-5. 2009
    ..The purpose of the present study was to clarify a role of HA and CD44 in the development of choroidal neovascularization (CNV)...
  44. pmc Interleukin-6 receptor-mediated activation of signal transducer and activator of transcription-3 (STAT3) promotes choroidal neovascularization
    Kanako Izumi-Nagai
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Am J Pathol 170:2149-58. 2007
    ....
  45. pmc Transcriptional factors associated with epithelial-mesenchymal transition in choroidal neovascularization
    Manabu Hirasawa
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Mol Vis 17:1222-30. 2011
    ..To investigate the transcriptional factors associated with epithelial-mesenchymal transition (EMT) in choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD)...
  46. doi request reprint Expression of vascular endothelial growth factor in eyes with Coats' disease
    Satoru Kase
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Invest Ophthalmol Vis Sci 54:57-62. 2013
    ..To examine the expression of vascular endothelial growth factor (VEGF) and VEGF receptor (VEGFR)-2 in enucleated eyes with Coats' disease...
  47. doi request reprint Correlation between decreased choroidal blood flow velocity and the pathogenesis of acute zonal occult outer retinopathy
    Michiyuki Saito
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Clin Experiment Ophthalmol 42:139-50. 2014
    ..To evaluate changes of choroidal circulation quantitatively using laser speckle flowgraphy in patients with acute zonal occult outer retinopathy...
  48. doi request reprint Photodynamic therapy combined with intravitreal bevacizumab and sub-tenon triamcinolone acetonide injections for age-related macular degeneration
    Chikako Yoshizawa
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, N 15, W 7, Kita ku, Sapporo 060 8638, Japan
    Jpn J Ophthalmol 57:68-73. 2013
    ....
  49. doi request reprint Two cases of subfoveal choroidal neovascularization with tubulointerstitial nephritis and uveitis syndrome
    Yuko Takemoto
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Eur J Ophthalmol 23:255-7. 2013
    ..We report 2 children with TINU syndrome complicated by subfoveal choroidal neovascularization (CNV)...
  50. pmc von Hippel-Lindau protein regulates transition from the fetal to the adult circulatory system in retina
    Toshihide Kurihara
    Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Development 137:1563-71. 2010
    ..Our results suggest that not only macrophages but also tissue oxygen-sensing mechanisms regulate the transition from the fetal to the adult circulatory system in the retina...
  51. ncbi request reprint Jamming of 25-gauge instruments in the cannula during vitrectomy for vitreous haemorrhage
    Hajime Shinoda
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Acta Ophthalmol 86:160-4. 2008
    ..To report the jamming of 25-gauge instruments in the cannula during vitreous surgery for non-clearing vitreous haemorrhage...
  52. ncbi request reprint Visual recovery after vitrectomy for macular hole using 25-gauge instruments
    Hajime Shinoda
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Acta Ophthalmol 86:151-5. 2008
    ..To determine whether vitrectomy with 25-gauge instruments contributes to better postoperative visual recovery after macular hole (MH) surgery...
  53. ncbi request reprint Suprachoroidal hemorrhage caused by breakage of a 25-gauge cannula
    Chieh Jen Chen
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Ophthalmic Surg Lasers Imaging 39:323-4. 2008
    ..The retained cannula tip might have acted as a channel allowing vitreous fluid into the suprachoroidal space, resulting in choroidal detachment, hemorrhage, and hypotony...
  54. doi request reprint Retinal outer layer thickness increases after vitrectomy for epiretinal membrane, and visual improvement positively correlates with photoreceptor outer segment length
    Yuki Hashimoto
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Graefes Arch Clin Exp Ophthalmol 252:219-26. 2014
    ..To investigate postoperative thickness changes in the retinal layers in eyes with epiretinal membrane (ERM). Correlations between these changes and visual outcomes were also examined...
  55. doi request reprint Expression of vascular endothelial growth factor and intravitreal anti-VEGF therapy with bevacizumab in vasoproliferative retinal tumors
    Wataru Saito
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Retina 33:1959-67. 2013
    ..To examine whether vasoproliferative retinal tumors (VPRTs) express vascular endothelial growth factor and respond to intravitreal bevacizumab injection...
  56. ncbi request reprint Expression of αB-crystallin and vascular endothelial growth factor in conjunctival squamous cell carcinoma
    Zhenyu Dong
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, n7, W15, Kita ku, Sapporo, Hokkaido 060 8638, Japan
    Anticancer Res 33:3745-51. 2013
    ..To examine the expression of αB-crystallin and vascular endothelial growth factor (VEGF) in conjunctival squamous cell carcinoma (CSCC)...
  57. ncbi request reprint Suppression of choroidal neovascularization by dendritic cell vaccination targeting VEGFR2
    Hiroshi Mochimaru
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Shinanomachi, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:4795-801. 2007
    ..To investigate whether the induction of cellular immunity against vascular endothelial growth factor receptor (VEGFR) 2 inhibits the development of choroidal neovascularization (CNV)...
  58. doi request reprint Macular choroidal blood flow velocity decreases with regression of acute central serous chorioretinopathy
    Michiyuki Saito
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Br J Ophthalmol 97:775-80. 2013
    ..To quantitatively evaluate the time course of macular choroidal blood flow velocity in acute central serous chorioretinopathy (CSC)...
  59. doi request reprint Immunolocalization of vascular adhesion protein-1 in human conjunctival tumors
    Junichi Fukuhara
    Laboratory of Ocular Cell Biology and Visual Science, Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Ophthalmic Res 48:33-7. 2012
    ..We analyzed the expression and immunolocalization of vascular adhesion protein (VAP)-1 in conjunctival tumors and normal conjunctival tissue of humans...
  60. pmc Neuroprotective response after photodynamic therapy: role of vascular endothelial growth factor
    Misa Suzuki
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Shinanomachi, Shinjuku ku, Tokyo, Japan
    J Neuroinflammation 8:176. 2011
    ..Concern that PDT might induce VEGF and exacerbate the disease has led us to current practice of using anti-VEGF drugs with PDT simultaneously. However, the underlying molecular mechanisms of these therapies are not well understood...
  61. pmc Blockade of vascular adhesion protein-1 attenuates choroidal neovascularization
    Nami Yoshikawa
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Mol Vis 18:593-600. 2012
    ..The purpose of this study was to investigate the role of VAP-1 in ocular inflammatory neovascularization using a mouse laser-induced choroidal neovascularization (CNV) model...
  62. doi request reprint Astaxanthin increases choroidal blood flow velocity
    Michiyuki Saito
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Nishi 7 chome, Kita 15 jou, Kita ku, Sapporo 060 8638, Japan
    Graefes Arch Clin Exp Ophthalmol 250:239-45. 2012
    ....
  63. ncbi request reprint Retinal blood flow in the macular area before and after scleral buckling procedures for rhegmatogenous retinal detachment without macular involvement
    Tadahiko Eshita
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Jpn J Ophthalmol 48:358-63. 2004
    ..To investigate retinal microcirculation changes in patients with rhegmatogenous retinal detachment (RRD)...
  64. doi request reprint Incidence of increased intraocular pressure after subtenon injection of triamcinolone acetonide
    Ryosuke Kawamura
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    J Ocul Pharmacol Ther 27:299-304. 2011
    ..To determine the incidence of eyes that have an increase in the intraocular pressure (IOP) after subtenon injections of triamcinolone acetonide (TA)...
  65. ncbi request reprint Pathologic roles of prorenin and (pro)renin receptor in the eye
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Front Biosci 13:3884-95. 2008
    ..These findings demonstrate that nonproteolytically activated prorenin plays a significant role in the ocular inflammation and neovascularization...
  66. doi request reprint Improvement of visual acuity after transcorneal electrical stimulation in case of Best vitelliform macular dystrophy
    Naoki Ozeki
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Graefes Arch Clin Exp Ophthalmol 251:1867-70. 2013
    ..To report an improvement of the visual acuity after transcorneal electrical stimulation (TES) in a case of Best vitelliform macular dystrophy (BVMD)...
  67. doi request reprint Angiopoietin-like protein 2 mediates endotoxin-induced acute inflammation in the eye
    Atsuhiro Kanda
    Laboratory of Ocular Cell Biology and Visual Science, Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Lab Invest 92:1553-63. 2012
    ....
  68. doi request reprint Presence and physiologic function of the renin-angiotensin system in mouse lacrimal gland
    Saori Yaguchi
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 53:5416-25. 2012
    ..To investigate the expression, localization, and physiologic function of renin-angiotensin system (RAS) components in the mouse lacrimal gland...
  69. ncbi request reprint Surgical effects and complications of indocyanine green-assisted internal limiting membrane peeling for idiopathic macular hole
    Norihiro Nagai
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Acta Ophthalmol Scand 85:883-9. 2007
    ..To compare the surgical outcomes and complications of vitrectomy with internal limiting membrane (ILM) peeling with or without indocyanine green (ICG) staining in eyes with an idiopathic macular hole...
  70. pmc Retinal phototoxicity in a novel murine model of intraocular lens implantation
    Toshihide Kurihara
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Mol Vis 15:2751-61. 2009
    ..To establish a novel murine intraocular lens (IOL) implantation model to study the protective effects of colored-IOLs against retinal phototoxicity...
  71. doi request reprint Calcium channel blocker nilvadipine, but not diltiazem, inhibits ocular inflammation in endotoxin-induced uveitis
    Susumu Ishida
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Jpn J Ophthalmol 54:594-601. 2010
    ..The aim of the present study was to examine whether the CCBs nilvadipine and diltiazem reduce ocular inflammation in endotoxin-induced uveitis (EIU)...
  72. ncbi request reprint A clinicopathologic case report on macular hole associated with von Hippel-Lindau disease: a novel ultrastructural finding of wormlike, wavy tangles of filaments
    Makoto Inoue
    Department of Ophthalmology, Keio University, 35 Shinanomachi, Shinjuku ku, 160 8582, Tokyo, Japan
    Graefes Arch Clin Exp Ophthalmol 242:881-6. 2004
    ..We describe a novel ultrastructural finding observed in an epiretinal membrane excised from a patient with von Hippel-Lindau disease...
  73. ncbi request reprint Detecting vitreomacular adhesions in eyes with asteroid hyalosis with triamcinolone acetonide
    Takefumi Yamaguchi
    Department of Ophthalmology, Keio University, School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    Graefes Arch Clin Exp Ophthalmol 245:305-8. 2007
    ..To report the incidence of posterior vitreous detachments (PVDs) and the surgical results of vitrectomy with intravitreal triamcinolone acetonide (TA) to detect vitreomacular adhesions in eyes with asteroid hyalosis (AH)...
  74. doi request reprint Replication of a microsatellite genome-wide association study of Behcet's disease in a Korean population
    Yukihiro Horie
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Kita 15, Nishi 7, Kita ku, Sapporo 060 8638, Japan
    Rheumatology (Oxford) 51:983-6. 2012
    ..To confirm our recent results, these microsatellite markers were examined in a Korean population as a replication study...
  75. pmc Amelioration of ultraviolet-induced photokeratitis in mice treated with astaxanthin eye drops
    Anton Lennikov
    Laboratory of Ocular Cell Biology and Visual Science, Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Mol Vis 18:455-64. 2012
    ..In the present study, we examined whether topical administration of AST has preventive and therapeutic effects on UV-photokeratitis in mice...
  76. ncbi request reprint Production and activation of matrix metalloproteinase-2 in proliferative diabetic retinopathy
    Kousuke Noda
    Department of Pathology, Keio University School of Medicine, Toyama, Japan
    Invest Ophthalmol Vis Sci 44:2163-70. 2003
    ..To investigate the matrix metalloproteinase (MMP) species and their activation associated with the pathogenesis of proliferative diabetic retinopathy (PDR)...
  77. ncbi request reprint [Significance of leukocytes in the regulation of retinal edema, ischemia, and angiogenesis]
    Susumu Ishida
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nihon Ganka Gakkai Zasshi 108:193-201. 2004
    ..The accumulated evidence will lead to an integrated understanding of the relationship between leukocytes and retinal disorders, which is required for clinical applications of new medical treatment...
  78. doi request reprint Dehiscence of levator aponeurosis in ptosis after sub-Tenon injection of triamcinolone acetonide
    Shinji Ideta
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Can J Ophthalmol 44:668-72. 2009
    ..To report the incidence, intraoperative findings, and surgical outcome of secondary ptosis that developed after a sub-Tenon injection of triamcinolone acetonide (TA)...
  79. ncbi request reprint 25-gauge cannula system with microvitreoretinal blade trocar
    Makoto Inoue
    Department of Ophthalmology, Keio University School of Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Ophthalmol 144:302-4. 2007
    ..To report a 25-gauge trocar-cannula that enhances wound closure and reduces the incidence of postoperative hypotony...
  80. pmc Retinal dysfunction and progressive retinal cell death in SOD1-deficient mice
    Kouhei Hashizume
    Department of Ophthalmology, Inaida Laboratory, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Am J Pathol 172:1325-31. 2008
    ..Our results indicate that Sod1(-/-) mice may be a good model system in which to study the mechanism of reactive oxygen species-mediated retinal degeneration...
  81. doi request reprint EXTEND-I: safety and efficacy of ranibizumab in Japanese patients with subfoveal choroidal neovascularization secondary to age-related macular degeneration
    Yasuo Tano
    Department of Ophthalmology, Osaka University Medical School, Japan
    Acta Ophthalmol 88:309-16. 2010
    ..To evaluate the efficacy and safety of intravitreal ranibizumab for subfoveal choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) in Japanese patients...
  82. ncbi request reprint Rhegmatogenous retinal detachment associated with primary congenital glaucoma
    Shingo Satofuka
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 0016, Japan
    Int Ophthalmol 28:369-71. 2008
    ..We present the characteristics and surgical outcomes of three cases with a RRD who had CG and had undergone surgery many years earlier...
  83. ncbi request reprint Two-step oblique incision during 25-gauge vitrectomy reduces incidence of postoperative hypotony
    Makoto Inoue
    Department of Ophthalmology, Keio University School of Medicine, and Kyorin Eye Center, Kyorin University School of Medicine, Tokyo, Japan
    Clin Exp Ophthalmol 35:693-6. 2007
    ..001, Wilcoxon rank test). Twenty-five-gauge vitrectomy with two-step oblique incisions will reduce the incidence of postoperative hypotony on the first postoperative day...
  84. ncbi request reprint Intraocular lens implantation after atopic cataract surgery decreases incidence of postoperative retinal detachment
    Makoto Inoue
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Ophthalmology 112:1719-24. 2005
    ..To investigate the efficacy of intraocular lens (IOL) implantation in reducing the incidence of postoperative retinal detachment after cataract surgery in patients with atopic dermatitis...
  85. ncbi request reprint Pars plana vitrectomy with internal limiting membrane removal for macular hole associated with proliferative diabetic retinopathy
    Toshihide Kurihara
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Graefes Arch Clin Exp Ophthalmol 243:724-6. 2005
    ....
  86. doi request reprint Proliferative diabetic retinopathy with lymphocyte-rich epiretinal membrane associated with poor visual prognosis
    Satoru Kase
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    Invest Ophthalmol Vis Sci 50:5909-12. 2009
    ..The aim of this study was to analyze lymphocyte infiltration using immunohistochemistry in proliferative diabetic retinopathy (PDR) membranes...
  87. ncbi request reprint Intraoperative breakage of a 25-gauge vitreous cutter
    Makoto Inoue
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Ophthalmol 138:867-9. 2004
    ..To report breakage of a 25-gauge vitreous cutter during vitreous surgery...
  88. doi request reprint Cyclo-oxygenase-2 expression in human idiopathic epiretinal membrane
    Satoru Kase
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido, Japan
    Retina 30:719-23. 2010
    ..The purpose of this study was to examine the expression of cyclo-oxygenase (COX)-2 in the idiopathic epiretinal membrane (IERM), inner limiting membrane (ILM), and proliferative diabetic retinopathy membrane...
  89. ncbi request reprint Binding of ADAM28 to P-selectin glycoprotein ligand-1 enhances P-selectin-mediated leukocyte adhesion to endothelial cells
    Masayuki Shimoda
    Department of Pathology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 0016, Japan
    J Biol Chem 282:25864-74. 2007
    ....
  90. ncbi request reprint Patients' descriptions of visual sensations during pars plana vitrectomy under retrobulbar anesthesia
    Eiko Sugisaka
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Ophthalmol 144:245-51. 2007
    ..To investigate the visual sensations experienced by patients during vitrectomy under retrobulbar anesthesia...
  91. pmc Knee pain and future self-reliance in older adults: evidence from a community-based 3-year cohort study in Japan
    Yuji Nishiwaki
    Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    J Epidemiol 21:184-90. 2011
    ..The aim of this 3-year cohort study was to investigate the association of knee pain with dependence in activities of daily living (ADL) and mortality in community-dwelling older Japanese adults...
  92. pmc Gender-specific associations of vision and hearing impairments with adverse health outcomes in older Japanese: a population-based cohort study
    Takehiro Michikawa
    Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    BMC Geriatr 9:50. 2009
    ..Therefore, we examined the association of vision and hearing impairments (as measured by objective methods) with AHOs (dependence in activities of daily living or death), and whether this association differed by gender...
  93. ncbi request reprint Successful treatment of subfoveal choroidal neovascularization associated with combined hamartoma of the retina and retinal pigment epithelium
    Makoto Inoue
    Ophthalmology Department, Keio University School of Medicine, 35 Shianomachi, Shinjyuku, Tokyo 160 8582, Japan
    Am J Ophthalmol 138:155-6. 2004
    ..To describe a patient with subfoveal choroidal neovascularization (CNV) associated with combined hamartoma of the retina and retinal pigment epithelium (CHRRPE), treated successfully by submacular surgery...
  94. ncbi request reprint Indocyanine green can distinguish posterior vitreous cortex from internal limiting membrane during vitrectomy with removal of epiretinal membrane
    Tadahiko Eshita
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Retina 22:104-6. 2002
  95. ncbi request reprint [Two cases of retinal detachment following laser in Situ keratomileusis repaired by scleral buckling surgery]
    Tatsuya Onguchi
    Department of Ophthalmology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nihon Ganka Gakkai Zasshi 106:103-8. 2002
    ..However, since it has not been reported yet here in Japan, we report two cases of retinal detachment following LASIK with suggestions based on our experience...
  96. ncbi request reprint ON-pathway disturbance in two siblings
    Kei Shinoda
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Acta Ophthalmol Scand 80:219-23. 2002
    ..To present two clinical cases diagnosed with predominant cone dystrophy and demonstrating early disturbance in the on-centre bipolar cells (ON-pathway)...
  97. ncbi request reprint [The correlation between retinal circulation and function in branch retinal artery occlusion]
    Karin Ishikawa
    Department of Ophthalmology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nihon Ganka Gakkai Zasshi 106:215-20. 2002
    ..To investigate retinal circulation and function in eyes with branch retinal artery occlusion(BRAO) using a scanning laser Doppler flow-meter (SLDF) and multifocal electroretinogram (mERG)...
  98. ncbi request reprint Serum antioxidants and age-related macular degeneration among older Japanese
    Takehiro Michikawa
    Department of Preventive Medicine and Public Health, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    Asia Pac J Clin Nutr 18:1-7. 2009
    ..Our findings support the hypothesis that a combination of serum antioxidants obtained from the traditional Japanese diet is protective for late AMD, but not for early AMD...
  99. ncbi request reprint Adherence of intravitreally injected triamcinolone acetonide to the denuded retinal surface after internal limiting membrane peeling
    Shingo Satofuka
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Retina 25:672-3. 2005
  100. ncbi request reprint Treatment of cystoid macular edema with oral acetazolamide in a patient with best vitelliform macular dystrophy
    Kuniko Hori
    Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Retina 24:481-2. 2004
  101. pmc Evaluation of PTPN22 polymorphisms and Vogt-Koyanagi-Harada disease in Japanese patients
    Yukihiro Horie
    Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Kita ku, Sapporo, Japan
    Mol Vis 15:1115-9. 2009
    ..In this study, genetic susceptibility to VKH disease was investigated by screening for single nucleotide polymorphisms (SNPs) of PTPN22...