T Nagase

Summary

Affiliation: Kazusa DNA Research Institute
Country: Japan

Publications

  1. ncbi request reprint Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones (supplement)
    Daisuke Nakajima
    Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 9:107-15. 2002
  2. ncbi request reprint The Kazusa cDNA project for identification of unknown human transcripts
    Takahiro Nagase
    Department of Human Gene Research, Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0818, Japan
    C R Biol 326:959-66. 2003
  3. ncbi request reprint CRM1-dependent, but not ARE-mediated, nuclear export of IFN-alpha1 mRNA
    Tominori Kimura
    Department of Microbiology, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
    J Cell Sci 117:2259-70. 2004
  4. ncbi request reprint Temporal change in mKIAA gene expression during the early stage of retinoic acid-induced neurite outgrowth
    Kazuhide Imai
    Chiba Industry Advancement Center, 2 6 Nakase, Mihama ku, Chiba 261 7126, Japan
    Gene 364:114-22. 2005
  5. ncbi request reprint Kazusa mammalian cDNA resources: towards functional characterization of KIAA gene products
    Takahiro Nagase
    Department of Human Gene Research, Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0818, Japan
    Brief Funct Genomic Proteomic 5:4-7. 2006
  6. pmc Galectin-1 and Galectin-3 Mediate Protocadherin-24-Dependent Membrane Localization of β-catenin in Colon Cancer Cell Line HCT116
    Rui Ose
    Department of Human Genome Research, Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0818, Japan Graduate School of Pharmaceutical Sciences and Faculty of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    Curr Chem Genomics 6:18-26. 2012
  7. ncbi request reprint Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
    T Nagase
    Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 7:143-50. 2000
  8. pmc Exploration of human ORFeome: high-throughput preparation of ORF clones and efficient characterization of their protein products
    Takahiro Nagase
    Department of Human Genome Research, Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0818, Japan
    DNA Res 15:137-49. 2008
  9. ncbi request reprint Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
    T Nagase
    Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 6:337-45. 1999
  10. ncbi request reprint Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro
    T Nagase
    Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 7:65-73. 2000

Collaborators

Detail Information

Publications59

  1. ncbi request reprint Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones (supplement)
    Daisuke Nakajima
    Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 9:107-15. 2002
  2. ncbi request reprint The Kazusa cDNA project for identification of unknown human transcripts
    Takahiro Nagase
    Department of Human Gene Research, Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0818, Japan
    C R Biol 326:959-66. 2003
    ..In the second phase of the project, which aims at bridging the human genome and proteome using the output of the first phase, we are very carefully evaluating our cDNA clones and, when necessary, experimentally revising them...
  3. ncbi request reprint CRM1-dependent, but not ARE-mediated, nuclear export of IFN-alpha1 mRNA
    Tominori Kimura
    Department of Microbiology, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
    J Cell Sci 117:2259-70. 2004
    ..However, truncation of the 3' UTR did not negatively affect the nuclear export of IFN-alpha1 mRNA that lacked the ARE, unexpectedly indicating that this CRM1-dependent mRNA export may not be mediated via the ARE...
  4. ncbi request reprint Temporal change in mKIAA gene expression during the early stage of retinoic acid-induced neurite outgrowth
    Kazuhide Imai
    Chiba Industry Advancement Center, 2 6 Nakase, Mihama ku, Chiba 261 7126, Japan
    Gene 364:114-22. 2005
    ..These results indicate that some mKIAA genes are apparently relevant to retinoic acid-induced neurite outgrowth...
  5. ncbi request reprint Kazusa mammalian cDNA resources: towards functional characterization of KIAA gene products
    Takahiro Nagase
    Department of Human Gene Research, Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0818, Japan
    Brief Funct Genomic Proteomic 5:4-7. 2006
    ..In this review, we describe the current status of the Kazusa mammalian cDNA resources and the future direction of the functional characterization of KIAA genes...
  6. pmc Galectin-1 and Galectin-3 Mediate Protocadherin-24-Dependent Membrane Localization of β-catenin in Colon Cancer Cell Line HCT116
    Rui Ose
    Department of Human Genome Research, Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0818, Japan Graduate School of Pharmaceutical Sciences and Faculty of Pharmaceutical Sciences, Chiba University, 1 8 1 Inohana, Chuo Ku, Chiba 260 8675, Japan
    Curr Chem Genomics 6:18-26. 2012
    ....
  7. ncbi request reprint Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
    T Nagase
    Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 7:143-50. 2000
    ....
  8. pmc Exploration of human ORFeome: high-throughput preparation of ORF clones and efficient characterization of their protein products
    Takahiro Nagase
    Department of Human Genome Research, Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0818, Japan
    DNA Res 15:137-49. 2008
    ..Results thus obtained have demonstrated that our Flexi ORF clones are efficient for the production of HaloTag-fusion proteins that can provide a new versatile set for a variety of functional analyses of human genes...
  9. ncbi request reprint Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
    T Nagase
    Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 6:337-45. 1999
    ....
  10. ncbi request reprint Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro
    T Nagase
    Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 7:65-73. 2000
    ....
  11. ncbi request reprint Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
    T Nagase
    Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 7:273-81. 2000
    ....
  12. ncbi request reprint Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
    T Nagase
    Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 8:85-95. 2001
    ....
  13. ncbi request reprint Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins
    T Nagase
    Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 8:179-87. 2001
    ....
  14. ncbi request reprint Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins
    T Nagase
    Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 8:319-27. 2001
    ....
  15. ncbi request reprint Characterization of cDNA clones in size-fractionated cDNA libraries from human brain
    N Seki
    Kazusa DNA Research Institute, Chiba, Japan
    DNA Res 4:345-9. 1997
    ....
  16. ncbi request reprint Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro
    T Nagase
    Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 6:63-70. 1999
    ....
  17. ncbi request reprint Identification of high-molecular-weight proteins with multiple EGF-like motifs by motif-trap screening
    M Nakayama
    Kazusa DNA Research Institute, 1532 3 Yana, Kisarazu, 292 0812, Japan
    Genomics 51:27-34. 1998
    ....
  18. ncbi request reprint Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1
    T Nagase
    Kazusa DNA Research Institute, Chiba, Japan
    DNA Res 2:37-43. 1995
    ..4 kb, respectively. As judged by Northern hybridization profiles, small-sized cDNAs appeared to be expressed more ubiquitously and abundantly in various tissues, compared with that of medium-sized cDNAs...
  19. ncbi request reprint Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins
    O Ohara
    Kazusa DNA Research Institute, Chiba, Japan
    DNA Res 4:53-9. 1997
    ..The set of libraries constructed here should be very useful for the accumulation of sequence data on large proteins in the human brain...
  20. ncbi request reprint Gene identification in 1.6-Mb region of the Down syndrome region on chromosome 21
    M Ohira
    Laboratory of Gene Structure 1, Kazusa DNA Research Institute, Chiba, Japan
    Genome Res 7:47-58. 1997
    ..These nearly full-length cDNA sequences should facilitate understanding of the detailed genome structure of the DS region and help to elucidate their role in the etiology of DS...
  21. ncbi request reprint Identification of novel transcribed sequences on human chromosome 22 by expressed sequence tag mapping
    M Hirosawa
    Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 8:1-9. 2001
    ..In conclusion, the mapping of ESTs derived from long cDNAs followed by sequencing of the entire cDNAs provided indispensable information for the precise annotation of genes on the genome together with ESTs derived from short cDNAs...
  22. ncbi request reprint Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1
    M Ohira
    Laboratory of Gene Structure, Kazusa DNA Research Institute, Chiba, Japan
    Genomics 47:300-6. 1998
    ..Both the prospective function and the chromosomal location suggest that this gene may be a DS candidate gene, contributing to certain DS phenotypes, and is possibly involved in certain features of monosomy 21...
  23. ncbi request reprint Identification of three novel non-classical cadherin genes through comprehensive analysis of large cDNAs
    D Nakajima
    Department of Human Gene Research, Kazusa DNA Research Institute, 1532 3 Yana, Kisarazu, 292 0812, Chiba, Japan
    Brain Res Mol Brain Res 94:85-95. 2001
    ....
  24. ncbi request reprint Characterization of long cDNA clones from human adult spleen
    A Hattori
    Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 7:357-66. 2000
    ..The results indicated that spleen could be used as an additional source of human long cDNAs to complement the list of human genes...
  25. pmc HUGE: a database for human large proteins identified in the Kazusa cDNA sequencing project
    R Kikuno
    Kazusa DNA Research Institute, 1532 3 Yana, Kisarazu, Chiba 292 0812, Japan
    Nucleic Acids Res 28:331-2. 2000
    ..HUGE is available through the WWW at http://www.kazusa.or.jp/huge..
  26. ncbi request reprint Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1 (supplement)
    T Nagase
    Kazusa DNA Research Institute, Chiba, Japan
    DNA Res 3:43-53. 1996
  27. ncbi request reprint Prediction of the coding sequences of unidentified human genes. V. The coding sequences of 40 new genes (KIAA0161-KIAA0200) deduced by analysis of cDNA clones from human cell line KG-1
    T Nagase
    Kazusa DNA Research Institute, Chiba, Japan
    DNA Res 3:17-24. 1996
    ..Another novel repeat composed of alternating Arg and Glu was identified in KIAA0182. Northern hybridization analysis demonstrated that 10 genes are expressed in a cell- or tissue-specific manner...
  28. ncbi request reprint Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 (supplement)
    N Nomura
    Kazusa DNA Research Institute, Chiba, Japan
    DNA Res 1:251-62. 1994
  29. ncbi request reprint Prediction of the coding sequences of mouse homologues of KIAA gene: III. the complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries
    Noriko Okazaki
    Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0818, Japan
    DNA Res 10:167-80. 2003
    ..Notably, a homology search against the public database indicated that 4 out of 13 novel cDNA clones were homologous to the disease-related genes...
  30. ncbi request reprint Identification and characterization of a new gene physically linked to the ATM gene
    T Imai
    Genome Research Group, National Institute of Radiological Sciences, Chiba, Japan
    Genome Res 6:439-47. 1996
    ..It may be possible to propose the idea that the promoter region could be shared by both housekeeping genes and that each gene could influence the expression of the other...
  31. ncbi request reprint Identification of a novel human gene containing the tetratricopeptide repeat domain from the Down syndrome region of chromosome 21
    M Ohira
    Laboratory of Gene Structure 1, Kazusa DNA Research Institute, Chiba, Japan
    DNA Res 3:9-16. 1996
    ..The TPRD gene, the novel gene which was proved to be in the 1.6-Mb region and to have the interesting features described above, is a candidate for genes responsible for the DS phenotypes...
  32. ncbi request reprint Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones
    Daisuke Nakajima
    Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 9:99-106. 2002
    ..The total length of the resultant extensions at amino- and carboxy-terminals of KIAA gene products reached 97,000 and 7,216 amino acid residues, respectively, and various protein domains were found in these extended portions...
  33. ncbi request reprint Influence of the 3'-UTR-length of mKIAA cDNAs and their sequence features to the mRNA expression level in the brain
    Noriko Okazaki
    Kazusa DNA Research Institute, Kazusa Kamatari, Kisarazu, Chiba, Japan
    DNA Res 12:181-9. 2005
    ..Furthermore, we searched sequence elements in the 3'-UTR possibly related with their expression and found some candidates regarding the brain-specific expression...
  34. ncbi request reprint A comprehensive approach for establishment of the platform to analyze functions of KIAA proteins II: public release of inaugural version of InGaP database containing gene/protein expression profiles for 127 mouse KIAA genes/proteins
    Hisashi Koga
    Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0818, Japan
    DNA Res 11:293-304. 2004
    ..This database will be a resource for the neuroscience community by seamlessly integrating the genomic and proteomic information about the mouse KIAA genes/proteins...
  35. ncbi request reprint Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries
    Noriko Okazaki
    Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0818, Japan
    DNA Res 11:205-18. 2004
    ..Furthermore, 3 out of 4 proteins encoded in the novel cDNA clones showed moderate sequence similarity with human KIAA proteins, thus we could obtain new members of KIAA protein families through our mouse cDNA projects...
  36. ncbi request reprint [Comprehensive analysis of human large cDNAs which directs the synthesis of large proteins]
    Osamu Ohara
    Tanpakushitsu Kakusan Koso 47:991-6. 2002
  37. pmc HUGE: a database for human large proteins identified in the Kazusa cDNA sequencing project
    Reiko Kikuno
    Kazusa DNA Research Institute, 1532 3 Yana, Kisarazu, Chiba 292 0812, Japan
    Nucleic Acids Res 30:166-8. 2002
    ..More interestingly, in some cases, the ability to compare cDNA with genomic sequences allows us to identify candidate sites of RNA editing. HUGE is available on the World Wide Web at http://www.kazusa.or.jp/huge...
  38. ncbi request reprint Characterization of size-fractionated cDNA libraries generated by the in vitro recombination-assisted method
    Osamu Ohara
    Department of Human Gene Research, Kazusa DNA Research Institute, Kisarazu, Chiba, Japan
    DNA Res 9:47-57. 2002
    ..Taking all these results together, we here conclude that this new method for the construction of size-fractionated cDNA libraries makes it possible to analyze cDNAs efficiently and comprehensively...
  39. pmc HUGE: a database for human KIAA proteins, a 2004 update integrating HUGEppi and ROUGE
    Reiko Kikuno
    Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba, 292 0818, Japan
    Nucleic Acids Res 32:D502-4. 2004
    ..ROUGE summarizes the results of computer-assisted analyses of approximately 1000 mouse homologues of human large cDNAs that we identified...
  40. ncbi request reprint A human homolog of the mitochondrial protein import receptor Mom19 can assemble with the yeast mitochondrial receptor complex
    N Seki
    Kazusa DNA Research Institute, Chiba, Japan
    FEBS Lett 375:307-10. 1995
    ..When synthesized in vitro, the human Mom19 homolog is targeted to isolated yeast mitochondria and specifically associates with the outer membrane receptor complex, suggesting that indeed a mitochondrial import receptor was identified...
  41. ncbi request reprint Preparation of a set of expression-ready clones of mammalian long cDNAs encoding large proteins by the ORF trap cloning method
    Daisuke Nakajima
    Department of Human Gene Research, Kazusa DNA Research Institute, Kazusa Kamatari, Kisarazu, Chiba, Japan
    DNA Res 12:257-67. 2005
    ....
  42. ncbi request reprint Characterization of long cDNA clones from human adult spleen. II. The complete sequences of 81 cDNA clones
    Hiroyuki Jikuya
    Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Chiba 292 0818, Japan
    DNA Res 10:49-57. 2003
    ....
  43. ncbi request reprint Prediction of the coding sequences of mouse homologues of FLJ genes: the complete nucleotide sequences of 110 mouse FLJ-homologous cDnas identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries
    Noriko Okazaki
    Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0818, Japan
    DNA Res 11:127-35. 2004
    ..Homology and/or motif search against public databases revealed new domains and/or motifs in 26 mFLJ gene products which provide additional speculation regarding the function of FLJ genes...
  44. ncbi request reprint Complete sequencing and characterization of 21,243 full-length human cDNAs
    Toshio Ota
    Helix Research Institute, 1532 3 Yana, Kisarazu, Chiba 292 0812, Japan
    Nat Genet 36:40-5. 2004
    ..About one-fourth of them (1,378) showed a clear pattern of splicing. The distribution of GC content of noncoding cDNAs was narrow and had a peak at approximately 42%, relatively low compared with that of protein-coding cDNAs...
  45. ncbi request reprint Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries
    Noriko Okazaki
    Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0818, Japan
    DNA Res 10:35-48. 2003
    ..Furthermore, we successfully mapped all the mouse KIAA cDNAs along the genome using a recently published mouse genome draft sequence...
  46. doi request reprint The novel protein complex with SMARCAD1/KIAA1122 binds to the vicinity of TSS
    Noriko Okazaki
    Laboratory of Medical Genomics, Department of Human Genome Research, Kazusa DNA Research Institute, Kisarazu, Chiba 292 0818, Japan
    J Mol Biol 382:257-65. 2008
    ..From these findings, we propose a novel model for gene regulation via the SMARCAD1/KIAA1122 protein complex...
  47. ncbi request reprint Prediction of the coding sequences of mouse homologues of KIAA gene: I. The complete nucleotide sequences of 100 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries
    Noriko Okazaki
    Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0818, Japan
    DNA Res 9:179-88. 2002
    ..The average size of the 100 cDNA sequences reached 5.1 kb and that of mouse KIAA-homologous proteins predicted from these cDNAs was 989 amino acid residues...
  48. doi request reprint KAP1-independent transcriptional repression of SCAN-KRAB-containing zinc finger proteins
    Yasuhide Itokawa
    Department of Human Genome Research, Kazusa DNA Research Institute, 2 6 7 Kazusa Kamatari, Kisarazu, Chiba 292 0818, Japan
    Biochem Biophys Res Commun 388:689-94. 2009
    ..These results provide new insight into the functions of the members of the KRAB-ZNF family...
  49. doi request reprint Pulse-chase experiment for the analysis of protein stability in cultured mammalian cells by covalent fluorescent labeling of fusion proteins
    Kei Yamaguchi
    Laboratory of Human Gene Research, Department of Human Genome Research, Kazusa DNA Research Institute, Chiba, Japan
    Methods Mol Biol 577:121-31. 2009
    ..Herein, we demonstrated that the method allows analysis of the intracellular protein stability as regulated by protein-degradation signals or an exogenously expressed E3 ubiquitin ligase...
  50. pmc Phosphorylation of clock protein PER1 regulates its circadian degradation in normal human fibroblasts
    Koyomi Miyazaki
    Clock Cell Biology Group, IBRF Institute for Biological Resource and Function, National Institute of Advanced Industrial Science and Technology AIST, Tsukuba Central 6, 1 1 1, Higashi, Tsukuba, 305 8566, Japan
    Biochem J 380:95-103. 2004
    ..These findings indicate that circadian hPER1 degradation through a proteasomal pathway can be regulated through phosphorylation by CKI, but not by subcellular localization...
  51. ncbi request reprint Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes
    Katsutaka Oishi
    Clock Cell Biology Research Group, Institute for Biological Resources and Functions, National Institute of Advanced Industrial Science and Technology, Central 6, 1 1 1 Higashi, Tsukuba, Ibaraki 305 8566, Japan
    J Biol Chem 278:41519-27. 2003
    ....
  52. ncbi request reprint Genetic linkage map of the house musk shrew, Suncus murinus, constructed with PCR-based and RFLP markers
    Samuel Adjei
    Laboratory of Animal Genetics, Department of Applied Molecular Biosciences, Graduate School of Bioagricultural Sciences, Nagoya University, Nagoya, Aichi, Japan
    Exp Anim 57:129-34. 2008
    ..The new map comprises 42 markers that are distributed into 12 linkage groups, two of which are assigned to chromosomes, and spans 403.5 cM with an average inter-marker distance of 13.5 cM...
  53. ncbi request reprint Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain
    Masato Yoshizawa
    Department of Pathology and Tumor Biology, Graduate School of Medicine, Kyoto University, Yoshidakonoe cho, 606 8501 Kyoto, Japan
    Gene Expr Patterns 3:375-81. 2003
    ..Our study reveals the dynamic and coordinated expression profiles of the Dbl-GEFs and provides a basic framework for understanding the function of GEFs in neural development...
  54. doi request reprint Smurf1 directly targets hPEM-2, a GEF for Cdc42, via a novel combination of protein interaction modules in the ubiquitin-proteasome pathway
    Kei Yamaguchi
    Graduate School of Science and Technology, Chiba University, 648 Matsudo, Matsudo, Chiba 271 8510, Japan
    Biol Chem 389:405-13. 2008
    ..Our discovery that hPEM-2 is, in addition to RhoA, a target protein of Smurf1 suggests that Smurf1 plays a crucial role in the spatiotemporal regulation of Rho GTPase family members...
  55. ncbi request reprint Heterotrimeric G protein betagamma subunits stimulate FLJ00018, a guanine nucleotide exchange factor for Rac1 and Cdc42
    Hiroshi Ueda
    Department of Biomolecular Science, Faculty of Engineering, Gifu University, Yanagido 1 1, Gifu 501 1193, Japan
    J Biol Chem 283:1946-53. 2008
    ..These results provide evidence for a signaling pathway by which G(i)-coupled receptor specifically induces Rac and Cdc42 activation through direct interaction of Gbetagamma with FLJ00018...
  56. ncbi request reprint Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling
    Sey En Lin
    Department of Molecular and Tumor Pathology, Chiba University Graduate School of Medicine, 1 8 1 Inohana, Chuo Ku, Chiba 260 8670, Japan
    J Biol Chem 277:50612-20. 2002
    ..The multiplicity of Mam proteins in the mammalian system may help provide divergence to the strength of the Notch signals in different cell types...
  57. ncbi request reprint Utilization of mammalian cells for efficient and reliable evaluation of specificity of antibodies to unravel the cellular function of mKIAA proteins
    Akiyuki Ozaki
    Department of Biotechnology, Institute of Research and Innovation, 1201 Takada, Kashiwa, Chiba 277 0861, Japan
    Gene 360:35-44. 2005
    ..Importantly, these methods allow us to detect potential posttranslational modification of the mKIAA/KIAA proteins and to predict their biological function based on their subcellular localization...
  58. ncbi request reprint The CAP-Gly domain of CYLD associates with the proline-rich sequence in NEMO/IKKgamma
    Kohei Saito
    RIKEN Genomic Sciences Center, 1 7 22 Suehiro cho, Tsurumi, Yokohama 230 0045, Japan
    Structure 12:1719-28. 2004
    ..Therefore, CAP-Gly is likely to be a novel proline-rich sequence binding domain with a mechanism different from that of the SH3 domain...
  59. ncbi request reprint Alternative splice variants encoding unstable protein domains exist in the human brain
    Keiichi Homma
    Laboratory of Gene Product Informatics, Center for Information Biology DNA Data Bank of Japan, National Institute of Genetics, Research Organization of Information and Systems, Shizuoka 411 8540, Japan
    J Mol Biol 343:1207-20. 2004
    ..We propose that most unstable proteins encoded by alternative splice variants lack normal functions and are an evolutionary dead-end...