Kaoru Tohyama

Summary

Affiliation: Kawasaki Medical School
Country: Japan

Publications

  1. ncbi request reprint Improved detection of minimal acute myeloid leukemia cells by the use of the combined parameters of XE-2100 hematology analyzer
    Kaoru Tohyama
    Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Okayama, Japan
    Cytometry B Clin Cytom 66:18-24. 2005
  2. ncbi request reprint [Case conference of hematological diseases based on the morphology of blood cells: Chairman's introductory remarks]
    Kaoru Tohyama
    Department of Laboratory Medicine, Kawasaki Medical School, Kurashiki 701 0192, Japan
    Rinsho Byori 61:342-3. 2013
  3. ncbi request reprint Utility of DNA methyltransferase inhibitors for the treatment of myelodysplastic syndromes
    Kaoru Tohyama
    Department of Laboratory Medicine, Kawasaki Medical School, Okayama 701 0192, Japan
    Curr Pharm Des 18:3190-7. 2012
  4. ncbi request reprint [Systematic approaches to hematological diseases based on the partnership between clinical divisions and laboratories--summary]
    Kaoru Tohyama
    Department of Laboratory Medicine, Kawasaki Medical School, Kurashiki 701 0192, Japan
    Rinsho Byori 60:59-60. 2012
  5. ncbi request reprint [Towards better understanding of hematolymphoid malignancies--based on the WHO-2008 classification: summary]
    Kaoru Tohyama
    Department of Laboratory Medicine, Kawasaki Medical School, Kurashiki 701 0192, Japan
    Rinsho Byori 59:502-3. 2011
  6. ncbi request reprint Automated analysis of differentiation-induced leukemic cells during all-trans retinoic Acid therapy of acute promyelocytic leukemia
    Kaoru Tohyama
    Department of Laboratory Medicine and Central Clinical Laboratory, Kyoto University Hospital, Kyoto, Japan
    Arch Pathol Lab Med 127:e4-10. 2003
  7. doi request reprint Effects of DNA methyltransferase inhibitors (DNMTIs) on MDS-derived cell lines
    Takayuki Tsujioka
    Department of Laboratory Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, Japan
    Exp Hematol 41:189-97. 2013
  8. doi request reprint Validation of the revised 2008 WHO diagnostic criteria in 75 suspected cases of myeloproliferative neoplasm
    Toshinori Kondo
    Department of Laboratory Medicine, Kawasaki Medical School, Okayama, Japan
    Leuk Lymphoma 49:1784-91. 2008
  9. ncbi request reprint Effects of the tyrosine kinase inhibitor imatinib mesylate on a Bcr-Abl-positive cell line: suppression of autonomous cell growth but no effect on decreased adhesive property and morphological changes
    Toshio Nishihara
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Int J Hematol 78:233-40. 2003
  10. doi request reprint Transformation from follicular lymphoma to high-grade B-cell lymphoma/leukemia with additional t(2;8)(p12;q24), with inverse expressions of c-MYC and BCL-2, and light-chain switch
    Kiyohito Mannouji
    Division of Hematology, Department of Medicine, Kawasaki Medical School, Kurashiki, Japan
    Pathol Int 59:261-4. 2009

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Improved detection of minimal acute myeloid leukemia cells by the use of the combined parameters of XE-2100 hematology analyzer
    Kaoru Tohyama
    Department of Clinical Pathology and Laboratory Medicine, Kawasaki Medical School, Okayama, Japan
    Cytometry B Clin Cytom 66:18-24. 2005
    ..Although several automated hematology analyzers that carry blast-detecting programs have been developed, they do not exert sufficient detection sensitivity to exceed the sensitivity of manual eye counting method...
  2. ncbi request reprint [Case conference of hematological diseases based on the morphology of blood cells: Chairman's introductory remarks]
    Kaoru Tohyama
    Department of Laboratory Medicine, Kawasaki Medical School, Kurashiki 701 0192, Japan
    Rinsho Byori 61:342-3. 2013
    ..Finally, each presenter elucidated the final diagnosis of their own case and added an explanation. The importance of morphological evaluation was reconfirmed at this conference...
  3. ncbi request reprint Utility of DNA methyltransferase inhibitors for the treatment of myelodysplastic syndromes
    Kaoru Tohyama
    Department of Laboratory Medicine, Kawasaki Medical School, Okayama 701 0192, Japan
    Curr Pharm Des 18:3190-7. 2012
    ..The selection of responders and assessment of the long-term efficacy warrant further study...
  4. ncbi request reprint [Systematic approaches to hematological diseases based on the partnership between clinical divisions and laboratories--summary]
    Kaoru Tohyama
    Department of Laboratory Medicine, Kawasaki Medical School, Kurashiki 701 0192, Japan
    Rinsho Byori 60:59-60. 2012
    ..In particular, the recovery process of the hospital after the unfortunate earthquake let us realize the mutual cooperation of the laboratories and the clinics exactly...
  5. ncbi request reprint [Towards better understanding of hematolymphoid malignancies--based on the WHO-2008 classification: summary]
    Kaoru Tohyama
    Department of Laboratory Medicine, Kawasaki Medical School, Kurashiki 701 0192, Japan
    Rinsho Byori 59:502-3. 2011
    ....
  6. ncbi request reprint Automated analysis of differentiation-induced leukemic cells during all-trans retinoic Acid therapy of acute promyelocytic leukemia
    Kaoru Tohyama
    Department of Laboratory Medicine and Central Clinical Laboratory, Kyoto University Hospital, Kyoto, Japan
    Arch Pathol Lab Med 127:e4-10. 2003
    ..Our automated scattergram analysis of cell differentiation will contribute to general, objective, and real-time evaluation of differentiation-induction therapy of APL with ATRA...
  7. doi request reprint Effects of DNA methyltransferase inhibitors (DNMTIs) on MDS-derived cell lines
    Takayuki Tsujioka
    Department of Laboratory Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama, Japan
    Exp Hematol 41:189-97. 2013
    ..We conclude that this study provides in vitro models for understanding the effects of DNMTIs on cell growth and gene regulation, including differences in the possible action mechanism of DAC and AZA...
  8. doi request reprint Validation of the revised 2008 WHO diagnostic criteria in 75 suspected cases of myeloproliferative neoplasm
    Toshinori Kondo
    Department of Laboratory Medicine, Kawasaki Medical School, Okayama, Japan
    Leuk Lymphoma 49:1784-91. 2008
    ..In contrast, IE presented a good prognosis unlike MPN. Hereafter, the 2008 WHO criteria with JAK2 gene analysis are useful for precise diagnosis of MPN and the patients with erythrocytosis...
  9. ncbi request reprint Effects of the tyrosine kinase inhibitor imatinib mesylate on a Bcr-Abl-positive cell line: suppression of autonomous cell growth but no effect on decreased adhesive property and morphological changes
    Toshio Nishihara
    Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Int J Hematol 78:233-40. 2003
    ..The present data indicated that the Bcr-Abl-specific kinase inhibitor cannot control Bcr-Abl-induced cell alterations other than autonomous growth...
  10. doi request reprint Transformation from follicular lymphoma to high-grade B-cell lymphoma/leukemia with additional t(2;8)(p12;q24), with inverse expressions of c-MYC and BCL-2, and light-chain switch
    Kiyohito Mannouji
    Division of Hematology, Department of Medicine, Kawasaki Medical School, Kurashiki, Japan
    Pathol Int 59:261-4. 2009
    ..Downregulation of BCL-2 and light-chain switch have rarely been reported in previous cases of FL transformation involving c-MYC, suggesting that additional t(2;8) translocation may play a role in these events...
  11. ncbi request reprint Philadelphia chromosome-positive acute myeloid leukemia (Ph + AML) treated with imatinib mesylate (IM): a report with IM plasma concentration and bcr-abl transcripts
    Toshinori Kondo
    Division of Hematology Department of Medicine, Kawasaki Medical School, Okayama 701 0192, Japan
    Leuk Res 33:e137-8. 2009
    ..Our experience suggests that IM might have a positive role in consolidation and/or maintenance therapy in remission Ph + AML patients...
  12. ncbi request reprint Approach to new therapeutics: investigation by the use of MDS-derived cell lines
    Takayuki Tsujioka
    Department of Laboratory Medicine, Kawasaki Medical School, Kurashiki City, Okayama 701 0192, Japan
    Curr Pharm Des 18:3204-14. 2012
    ..The gene expression profiling showed decreased expression of M phase-related genes. These data contribute to the understanding of action mechanisms of lenalidomide on MDS with del(5q)...
  13. ncbi request reprint Immature granulocyte count after liver transplantation
    Shuichi Shiga
    Department of Central Clinical Laboratory, Kyoto University Hospital, Japan
    Clin Chem Lab Med 40:775-80. 2002
    ..We observed instances of inflammation with low C-reactive protein (CRP) value in the presence of IG. We believe that IG is a useful marker to monitor inflammation...
  14. doi request reprint Successful treatment of meningoencephalitis caused by methicillin-resistant Staphylococcus aureus with intravenous linezolid in an allogeneic cord blood stem cell transplant recipient
    Tomitaka Higa
    Division of Hematology and Department of Medicine, Kawasaki Medical School, Kurashiki, Japan
    Scand J Infect Dis 40:990-2. 2008
    ....
  15. ncbi request reprint Clinical evaluation of WT1 mRNA expression levels in peripheral blood and bone marrow in patients with myelodysplastic syndromes
    Yasunori Ueda
    Department of Hematology Oncology, Transfusion and Hemapheresis Center, Kurashiki Central Hospital, Okayama, Japan
    Leuk Lymphoma 54:1450-8. 2013
    ..85), and they tended to increase with disease stage progression and in those at higher risk of leukemic transformation. WT1 mRNA expression can be a useful marker for the diagnosis and risk evaluation of MDS...
  16. ncbi request reprint Clinical significance of phenotypic features of blasts in patients with myelodysplastic syndrome
    Kiyoyuki Ogata
    Division of Hematology, Nippon Medical School, Kyoto, Japan
    Blood 100:3887-96. 2002
    ..Further, CD7 positivity of EBCs was an independent variable for a poor prognosis in MDS. These data represent new, valuable information regarding MDS...
  17. ncbi request reprint Sustained activation of MEK1-ERK1/2 pathway in membrane skeleton occurs dependently on cell adhesion in megakaryocytic differentiation
    Chisato Mizutani
    The Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Biochem Biophys Res Commun 297:664-71. 2002
    ..Sustained activation of the MEK1-ERK1/2 pathway is generated in the membrane skeleton by continuous cell adhesion and seems to be essential to TPA-induced megakaryocytic differentiation of CMK cells...
  18. ncbi request reprint Clinical utility of the neutrophil distribution pattern obtained using the CELL-DYN SAPPHIRE hematology analyzer for the diagnosis of myelodysplastic syndrome
    Tohru Inaba
    Faculty of Clinical Laboratory, Kyoto Prefectural University of Medicine, Kawaramachi Hirokoji, Kamigyo ku, Kyoto, 602 8566, Japan
    Int J Hematol 94:169-77. 2011
    ..In conclusion, neutrophil distribution parameters, especially 90D NDW, appear to provide convenient and objective markers for the screening of patients with MDS in routine laboratory hematology...
  19. ncbi request reprint [Prevalence of anemia in Japan]
    Takayuki Tsujioka
    Department of Laboratory Medicine, Kawasaki Medical School
    Nihon Rinsho 66:429-32. 2008
    ..The frequency of myelodysplastic syndromes is now increasing with aging of the population. It is important to sustain our effort in assembling the data as to the prevalence of anemia...
  20. ncbi request reprint DNA ploidy and cell cycle analyses in the bone marrow cells of patients with megaloblastic anemia using laser scanning cytometry
    Takayuki Tsujioka
    Department of Laboratory Medicine, Kawasaki Medical School, Okayama 701 0192, Japan
    Cytometry B Clin Cytom 74:104-9. 2008
    ..Megaloblastic anemias are characterized by several hematopoietic cells with dysplastic nuclear morphology. The analyses of DNA ploidy and cell cycle of these cells are important to understand the property of such diseases...
  21. ncbi request reprint [Perspective on the treatment of myelodysplastic syndromes]
    Kaoru Tohyama
    Department of Laboratory Medicine, Kawasaki Medical School
    Nihon Rinsho 69:2257-66. 2011
    ....
  22. ncbi request reprint [Diagnostics and differential diagnosis of the myelodysplastic syndromes]
    Kaoru Tohyama
    Department of Laboratory Medicine, Kawasaki Medical School
    Nihon Rinsho 65:326-30. 2007
  23. ncbi request reprint Induction of apoptosis by epigallocatechin-3-gallate in human lymphoblastoid B cells
    Chiseko Noda
    Department of Nutrition Management, Faculty of Health Science, Hyogo University, Kakogawa, Hyogo 675 0101, Japan
    Biochem Biophys Res Commun 362:951-7. 2007
    ..Furthermore, we showed that combined-treatment with EGCG and a chemotherapeutic agent, etoposide, synergistically induced apoptosis in Ramos cells...
  24. ncbi request reprint Protein-tyrosine kinase Syk is required for pathogen engulfment in complement-mediated phagocytosis
    Yuhong Shi
    Department of Genome Sciences, Kobe University Graduate School of Medicine, Kobe 650 0017, Japan
    Blood 107:4554-62. 2006
    ....
  25. ncbi request reprint [Toxicological analyses over the past five years at a single institution]
    Kimiko Matsuda
    Department of Clinical Laboratory, Kawasaki Medical School Hospital, Kurashiki 701 0192
    Rinsho Byori 52:819-23. 2004
    ..Of 23 patients who died, 20 took Paraquat and Diquat, 2 took organophosphates and 1 took an overdose of antidepressants. The other 329 were transferred to different medical departments or were discharged from our hospital after recovery...
  26. ncbi request reprint A prospective study of cyclosporine A treatment of patients with low-risk myelodysplastic syndrome: presence of CD55(-)CD59(-) blood cells predicts platelet response
    Takayuki Ishikawa
    Department of Hematology and Oncology, Graduate School ofMedicine, Kyoto University, 54 Shogoin Kawaracho, Sakyo ku, Kyoto 606 8507, Japan
    Int J Hematol 86:150-7. 2007
    ..A minority of RA patients who did not possess such predictive variables achieved an isolated erythroid response. In conclusion, CSA may be a therapeutic option for patients with RA who do not have adverse prognostic factors...