Tomohiro Chiba

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. doi request reprint Targeting the JAK2/STAT3 axis in Alzheimer's disease
    Tomohiro Chiba
    Keio University School of Medicine, Department of Anatomy, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Expert Opin Ther Targets 13:1155-67. 2009
  2. doi request reprint Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons
    T Chiba
    Department of Anatomy, School of Medicine, Keio University, Tokyo, Japan
    Mol Psychiatry 14:206-22. 2009
  3. ncbi request reprint Neuroprotection against neurodegenerative diseases: development of a novel hybrid neuroprotective peptide Colivelin
    Tomohiro Chiba
    Department of Anatomy and Pharmacology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Mol Neurobiol 35:55-84. 2007
  4. ncbi request reprint Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin
    Yuichi Hashimoto
    Departments of Pharmacology and Anatomy, Keio University School of Medicine, General Research Building, 3rd and 6th Floors, 35 Shinanomachi, Tokyo 160 8582, Japan
    Eur J Neurosci 19:2356-64. 2004
  5. ncbi request reprint A humanin derivative, S14G-HN, prevents amyloid-beta-induced memory impairment in mice
    Hirohisa Tajima
    Department of Pharmacology and Neurosciences, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Neurosci Res 79:714-23. 2005
  6. ncbi request reprint Implanted cannula-mediated repetitive administration of Abeta25-35 into the mouse cerebral ventricle effectively impairs spatial working memory
    Marina Yamada
    Department of Pharmacology, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160 8582, Japan
    Behav Brain Res 164:139-46. 2005
  7. ncbi request reprint Characterization of V642I-AbetaPP-induced cytotoxicity in primary neurons
    Takako Niikura
    Department of Pharmacology, Keio University School of Medicine, Tokyo, Japan
    J Neurosci Res 77:54-62. 2004
  8. ncbi request reprint Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease-related neurotoxicity: functional potentiation by isomerization and dimerization
    Kenzo Terashita
    Department of Pharmacology, Keio University School of Medicine, Medical Research Center, Tokyo, Japan
    J Neurochem 85:1521-38. 2003
  9. pmc Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein
    Yuichi Hashimoto
    Department of Pharmacology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Mol Cell Biol 25:9304-17. 2005
  10. ncbi request reprint Transforming growth factor beta2 autocrinally mediates neuronal cell death induced by amyloid-beta
    Yuichi Hashimoto
    Department of Pharmacology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Neurosci Res 83:1039-47. 2006

Collaborators

Detail Information

Publications23

  1. doi request reprint Targeting the JAK2/STAT3 axis in Alzheimer's disease
    Tomohiro Chiba
    Keio University School of Medicine, Department of Anatomy, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Expert Opin Ther Targets 13:1155-67. 2009
    ....
  2. doi request reprint Amyloid-beta causes memory impairment by disturbing the JAK2/STAT3 axis in hippocampal neurons
    T Chiba
    Department of Anatomy, School of Medicine, Keio University, Tokyo, Japan
    Mol Psychiatry 14:206-22. 2009
    ..Our findings provide not only a novel pathological hallmark in AD but also a novel target in AD therapy...
  3. ncbi request reprint Neuroprotection against neurodegenerative diseases: development of a novel hybrid neuroprotective peptide Colivelin
    Tomohiro Chiba
    Department of Anatomy and Pharmacology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    Mol Neurobiol 35:55-84. 2007
    ..The neuroprotective effect of Colivelin provides novel insights into therapy for NDDs...
  4. ncbi request reprint Humanin antagonists: mutants that interfere with dimerization inhibit neuroprotection by Humanin
    Yuichi Hashimoto
    Departments of Pharmacology and Anatomy, Keio University School of Medicine, General Research Building, 3rd and 6th Floors, 35 Shinanomachi, Tokyo 160 8582, Japan
    Eur J Neurosci 19:2356-64. 2004
    ..This study provides a novel insight into the understanding of the in vivo function of HN, as well as into the development of clinically applicable HN neutralizers...
  5. ncbi request reprint A humanin derivative, S14G-HN, prevents amyloid-beta-induced memory impairment in mice
    Hirohisa Tajima
    Department of Pharmacology and Neurosciences, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Neurosci Res 79:714-23. 2005
    ..Taking these findings together, we conclude that S14G-HN has rescue activity against memory impairment caused by AD-related insults in vivo by activating the same intracellular neuroprotective machinery as elucidated previously in vitro...
  6. ncbi request reprint Implanted cannula-mediated repetitive administration of Abeta25-35 into the mouse cerebral ventricle effectively impairs spatial working memory
    Marina Yamada
    Department of Pharmacology, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160 8582, Japan
    Behav Brain Res 164:139-46. 2005
    ....
  7. ncbi request reprint Characterization of V642I-AbetaPP-induced cytotoxicity in primary neurons
    Takako Niikura
    Department of Pharmacology, Keio University School of Medicine, Tokyo, Japan
    J Neurosci Res 77:54-62. 2004
    ..The potential of neurotrophic factors and cytokines in AD therapy is also indicated...
  8. ncbi request reprint Two serine residues distinctly regulate the rescue function of Humanin, an inhibiting factor of Alzheimer's disease-related neurotoxicity: functional potentiation by isomerization and dimerization
    Kenzo Terashita
    Department of Pharmacology, Keio University School of Medicine, Medical Research Center, Tokyo, Japan
    J Neurochem 85:1521-38. 2003
    ..This study provides important clues to the understanding of the neuroprotective mechanism of HN, as well as to the development of novel AD therapeutics...
  9. pmc Transforming growth factor beta2 is a neuronal death-inducing ligand for amyloid-beta precursor protein
    Yuichi Hashimoto
    Department of Pharmacology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Mol Cell Biol 25:9304-17. 2005
    ....
  10. ncbi request reprint Transforming growth factor beta2 autocrinally mediates neuronal cell death induced by amyloid-beta
    Yuichi Hashimoto
    Department of Pharmacology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Neurosci Res 83:1039-47. 2006
    ..Combined with the finding in our recent study indicating that TGFbeta2 is a neuronal cell death-inducing ligand for APP, it is suggested that TGFbeta2 is an autocrinal mediator for Abeta42-induced death in PCNs...
  11. ncbi request reprint The cytoplasmic domain of Alzheimer's amyloid-beta protein precursor causes sustained apoptosis signal-regulating kinase 1/c-Jun NH2-terminal kinase-mediated neurotoxic signal via dimerization
    Yuichi Hashimoto
    Department of Pharmacology, Keio University School of Medicine, Medical Research Center, Tokyo, Japan
    J Pharmacol Exp Ther 306:889-902. 2003
    ..Understanding the function of AbetaPPCD and its downstream pathway should lead to effective anti-Alzheimer's disease therapeutics...
  12. ncbi request reprint Neuroprotective effect of activity-dependent neurotrophic factor against toxicity from familial amyotrophic lateral sclerosis-linked mutant SOD1 in vitro and in vivo
    Tomohiro Chiba
    Department of Pharmacology, Keio University School of Medicine, Tokyo, Japan
    J Neurosci Res 78:542-52. 2004
    ..Thus, the neuroprotective activity of ADNF provides a novel insight into the development of curative drugs for ALS...
  13. ncbi request reprint Nasal Colivelin treatment ameliorates memory impairment related to Alzheimer's disease
    Marina Yamada
    Department of Anatomy, Keio University School of Medicine, Tokyo, Japan
    Neuropsychopharmacology 33:2020-32. 2008
    ....
  14. ncbi request reprint Development of a femtomolar-acting humanin derivative named colivelin by attaching activity-dependent neurotrophic factor to its N terminus: characterization of colivelin-mediated neuroprotection against Alzheimer's disease-relevant insults in vitro and i
    Tomohiro Chiba
    Department of Pharmacology, Keio University School of Medicine, Tokyo 160 8582, Japan
    J Neurosci 25:10252-61. 2005
    ..Thus, Colivelin might serve as a novel drug candidate for treatment of AD...
  15. ncbi request reprint Colivelin prolongs survival of an ALS model mouse
    Tomohiro Chiba
    Department of Pharmacology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 343:793-8. 2006
    ....
  16. pmc D-serine is a key determinant of glutamate toxicity in amyotrophic lateral sclerosis
    Jumpei Sasabe
    Department of Anatomy, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    EMBO J 26:4149-59. 2007
    ..Collectively, Glu toxicity enhanced by D-Ser overproduced in glia is proposed as a novel mechanism underlying ALS motoneuronal death, and this mechanism may be regarded as a potential therapeutic target for ALS...
  17. ncbi request reprint Molecular mechanisms for neuronal cell death by Alzheimer's amyloid precursor protein-relevant insults
    Masaoki Kawasumi
    Department of Pharmacology and Neurosciences, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Neurosignals 11:236-50. 2002
    ..We also revise the roles of Abeta in neuronal death and survival...
  18. ncbi request reprint Targeted introduction of V642I mutation in amyloid precursor protein gene causes functional abnormality resembling early stage of Alzheimer's disease in aged mice
    Masaoki Kawasumi
    Department of Pharmacology, Keio University School of Medicine, Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Eur J Neurosci 19:2826-38. 2004
    ..This V642I-APP knock-in mutant line may serve as a model to study the early pathogenic processes of AD in vivo and to develop therapeutics for this stage...
  19. ncbi request reprint Humanin: after the discovery
    Takako Niikura
    Department of Pharmacology, Keio University School of Medicine, Medical Research Building, Tokyo 160 8582, Japan
    Mol Neurobiol 30:327-40. 2004
    ..Additionally, a recent study showed that intracellularly overexpressed HN suppressed mitochondria-mediated apoptosis by inhibiting Bax activity...
  20. doi request reprint D-Ser-containing humanin shows promotion of fibril formation
    Kanehiro Hayashi
    Department of Physical Chemistry, Research Institute of Pharmaceutical Sciences, Musashino University, 1 1 20 Shinmachi, Nishitokyo, Tokyo, 202 8585, Japan
    Amino Acids 42:2293-7. 2012
    ..A previous report showed that HN containing two D-Ser residues exerts neuroprotective activity. Our data, therefore, suggest that the fibril formation by HN that contains two D-Ser residues may promote HN neuroprotective activity...
  21. ncbi request reprint Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death
    Yuichi Hashimoto
    Departments of Pharmacology and Anatomy, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160 8582, Japan
    J Neurochem 84:864-77. 2003
    ..These findings demonstrate that JNK is involved in APP-mediated neuronal cell death as a downstream signal transducer of Go...
  22. ncbi request reprint Inhibitory effects of bakuchiol, bavachin, and isobavachalcone isolated from Piper longum on melanin production in B16 mouse melanoma cells
    Osamu Ohno
    Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University
    Biosci Biotechnol Biochem 74:1504-6. 2010
    ..These compounds and the crude extract of the fruits of P. longum may have suppressive effects against pigmentation by melanin in the skin...
  23. doi request reprint Suppressive effects of interleukin-18 on liver function in rat liver allografts
    Shigeshi Ono
    Department of Surgery, Keio University School of Medicine, Tokyo, Japan
    J Surg Res 176:293-300. 2012
    ..It is also a crucial regulator of lymphocyte production of interferon-γ (IFN-γ), which can promote acute cellular rejection of transplanted solid organs...