Research Topics
Genomes and Genes | Taro MaruyamaSummaryAffiliation: Kawasaki Municipal Hospital Country: Japan Publications
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Detail Information
Publications
Multicenter prevention trial of slowly progressive type 1 diabetes with small dose of insulin (the Tokyo study): preliminary reportTaro Maruyama
Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama, Japan
Ann N Y Acad Sci 1005:362-9. 2003..We recommend avoiding SU treatment and instead administering insulin to NIDDM patients with high GADA titer...
Latent autoimmune diabetes in an adultTaro Maruyama
Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama shi, Japan
Ann N Y Acad Sci 1150:267-9. 2008....- Heterogeneity among patients with latent autoimmune diabetes in adultsTaro Maruyama
Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama, Japan
Diabetes Metab Res Rev 27:971-4. 2011.... - GAD-reactive T cells were mainly detected in autoimmune-related type 1 diabetic patients with HLA DR9Arata Itoh
Department of Internal Medicine, Keio Univ. School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
Ann N Y Acad Sci 1037:33-40. 2004..There was an association between T cell reactivity against GAD and HLA DR9 in Japanese type 1 diabetes... - FOXP3/Scurfin gene polymorphism is associated with adult onset type 1 diabetes in Japanese, especially in women and slowly progressive-type patientsKyoko Iwase
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Autoimmunity 42:159-67. 2009..The FOXP3/Scurfin gene is known to be a master gene of Tregs. Therefore, we tried to analyze the relation between the gene polymorphism and adult onset type 1 diabetes and its subtype in the Japanese population... - Evidence for association between vitamin D receptor BsmI polymorphism and type 1 diabetes in JapaneseAkira Shimada
Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
J Autoimmun 30:207-11. 2008..Based upon these results, we propose that it may be worthwhile to focus on subjects with the BB genotype of this gene polymorphism as having high risk for type 1 diabetes... - Frequency of CTLA-4 gene CT60 polymorphism may not be affected by vitamin D receptor gene Bsm I polymorphism or HLA DR9 in autoimmune-related type 1 diabetes in the JapaneseYasuhiko Kanazawa
Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Ann N Y Acad Sci 1079:251-6. 2006..The frequency of the CT60 GG genotype did not appear to be affected by either the VDR gene Bsm I large B polymorphism or HLA DR9... - Analysis of the HLA and non-HLA susceptibility loci in Japanese type 1 diabetesHisakuni Yamashita
Department of Endocrinology and Diabetes, Faculty of Medicine, Saitama Medical University, Saitama, Japan
Diabetes Metab Res Rev 27:844-8. 2011..We previously reported the associations of human leukocyte antigen (HLA) (DRB1 and DQB1), INS, CTLA4, IL2RA, ERBB3 and CLEC16A with Japanese type 1 diabetes (T1D). In this study, we jointly analysed these loci in addition to IFIH1 and IL7R... - Relation between development of nephropathy and the p22phox C242T and receptor for advanced glycation end product G1704T gene polymorphisms in type 2 diabetic patientsSeiko Matsunaga-Irie
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Diabetes Care 27:303-7. 2004..We studied the relation between the genotypes of the NADPH p22phox C242T and RAGE G1704T polymorphisms and the development of diabetic nephropathy in type 2 diabetic patients... - MCP-1 gene A-2518G polymorphism and carotid artery atherosclerosis in patients with type 2 diabetesSachiko Yuasa
Division of Metabolism, Department of Internal Medicine, Keio University School of Medicine, Shinjuku ku, Tokyo, Japan
Diabetes Res Clin Pract 86:193-8. 2009..The objective of this study was to evaluate the relation between the genotypes of the MCP-1 A-2518G polymorphism and the development of carotid atherosclerosis in patients with type 2 diabetes... - Detection of GAD-reactive CD4+ cells in so-called "type 1B" diabetesAkira Shimada
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Ann N Y Acad Sci 1005:378-86. 2003..In this study, we tried to demonstrate the existence of islet-associated antigen-specific T cells in type 1 diabetes without islet-associated autoantibody... - NKT cell frequency in Japanese type 1 diabetesYoichi Oikawa
Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
Ann N Y Acad Sci 1005:230-2. 2003..Here, we combined the data of NKT cell frequency in Ab+ and Ab- "classic" type 1 diabetic patients and then analyzed the relationship between NKT cell frequency and disease activity... - T-cell function in anti-GAD65(+)diabetes with residual beta-cell functionRyuji Suzuki
Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan
J Autoimmun 20:83-90. 2003.... - Expression levels of CXC chemokine receptors 3 are associated with clinical phenotype of type 1 diabetesSatoru Yamada
Department of Internal Medicine, Kitasato Institute Hospital, 5 9 1 Shirokane, Minato ku, Tokyo 108 8642, Japan
Ann N Y Acad Sci 1079:186-9. 2006..CXCR3 expression level is associated with the onset pattern of type 1 diabetes. Further studies are needed to clarify the role of chemokines in type 1 diabetes... - Stromal cell-derived factor-1 chemokine gene polymorphism is not associated with onset age of Japanese type 1 diabetesToshikatsu Shigihara
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Ann N Y Acad Sci 1005:328-31. 2003..The SDF-1 gene polymorphism was not associated with onset age (or onset pattern) of type 1 diabetes in Japanese. Further study is necessary to conclude whether SDF-1 gene polymorphism affects the onset age in type 1 diabetes in general... 
GAD65 autoantibody responses in Japanese latent autoimmune diabetes in adult patientsTaro Maruyama
Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama, Japan
Diabetes Care 31:1602-7. 2008..To determine whether development of insulin requirement in patients with latent autoimmune diabetes in adults (LADA) is accompanied with the emergence of a type 1 diabetes-like autoimmune response...- Association of PTPN22 haplotypes with type 1 diabetes in the Japanese populationMatsuo Taniyama
Division of Endocrinology and Metabolism, Department of Internal Medicine, Showa University, Fujigaoka Hospital, Yokohama, Japan
Hum Immunol 71:795-8. 2010..This significant haplotype distribution difference suggests that polymorphisms in the PTPN22 gene other than R620W are involved in either predisposition to or protection from T1D in the Japanese population... - Vitamin D receptor gene polymorphism affects onset pattern of type 1 diabetesYoshiko Motohashi
Department of Internal Medicine, Keio University School of Medicine, Tokyo 160 8582, Japan
J Clin Endocrinol Metab 88:3137-40. 2003..Assessment of this VDR gene polymorphism may contribute to prediction of the onset pattern in individuals with a high risk of type 1 diabetes... - Nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase) P22 Phox C242T gene polymorphism in type 1 diabetesSeiko Matsunaga
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Ann N Y Acad Sci 1005:324-7. 2003..In conclusion, the p22 phox C242T gene polymorphism did not affect the susceptibility to and clinical course of Japanese type 1 diabetes... - Relationship between proinsulin-to-insulin ratio and advanced glycation endproducts in Japanese type 2 diabetic subjectsYoshifumi Saisho
Department of Internal Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku ku, Tokyo 160 8582, Japan
Diabetes Res Clin Pract 78:182-8. 2007..Therefore, in the present study we investigated the relationship between the P/I ratio, glycation and oxidative stress markers in patients with T2DM, using newly developed intact chemiluminescent immunoassay for proinsulin... - High frequency of valpha24(+) vbeta11(+) T-cells observed in type 1 diabetesYoichi Oikawa
Department of Internal Medicine, Keio University School of Medicine, Tokyo, Japan
Diabetes Care 25:1818-23. 2002..In this study, we measured the frequency of peripheral Valpha24(+) Vbeta11(+) T-cells, which include human NKT cells, in Japanese diabetic patients... - [Pharmacotherapies for type 1 diabetes mellitus]Taro Maruyama
Department of Internal Medicine, Saitama Social Insurance Hospital
Nippon Rinsho 60:190-5. 2002 - Anti-insulin-like growth factor-1 autoantibodies in type 1 diabetesTaro Maruyama
Department of Internal Medicine, Saitama Social Insurance Hospital, Saitama, 336 0002, Japan
Ann N Y Acad Sci 958:267-70. 2002..Further study is necessary to clarify whether anti-IGF-1 autoantibodies are existent in human type 1 diabetes and to determine the significance of IGF-1 in the pathogensesis of type 1 diabetes... - Time-course changes in nerve conduction velocity (NCV) in type 2 diabetesJiro Morimoto
Saitama Social Insurance Hospital the Department of Internal Medicine, Saitama, Japan
J Diabetes Complications 26:237-40. 2012..In addition, the natural course of diabetic sensorimotor polyneuropathy (DSPN) was discussed based on the findings... - Serum apolipoprotein j in health, coronary heart disease and type 2 diabetes mellitusTakeshi Kujiraoka
Department of Advanced Medical Technology and Development, BML Inc, Saitama, Japan
J Atheroscler Thromb 13:314-22. 2006..These findings suggest that apo J may be anti-atherogenic in humans, and that its concentration is raised by Type 2 diabetes... - De novo CD5+ diffuse large B cell lymphoma with basophilia in the peripheral blood: successful treatment with autologous peripheral blood stem cell transplantationMichihide Tokuhira
Division of Hematology, Department of Internal Medicine, Saitama Medical Center, Saitama Medical University, Kawagoe, Saitama, Japan
Am J Hematol 82:162-7. 2007..To the best of our knowledge, this is the first report of a case of de novo CD5+ DLBCL showing marked elevation of the PB basophil count... - Insulin intervention to preserve beta cells in slowly progressive insulin-dependent (type 1) diabetes mellitusTetsuro Kobayashi
Department of Endocrinology and Metabolism, Toranomon Hospital, Okinaka Memorial Institute for Medical Research, Tokyo, 105 8470, Japan
Ann N Y Acad Sci 958:117-30. 2002..Insulin intervention to preserve beta cell dysfunction in SPIDDM is effective and safe in patients with preserved beta cell function and high GADAb titers at the initiation of insulin... - Immunopathological and genetic features in slowly progressive insulin-dependent diabetes mellitus and latent autoimmune diabetes in adultsTetsuro Kobayashi
Third Department of Internal Medicine, School of Medicine, University of Yamanashi, Tamaho, Yamanashi 409 3898, Japan
Ann N Y Acad Sci 1079:60-6. 2006.... - High titer of autoantibodies to GAD identifies a specific phenotype of adult-onset autoimmune diabetes: response to Buzzetti et alTetsuro Kobayashi
Diabetes Care 30:e126; author reply e127. 2007 - Insulin intervention in slowly progressive insulin-dependent (type 1) diabetes mellitusTaro Maruyama
Third Department of Internal Medicine, Interdisciplinary Graduate School of Medicine and Engineering, University of Yamanashi, 1110 Shimokato, Chuo, Yamanashi, Japan
J Clin Endocrinol Metab 93:2115-21. 2008.... - [Association between intraabdominal disease and type 1 diabetes]Yoshinori Nakagawa
Department of Internal Medicine, Keio University, School of Medicine
Nippon Rinsho 60:641-5. 2002 - Fulminant type 1 diabetes: a nationwide survey in JapanAkihisa Imagawa
Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
Diabetes Care 26:2345-52. 2003..Flu-like symptoms are characteristic of disease onset. Metabolic derangement is more severe in this subtype than in autoimmune type 1 diabetes... - The ratio of serum paraoxonase/arylesterase activity using an improved assay for arylesterase activity to discriminate PON1(R192) from PON1(Q192)Mamoru Nakanishi
Department of Clinical Pathology, Hyogo College of Medicine, Hyogo, Japan
J Atheroscler Thromb 10:337-42. 2003..Therefore, when conducting epidemiological or mechanistic studies that examine the role of PON1 in organophosphorus or lipid metabolism, this ratio is more useful and informative than a PCR-based genotype alone... - The association of CTLA4 polymorphism with type 1 diabetes is concentrated in patients complicated with autoimmune thyroid disease: a multicenter collaborative study in JapanHiroshi Ikegami
Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Yamadaoka, Suita, Osaka 565 0871, Japan
J Clin Endocrinol Metab 91:1087-92. 2006..The low incidence of type 1 diabetes in Asian countries, however, makes it difficult to perform large-scale studies in Asia... - A sensitive radioimmunoassay of insulin autoantibody: reduction of non-specific binding of [125I]insulinHiroshi Murayama
Immunology Laboratory, Diagnostics Department, Yamasa Corporation, 2 10 1 Araoi cho, Choshi, Chiba 288 0056, Japan
J Autoimmun 26:127-32. 2006..7% and 30.9% with or without insulin competition, respectively, whereas that of the former assay without ProClin300 was only 20.0%... - Systematic search for single nucleotide polymorphisms in a lymphoid tyrosine phosphatase gene (PTPN22): association between a promoter polymorphism and type 1 diabetes in Asian populationsEiji Kawasaki
Department of Metabolism Diabetes and Clinical Nutrition, Nagasaki University Hospital of Medicine and Dentistry, Nagasaki, Japan
Am J Med Genet A 140:586-93. 2006..In conclusion, the type 1 diabetes association with PTPN22 is confirmed, but it cannot be attributed solely to the +1858C > T variant. The promoter -1123G > C SNP is a more likely causative variant in PTPN22... - Nationwide survey to compare the prevalence of transient elevation of liver transaminase during treatment of diabetic ketosis or ketoacidosis in new-onset acute and fulminant type 1 diabetes mellitusHiroko Takaike
Diabetes Center, Tokyo Women s Medical University, Japan
Ann Med 40:395-400. 2008..The aim of the present study was to assess the cause and prevalence of the elevation of liver transaminase levels in fulminant and acute-onset type 1 diabetic patients experiencing diabetic ketosis or ketoacidosis... - Insulin gene/IDDM2 locus in Japanese type 1 diabetes: contribution of class I alleles and influence of class I subdivision in susceptibility to type 1 diabetesTakuya Awata
Division of Endocrinology and Diabetes, Department of Medicine, Saitama Medical University, 38 Morohongo, Moroyama, Iruma gun, Saitama 350 0495, Japan
J Clin Endocrinol Metab 92:1791-5. 2007..It is suggested that insulin autoimmunity plays an important role in the development of type 1 diabetes in humans. However, the association between insulin gene (INS) region (IDDM2) and type 1 diabetes has been uncertain in Asians...