M Akiyama

Summary

Affiliation: Keio University
Country: Japan

Publications

  1. ncbi Regional difference in expression of characteristic abnormality of harlequin ichthyosis in affected fetuses
    M Akiyama
    Department of Biological Structure, Medicine Dermatology, University of Washington School of Medicine, Seattle, USA
    Prenat Diagn 18:425-36. 1998
  2. ncbi Prenatal diagnosis of harlequin ichthyosis by the examination of keratinized hair canals and amniotic fluid cells at 19 weeks' estimated gestational age
    M Akiyama
    Division of Dermatology, Kitasato Institute Hospital, Tokyo, Japan
    Prenat Diagn 19:167-71. 1999
  3. ncbi The pathogenesis of severe congenital ichthyosis of the neonate
    M Akiyama
    Division of Dermatology, Kitasato Institute Hospital, Tokyo, Japan
    J Dermatol Sci 21:96-104. 1999
  4. ncbi Precise ultrastructural localization of in vivo deposited IgG antibodies in fresh perilesional skin of patients with bullous pemphigoid
    M Sato
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Br J Dermatol 138:965-71. 1998
  5. ncbi MDM2 protein overexpression inhibits apoptosis of TF-1 granulocyte-macrophage colony-stimulating factor-dependent acute myeloblastic leukemia cells
    M Urashima
    Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan
    Blood 92:959-67. 1998
  6. ncbi Abnormalities of basal cell keratin in epidermolysis bullosa simplex do not affect the expression patterns of suprabasal keratins and cornified cell envelope proteins
    Y Sasaki
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Arch Dermatol Res 290:591-7. 1998
  7. ncbi Epimorphin expression during human foetal hair follicle development
    M Akiyama
    Division of Dermatology, Kitasato Institute Hospital, Tokyo 108 8642, Japan
    Br J Dermatol 141:447-52. 1999
  8. ncbi Dissociation of intra- and extracellular domains of desmosomal cadherins and E-cadherin in Hailey-Hailey disease and Darier's disease
    M Hakuno
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Br J Dermatol 142:702-11. 2000
  9. pmc Talc and amosite/crocidolite preferentially deposited in the lungs of nonoccupational female lung cancer cases in urban areas of Japan
    H Yamada
    Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Tokyo, Japan
    Environ Health Perspect 105:504-8. 1997
  10. ncbi Medical Internet exchange project in Japan
    H Mizushima
    National Cancer Center Research Institute, Tokyo, Japan
    Stud Health Technol Inform 52:417-9. 1998

Collaborators

Detail Information

Publications27

  1. ncbi Regional difference in expression of characteristic abnormality of harlequin ichthyosis in affected fetuses
    M Akiyama
    Department of Biological Structure, Medicine Dermatology, University of Washington School of Medicine, Seattle, USA
    Prenat Diagn 18:425-36. 1998
    ..In addition, the prenatal diagnosis or prenatal exclusion of HI is thought to be possible from whichever site of the fetal body the skin biopsy is taken in the late second trimester of the fetal period...
  2. ncbi Prenatal diagnosis of harlequin ichthyosis by the examination of keratinized hair canals and amniotic fluid cells at 19 weeks' estimated gestational age
    M Akiyama
    Division of Dermatology, Kitasato Institute Hospital, Tokyo, Japan
    Prenat Diagn 19:167-71. 1999
    ....
  3. ncbi The pathogenesis of severe congenital ichthyosis of the neonate
    M Akiyama
    Division of Dermatology, Kitasato Institute Hospital, Tokyo, Japan
    J Dermatol Sci 21:96-104. 1999
    ..Mutations within the rod domain, not in the beginning or the end of the rod domain, of keratin 10 were reported in annular epidermolytic ichthyosis (AEI), the distinct subtype of bullous congenital ichthyosiform erythroderma...
  4. ncbi Precise ultrastructural localization of in vivo deposited IgG antibodies in fresh perilesional skin of patients with bullous pemphigoid
    M Sato
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Br J Dermatol 138:965-71. 1998
    ....
  5. ncbi MDM2 protein overexpression inhibits apoptosis of TF-1 granulocyte-macrophage colony-stimulating factor-dependent acute myeloblastic leukemia cells
    M Urashima
    Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan
    Blood 92:959-67. 1998
    ..These results suggest that GM-CSF-independent growth of AML cells is associated with overexpression of MDM2 protein and related modulation of p53 expression...
  6. ncbi Abnormalities of basal cell keratin in epidermolysis bullosa simplex do not affect the expression patterns of suprabasal keratins and cornified cell envelope proteins
    Y Sasaki
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    Arch Dermatol Res 290:591-7. 1998
    ..Thus, the abnormality in basal cell keratins in patients with EBS did not appear to alter the patterns of expression of the keratins and CCE precursor proteins...
  7. ncbi Epimorphin expression during human foetal hair follicle development
    M Akiyama
    Division of Dermatology, Kitasato Institute Hospital, Tokyo 108 8642, Japan
    Br J Dermatol 141:447-52. 1999
    ..This suggests that epimorphin may have an important part in induction of morphogenesis during human foetal hair follicle development...
  8. ncbi Dissociation of intra- and extracellular domains of desmosomal cadherins and E-cadherin in Hailey-Hailey disease and Darier's disease
    M Hakuno
    Department of Dermatology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo 160 8582, Japan
    Br J Dermatol 142:702-11. 2000
    ..This common phenomenon in HHD and DD might be closely related to the pathophysiological mechanisms in both conditions...
  9. pmc Talc and amosite/crocidolite preferentially deposited in the lungs of nonoccupational female lung cancer cases in urban areas of Japan
    H Yamada
    Research Institute of Tuberculosis, Japan Anti Tuberculosis Association, Tokyo, Japan
    Environ Health Perspect 105:504-8. 1997
    ....
  10. ncbi Medical Internet exchange project in Japan
    H Mizushima
    National Cancer Center Research Institute, Tokyo, Japan
    Stud Health Technol Inform 52:417-9. 1998
    ..For this purpose, we are currently asking other countries to form a structure similar to MDX-Japan. The concept, hardware system, software system, firewall configuration, and routing policy will be also discussed...
  11. ncbi Upregulation of P-cadherin expression in the lesional skin of pemphigus, Hailey-Hailey disease and Darier's disease
    M Hakuno
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Cutan Pathol 28:277-81. 2001
    ..The purpose of the present study was to determine whether altered P-cadherin expression is present in these diseases...
  12. ncbi The extracellular domain of BPAG2 has a loop structure in the carboxy terminal flexible tail in vivo
    S Nonaka
    Department of Dermatology, Keio University School of Medicine, Tokyo, Japan
    J Invest Dermatol 115:889-92. 2000
    ..This unique structure of the antigen is thought to contribute to dermo- epidermal adhesion by intertwining with other basement membrane components...
  13. ncbi Interleukin-8 and monocyte chemotactic protein-1 production by a human glioblastoma cell line, T98G in coculture with monocytes: involvement of monocyte-derived interleukin-1alpha
    T Kasahara
    Department of Biochemistry, Kyoritsu College of Pharmacy, Tokyo, Japan
    Eur Cytokine Netw 9:47-55. 1998
    ..e., juxtacrine interaction in unfixed conditions...
  14. ncbi An oral CD40 ligand gene therapy against lymphoma using attenuated Salmonella typhimurium
    M Urashima
    Department of Pediatrics, The Jikei University School of Medicine, Tokyo, Japan
    Blood 95:1258-63. 2000
    ..These results have the potential to be a simple, effective, and above all, safe immune-gene therapy against BCL. (Blood. 2000;95:1258-1263)..
  15. ncbi Drug eruptions to contrast media in Japan
    T Nakada
    Department of Dermatology, Showa University School of Medicine, Hatanodai, Tokyo, Japan
    Clin Exp Dermatol 31:361-4. 2006
    ..In Japan, drug eruptions to nonionic iodinated contrast media have been reported since the products appeared on the market in 1986...
  16. doi Revascularization by percutaneous transluminal angioplasty improved abruptly deteriorated ischaemic symptoms in cutaneous polyarteritis nodosa
    S Osada
    Department of Dermatology, Nippon Medical School, Bunkyo ku, Tokyo, Japan
    Clin Exp Dermatol 36:502-5. 2011
    ..The occluded segment was revascularized by percutaneous transluminal angioplasty, resulting in a dramatic improvement in the ischaemic symptoms...
  17. ncbi Migration of the Japanese healthcare enterprise from a financial to integrated management: strategy and architecture
    M Akiyama
    Department of Medical Informatics, International Medical Center of Japan, Tokyo, 162 8655, Japan
    Stud Health Technol Inform 84:715-8. 2001
    ..Finally, it reduces costs, raises efficiency, increases the quality of patient care, and ultimately saves lives. Now, we are going to integrate all remaining hospital departments, and ultimately, all hospital functions...
  18. pmc Restoration of p16INK4A protein induces myogenic differentiation in RD rhabdomyosarcoma cells
    M Urashima
    Department of Pediatrics, Jikei University School of Medicine, Tokyo, Japan
    Br J Cancer 79:1032-6. 1999
    ..These suggest that deletion of p16 gene may not only facilitate growth but also inhibit the myogenic differentiation of RD RMS cells...
  19. ncbi A novel asparagine-->aspartic acid mutation in the rod 1A domain in keratin 2e in a Japanese family with ichthyosis bullosa of Siemens
    Y Takizawa
    Department of Dermatology, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
    J Invest Dermatol 114:193-5. 2000
    ..Our data indicate aspartic acid substitution in codon 192 in the 1A helix initiation site is deleterious to keratin filament network integrity and leads to ichthyosis bullosa of Siemens phenotype...
  20. ncbi Genetic instability in intestinal metaplasia is a frequent event leading to well-differentiated early adenocarcinoma of the stomach
    K Kobayashi
    Department of Surgery II, Jikei University School of Medicine, 3 25 8 Nishi shinbashi, Minato ku, 105 8461, Tokyo, Japan
    Eur J Cancer 36:1113-9. 2000
    ..These findings suggest that metaplasia and well-differentiated adenocarcinoma in the stomach may have the same molecular backgrounds, and that these two lesions may be chronologically connected...
  21. ncbi Ichthyosis bullosa of Siemens: its correct diagnosis facilitated by molecular genetic testing
    M Akiyama
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo 060 8638, Japan
    Br J Dermatol 152:1353-6. 2005
    ..The present results indicate that IBS is not such a rare entity as was previously thought, and accurate diagnosis is now available by mutation analysis...
  22. ncbi An outbreak of food poisoning due to egg yolk reaction-negative Staphylococcus aureus
    N Miwa
    Shizuoka Institute of Environment and Hygiene, Japan
    Int J Food Microbiol 64:361-6. 2001
    ..aureus. The present outbreak suggested that EY reaction-negative isolates should be subjected to further analysis to detect the causative agents of staphylococcal food poisoning...
  23. ncbi [Epidemiological analysis of influenza B virus belonging to B/Victoria/2/87 lineage isolated in off-season of 1998 and late epidemic season in Shizuoka Prefecture]
    K Sahara
    Department of Microbiology, Shizuoka Institute of Environment and Hygiene
    Kansenshogaku Zasshi 74:481-5. 2000
    ..This indicates that the herald viruses are not always the parental viruses for the following influenza season...
  24. ncbi A novel ABCA12 mutation 3270delT causes harlequin ichthyosis
    M Akiyama
    Institut fur Humangenetik und Anthropologie, Albert Ludwigs Universitat Freiburg, Freiburg, Germany
    Br J Dermatol 155:1064-6. 2006
  25. ncbi A novel mutation in the VDR gene in hereditary vitamin D-resistant rickets
    K Arita
    Genetic Skin Disease Group, St John s Institute of Dermatology, Division of Genetics and Molecular Medicine, The Guy s, King s College and St Thomas School of Medicine, London, UK
    Br J Dermatol 158:168-71. 2008
  26. ncbi Risk management and measuring productivity with POAS--Point of Act System--a medical information system as ERP (Enterprise Resource Planning) for hospital management
    M Akiyama
    Sloan School of Management, Massachusetts Institute of Technology, Cambridge, MA, USA
    Methods Inf Med 46:686-93. 2007
    ....
  27. ncbi Detection of 1733insC mutations in an Asian family with Birt-Hogg-Dubé syndrome
    H Kawasaki
    Department of Dermatology, Hokkaido University Graduate School of Medicine, North 15 West 7, Kita ku, Sapporo 060 8638, Japan
    Br J Dermatol 152:142-5. 2005
    ..The defective gene in BHD has been recently identified and is suspected of being a tumour suppressor gene. Several mutations of the BHD gene have been reported only in Caucasian patients...