Research Topics

Genomes and Genes


Mineki Saito


Affiliation: Kawasaki Medical School
Country: Japan


  1. Naito T, Yasunaga J, Mitobe Y, Shirai K, Sejima H, Ushirogawa H, et al. Distinct gene expression signatures induced by viral transactivators of different HTLV-1 subgroups that confer a different risk of HAM/TSP. Retrovirology. 2018;15:72 pubmed publisher
    ..Differential expression of pathogenesis-related genes by subgroup-specific Tax or HBZ may be associated with the onset of HAM/TSP. ..
  2. Yasuma K, Matsuzaki T, Yamano Y, Takashima H, Matsuoka M, Saito M. HTLV-1 subgroups associated with the risk of HAM/TSP are related to viral and host gene expression in peripheral blood mononuclear cells, independent of the transactivation functions of the viral factors. J Neurovirol. 2016;22:416-30 pubmed publisher
  3. Shiohama Y, Naito T, Matsuzaki T, Tanaka R, Tomoyose T, Takashima H, et al. Absolute quantification of HTLV-1 basic leucine zipper factor (HBZ) protein and its plasma antibody in HTLV-1 infected individuals with different clinical status. Retrovirology. 2016;13:29 pubmed publisher
    ..However, there is a possibility that the low but distinct expression of HBZ protein in PBMCs is associated with the survival of HTLV-1-infected cells and the development of ATL. ..
  4. Ushirogawa H, Naito T, Tokunaga H, Tanaka T, Nakano T, Terada K, et al. Re-emergence of H3N2 strains carrying potential neutralizing mutations at the N-linked glycosylation site at the hemagglutinin head, post the 2009 H1N1 pandemic. BMC Infect Dis. 2016;16:380 pubmed publisher
    ..Our data suggest that the newly acquired NGSs in the HA globular head may play an important role in the re-emergence of endemic seasonal H3N2 strain by aiding the escape from humoral immunity. ..
  5. Saito M, Tanaka R, Arishima S, Matsuzaki T, Ishihara S, Tokashiki T, et al. Increased expression of OX40 is associated with progressive disease in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis. Retrovirology. 2013;10:51 pubmed publisher
    ..Our study identified OX40 as a key molecule and biomarker for rapid progression of HAM/TSP. Furthermore, blocking OX40 may have potential in therapeutic intervention for HAM/TSP. ..
  6. Okino T, Ushirogawa H, Matoba K, Nishimatsu S, Saito M. Establishment of the complete life cycle of Spirometra (Cestoda: Diphyllobothriidae) in the laboratory using a newly isolated triploid clone. Parasitol Int. 2017;66:116-118 pubmed publisher
    ..Our system will be particularly useful for studies of S. erinaceieuropaei infection and human sparganosis. ..
  7. Shiohama Y, Naito T, Matsuzaki T, Tanaka R, Tomoyose T, Takashima H, et al. Prevalence of plasma autoantibody against cancer testis antigen NY-ESO-1 in HTLV-1 infected individuals with different clinical status. Virol J. 2017;14:130 pubmed publisher
    ..Rather, it might reflect chronic and generalized immune activation in infected individuals. ..
  8. Saito M, Sejima H, Naito T, Ushirogawa H, Matsuzaki T, Matsuura E, et al. The CC chemokine ligand (CCL) 1, upregulated by the viral transactivator Tax, can be downregulated by minocycline: possible implications for long-term treatment of HTLV-1-associated myelopathy/tropical spastic paraparesis. Virol J. 2017;14:234 pubmed publisher