Fumio Arai

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. doi request reprint Wnt signaling in the niche
    Toshio Suda
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Cell 132:729-30. 2008
  2. ncbi request reprint Regulation of hematopoiesis and its interaction with stem cell niches
    Fumio Arai
    Department of Cell Differentiation, Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Tokyo, Japan
    Int J Hematol 82:371-6. 2005
  3. doi request reprint Niche regulation of hematopoietic stem cells in the endosteum
    Fumio Arai
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Tokyo, Japan
    Ann N Y Acad Sci 1176:36-46. 2009
  4. ncbi request reprint Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche
    Fumio Arai
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Ann N Y Acad Sci 1106:41-53. 2007
  5. ncbi request reprint Regulation of hematopoietic stem cells by the niche
    Fumio Arai
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Trends Cardiovasc Med 15:75-9. 2005
  6. ncbi request reprint Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction
    Kentaro Hosokawa
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 363:578-83. 2007
  7. ncbi request reprint Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes
    Keisuke Ito
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Tokyo, Japan
    J Immunol 178:103-10. 2007
  8. doi request reprint Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrest
    Keiyo Takubo
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Cell Stem Cell 2:170-82. 2008
  9. doi request reprint Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells
    Yoshiko Matsumoto Ikushima
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 430:20-5. 2013
  10. doi request reprint Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells
    Yuka Nakamura
    Department of Cell Differentiation, Keio University, Tokyo, Japan
    Blood 116:1422-32. 2010

Collaborators

Detail Information

Publications40

  1. doi request reprint Wnt signaling in the niche
    Toshio Suda
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Cell 132:729-30. 2008
    ..These findings show that Wnt/beta-catenin activity is crucial for the maintenance of HSC quiescence in the bone marrow niche...
  2. ncbi request reprint Regulation of hematopoiesis and its interaction with stem cell niches
    Fumio Arai
    Department of Cell Differentiation, Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Tokyo, Japan
    Int J Hematol 82:371-6. 2005
    ..HSCs keep a balance between quiescence and cell division/proliferation in the osteoblastic niche. The specific properties of HSCs are controlled dynamically by signaling of receptor/ligand and cell adhesion molecules produced by OBs...
  3. doi request reprint Niche regulation of hematopoietic stem cells in the endosteum
    Fumio Arai
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Tokyo, Japan
    Ann N Y Acad Sci 1176:36-46. 2009
    ....
  4. ncbi request reprint Maintenance of quiescent hematopoietic stem cells in the osteoblastic niche
    Fumio Arai
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Ann N Y Acad Sci 1106:41-53. 2007
    ..In particular, the quiescent state is thought to be an essential mechanism to protect HSCs from stress and to sustain long-term hematopoiesis...
  5. ncbi request reprint Regulation of hematopoietic stem cells by the niche
    Fumio Arai
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Trends Cardiovasc Med 15:75-9. 2005
    ..Ang-1 produced by OBs activates Tie2 on HSCs and promotes tight adhesion of HSCs to the niche, resulting in quiescence and enhanced survival of HSCs...
  6. ncbi request reprint Function of oxidative stress in the regulation of hematopoietic stem cell-niche interaction
    Kentaro Hosokawa
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 363:578-83. 2007
    ..Administration of a potent anti-oxidant, N-acetyl cystein (NAC) suppressed the shift from SP cells. These data suggest that ROS suppressed the N-cadherin-mediated cell adhesion, and induce the exit of HSCs from the niche...
  7. ncbi request reprint Regulation of reactive oxygen species by Atm is essential for proper response to DNA double-strand breaks in lymphocytes
    Keisuke Ito
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Tokyo, Japan
    J Immunol 178:103-10. 2007
    ..We conclude that Atm-mediated ROS regulation is essential for proper DNA recombination, preventing immunodeficiency, and lymphomagenesis...
  8. doi request reprint Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell-cycle arrest
    Keiyo Takubo
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Cell Stem Cell 2:170-82. 2008
    ....
  9. doi request reprint Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells
    Yoshiko Matsumoto Ikushima
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 430:20-5. 2013
    ..These data indicate that Angpt1-Tie2 signaling affects the differentiation capacity of hematopoietic lineages during development and increases the stem cell activity of HSCs...
  10. doi request reprint Isolation and characterization of endosteal niche cell populations that regulate hematopoietic stem cells
    Yuka Nakamura
    Department of Cell Differentiation, Keio University, Tokyo, Japan
    Blood 116:1422-32. 2010
    ..Altogether, these data suggest that multiple subsets of osteoblasts and mesenchymal progenitor cells constitute the endosteal niche and regulate HSCs in adult bone marrow...
  11. doi request reprint Functional differences between two Tie2 ligands, angiopoietin-1 and -2, in regulation of adult bone marrow hematopoietic stem cells
    Yumiko Gomei
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Tokyo, Japan
    Exp Hematol 38:82-9. 2010
    ..Here, we investigated the functional differences between Ang-1 and Ang-2 in the maintenance of HSCs...
  12. doi request reprint N-cadherin+ HSCs in fetal liver exhibit higher long-term bone marrow reconstitution activity than N-cadherin- HSCs
    Hirofumi Toyama
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 428:354-9. 2012
    ..5. The down-regulation of N-cad during FL hematopoiesis may help us better understand the regulation and mobility of HSCs before migration into BM...
  13. ncbi request reprint Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells
    Keisuke Ito
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Nat Med 12:446-51. 2006
    ..These data show that inactivation of p38 MAPK protects HSCs against loss of self-renewal capacity. Our characterization of molecular mechanisms that limit HSC lifespan may lead to beneficial therapies for human disease...
  14. doi request reprint Foxo3a is essential for maintenance of the hematopoietic stem cell pool
    Kana Miyamoto
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Shinjuku ku, Tokyo 160 8582, Japan
    Cell Stem Cell 1:101-12. 2007
    ..Finally, HSC frequencies were significantly decreased in aged Foxo3a(-/-) mice compared to the littermate controls. Our results demonstrate that Foxo3a plays a pivotal role in maintaining the HSC pool...
  15. ncbi request reprint Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche
    Fumio Arai
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo, 160 8582, Japan
    Cell 118:149-61. 2004
    ..These data suggest that the Tie2/Ang-1 signaling pathway plays a critical role in the maintenance of HSCs in a quiescent state in the BM niche...
  16. doi request reprint Reconstitution activity of hypoxic cultured human cord blood CD34-positive cells in NOG mice
    Haruko Shima
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 378:467-72. 2009
    ..Taken together, these results demonstrate the significance of hypoxia in the maintenance of quiescent human cord blood HSCs...
  17. doi request reprint Knockdown of N-cadherin suppresses the long-term engraftment of hematopoietic stem cells
    Kentaro Hosokawa
    Department of Cell Differentiation, Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo, Japan
    Blood 116:554-63. 2010
    ..These findings suggest that N-cad-mediated cell adhesion is functionally required for the establishment of hematopoiesis in the BM niche after BM transplantation...
  18. ncbi request reprint Premeiotic germ cell defect in seminiferous tubules of Atm-null testis
    Keiyo Takubo
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Biochem Biophys Res Commun 351:993-8. 2006
    ....
  19. ncbi request reprint Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
    Keisuke Ito
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Nature 431:997-1002. 2004
    ..These results show that the self-renewal capacity of HSCs depends on ATM-mediated inhibition of oxidative stress...
  20. ncbi request reprint Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche
    Hiroki Yoshihara
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University, 35 Shinano machi, Tokyo, 160 8582, Japan
    Cell Stem Cell 1:685-97. 2007
    ..Altogether, these observations suggest that THPO/MPL signaling plays a critical role of LT-HSC regulation in the osteoblastic niche...
  21. doi request reprint Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism
    Eriko Nitta
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, Tokyo, Japan
    Blood 117:4169-80. 2011
    ..The current study demonstrates that TERT mitigates aging by protecting HSCs under stressful conditions through telomere length-independent mechanisms...
  22. doi request reprint Nucleostemin is indispensable for the maintenance and genetic stability of hematopoietic stem cells
    Masayuki Yamashita
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan Research Fellow of the Japan Society for the Promotion of Science, Kojimachi Business Center Building, 5 3 1 Kojimachi, Chiyoda ku, Tokyo 102 0083, Japan
    Biochem Biophys Res Commun 441:196-201. 2013
    ..Taken together, our study demonstrates that nucleostemin protects HSCs from DNA damage accumulation and is required for the maintenance of HSCs. ..
  23. doi request reprint Angiopoietins contribute to lung development by regulating pulmonary vascular network formation
    Tai Hato
    Department of Cell Differentiation, Keio University School of Medicine, Shinanomachi 35, Shinjuku ku, Tokyo 160 8556, Japan
    Biochem Biophys Res Commun 381:218-23. 2009
    ..Thus, the precise regulation of Tie2 signaling through an Ang1/Ang2 expression switch is important to construct a mature lung vascular network system required for normal lung development...
  24. doi request reprint Role of N-cadherin in the regulation of hematopoietic stem cells in the bone marrow niche
    Fumio Arai
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Tokyo, Japan
    Ann N Y Acad Sci 1266:72-7. 2012
    ..These findings suggest that N-cadherin-mediated cell adhesion is functionally essential for the regulation of HSPC activities in the BM niche...
  25. pmc OP9 bone marrow stroma cells differentiate into megakaryocytes and platelets
    Yumiko Matsubara
    Department of Laboratory Medicine, Keio University School of Medicine, Tokyo, Japan
    PLoS ONE 8:e58123. 2013
    ..OP9 cells have critical factors for megakaryopoiesis and thrombopoiesis, which might be involved in a mechanism of this differentiation. p45NF-E2 might also play important roles in the differentiation of OP9 cells into MK lineages cells...
  26. doi request reprint Prostaglandin E(2) regulates murine hematopoietic stem/progenitor cells directly via EP4 receptor and indirectly through mesenchymal progenitor cells
    Yoshiko Matsumoto Ikushima
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Tokyo, Japan
    Blood 121:1995-2007. 2013
    ..Altogether, these data suggest that EP4 is a key receptor for PGE(2)-mediated direct and indirect regulation of HSPCs...
  27. doi request reprint Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver
    Hiroko Iwasaki
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan
    Blood 116:544-53. 2010
    ..In conclusion, EPCR(+) HSCs resided in the perisinusoidal niche in mouse FL...
  28. doi request reprint Acquisition of G₀ state by CD34-positive cord blood cells after bone marrow transplantation
    Haruko Shima
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo, Japan
    Exp Hematol 38:1231-40. 2010
    ..The aim of this study was to understand this process in human hematopoietic stem cells after bone marrow transplantation...
  29. pmc Angiopoietin-related growth factor (AGF) promotes epidermal proliferation, remodeling, and regeneration
    Yuichi Oike
    Department of Cell Differentiation, The Sakaguchi Laboratory, Keio University School of Medicine, Tokyo 160 8582, Japan
    Proc Natl Acad Sci U S A 100:9494-9. 2003
    ..These findings demonstrate that biological functions of AGF in epidermal keratinocytes could lead to novel therapeutic strategies for wound care and epidermal regenerative medicine...
  30. doi request reprint TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool
    Hideaki Nakajima
    Division of Hematology, Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
    Blood 116:4474-82. 2010
    ....
  31. pmc Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL
    Sahoko Matsuoka
    Department of Cell Differentiation, The Sakaguchi Laboratory, School of Medicine, Keio University, Tokyo 160 8582, Japan
    Genes Dev 22:986-91. 2008
    ..Thus, Fbxw7 functions as a fail-safe mechanism against both premature HSC loss and leukemogenesis...
  32. ncbi request reprint Regulation of hematopoietic stem cells in the osteoblastic niche
    Fumio Arai
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Adv Exp Med Biol 602:61-7. 2007
  33. ncbi request reprint Regulation of cell cycle in hematopoietic stem cells by the niche
    Atsushi Hirao
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, Shinjuku ku, Tokyo, Japan
    Cell Cycle 3:1481-3. 2004
    ..The understanding of cell cycle control in stem cells leads to development of new strategy for progress in regenerative medicine...
  34. ncbi request reprint Hematopoietic stem cells and their niche
    Toshio Suda
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University, 35 Shinano machi, Shinjuku ku, Tokyo 160 8582, Japan
    Trends Immunol 26:426-33. 2005
    ..The understanding of the relationship between normal and cancer stem cells and their niches should lead to the development of new strategies directed toward regeneration medicine and cancer therapeutics...
  35. ncbi request reprint Regulation of stem cells in the niche
    Toshio Suda
    Department of Cell Differentiation, Sakaguchi Laboratory of Developmental Biology and Department of Ophthalmology, School of Medicine, Keio University, Japan
    Cornea 24:S12-S17. 2005
    ..Understanding of the relationships of stem cells to their niches should lead to development of new strategies directed toward regeneration...
  36. ncbi request reprint Regulation of vasculogenesis and angiogenesis by EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells
    Yuichi Oike
    Department of Cell Differentiation, the Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan
    Blood 100:1326-33. 2002
    ..EphB/ephrin-B2 signaling between endothelial cells and surrounding mesenchymal cells plays an essential role in vasculogenesis, angiogenesis, and vessel maturation...
  37. ncbi request reprint [Regulation of hematopoiesis by the osteoblastic niche]
    Fumio Arai
    Department of Cell Differentiation, The Sakaguchi Laboratory of Developmental Biology, School of Medicine, Keio University
    Clin Calcium 15:73-9. 2005
    ..The HSC specific properties are dynamically controlled by the signalings of receptors/ligands and cell adhesion molecules produced by osteoblasts...
  38. pmc Mesenchymal stem cells in perichondrium express activated leukocyte cell adhesion molecule and participate in bone marrow formation
    Fumio Arai
    Department of Cell Differentiation, Institute of Molecular Embryology and Genetics IMEG, Kumamoto University School of Medicine, Japan
    J Exp Med 195:1549-63. 2002
    ..These findings suggest that perichondrium might serve as a stem cell reservoir and play an important role in the early development of a bone and bone marrow...
  39. ncbi request reprint [Regulation of self-renewal of hematopoietic stem cells in the niche]
    Atsushi Hirao
    Tanpakushitsu Kakusan Koso 50:886-91. 2005
  40. ncbi request reprint [Regulation of hematopoietic stem cells in the niche]
    Fumio Arai
    Rinsho Ketsueki 47:355-62. 2006