Naoyuki Miyashita

Summary

Affiliation: Kawasaki Medical School
Country: Japan

Publications

  1. doi request reprint Transmission of macrolide-resistant Mycoplasma pneumoniae within a family
    Naoyuki Miyashita
    Department of Internal Medicine I, Kawasaki Medical School, 2 1 80 Nakasange, Kita ku, Okayama, 700 8505, Japan
    J Infect Chemother 19:1196-201. 2013
  2. doi request reprint Atelectasis caused by macrolide-resistant Mycoplasma pneumoniae pneumonia in an adult patient
    Naoyuki Miyashita
    Department of Internal Medicine I, Kawasaki Medical School, 2 1 80 Nakasange, Kita ku, Okayama, 700 8505, Japan
    J Infect Chemother 19:1161-6. 2013
  3. ncbi request reprint Chlamydophila pneumoniae serology: cross-reaction with Mycoplasma pneumoniae infection
    Naoyuki Miyashita
    Department of Internal Medicine I, Kawasaki Medical School, 2 1 80 Nakasange, Kita ku, Okayama, Japan
    J Infect Chemother 19:256-60. 2013
  4. ncbi request reprint Evaluation of serological tests for diagnosis of Chlamydophila pneumoniae pneumonia in patients with nursing and healthcare-associated pneumonia
    Naoyuki Miyashita
    Department of Internal Medicine I, Kawasaki Medical School, 2 1 80 Nakasange, Kita ku, Okayama, Japan
    J Infect Chemother 19:249-55. 2013
  5. pmc Diagnostic value of symptoms and laboratory data for pertussis in adolescent and adult patients
    Naoyuki Miyashita
    Department of Internal Medicine I, Kawasaki Medical School, 2 1 80 Nakasange, Kita ku, Okayama, 700 8505, Japan
    BMC Infect Dis 13:129. 2013
  6. pmc Macrolide-resistant Mycoplasma pneumoniae in adolescents with community-acquired pneumonia
    Naoyuki Miyashita
    Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan
    BMC Infect Dis 12:126. 2012
  7. doi request reprint Influence of age on the clinical differentiation of atypical pneumonia in adults
    Naoyuki Miyashita
    Department of Internal Medicine I, Kawasaki Medical School, Kita ku, Okayama, Japan
    Respirology 17:1073-9. 2012
  8. ncbi request reprint Clinical features and the role of atypical pathogens in nursing and healthcare-associated pneumonia (NHCAP): differences between a teaching university hospital and a community hospital
    Naoyuki Miyashita
    Department of Internal Medicine I, Kawasaki Medical School, Japan
    Intern Med 51:585-94. 2012
  9. ncbi request reprint Clinical efficacy of macrolide antibiotics against genetically determined macrolide-resistant Mycoplasma pneumoniae pneumonia in paediatric patients
    Yasuhiro Kawai
    Department of Pediatrics, Kawasaki Medical School, Okayama, Japan
    Respirology 17:354-62. 2012
  10. ncbi request reprint Outbreak of Chlamydophila pneumoniae infection in long-term care facilities and an affiliated hospital
    Naoyuki Miyashita
    Division of Respiratory Disease, Department of Internal Medicine and Department of Pediatrics, Kawasaki Medical School, Kurashiki City, Japan
    J Med Microbiol 54:1243-7. 2005

Detail Information

Publications98

  1. doi request reprint Transmission of macrolide-resistant Mycoplasma pneumoniae within a family
    Naoyuki Miyashita
    Department of Internal Medicine I, Kawasaki Medical School, 2 1 80 Nakasange, Kita ku, Okayama, 700 8505, Japan
    J Infect Chemother 19:1196-201. 2013
    ..To prevent outbreaks of M. pneumoniae infection, especially MR M. pneumoniae, in closed populations, physicians should pay careful attention to the potential occurrence of infections involving MR M. pneumoniae. ..
  2. doi request reprint Atelectasis caused by macrolide-resistant Mycoplasma pneumoniae pneumonia in an adult patient
    Naoyuki Miyashita
    Department of Internal Medicine I, Kawasaki Medical School, 2 1 80 Nakasange, Kita ku, Okayama, 700 8505, Japan
    J Infect Chemother 19:1161-6. 2013
    ..pneumoniae is thought to be a common associated finding in pediatric patients, but it is rare in adults. In addition, our patient showed extremely unusual findings with obstruction caused by complete edematous swelling...
  3. ncbi request reprint Chlamydophila pneumoniae serology: cross-reaction with Mycoplasma pneumoniae infection
    Naoyuki Miyashita
    Department of Internal Medicine I, Kawasaki Medical School, 2 1 80 Nakasange, Kita ku, Okayama, Japan
    J Infect Chemother 19:256-60. 2013
    ..To accurately diagnose C. pneumoniae infection in various studies, including respiratory infections, researchers should consider the IgM false-positive reaction with ELISA in patients with suspected atypical pneumonia...
  4. ncbi request reprint Evaluation of serological tests for diagnosis of Chlamydophila pneumoniae pneumonia in patients with nursing and healthcare-associated pneumonia
    Naoyuki Miyashita
    Department of Internal Medicine I, Kawasaki Medical School, 2 1 80 Nakasange, Kita ku, Okayama, Japan
    J Infect Chemother 19:249-55. 2013
    ..To increase the diagnostic rate in patients with NHCAP, physicians should measure IgG antibody rather than IgM antibody using paired sera...
  5. pmc Diagnostic value of symptoms and laboratory data for pertussis in adolescent and adult patients
    Naoyuki Miyashita
    Department of Internal Medicine I, Kawasaki Medical School, 2 1 80 Nakasange, Kita ku, Okayama, 700 8505, Japan
    BMC Infect Dis 13:129. 2013
    ..Furthermore, we measured fractional exhaled nitric oxide (FeNO) with regard to whether we could distinguish eosinophilic inflammation of the airway and pertussis. FeNO is not expected to be associated with pertussis...
  6. pmc Macrolide-resistant Mycoplasma pneumoniae in adolescents with community-acquired pneumonia
    Naoyuki Miyashita
    Department of Internal Medicine, Kawasaki Medical School, Okayama, Japan
    BMC Infect Dis 12:126. 2012
    ..The purpose of this study was to clarify the prevalence and clinical characteristics of macrolide-resistant M. pneumoniae in adolescent patients with community-acquired pneumonia...
  7. doi request reprint Influence of age on the clinical differentiation of atypical pneumonia in adults
    Naoyuki Miyashita
    Department of Internal Medicine I, Kawasaki Medical School, Kita ku, Okayama, Japan
    Respirology 17:1073-9. 2012
    ..In the present study, we evaluated the accuracy and usefulness of the JRS scoring system for diagnosing atypical pneumonia in different age groups...
  8. ncbi request reprint Clinical features and the role of atypical pathogens in nursing and healthcare-associated pneumonia (NHCAP): differences between a teaching university hospital and a community hospital
    Naoyuki Miyashita
    Department of Internal Medicine I, Kawasaki Medical School, Japan
    Intern Med 51:585-94. 2012
    ..In addition, to clarify the strategy for treatment of NHCAP, we investigated the role of atypical pathogens...
  9. ncbi request reprint Clinical efficacy of macrolide antibiotics against genetically determined macrolide-resistant Mycoplasma pneumoniae pneumonia in paediatric patients
    Yasuhiro Kawai
    Department of Pediatrics, Kawasaki Medical School, Okayama, Japan
    Respirology 17:354-62. 2012
    ..To determine the efficacy of macrolides against MR M. pneumoniae pneumonia, microbiological and clinical efficacies were compared during the antibiotic treatment...
  10. ncbi request reprint Outbreak of Chlamydophila pneumoniae infection in long-term care facilities and an affiliated hospital
    Naoyuki Miyashita
    Division of Respiratory Disease, Department of Internal Medicine and Department of Pediatrics, Kawasaki Medical School, Kurashiki City, Japan
    J Med Microbiol 54:1243-7. 2005
    ..Physicians and other health care providers in long-term care facilities should consider C. pneumoniae in the differential diagnosis of an outbreak of respiratory infection...
  11. doi request reprint Comparison of serological tests for detection of immunoglobulin M antibodies to Chlamydophila pneumoniae
    Naoyuki Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki City, Japan
    Respirology 13:427-31. 2008
    ..To evaluate an enzyme immunoassay (EIA) (AniLab C. pneumoniae) for detecting anti-Chlamydophila pneumoniae-specific IgM antibody, by comparing it with an ELISA, Hitazyme C. pneumoniae, and a micro-immunofluorescence (MIF) test...
  12. doi request reprint Community-acquired macrolide-resistant Mycoplasma pneumoniae pneumonia in patients more than 18 years of age
    Naoyuki Miyashita
    Department of Respiratory Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan
    J Infect Chemother 17:114-8. 2011
    ..In Japan, macrolide-resistant M. pneumoniae infections are common in pediatric patients but not in adults. However, physicians should pay attention to macrolide-resistant M. pneumoniae not only in children but also in adults...
  13. ncbi request reprint Outbreak of pertussis in a university laboratory
    Naoyuki Miyashita
    Department of Internal Medicine 1, Kawasaki Medical School, Japan
    Intern Med 50:879-85. 2011
    ..To prevent and control the outbreak, we conducted a survey of the laboratory staff and their family members, and we investigated the clinical features of adult pertussis...
  14. pmc Rapid and simple diagnosis of Chlamydophila pneumoniae pneumonia by an immunochromatographic test for detection of immunoglobulin M antibodies
    Naoyuki Miyashita
    Department of Medicine, Division of Respiratory Diseases, Kawasaki Medical School, 577 Matsushima, Kurashiki City, Okayama 701 0192, Japan
    Clin Vaccine Immunol 15:1128-31. 2008
    ..The sensitivity and specificity of the MySet test were 100% and 92.9%, respectively. The MySet test is rapid and simple to use and is thought to be a useful tool for the selection of appropriate antibiotic therapy...
  15. ncbi request reprint Clinical features of severe Mycoplasma pneumoniae pneumonia in adults admitted to an intensive care unit
    Naoyuki Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Okayama 701 0192, Japan
    J Med Microbiol 56:1625-9. 2007
    ..The delayed administration of adequate antibiotics may contribute to the severity of M. pneumoniae pneumonia. Early corticosteroid therapy with adequate antibiotics should be considered...
  16. ncbi request reprint Evaluation of the diagnostic usefulness of real-time PCR for detection of Chlamydophila pneumoniae in acute respiratory infections
    Naoyuki Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701 0192, Japan
    J Infect Chemother 13:183-7. 2007
    ..pneumoniae acute infections and persistent ones or nasopharyngeal carriage. In addition, the detection of C. pneumoniae DNA in PBMCs does not seem to be a suitable method for the diagnosis of acute respiratory C. pneumoniae infections...
  17. ncbi request reprint Is it possible to distinguish between atypical pneumonia and bacterial pneumonia?: evaluation of the guidelines for community-acquired pneumonia in Japan
    Naoyuki Miyashita
    Division of Respiratory Diseases, Department of Internal Medicine, Kawasaki Medical School, Kurashiki City, Okayama, Japan
    Respir Med 98:952-60. 2004
    ..5% and 90.9%, respectively. Our results indicated that the differentiation of pneumonia in the JRS guidelines is useful for the diagnosis of M. pneumoniae pneumonia, but difficult to apply to the diagnosis of C. pneumoniae pneumonia...
  18. ncbi request reprint Assessment of the usefulness of sputum Gram stain and culture for diagnosis of community-acquired pneumonia requiring hospitalization
    Naoyuki Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan
    Med Sci Monit 14:CR171-6. 2008
    ..The usefulness of sputum Gram stain and culture in guiding microbiological diagnosis of community-acquired pneumonia (CAP) is controversial. We evaluated the role of sputum examination at a university teaching hospital...
  19. doi request reprint Clinical potential of diagnostic methods for the rapid diagnosis of Mycoplasma pneumoniae pneumonia in adults
    N Miyashita
    Department of Respiratory Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan
    Eur J Clin Microbiol Infect Dis 30:439-46. 2011
    ..If there is a correlation of three or four parameters in the JRS scoring system, chest computed tomography (CT) findings are helpful for the presumptive diagnosis of M. pneumoniae pneumonia...
  20. ncbi request reprint Community-acquired pneumonia in Japan: a prospective ambulatory and hospitalized patient study
    Naoyuki Miyashita
    Division of Respiratory Disease, Department of Internal Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki City, Okayama 701 0192, Japan
    J Med Microbiol 54:395-400. 2005
    ..pneumoniae and Haemophilus influenzae was higher among the hospitalized patients. Recognition of these results will allow prompt and appropriate antimicrobial therapy to be provided using Japanese CAP guidelines...
  21. ncbi request reprint [Chlamydia pneumoniae infections]
    Naoyuki Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki shi, Okayama 701 0192 Japan
    Kekkaku 81:581-8. 2006
    ..Since repeated infection can certainly be documented in many clinical settings, persistence is thought to also play a role...
  22. doi request reprint Evaluation of enzyme-linked immunosorbent assay for Chlamydophila pneumoniae-specific immunoglobulin M in acute respiratory tract infection
    Naoyuki Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan
    Respirology 13:299-302. 2008
    ..The study evaluated a newly developed ELISA (Hitazyme Chlamydophila pneumoniae) for detecting anti-C. pneumoniae-specific IgM antibody, by comparing the ELISA assay to a microimmunofluorescence (MIF) test and immunoblotting...
  23. pmc Radiographic features of Mycoplasma pneumoniae pneumonia: differential diagnosis and performance timing
    Naoyuki Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan
    BMC Med Imaging 9:7. 2009
    ..pneumoniae pneumonia from Streptococcus pneumoniae pneumonia...
  24. ncbi request reprint Mycoplasma pneumoniae pneumonia in the elderly
    Naoyuki Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan
    Med Sci Monit 14:CR387-91. 2008
    ..Mycoplasma pneumoniae is one of the most common causes of community-acquired pneumonia (CAP). This infection occurs predominantly in school-aged children and younger adults, but may also occur in the elderly...
  25. ncbi request reprint Multiplex PCR for the simultaneous detection of Chlamydia pneumoniae, Mycoplasma pneumoniae and Legionella pneumophila in community-acquired pneumonia
    Naoyuki Miyashita
    Division of Respiratory Diseases, Department of Internal Medicine, Kawasaki Medical School, 577 Matushima, Kurashiki City, Okayama 701 0192, Japan
    Respir Med 98:542-50. 2004
    ..Our multiplex PCR assay could potentially be used as a diagnostic and epidemiological tool. Further prospective studies are needed to establish its clinical usefulness...
  26. pmc Seroepidemiology of Chlamydia pneumoniae in Japan between 1991 and 2000
    N Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashika City, Okayama, Japan
    J Clin Pathol 55:115-7. 2002
    ..To clarify the endemic and epidemic status of Chlamydia pneumoniae in Japan, the incidence of anti-C pneumoniae antibody was evaluated over a period of 10 years...
  27. pmc In vitro and in vivo activities of sitafloxacin against Chlamydia spp
    N Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki City, Okayama 701 0192, Japan
    Antimicrob Agents Chemother 45:3270-2. 2001
    ..031 to 0.125 microg/ml. Sitafloxacin had an excellent therapeutic effect on experimental Chlamydia psittaci pneumonia and was more potent than tosufloxacin, ofloxacin, and ciproflxacin, although slightly less potent than sparfloxacin...
  28. ncbi request reprint Clinical presentation of community-acquired Chlamydia pneumoniae pneumonia in adults
    Naoyuki Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Okayama, Japan
    Chest 121:1776-81. 2002
    ..To investigate the clinical presentation of community-acquired Chlamydia pneumoniae pneumonia in adults...
  29. ncbi request reprint In vitro activity of telithromycin, a new ketolide, against Chlamydia pneumoniae
    N Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki City, Okayama 701 0192, Japan
    J Antimicrob Chemother 48:403-5. 2001
    ..These results appear to indicate that telithromycin is an effective antibiotic that should play some role in the treatment of respiratory tract infections caused by C. pneumoniae...
  30. ncbi request reprint The 7.5-kb common plasmid is unrelated to the drug susceptibility of Chlamydia trachomatis
    N Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701 0192, Japan
    J Infect Chemother 7:113-6. 2001
    ..No difference was detected for any of the antibiotics tested, indicating that the 7.5-kb common plasmid is unrelated to the drug susceptibility of C. trachomatis...
  31. ncbi request reprint Chlamydia pneumoniae infection in adult patients with persistent cough
    Naoyuki Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701 0192, Japan
    J Med Microbiol 52:265-9. 2003
    ..pneumoniae infection may cause persistent cough in adults. Furthermore, these data also indicate that it may be necessary to eradicate the organism when C. pneumoniae is detected by culture and/or PCR in patients with persistent cough...
  32. ncbi request reprint In-vitro activity of moxifloxacin and other fluoroquinolones against Chlamydia species
    Naoyuki Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701 0192, Japan
    J Infect Chemother 8:115-7. 2002
    ..The minimal chlamydiacidal concentration of moxifloxacin ranged from 0.031 to 0.125 microg/ml. These results suggest that moxifloxacin has potential effects against Chlamydia species...
  33. ncbi request reprint Prevalence of asymptomatic infection with Chlamydia pneumoniae in subjectively healthy adults
    N Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki City, Okayama, Japan
    Chest 119:1416-9. 2001
    ..To investigate the prevalence of asymptomatic infection with Chlamydia pneumoniae in subjectively healthy adults...
  34. ncbi request reprint In vitro activity of cethromycin, a novel antibacterial ketolide, against Chlamydia pneumoniae
    Naoyuki Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki City, Okayama 701 0192, Japan
    J Antimicrob Chemother 52:497-9. 2003
    ..To investigate the in vitro activity of cethromycin, a new ketolide, against Chlamydia pneumoniae...
  35. ncbi request reprint Seroprevalence of antibodies to Chlamydia spp. in human immunodeficiency virus-infected subjects in Japan
    N Miyashita
    Department of Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan
    Microbiol Immunol 44:781-5. 2000
    ..These data indicate that the higher C. pneumoniae and C. trachomatis seroprevalence among HIV-infected subjects is probably due to an HIV risk factor, such as promiscuous sexual behavior, rather than to HIV infection itself...
  36. ncbi request reprint In vitro susceptibility of 7.5-kb common plasmid-free Chlamydia trachomatis strains
    N Miyashita
    Department of Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan
    Microbiol Immunol 44:267-9. 2000
    ..No difference was detected for any of the agents tested, indicating that the 7.5-kb common plasmid is unrelated to the drug resistance of C. trachomatis...
  37. ncbi request reprint Evaluation of serological tests detecting Chlamydophila pneumoniae-specific immunoglobulin M antibody
    Naoyuki Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Okayama
    Intern Med 45:1127-31. 2006
    ..pneumoniae) detecting Chlamydophila pneumoniae-specific immunoglobulin M (IgM) antibody, we compared the assay with culturing, immunoblotting and the microimmunofluorescence (MIF) test...
  38. doi request reprint Clinical evaluation for diagnosing active TB disease and transitional change of two commercial blood tests
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Matsushima, Kurashiki, Japan
    Scand J Infect Dis 40:629-34. 2008
    ..In conclusion, both blood assays seemed to be more useful than TST for the identification of patients with active TB disease. However, neither of the 2 blood tests appears to provide any certainty regarding the cure of infection...
  39. pmc Nationwide surveillance of macrolide-resistant Mycoplasma pneumoniae infection in pediatric patients
    Yasuhiro Kawai
    Department of Pediatrics, Kawasaki Medical School, Okayama, Japan
    Antimicrob Agents Chemother 57:4046-9. 2013
    ..These regional differences were closely related to the previous administration of macrolides. ..
  40. ncbi request reprint Chronic necrotizing pulmonary aspergillosis as a complication of pulmonary Mycobacterium avium complex disease
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki, Japan
    Respirology 11:809-13. 2006
    ..To investigate the characteristic clinical features of chronic necrotizing pulmonary aspergillosis (CNPA) as a complication of pulmonary Mycobacterium avium complex (MAC) disease...
  41. doi request reprint QuantiFERON TB-2G test for patients with active tuberculosis stratified by age groups
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki, Japan
    Scand J Infect Dis 41:841-6. 2009
    ..Although the positive rate on QFT-2G test decreased with age in adults, it is thought to be a useful supportive diagnostic method for active TB disease compared to the TST, except in younger patients aged < or =9 years old...
  42. ncbi request reprint Community-acquired Chlamydia pneumoniae pneumonia in Japan: a prospective multicenter community-acquired pneumonia study
    Naoyuki Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki, Okayama
    Intern Med 41:943-9. 2002
    ..To investigate the clinical features of Chlamydia pneumoniae pneumonia in Japan and to evaluate the newly created Japanese community-acquired pneumonia (CAP) guidelines...
  43. ncbi request reprint [A case of pulmonary Mycobacterium intracellulare infectious disease with a solitary pulmonary nodule in the peripheral lung field]
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
    Nihon Kokyuki Gakkai Zasshi 42:831-6. 2004
    ..We report a rare case with a solitary nodule caused by pulmonary Mycobacterium intracellulare infectious disease which is indicative of lung cancer...
  44. pmc Comparison of T-cell interferon-gamma release assays for Mycobacterium tuberculosis-specific antigens in patients with active and latent tuberculosis
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Japan
    Lung 188:283-7. 2010
    ..However, there was an overlap in the IFN-gamma levels between active TB disease and LTBI groups. Therefore, it would be difficult to use the QFT-2G test to completely discriminate active TB disease from LTBI...
  45. ncbi request reprint An asymptomatic case of pulmonary cryptococcosis with endobronchial polypoid lesions and bilateral infiltrative shadow
    Hiroki Shimizu
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701 0192, Japan
    J Infect Chemother 14:315-8. 2008
    ..Histopathological examination of transbronchial biopsy specimens demonstrated cryptococcal organisms. After fluconazole therapy for 4 months, the infiltrate had decreased in size and the bronchial polypoid lesions had disappeared...
  46. ncbi request reprint Clinical utility of the QuantiFERON TB-2G test for elderly patients with active tuberculosis
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, 701 0192, Japan
    Chest 133:1196-202. 2008
    ....
  47. ncbi request reprint Clinical evaluation of QuantiFERON TB-2G test in patients with healed pulmonary tuberculosis
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki 701 0192, Japan
    J Infect Chemother 15:288-92. 2009
    ....
  48. doi request reprint Stability of sealed-bag samples for off-line measurement of fractional exhaled nitric oxide
    Hiroki Shimizu
    Department of Respiratory Medicine, Kawasaki Medical School, Japan
    Ann Allergy Asthma Immunol 106:378-80. 2011
    ..It can be measured with on- and off-line methods. In the latter, sample storage is possible; this is useful in Japan, because the number of facilities in which this instrument has been installed is limited...
  49. doi request reprint Transitional changes in T-cell responses to Mycobacterium tuberculosis-specific antigens during treatment
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan
    J Infect 58:197-204. 2009
    ..Therefore, we studied the usefulness of two commercial IFN-gamma assays (QuantiFERON TB-2G (QFT-2G) and T-SPOT.TB tests) for monitoring clinical efficacy...
  50. ncbi request reprint Four cases of pulmonary Mycobacterium avium intracellulare complex presenting as a solitary pulmonary nodule and a review of other cases in Japan
    Yoshihiro Kobashi
    Department of Medicine, Division of Respiratory Diseases, Kawasaki Medical School, Kawasaki, Japan
    Respirology 11:317-21. 2006
    ..To evaluate clinical findings of patients with a solitary pulmonary nodule in Japan caused by pulmonary Mycobacterium avium complex (MAC) disease...
  51. ncbi request reprint Relationship between clinical efficacy of treatment of pulmonary Mycobacterium avium complex disease and drug-sensitivity testing of Mycobacterium avium complex isolates
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki 701 0192, Japan
    J Infect Chemother 12:195-202. 2006
    ..Although the ATS has not yet recommended routine drug susceptibility testing of CAM, we believe that drug susceptibility testing of CAM should be performed before the initial treatment is undertaken for pulmonary MAC disease...
  52. ncbi request reprint Pulmonary Mycobacterium intracellulare disease with a solitary pulmonary nodule detected at the onset of pneumothorax
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki 701 0192, Japan
    J Infect Chemother 12:203-6. 2006
    ..We have reported a peculiar case of pulmonary M. intracellulare disease, detected at the onset of left secondary pneumothorax caused by pulmonary emphysema, which required differentiation from pulmonary adenocarcinoma...
  53. ncbi request reprint Clinical evaluation of the T-SPOT.TB test for patients with indeterminate results on the QuantiFERON TB-2G test
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki, Japan
    Intern Med 48:137-42. 2009
    ..To evaluate the clinical utility of the T-SPOT.TB test for patients with indeterminate results on the QFT-2G test...
  54. ncbi request reprint False negative results of QuantiFERON TB-2G test in patients with active tuberculosis
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Matsushima, Kurashiki, Japan
    Jpn J Infect Dis 62:300-2. 2009
    ....
  55. ncbi request reprint Chronic necrotizing pulmonary aspergillosis complicated by a cavitary lesion caused by Pulmonary Mycobacterium-avium complex disease
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki 701 0192
    Intern Med 44:246-50. 2005
    ....
  56. ncbi request reprint [Comparison of clinical presentation of mixed pneumonia with Chlamydia pneumoniae and Streptococcus pneumoniae and S. pneumoniae pneumonia]
    Hiroshi Fukano
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
    Kansenshogaku Zasshi 78:108-13. 2004
    ..Our results indicated that C. pneumoniae may not be the primary cause of community-acquired pneumonia but it might descript the normal clearance mechanisms, enabling other pathogens to invade...
  57. ncbi request reprint Pulmonary Mycobacterium avium disease with a solitary pulmonary nodule requiring differentiation from recurrence of pulmonary adenocarcinoma
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki
    Intern Med 43:855-60. 2004
    ..As the causative pathogen, Mycobacterium avium complex (MAC) disease should be considered in the differential diagnosis of a rapidly increasing solitary nodule through this peculiar case of pulmonary MAC disease...
  58. ncbi request reprint Self-limiting pneumonia due to Chlamydia pneumoniae
    Naoyuki Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan
    Intern Med 44:870-4. 2005
    ..pneumoniae pneumonia is rarely encountered, although self-limiting upper respiratory tract infections due to C. pneumoniae are common. Thus, most self-limiting C. pneumoniae pneumonia may be missed when symptoms are minimal...
  59. ncbi request reprint Clinical reevaluation of the QuantiFERON TB-2G test as a diagnostic method for differentiating active tuberculosis from nontuberculous mycobacteriosis
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki, 701 0192, Japan
    Clin Infect Dis 43:1540-6. 2006
    ....
  60. ncbi request reprint Clinical features of immunocompromised and nonimmunocompromised patients with pulmonary tuberculosis
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki 701 0192, Japan
    J Infect Chemother 13:405-10. 2007
    ..We must perform the acid-fast bacilli examination for patients who have a fever and continuous cough, and antituberculous drugs should be administered as soon as possible when the results are positive...
  61. ncbi request reprint [Clinical usefulness of the (1-->3)-beta-D-glucan measurement kit using the improved alkaline pretreatment method--comparison with conventional method]
    Koichiro Yoshida
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
    Kansenshogaku Zasshi 80:701-5. 2006
    ..Then, the specificity of new MK assay was improved by using improved alkaline pretreatment reagent, without decreasing the sensitivity. Thus, the present findings indicate that the new MK assay is clinically quite useful...
  62. ncbi request reprint [Clinical analysis of pulmonary actinomycosis]
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
    Kansenshogaku Zasshi 79:111-6. 2005
    ..Because penicillin antibiotics were administered for a long time for all patients after obtaining a definite diagnosis, the prognosis was good and there were no relapse...
  63. ncbi request reprint Transitional change in the clinical features of pulmonary tuberculosis
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki, Japan
    Respiration 75:304-9. 2008
    ..An aging population, increased use of immunosuppressive therapy and an increase in patients with risk factors for tuberculosis have induced changes in the clinical features of pulmonary tuberculosis in Japan...
  64. ncbi request reprint [Non-specific reactions in four methods measuring (1-->3)-beta-D-glucan levels in plasma]
    Koichiro Yoshida
    Division of Repiratory Disease, Department of Medicine, Kawasaki Medical School
    Kansenshogaku Zasshi 79:329-40. 2005
    ..Finally, to measure plasma beta-glucan levels accurately, non-specific reactions should be excluded as possible by further improvement of measurement methods...
  65. doi request reprint Clinical utility of a T cell-based assay in the diagnosis of extrapulmonary tuberculosis
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Matsushima, Kurashiki, Japan
    Respirology 14:276-81. 2009
    ....
  66. ncbi request reprint Solitary pulmonary nodule due to Mycobacterium kansasii
    Masaaki Abe
    Department of Medicine, Kawasaki Medical School, Japan
    Intern Med 50:775-8. 2011
    ..Smear test of the resected tissue was positive for acid-fast bacilli and culture was positive for mycobacteria, which was identified as Mycobacterium kansasii. There are a few case reports of solitary nodule due to M. kansasii...
  67. ncbi request reprint Hermansky-Pudlak syndrome with interstitial pneumonia without mutation of HSP1 gene
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Matsushima, Kurashiki
    Intern Med 44:616-21. 2005
    ..Concerning treatment, although corticosteroid therapy was administered, his clinical symptoms and abnormal chest shadow have not changed...
  68. ncbi request reprint Evaluating the use of a Streptococcus pneumoniae urinary antigen detection kit for the management of community-acquired pneumonia in Japan
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki, Japan
    Respiration 74:387-93. 2007
    ..The urinary antigen detection kit for Streptococcus pneumoniae was tested...
  69. ncbi request reprint Long-term follow-up of the QuantiFERON TB-2G test for active tuberculosis disease
    Yoshihiro Kobashi
    Department of Medicine, Division of Respiratory Diseases, Kawasaki Medical School, Kurashiki
    Intern Med 47:1957-61. 2008
    ..To evaluate transitional changes in QuantiFERON TB-2G (QFT-2G) test results in the serial testing on the same patients and to reevaluate the optimal threshold of positive response of QFT-2G test as a cure of TB infection...
  70. ncbi request reprint Clinical usefulness of QuantiFERON TB-2G test for the early diagnosis of pulmonary Mycobacterium kansasii disease
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki 701 0192, Japan
    Jpn J Infect Dis 62:239-41. 2009
    ..The QFT-2G test may be useful as a rapid supportive diagnostic method for pulmonary infection due to MK possessing the same MTB-specific antigen...
  71. ncbi request reprint [Countermeasures against non-specific reactions in the measurement of beta-glucan in plasma by alkaline treatment, chromogenic automated kinetic assay]
    Koichiro Yoshida
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
    Kansenshogaku Zasshi 78:435-41. 2004
    ..By so doing, unnecessary initiation of anti fugal therapy in response to non-specific reactions can be avoided. Further prospective and radical studies of non-specific reactions in the alkaline-kinetic assay are necessary...
  72. ncbi request reprint Usefulness of the QuantiFERON TB-2G test for the differential diagnosis of pulmonary tuberculosis
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki, Japan
    Intern Med 47:237-43. 2008
    ..We prospectively evaluated the usefulness of the QuantiFERON TB-2G (QFT-2G) compared to that of tuberculin skin test (TST) as a supportive method of diagnosing pulmonary tuberculosis (TB) without invasive examinations...
  73. ncbi request reprint Clinical differentiation of atypical pneumonia using Japanese guidelines
    Tadashi Ishida
    Department of Respiratory Medicine, Kurashiki Central Hospital, Miwa, Japan
    Respirology 12:104-10. 2007
    ..Atypical pneumonia occupies an important position in community-acquired pneumonia. The aim of this study was to examine whether making a diagnosis of atypical pneumonia is possible based upon the Japanese Respiratory Society guidelines...
  74. ncbi request reprint Thoracic actinomycosis with mainly pleural involvement
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, 701 0192, Kurashiki, Japan
    J Infect Chemother 10:172-7. 2004
    ....
  75. ncbi request reprint [Clinical analysis of pulmonary tuberculosis detected during follow-up of other underlying diseases]
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki shi, Okayama 701 0192, Japan
    Kekkaku 79:1-6. 2004
    ....
  76. ncbi request reprint [A case of pulmonary Mycobacterium avium complex disease complicated by interstitial pneumonia with collagen vascular disease]
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki shi, Okayama 701 0192, Japan
    Kekkaku 78:487-90. 2003
    ....
  77. ncbi request reprint Rapid diagnosis of tuberculous pleuritis by a T-cell interferon-gamma release assay
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki, Japan
    Scand J Infect Dis 41:232-6. 2009
    ..to analyze MTB-specific T-cells in pleural effusion mononuclear cells by ELISpot is feasible in routine clinical practice and may be useful for a rapid and accurate diagnosis of tuberculous pleuritis...
  78. ncbi request reprint [Clinical analysis of pulmonary tuberculosis found by mass screening medical examination]
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki shi, Okayama 701 0192, Japan
    Kekkaku 78:383-7. 2003
    ..However, early diagnosis using bronchoscopy and early treatment seems to be useful, when Mycobacterium tuberculosis is not detected in the sputum...
  79. ncbi request reprint Etiology and management of community-acquired pneumonia in Asia
    Toshiharu Matsushima
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki, Japan
    Curr Opin Infect Dis 15:157-62. 2002
    ..pneumoniae. Some Asian countries have their own guidelines for community-acquired pneumonia, but these are written in their own languages...
  80. ncbi request reprint Effect of pazufloxacin mesilate on the serum concentration of theophylline
    Yoshihito Niki
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki, Okayama 701 0192, Japan
    J Infect Chemother 8:33-6. 2002
    ....
  81. ncbi request reprint Recurrent pneumonia due to persistent Chlamydia pneumoniae infection
    Naoyuki Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki, Okayama
    Intern Med 41:30-3. 2002
    ..These data indicate that new treatment strategies may be necessary to eradicate the organism in patients prone to persistent infection...
  82. ncbi request reprint [Current status of patients discharging Mycobacterium tuberculosis after admission to Kawasaki Medical School Hospital]
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki shi, Okayama 701 0192, Japan
    Kekkaku 80:57-62. 2005
    ..To investigate the current status of patients with tuberculosis in Kawasaki Medical School Hospital which has closed tuberculosis isolation ward and review the nosocomial tuberculosis infection control...
  83. ncbi request reprint Rapid diagnosis of tuberculous pericarditis by ELISPOT assay
    Yoshihiro Kobashi
    Department of Medicine, Kawasaki Medical School, Matsushima, Kurashiki, Japan
    Scand J Infect Dis 42:712-5. 2010
    ..The analysis of MTB-specific T-cells in PEMCs by ELISPOT may be useful for rapid decision-making in anti-tuberculous treatment...
  84. doi request reprint Pulmonary mucormycosis (Cunninghamella bertholletiae) with cavitation diagnosed using ultra-thin fibre-optic bronchoscopy
    Shin ichi Yagi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki, Okayama, Japan
    Respirology 13:312-4. 2008
    ..bertholletiae) complicating an immunocompromised state was diagnosed. Ultra-thin bronchoscopy is useful to diagnose complex pulmonary infections and more research is needed to verify its clinical indications and utility...
  85. ncbi request reprint Usefulness of QuantiFERON TB-2G, a diagnostic method for latent tuberculosis infection, in a contact investigation of health care workers
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki
    Intern Med 46:1543-9. 2007
    ..To evaluate the usefulness of QuantiFERON TB-2G (QFT-2G) for detecting latent tuberculosis infection (LTBI) in a contact investigation of health care workers...
  86. ncbi request reprint Infectious bulla of the lung caused by Mycobacterium intracellulare
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki 701 0192, Japan
    J Infect Chemother 11:293-6. 2005
    ..We report this case because there have been no previous reports in the literature of infectious lung bulla caused by M. intracellulare although there have been several reports dealing with lung bulla caused by Mycobacterium tuberculosis...
  87. ncbi request reprint The JRS guidelines for the management of community-acquired pneumonia in adults: an update and new recommendations
    Naoyuki Miyashita
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Kurashiki
    Intern Med 45:419-28. 2006
    ..In addition, the JRS guidelines have recommended short-term usage of antibiotics of an appropriate dose and pathogen-specific treatment using rapid diagnostic methods if possible...
  88. ncbi request reprint [A case of pulmonary adenocarcinoma coexistent with Igusa pneumoconiosis in one segment of the lung]
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, 577 Matsushima, Kurashiki
    Nihon Kokyuki Gakkai Zasshi 42:537-41. 2004
    ....
  89. ncbi request reprint Multifocal micronodular pneumocyte hyperplasia in a man with tuberous sclerosis
    Yoshihiro Kobashi
    Division of Respiratory Diseases, The Department of Medicine, Kurashiki Medical School, Japan
    Intern Med 44:462-6. 2005
    ....
  90. ncbi request reprint Evaluation of clinical dosage of gatifloxacin for respiratory tract infections in elderly patients based on pharmacokinetics/pharmacodynamics (PK/PD)
    Yoshihito Niki
    School of Medicine, Department of Clinical Infectious Diseases, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    J Infect Chemother 14:296-304. 2008
    ..The results of PPK analysis with the dosage management also support the efficacy of GFLX...
  91. ncbi request reprint Problem of Chlamydia pneumoniae serology today
    Naoyuki Miyashita
    Intern Med 42:919. 2003
  92. ncbi request reprint Synchronus presentation of early-stage small cell carcinoma and adenocarcinoma in the same lung lobe
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School, Matsushima, Kurashiki
    Intern Med 45:287-91. 2006
    ....
  93. ncbi request reprint [Evaluation of a new standard beta-glucan CSBG in the measurement of beta-glucan in plasma by alkaline treatment, chromogenic automated kinetic assay]
    Koichiro Yoshida
    Kansenshogaku Zasshi 78:519-21. 2004
  94. ncbi request reprint [Epidemic status of influenza virus between 2004-2005 and 2005-2006 at Kawasaki Medical School Hospital]
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
    Kansenshogaku Zasshi 81:435-40. 2007
    ..In spite of influenza vaccination inoculation in 20% of patients with influenza in 2004-2005 and 2005-2006, influenza spread. The prognosis of these patients, however, was comparatively good...
  95. ncbi request reprint [Mycoplasma pneumonia]
    Naoyuki Miyashita
    Nihon Naika Gakkai Zasshi 94:2261-6. 2005
  96. ncbi request reprint [Clinical utility of serum Candida mannan antigen detection kits using ELISA]
    Koichiro Yoshida
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
    Kansenshogaku Zasshi 76:536-41. 2002
    ..A larger number of cases should be evaluated to clarify the characteristics of these new kits...
  97. ncbi request reprint [A case of pulmonary adenosquamous cell carcinoma with thin-wall cavities]
    Yoshihiro Kobashi
    Division of Respiratory Diseases, Department of Medicine, Kawasaki Medical School
    Nihon Kokyuki Gakkai Zasshi 43:59-62. 2005
    ..Herein, we have reported a rare case of histological diagnosis of pulmonary adenosquamous cell carcinoma with cavity formation...
  98. ncbi request reprint [Cold syndrome and related diseases--re-examination of the syndrome]
    Keisuke Tomii
    Nihon Naika Gakkai Zasshi 97:190-9. 2008