Atsuhiro Ichihara

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. doi Association of (pro)renin receptor mRNA expression with angiotensin-converting enzyme mRNA expression in human artery
    Tomoko Takemitsu
    Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Nephrol 30:361-70. 2009
  2. pmc Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Invest 114:1128-35. 2004
  3. ncbi Long-term effects of statins on arterial pressure and stiffness of hypertensives
    A Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Hum Hypertens 19:103-9. 2005
  4. doi Possible roles of human (pro)renin receptor suggested by recent clinical and experimental findings
    Atsuhiro Ichihara
    Department of Endocrinology and Anti Aging Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan
    Hypertens Res 33:177-80. 2010
  5. ncbi Low doses of losartan and trandolapril improve arterial stiffness in hemodialysis patients
    Atsuhiro Ichihara
    Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Kidney Dis 45:866-74. 2005
  6. ncbi The (pro)renin receptor and the kidney
    Atsuhiro Ichihara
    Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Semin Nephrol 27:524-8. 2007
  7. ncbi Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertension 47:894-900. 2006
  8. ncbi Ambulatory blood pressure variability and brachial-ankle pulse wave velocity in untreated hypertensive patients
    A Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Hum Hypertens 20:529-36. 2006
  9. ncbi Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, 160 8582, Japan
    J Am Soc Nephrol 17:1950-61. 2006
  10. ncbi Effects of amlodipine and valsartan on vascular damage and ambulatory blood pressure in untreated hypertensive patients
    A Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Hum Hypertens 20:787-94. 2006

Detail Information

Publications121 found, 100 shown here

  1. doi Association of (pro)renin receptor mRNA expression with angiotensin-converting enzyme mRNA expression in human artery
    Tomoko Takemitsu
    Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Nephrol 30:361-70. 2009
    ..A significant role of (pro)renin receptor in the pathogenesis of end-organ damage has been suggested only in animal studies. This study was conducted to examine the mRNA expression of (pro)renin receptor in human artery...
  2. pmc Inhibition of diabetic nephropathy by a decoy peptide corresponding to the "handle" region for nonproteolytic activation of prorenin
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Clin Invest 114:1128-35. 2004
    ..The mechanism and substances causing nonproteolytic activation of prorenin may serve as important therapeutic targets for the prevention of diabetic organ damage...
  3. ncbi Long-term effects of statins on arterial pressure and stiffness of hypertensives
    A Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Hum Hypertens 19:103-9. 2005
    ..These results suggest that long-term use of fluvastatin by hyperlipidaemic hypertensive patients is associated with a significant reduction in aortic stiffness without any effect on BP...
  4. doi Possible roles of human (pro)renin receptor suggested by recent clinical and experimental findings
    Atsuhiro Ichihara
    Department of Endocrinology and Anti Aging Medicine, Keio University School of Medicine, Shinjuku, Tokyo, Japan
    Hypertens Res 33:177-80. 2010
    ....
  5. ncbi Low doses of losartan and trandolapril improve arterial stiffness in hemodialysis patients
    Atsuhiro Ichihara
    Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Kidney Dis 45:866-74. 2005
    ....
  6. ncbi The (pro)renin receptor and the kidney
    Atsuhiro Ichihara
    Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Semin Nephrol 27:524-8. 2007
    ....
  7. ncbi Nonproteolytic activation of prorenin contributes to development of cardiac fibrosis in genetic hypertension
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertension 47:894-900. 2006
    ....
  8. ncbi Ambulatory blood pressure variability and brachial-ankle pulse wave velocity in untreated hypertensive patients
    A Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Hum Hypertens 20:529-36. 2006
    ..In conclusion, untreated hypertensive patients with a higher 24-h ambulatory systolic BP variability had stiffer arterial walls. Ambulatory systolic BP variability may be involved in stiffening of the arteries of hypertensive patients...
  9. ncbi Prorenin receptor blockade inhibits development of glomerulosclerosis in diabetic angiotensin II type 1a receptor-deficient mice
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, 160 8582, Japan
    J Am Soc Nephrol 17:1950-61. 2006
    ..It is not only AngII but also intraglomerular activation of MAPK by the receptor-associated prorenin that plays a pivotal role in diabetic nephropathy...
  10. ncbi Effects of amlodipine and valsartan on vascular damage and ambulatory blood pressure in untreated hypertensive patients
    A Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Hum Hypertens 20:787-94. 2006
    ....
  11. ncbi Contribution of nonproteolytically activated prorenin in glomeruli to hypertensive renal damage
    Atsuhiro Ichihara
    Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, 160 8582, Japan
    J Am Soc Nephrol 17:2495-503. 2006
    ..These studies clearly demonstrated that nonproteolytic activation of prorenin in glomeruli is critically involved in renal tissue RAS activation, leading to renal damage in hypertensive animals...
  12. ncbi Add-on amlodipine improves arterial function and structure in hypertensive patients treated with an angiotensin receptor blocker
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Cardiovasc Pharmacol 49:161-6. 2007
    ..The antiatherogenic pleiotropic properties of amlodipine have a preventive effect on the progression of arterial stiffness in hypertensive patients treated with an ARB...
  13. ncbi New approaches to blockade of the renin-angiotensin-aldosterone system: characteristics and usefulness of the direct renin inhibitor aliskiren
    Atsuhiro Ichihara
    Department of Anti Aging Medicine, Keio University School of Medicine, Tokyo, Japan
    J Pharmacol Sci 113:296-300. 2010
    ....
  14. ncbi [(Pro) renin receptor]
    Atsuhiro Ichihara
    Nihon Yakurigaku Zasshi 132:124-6. 2008
  15. doi Cardio-ankle vascular index and ankle pulse wave velocity as a marker of arterial fibrosis in kidney failure treated by hemodialysis
    Atsuhiro Ichihara
    Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Kidney Dis 52:947-55. 2008
    ..This study sought to compare the strength of predictions of arterial fibrosis by using a new parameter, the cardio-ankle vascular index (CAVI), versus pulse wave velocity (PWV) in patients with kidney failure treated with hemodialysis...
  16. ncbi Fluvastatin prevents development of arterial stiffness in haemodialysis patients with type 2 diabetes mellitus
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Nephrol Dial Transplant 17:1513-7. 2002
    ..We studied the preventive effects of a 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, fluvastatin, on arterial PWV values in this population...
  17. ncbi Renin, prorenin and the kidney: a new chapter in an old saga
    Atsuhiro Ichihara
    Departments of Anti Aging Medicine and Endocrinology, Keio University School of Medicine, Shinjuku ku, Tokyo Japan
    J Nephrol 22:306-11. 2009
    ..Consequently, renin, prorenin and the (pro) renin receptor may be important therapeutic targets for the prevention and regression of nephropathy in patients with diabetes and/or hypertension...
  18. ncbi Drug discovery for overcoming chronic kidney disease (CKD): new therapy for CKD by a (pro)renin-receptor-blocking decoy peptide
    Atsuhiro Ichihara
    Department of Anti Aging Medicine and Endocrinology, Keio University School of Medicine, Tokyo, Japan
    J Pharmacol Sci 109:20-3. 2009
    ..Thus, (pro)renin-receptor blockade can be a useful therapy for chronic kidney disease with low renin levels in the plasma...
  19. ncbi Blunted tubuloglomerular feedback by absence of angiotensin type 1A receptor involves neuronal NOS
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertension 40:934-9. 2002
    ..2+/-6.4% and 59.5+/-4.4%, respectively). These results suggest that AT1A receptors enhance tubuloglomerular feedback-mediated afferent arteriolar constriction, at least in part, through reducing the counteracting modulation by nNOS...
  20. pmc Involvement of (pro)renin receptor in the glomerular filtration barrier
    Atsuhiro Ichihara
    Departments of Anti Aging Medicine and Endocrinology and Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    J Mol Med (Berl) 86:629-35. 2008
    ..Thus, the (pro)renin receptor may be upregulated in podocytes under hypertensive conditions and may contribute to the breakdown of the glomerular filtration barrier...
  21. ncbi Long-term effects of intensive blood-pressure lowering on arterial wall stiffness in hypertensive patients
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Hypertens 16:959-65. 2003
    ..To determine the long-term effects of intensive blood pressure (BP) lowering by antihypertensive drug therapy on aortic stiffness assessed by PWV, a single-blind randomized prospective study was performed...
  22. ncbi Angiotensin II type 2 receptor inhibits prorenin processing in juxtaglomerular cells
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 26:915-21. 2003
    ..Long-term treatment with an ARB may decrease PRA in part by diminishing the storage of active renin in JG cells...
  23. doi Activated prorenin as a therapeutic target for diabetic nephropathy
    Atsuhiro Ichihara
    Anti Aging Medicine and Endocrinology and Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Diabetes Res Clin Pract 82:S63-6. 2008
    ..Receptor-bound prorenin may prove useful as an important therapeutic target for the prevention and regression of end-organ damage in patients with diabetes...
  24. doi Candesartan and insulin reduce renal sympathetic nerve activity in hypertensive type 1 diabetic rats
    Chie Takimoto
    Divison of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 31:1941-51. 2008
    ....
  25. pmc (Pro)renin receptor promotes choroidal neovascularization by activating its signal transduction and tissue renin-angiotensin system
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Inaida Endowed Department of Anti Aging Ophthalmology, Keio University School of Medicine, Tokyo, Japan
    Am J Pathol 173:1911-8. 2008
    ..These results indicate the significant contribution of RAPS to CNV pathogenesis...
  26. ncbi Role of nonproteolytically activated prorenin in pathologic, but not physiologic, retinal neovascularization
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Invest Ophthalmol Vis Sci 48:422-9. 2007
    ..The purpose of the present study was to investigate whether nonproteolytically activated prorenin plays a role in ischemia-induced retinal neovascularization...
  27. doi Aliskiren inhibits intracellular angiotensin II levels without affecting (pro)renin receptor signals in human podocytes
    Mariyo Sakoda
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Hypertens 23:575-80. 2010
    ..Because (P)RR is present in the podocytes, a central component of the glomerular filtration barrier, we hypothesized that aliskiren influences the (P)RR-induced two pathways in human podocytes...
  28. pmc (Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammation
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Diabetes 58:1625-33. 2009
    ..The aim of the present study was to define the association of the RAPS with diabetes-induced retinal inflammation...
  29. doi "Pulse" treatment with high-dose angiotensin blocker reverses renal arteriolar hypertrophy and regresses hypertension
    Kimiko Ishiguro
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Hypertension 53:83-9. 2009
    ....
  30. doi Regression of glomerulosclerosis in response to transient treatment with angiotensin II blockers is attenuated by blockade of matrix metalloproteinase-2
    Kaori Hayashi
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Kidney Int 78:69-78. 2010
    ..Our results suggest that transient high-dose angiotensin receptor blocker treatment effectively induced sustained regression of glomerulosclerosis by a mechanism mediated, in part, by changes in MMP-2 activity...
  31. ncbi Add-on blockade of (pro)renin receptor in imidapril-treated diabetic SHRsp
    Yasufumi Seki
    Department of Endocrinology and Anti Aging Medicine, Keio University School of Medicine, Tokyo, Japan
    Front Biosci (Elite Ed) 2:972-9. 2010
    ..Thus, (pro)renin receptor contributes to the accelerated pathogenesis in the heart and kidneys of diabetic SHRsp...
  32. ncbi Role of asymmetric dimethylarginine in vascular injury in transgenic mice overexpressing dimethylarginie dimethylaminohydrolase 2
    Kazuhiro Hasegawa
    Department of Internal Medicine, Keio University, Shinanomachi, Shinjuku ku, Tokyo, Japan
    Circ Res 101:e2-10. 2007
    ..Collectively, the DDAH2/ADMA pathway can be a novel therapeutic target for vasculopathy in the ADMA or angiotensin II-induced pathophysiological conditions...
  33. ncbi Developmental activity of the renin-angiotensin system during the "critical period" modulates later L-NAME-induced hypertension and renal injury
    Kimiko Ishiguro
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Hypertens Res 30:63-75. 2007
    ..Conversely, developmental exposure to Ang II during this "critical" period had the opposite effect, predisposing rats to higher blood pressure, renal injury, and oxidative stress after L-NAME administration...
  34. doi Add-on benefits of amlodipine and thiazide in nondiabetic chronic kidney disease stage 1/2 patients treated with valsartan
    Yuki Kaneshiro
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Kidney Blood Press Res 32:51-8. 2009
    ..These results suggest that 12 months of add-on treatment with either amlodipine or hydrochlorothiazide could have beneficial effects in nondiabetic chronic kidney disease stage 1/2 patients already being treated with valsartan...
  35. pmc Natriuretic peptides/cGMP/cGMP-dependent protein kinase cascades promote muscle mitochondrial biogenesis and prevent obesity
    Kazutoshi Miyashita
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Diabetes 58:2880-92. 2009
    ..Recent clinical studies have shown that plasma NP levels were lower in subjects with the metabolic syndrome. The present study was conducted to elucidate the roles for NP/cGK cascades in energy metabolism...
  36. ncbi Effects of 12-month valsartan therapy on glycation and oxidative stress markers in type 2 diabetic subjects with hypertension
    Naoko Komiya
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Int Heart J 49:681-9. 2008
    ..In conclusion, the findings suggest that treatment with valsartan, even at a low dose, may ameliorate some glycation and oxidative stress markers independently of an effect on blood pressure in hypertensive type 2 diabetic subjects...
  37. doi Relation of blood pressure quantitative trait locus on rat chromosome 1 to hyperactivity of rostral ventrolateral medulla
    Kamon Iigaya
    Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo
    Hypertension 53:42-8. 2009
    ..The QTL on rat chromosome 1 was primarily related to the postsynaptic response of RVLM bulbospinal neurons to brain angiotensin II, whereas both the QTL and other genomic regions influenced the basal activity of RVLM neurons...
  38. pmc Blood pressure-independent effect of candesartan on cardio-ankle vascular index in hypertensive patients with metabolic syndrome
    Kanako Bokuda
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Vasc Health Risk Manag 6:571-8. 2010
    ..Candesartan may be a better antihypertensive drug than CCBs to improve subclinical atherosclerosis of patients with MetS...
  39. ncbi (Pro)renin receptor-mediated activation of mitogen-activated protein kinases in human vascular smooth muscle cells
    Mariyo Sakoda
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 30:1139-46. 2007
    ..The (pro)renin receptor-mediated ERK signal transduction is thus a possible new therapeutic target for preventing vascular complications...
  40. ncbi Slowly progressive, angiotensin II-independent glomerulosclerosis in human (pro)renin receptor-transgenic rats
    Yuki Kaneshiro
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Am Soc Nephrol 18:1789-95. 2007
    ..This study clearly provided in vivo evidence for the AngII-independent MAPK activation by human (pro)renin receptor and induction of glomerulosclerosis with increased TGF-beta1 expression...
  41. pmc NF-YC functions as a corepressor of agonist-bound mineralocorticoid receptor
    Ayano Murai-Takeda
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160 8582, Japan
    J Biol Chem 285:8084-93. 2010
    ..These findings indicate that NF-YC functions as a new corepressor of agonist-bound MR via alteration of aldosterone-induced MR conformation...
  42. doi Monosynaptic excitatory connection from the rostral ventrolateral medulla to sympathetic preganglionic neurons revealed by simultaneous recordings
    Naoki Oshima
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Hypertens Res 31:1445-54. 2008
    ..The results explain the mechanism by which Ang II in the RVLM area increases peripheral sympathetic activity and blood pressure...
  43. doi Human C-reactive protein exacerbates metabolic disorders in association with adipose tissue remodelling
    Hidehiro Kaneko
    Division of Cardiology, Department of Medicine, Keio University School of Medicine, Tokyo, Japan
    Cardiovasc Res 91:546-55. 2011
    ..C-reactive protein (CRP) expression is increased with metabolic alterations. We sought to clarify the effect of CRP on the development of obesity-induced metabolic disorders using human CRP-overexpressing transgenic mice (CRPTG)...
  44. ncbi Combination of C-reactive protein and high molecular weight (HMW)-adiponectin reflects further metabolic abnormalities compared with each of them alone in Japanese type 2 diabetic subjects
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Endocr J 55:331-8. 2008
    ..In the present study, we investigated whether the combination of CRP and adiponectin is associated with further metabolic abnormalities compared to each of them alone...
  45. ncbi Benefits of candesartan on arterial and renal damage of non-diabetic hypertensive patients treated with calcium channel blockers
    Atsuhiro Ichihara
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Am J Nephrol 26:462-8. 2006
    ..The present study was conducted to examine add-on benefits of candesartan therapy on hypertensive patients treated with CCBs for at least 12 months...
  46. doi Effects of telmisartan on arterial stiffness assessed by the cardio-ankle vascular index in hypertensive patients
    Kenichiro Kinouchi
    Department of Endocrinology, Metabolism, and Nephrology, Keio University School of Medicine, Tokyo, Japan
    Kidney Blood Press Res 33:304-12. 2010
    ..This study was conducted to determine the effect of telmisartan on the cardio-ankle vascular index (CAVI), a novel blood pressure (BP)-independent marker for arterial stiffness in hypertensive patients...
  47. ncbi Transmural pressure control of prorenin processing and secretion in diabetic rat juxtaglomerular cells
    Nobuhisa Hirota
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 26:493-501. 2003
    ..Pressure-induced inhibition of prorenin processing in JG cells via phospholipase D-dependent pathways is enhanced in late diabetes...
  48. doi Involvement of activated prorenin in the pathogenesis of slowly progressive nephropathy in the non-clipped kidney of two kidney, one-clip hypertension
    Masaki Ryuzaki
    Department of Endocrinology and Anti Aging Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 34:301-7. 2011
    ..These results suggest that the ((P)RR)-dependent activation of prorenin contributes to the pathogenesis of slowly progressive nephropathy in the intact kidney in a rat model of renovascular hypertension...
  49. pmc Kidney-specific overexpression of Sirt1 protects against acute kidney injury by retaining peroxisome function
    Kazuhiro Hasegawa
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160 8582, Japan
    J Biol Chem 285:13045-56. 2010
    ..Renal Sirt1 can be a potential therapeutic target for the treatment of AKI...
  50. doi Absence of gelatinase (MMP-9) or collagenase (MMP-13) attenuates adriamycin-induced albuminuria and glomerulosclerosis
    Yusuke Sakamaki
    Department of Internal Medicine, Keio University, Tokyo, Japan
    Nephron Exp Nephrol 115:e22-32. 2010
    ..To investigate the role of individual MMPs, we examined the course of Adriamycin-induced albuminuria and glomerulosclerosis in mice lacking either a gelatinase (MMP-9) or a collagenase (MMP-13)...
  51. doi Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis
    Naoki Washida
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Nephrol Dial Transplant 26:2770-9. 2011
    ..The small G protein, Rho, and its downstream effector Rho-kinase have been shown to be involved in the tissue fibrosis process. This study was undertaken to investigate the role of Rho-kinase in the pathogenesis of these alterations...
  52. doi Effects of olmesartan medoxomil, an angiotensin II type 1 receptor antagonist, on plasma concentration of B-type natriuretic peptide, in hypertensive patients with type 2 diabetes mellitus: a preliminary, observational, open-label study
    Toshihide Kawai
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Clin Drug Investig 31:237-45. 2011
    ..The objective of this study was to determine the effects of olmesartan medoxomil, a novel ARB, on the plasma level of BNP in hypertensive patients with type 2 diabetes...
  53. doi MCP-1 gene A-2518G polymorphism and carotid artery atherosclerosis in patients with type 2 diabetes
    Sachiko Yuasa
    Division of Metabolism, Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Diabetes Res Clin Pract 86:193-8. 2009
    ..The objective of this study was to evaluate the relation between the genotypes of the MCP-1 A-2518G polymorphism and the development of carotid atherosclerosis in patients with type 2 diabetes...
  54. pmc Coactivation of SF-1-mediated transcription of steroidogenic enzymes by Ubc9 and PIAS1
    Noriko Suda
    Department of Internal Medicine, School of Medicine, Keio University, Shinjujku ku, Tokyo 160 8582, Japan
    Endocrinology 152:2266-77. 2011
    ..These results showed the physiological roles of Ubc9 and PIAS1 as SF-1 coactivators beyond sumoylation enzymes in adrenocortical steroidogenesis and suggested their possible pathophysiological roles in human cortisol-producing adenomas...
  55. doi High-molecular-weight adiponectin is a predictor of progression to metabolic syndrome: a population-based 6-year follow-up study in Japanese men
    Yoshie Seino
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Metabolism 58:355-60. 2009
    ..Furthermore, it was suggested longitudinally that measuring HMW adiponectin is efficient to predict the progression to metabolic syndrome compared with measuring total adiponectin or HMW-total adiponectin ratio...
  56. doi The (pro)renin receptor/ATP6AP2 is essential for vacuolar H+-ATPase assembly in murine cardiomyocytes
    Kenichiro Kinouchi
    Department of Endocrinology, Metabolism, and Nephrology, Keio University School of Medicine, Tokyo, Japan
    Circ Res 107:30-4. 2010
    ..A truncated form of (P)RR, termed M8.9, was also found to be associated with the vacuolar H(+)-ATPase (V-ATPase), implicating a non-RAS-related function of ATP6AP2...
  57. doi Renoprotective effects of mineralocorticoid receptor blockade in heminephrectomized (pro)renin receptor transgenic rats
    Yuki Mizuguchi
    Endocrinology and Anti Ageing Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Clin Exp Pharmacol Physiol 37:569-73. 2010
    ..5. The results of the present study suggest that the improvement in proteinuria following eplerenone treatment is independent of its effects on sodium balance and may be mediated by effects on the expression of slit diaphragm proteins...
  58. doi Sirt1 protects against oxidative stress-induced renal tubular cell apoptosis by the bidirectional regulation of catalase expression
    Kazuhiro Hasegawa
    Department of Internal Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 1608582, Japan
    Biochem Biophys Res Commun 372:51-6. 2008
    ..In contrast, excess ROS upregulates Sirt1, which activates FoxO3a and catalase leading to rescuing apoptosis. Thus, Sirt1 constitutes a determinant of renal tubular cell apoptosis by regulating cellular ROS levels...
  59. doi Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch
    Yoshikazu Hara
    Department of Internal Medicine, School of Medicine, Keio University, Shinjuku ku, Tokyo 160 8582, Japan
    Sci Signal 4:ra3. 2011
    ..Thus, inhibition of Rho-Rho-kinase signaling may provide a therapeutic strategy for disrupting a vicious cycle of adipocyte stretch, Rho-Rho-kinase signaling, and inflammation of adipose tissue that contributes to and aggravates obesity...
  60. ncbi Pathologic roles of prorenin and (pro)renin receptor in the eye
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Keio University School of Medicine, Tokyo, Japan
    Front Biosci 13:3884-95. 2008
    ..These findings demonstrate that nonproteolytically activated prorenin plays a significant role in the ocular inflammation and neovascularization...
  61. doi Prediction of gestational diabetes mellitus by soluble (pro)renin receptor during the first trimester
    Noriyoshi Watanabe
    Department of Endocrinology and Hypertension, Tokyo Women s Medical University, 8 1 Kawada cho, Shinjuku, Tokyo, 162 8666, Japan
    J Clin Endocrinol Metab 98:2528-35. 2013
    ..There are currently no factors that have been shown to predict gestational diabetes mellitus (GDM) during early pregnancy. The soluble (pro)renin receptor [s(P)RR] may contribute to the development of GDM...
  62. doi Safety and benefits of a tablet combining losartan and hydrochlorothiazide in Japanese diabetic patients with hypertension
    Kenichiro Kinouchi
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertens Res 32:1143-7. 2009
    ..Thus, the L/HCTZ tablet could be a useful drug for Japanese diabetic patients with hypertension...
  63. ncbi Anandamide decreases glomerular filtration rate through predominant vasodilation of efferent arterioles in rat kidneys
    Yukako Koura
    Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    J Am Soc Nephrol 15:1488-94. 2004
    ..These results suggest that ANA causes afferent arteriolar dilation via both CB1 and non-CB1 receptors and greater efferent arteriolar dilation via CB1 receptors, resulting in a decreased GFR and an increased RBF without affecting MAP...
  64. ncbi Beta cell dysfunction and its clinical significance in gestational diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Endocr J 57:973-80. 2010
    ..The level of beta cell dysfunction in GDM was associated with the severity of glucose intolerance and total insulin dosage required. These findings underpin clinical significance of beta cell dysfunction in GDM...
  65. ncbi A case of membranous nephropathy with primary biliary cirrhosis and cyclosporine-induced remission
    Yusuke Sakamaki
    Division of Endocrinology, Metabolism and Nephrology, Department of Internal Medicine, Keio University, Japan
    Intern Med 50:233-8. 2011
    ..68 g/day) within six months without any significant side effects. This case suggests that CsA monotherapy is effective for the treatment of both liver dysfunction and membranous nephropathy associated with PBC...
  66. ncbi Usefulness of C-reactive protein to high-molecular-weight adiponectin ratio to predict insulin resistance and metabolic syndrome in Japanese men
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 17:944-52. 2010
    ..We questioned whether the ratio of C-reactive protein to high-molecular-weight adiponectin (C/A ratio), compared to each value alone, is more useful to predict insulin resistance and/or metabolic syndrome...
  67. doi Induction of anti-whole GAD65 reactivity in vivo results in disease suppression in type 1 diabetes
    Yasuhiko Kanazawa
    Department of Internal Medicine, Keio University School of Medicine, Shimanomachi Shinjuku ku, Tokyo, Japan
    J Autoimmun 32:104-9. 2009
    ..Based upon these results, we propose that anti-whole GAD65-reactive T cells have the ability to regulate the development of type 1 diabetes...
  68. pmc Renal renin-angiotensin system
    Atsuhiro Ichihara
    Keio University School of Medicine, Tokyo, USA
    Contrib Nephrol 143:117-30. 2004
  69. ncbi Ovariectomy enhances renal cortical expression and function of cyclooxygenase-2
    Yuko Tada
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Kidney Int 66:1966-76. 2004
    ..This study was performed to determine the renal expression of COX-2 and on COX-2-dependent regulation of renal blood flow (RBF) in ovariectomized rats...
  70. doi Significance of leptin and high-molecular weight adiponectin in the general population of Japanese male adolescents
    Hiroshi Nakatani
    Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
    Metabolism 57:157-62. 2008
    ..The inverse correlation between adiponectin and insulin resistance may manifest in the later phase of obesity development...
  71. pmc Determinants of decline in glomerular filtration rate in nonproteinuric subjects with or without diabetes and hypertension
    Hiroki Yokoyama
    Jiyugaoka Medical Clinic, Internal Medicine, Obihiro 080 0016, Japan
    Clin J Am Soc Nephrol 4:1432-40. 2009
    ..This study investigated whether the slope of estimated GFR is different between nonproteinuric subjects with and without diabetes, and what clinical factors are associated with the GFR slope...
  72. doi FOXP3/Scurfin gene polymorphism is associated with adult onset type 1 diabetes in Japanese, especially in women and slowly progressive-type patients
    Kyoko Iwase
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Autoimmunity 42:159-67. 2009
    ..The FOXP3/Scurfin gene is known to be a master gene of Tregs. Therefore, we tried to analyze the relation between the gene polymorphism and adult onset type 1 diabetes and its subtype in the Japanese population...
  73. pmc Prorenin receptor is essential for normal podocyte structure and function
    Yoichi Oshima
    Department of Endocrinology and Anti Aging Medicine and Internal Medicine, Keio University School of Medicine, 35 Shinanomachi Shinjuku ku, Tokyo, 160 8582, Japan
    J Am Soc Nephrol 22:2203-12. 2011
    ..In conclusion, the prorenin receptor is important for the maintenance of normal podocyte structure and function...
  74. doi Clinical importance of Stenotrophomonas maltophilia nosocomial pneumonia due to its high mortality in hemodialysis patients
    Shu Wakino
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Ther Apher Dial 13:193-8. 2009
    ..maltophilia. For pneumonia due to S. maltophilia, new generation fluoroquinolones can be the treatment of choice, although S. maltophilia-related pneumonia should be treated very carefully because of its high fatality rate...
  75. ncbi [Effects of ARB in metabolic syndrome]
    Hiroo Kumagai
    Department of Internal Medicine, Keio University School of Medicine
    Nihon Rinsho 64:599-606. 2006
  76. pmc Angiotensin II reduces mitochondrial content in skeletal muscle and affects glycemic control
    Masanori Mitsuishi
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Diabetes 58:710-7. 2009
    ..Blockade of angiotensin (Ang) II has been shown to prevent new-onset type 2 diabetes. We focused on the effects of AngII on muscle mitochondria, especially on their biogenesis, as an underlining mechanism of type 2 diabetes...
  77. ncbi Regression of nephropathy developed in diabetes by (Pro)renin receptor blockade
    Hidena Takahashi
    Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Tokyo, Japan
    J Am Soc Nephrol 18:2054-61. 2007
    ..These results suggest that (pro)renin receptor blockade does not only inhibit the progression of nephropathy but also reverses the glomerulosclerosis that has already developed in diabetic rats...
  78. pmc The role of individual domains and the significance of shedding of ATP6AP2/(pro)renin receptor in vacuolar H(+)-ATPase biogenesis
    Kenichiro Kinouchi
    Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 8:e78603. 2013
    ..The V-ATPase assembly occurs prior to its delivery to the trans-Golgi network and hence shedding of ATP6AP2/PRR would not affect the biogenesis of active V-ATPase. ..
  79. doi Prediction of pregnancy-induced hypertension by a shift of blood pressure class according to the JSH 2009 guidelines
    Seung Chik Jwa
    Department of Maternal Fetal and Neonatal Medicine, National Center for Child Health and Development, Tokyo, Japan
    Hypertens Res 34:1203-8. 2011
    ..05). Within JSH 2009 Classes I, II and III, a shift in BP from a low to a high class between 16 and 20 weeks of gestation predicts the subsequent development of PIH...
  80. ncbi Phospholipase D contributes to transmural pressure control of prorenin processing in juxtaglomerular cell
    Nobuhisa Hirota
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Hypertension 39:363-7. 2002
    ..These results indicate that transmural pressure inhibits renin secretion via PLC-dependent pathways and prevents conversion of inactive renin to active renin via PLD-dependent mechanisms in JG cells...
  81. ncbi Suppression of ocular inflammation in endotoxin-induced uveitis by inhibiting nonproteolytic activation of prorenin
    Shingo Satofuka
    Laboratory of Retinal Cell Biology, Department of Ophthalmology, Keio University School of Medicine, Tokyo, and Department of Ophthalmology, Kobe City General Hospital, Japan
    Invest Ophthalmol Vis Sci 47:2686-92. 2006
    ..The purpose of the present study was to elucidate the role of the receptor-dependent nonproteolytic activation of prorenin in ocular inflammation in endotoxin-induced uveitis (EIU)...
  82. ncbi [Case of nephrotic syndrome due to AL-type primary amyloidosis associated with renal cell carcinoma]
    Morito Takano
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Nihon Jinzo Gakkai Shi 49:1014-9. 2007
    ....
  83. doi Atp6ap2/(pro)renin receptor interacts with Par3 as a cell polarity determinant required for laminar formation during retinal development in mice
    Atsuhiro Kanda
    Laboratory of Ocular Cell Biology and Visual Science, Department of Ophthalmology, Hokkaido University Graduate School of Medicine, Sapporo, Hokkaido 060 8638, Japan, Department of Ophthalmology, Keio University School of Medicine, Tokyo 160 8582, Japan, Laboratory for Molecular and Developmental Biology, Institute for Protein Research, Osaka University, and JST, CREST, Suita, Osaka, 565 0871, Japan, and Department of Endocrinology and Hypertension, Tokyo Women s Medical University, Tokyo 162 8666, Japan
    J Neurosci 33:19341-51. 2013
    ..We propose that this cellular activity associated with the Par-aPKC system, in addition to the v-ATPase function and tissue RAS activation, is the third biological role of Atp6ap2/(P)RR. ..
  84. ncbi Effects of adding ezetimibe to fluvastatin on kidney function in patients with hypercholesterolemia: a randomized control trial
    Kenichiro Kinouchi
    Division of Endocrinology, Metabolism, and Nephrology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Atheroscler Thromb 20:245-56. 2013
    ..Ezetimibe, a cholesterol-absorption inhibitor, also lowers LDL cholesterol levels when added to statins; however, the effect of add-on ezetimibe on kidney function has had conflicting results...
  85. ncbi [A case of diabetic glomerulosclerosis without concurrent diabetes mellitus]
    Yusuke Jo
    Departments of Internal Medicine and Pathology, Keio University School of Medicine, Tokyo, Japan
    Nihon Jinzo Gakkai Shi 44:552-7. 2002
    ..Renal biopsy revealed nodular and diffuse glomerulosclerosis characteristic of diabetic nephropathy. The present case demonstrates that nodular glomerulosclerosis may be present without clinically overt diabetes mellitus...
  86. ncbi Podocytes as a target of prorenin in diabetes
    Mariyo Sakoda
    Department of Internal Medicine, School of Medicine, Keio University of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Curr Diabetes Rev 7:17-21. 2011
    ..Further inquiry regarding podocyte (P)RR intracellular signal transduction will be needed to develop a new therapeutic approach targeting podocyte (P)RR in patients with diabetic nephropathy...
  87. ncbi Comparison of the effects of calcitriol and maxacalcitol on secondary hyperparathyroidism in patients on chronic haemodialysis: a randomized prospective multicentre trial
    Matsuhiko Hayashi
    Department of Internal Medicine, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Nephrol Dial Transplant 19:2067-73. 2004
    ....
  88. doi Involvement of receptor-bound prorenin in development of nephropathy in diabetic db/db mice
    Atsuhiro Ichihara
    Deparment of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    J Am Soc Hypertens 2:332-40. 2008
    ..Thus prorenin also contributes to the development of nephropathy in type II diabetes, probably through a (pro)renin receptor-dependent mechanism...
  89. doi Prevention and regression of hypertension: role of renal microvascular protection
    Hiroyuki Sasamura
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Hypertens Res 32:658-64. 2009
    ..These results suggest that changes in the renal microvasculature may have an important role in the mechanisms of hypertension prevention and regression by ARB...
  90. doi Licochalcone A potently inhibits tumor necrosis factor alpha-induced nuclear factor-kappaB activation through the direct inhibition of IkappaB kinase complex activation
    Megumi Funakoshi-Tago
    Department of Biochemistry, Keio University, 1 5 30 Shibakoen, Minato ku, Tokyo, Japan
    Mol Pharmacol 76:745-53. 2009
    ..Taken together, licochalcone A might contribute to the potent anti-inflammatory effect of G. inflata through the inhibition of IKK activation...
  91. doi Pancreatic beta-cell function and fetal growth in gestational impaired glucose tolerance
    Kei Miyakoshi
    Department of Obstetrics and Gynecology, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Acta Obstet Gynecol Scand 89:769-75. 2010
    ..To investigate the metabolic phenotype and pregnancy outcomes of gestational impaired glucose tolerance (IGT) defined by isolated hyperglycemia during an oral glucose tolerance test (OGTT)...
  92. ncbi T-type Ca channel blockade as a determinant of kidney protection
    Koichi Hayashi
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Keio J Med 59:84-95. 2010
    ..Thus, the strategy for hypertension treatment with CCBs has entered a new era: treatment selection depends not only on blood pressure control but also on the subtypes of CCBs...
  93. doi Effects of epalrestat, an aldose reductase inhibitor, on diabetic peripheral neuropathy in patients with type 2 diabetes, in relation to suppression of N(ɛ)-carboxymethyl lysine
    Toshihide Kawai
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Diabetes Complications 24:424-32. 2010
    ..We investigated the efficacy of epalrestat, an aldose reductase inhibitor, for diabetic peripheral neuropathy in Japanese patients with type 2 diabetes...
  94. ncbi Postprandial serum C-peptide to plasma glucose ratio as a predictor of subsequent insulin treatment in patients with type 2 diabetes
    Yoshifumi Saisho
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Endocr J 58:315-22. 2011
    ..Our study indicates that among CPR measurements, postprandial CPR index is the best predictive marker for future insulin therapy...
  95. ncbi Brachial-ankle pulse wave velocity predicts silent cerebrovascular diseases in patients with end-stage renal diseases
    Naoki Washida
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    J Atheroscler Thromb 17:165-72. 2010
    ..The purpose of this study was to examine whether factors associated with arterial stiffness contributed to the development of CVD in patients with ESRD...
  96. doi Celecoxib potently inhibits TNFalpha-induced nuclear translocation and activation of NF-kappaB
    Megumi Funakoshi-Tago
    Department of Biochemistry, Faculty of Pharmacy, Keio University, 1 5 30 Shibakoen, Minato ku, Tokyo 105 8512, Japan
    Biochem Pharmacol 76:662-71. 2008
    ..This negative regulation of NF-kappaB activation by Celecoxib might be an important mechanism leading to its anti-inflammatory activity...
  97. ncbi Effects of pretreatment with low-dose metformin on metabolic parameters and weight gain by pioglitazone in Japanese patients with type 2 diabetes
    Toshihide Kawai
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Intern Med 47:1181-8. 2008
    ..We investigated whether or not "low dose" metformin could prevent weight gain induced by pioglitazone...
  98. pmc Association between soluble (Pro)renin receptor concentration in cord blood and small for gestational age birth: a cross-sectional study
    Noriyoshi Watanabe
    Department of Endocrinology and Hypertension, Tokyo Women s Medical University, Shinjuku, Tokyo, Japan
    PLoS ONE 8:e60036. 2013
    ..The purpose of this study was to assess the association between plasma soluble (P)RR [s(P)RR] concentration in human cord blood (i.e., neonatal blood at birth) and small for gestational age (SGA) birth...
  99. ncbi Functional characterization of (pro)renin receptor in association with V-ATPase
    Kenichiro Kinouchi
    Department of Endocrinology, Metabolism, and Nephrology, Keio University School of Medicine, Tokyo, 160 8582, Japan
    Front Biosci (Landmark Ed) 16:3216-23. 2011
    ..Thus, the (P)RR is a multi-functional molecule that shows the complex structure and behaviour. This review highlights the current insights and the future perspectives in research regarding the (P)RR and mammalian V-ATPase...
  100. ncbi [Left renal infarction due to dissecting aneurysm of the renal arterial branch]
    Yukako Kamiya
    Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Nihon Jinzo Gakkai Shi 45:695-700. 2003
    ..Therefore, the present case is thought to be unique because he was a normotensive patient with normal plasma renin activity and the renal arterial branch was only dissected...
  101. doi Differential effects of transient treatment of spontaneously hypertensive rats with various antihypertensive agents on the subsequent development of diabetic nephropathy
    Kimiko Ishiguro
    Department of Internal Medicine, School of Medicine, Keio University, Tokyo, Japan
    Nephron Exp Nephrol 109:e20-8. 2008
    ....