Yoshihiro Kobashi

..We evaluated the clinical usefulness of glycopeptidolipid (GPL) core antigen for diagnosing Mycobacterium avium complex (MAC) pulmonary disease (MAC-PD), including patients with clinically suspected MAC-PD...

..Clarithromycin and levofloxacin were administered after identification of M. kyorinense using a 16S rRNA gene sequence. Subsequently his symptoms improved following combined therapy with clarithromycin and levofloxacin...

..Good clinical efficacy, including the sputum conversion rate, was obtained with an increased dose of CAM in the later period. We speculate that the increased dose of CAM influenced the good clinical effect in both periods...

..TB] as the supportive method for diagnosing pulmonary tuberculosis (TB)...

..pneumoniae pneumonia from Streptococcus pneumoniae pneumonia...

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..To evaluate the usefulness of QuantiFERON TB-2G (QFT-2G) for detecting latent tuberculosis infection (LTBI) in a contact investigation of health care workers...

..We must perform the acid-fast bacilli examination for patients who have a fever and continuous cough, and antituberculous drugs should be administered as soon as possible when the results are positive...

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..We prospectively evaluated the usefulness of the QuantiFERON TB-2G (QFT-2G) compared to that of tuberculin skin test (TST) as a supportive method of diagnosing pulmonary tuberculosis (TB) without invasive examinations...

..We must consider MMPH as part of the differential diagnosis along with multiple AAH when multiple small nodules with ground-glass opacity were observed on chest CT in patients with TSC...

..The duration of hospitalization was 19.6 days. The clinical effect of treatment was comparatively good (93%), and the prognosis was also good (mortality rate 7%)...

..An aging population, increased use of immunosuppressive therapy and an increase in patients with risk factors for tuberculosis have induced changes in the clinical features of pulmonary tuberculosis in Japan...

..As the origin and pathology of inflammatory pseudotumor is not clearly understood, there has recently been some confusion regarding the diagnosis of inflammatory pseudotumor...

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..We suspect that they were infected by different species of Mycobacterium avium in the same environment rather than by droplet infection from the younger brother to the older brother...

..To investigate the characteristic clinical features of chronic necrotizing pulmonary aspergillosis (CNPA) as a complication of pulmonary Mycobacterium avium complex (MAC) disease...

..We have reported a peculiar case of pulmonary M. intracellulare disease, detected at the onset of left secondary pneumothorax caused by pulmonary emphysema, which required differentiation from pulmonary adenocarcinoma...

..Although the ATS has not yet recommended routine drug susceptibility testing of CAM, we believe that drug susceptibility testing of CAM should be performed before the initial treatment is undertaken for pulmonary MAC disease...

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..In conclusion, both blood assays seemed to be more useful than TST for the identification of patients with active TB disease. However, neither of the 2 blood tests appears to provide any certainty regarding the cure of infection...

..This study investigated the clinical and pathological findings of lung disease in tuberous sclerosis complex (TSC) as previously reported in Japan...

..Therefore, we studied the usefulness of two commercial IFN-gamma assays (QuantiFERON TB-2G (QFT-2G) and T-SPOT.TB tests) for monitoring clinical efficacy...

..However, he died of respiratory failure and septic shock. There are few case reports of pulmonary lesion with septicemia due to Mycobacterium massiliense...

..However, there was an overlap in the IFN-gamma levels between active TB disease and LTBI groups. Therefore, it would be difficult to use the QFT-2G test to completely discriminate active TB disease from LTBI...

..The analysis of MTB-specific T-cells in PEMCs by ELISPOT may be useful for rapid decision-making in anti-tuberculous treatment...

..We analyzed the clinical characteristics of pulmonary infection due to Mycobacterium abscessus...

..Although the positive rate on QFT-2G test decreased with age in adults, it is thought to be a useful supportive diagnostic method for active TB disease compared to the TST, except in younger patients aged < or =9 years old...

..To evaluate the clinical usefulness of the QuantiFERON TB-2G (QFT-2G) test in patients with non-tuberculous mycobacterial (NTM) disease without a previous history of tuberculosis (TB)...

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..The QFT-2G test may be useful as a rapid supportive diagnostic method for pulmonary infection due to MK possessing the same MTB-specific antigen...

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..To evaluate the clinical utility of the T-SPOT.TB test for patients with indeterminate results on the QFT-2G test...

..We also studied when to terminate the combined chemotherapy...

..When scoring QuantiFERON TB-2G test results for elderly and immunocompromised patients, one must be careful because the possibility of obtaining determinate results may be low even if the test is repeated...

..to analyze MTB-specific T-cells in pleural effusion mononuclear cells by ELISpot is feasible in routine clinical practice and may be useful for a rapid and accurate diagnosis of tuberculous pleuritis...

..To evaluate transitional changes in QuantiFERON TB-2G (QFT-2G) test results in the serial testing on the same patients and to reevaluate the optimal threshold of positive response of QFT-2G test as a cure of TB infection...

..To evaluate clinical findings of patients with a solitary pulmonary nodule in Japan caused by pulmonary Mycobacterium avium complex (MAC) disease...

..The urinary antigen detection kit for Streptococcus pneumoniae was tested...

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..This patient was treated with antituberculous drugs 3 days after admission, but he died of multiple organ failure 6 days after admission...

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..We report a rare case with a solitary nodule caused by pulmonary Mycobacterium intracellulare infectious disease which is indicative of lung cancer...

..As the causative pathogen, Mycobacterium avium complex (MAC) disease should be considered in the differential diagnosis of a rapidly increasing solitary nodule through this peculiar case of pulmonary MAC disease...

..Therefore, we anticipate the development of new companion drugs for pulmonary MAC disease that are as active as CAM...

..It can be measured with on- and off-line methods. In the latter, sample storage is possible; this is useful in Japan, because the number of facilities in which this instrument has been installed is limited...

..The usefulness of sputum Gram stain and culture in guiding microbiological diagnosis of community-acquired pneumonia (CAP) is controversial. We evaluated the role of sputum examination at a university teaching hospital...

..To investigate the current status of patients with tuberculosis in Kawasaki Medical School Hospital which has closed tuberculosis isolation ward and review the nosocomial tuberculosis infection control...

..Histopathological examination of transbronchial biopsy specimens demonstrated cryptococcal organisms. After fluconazole therapy for 4 months, the infiltrate had decreased in size and the bronchial polypoid lesions had disappeared...

..Because penicillin antibiotics were administered for a long time for all patients after obtaining a definite diagnosis, the prognosis was good and there were no relapse...

..The difficulty of treatment for pulmonary Mycobacterium avium complex (MAC) in Japan...

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..pneumoniae and Haemophilus influenzae was higher among the hospitalized patients. Recognition of these results will allow prompt and appropriate antimicrobial therapy to be provided using Japanese CAP guidelines...

..Mycoplasma pneumoniae is one of the most common causes of community-acquired pneumonia (CAP). This infection occurs predominantly in school-aged children and younger adults, but may also occur in the elderly...

..Concerning treatment, although corticosteroid therapy was administered, his clinical symptoms and abnormal chest shadow have not changed...

..However, this combined therapy was unsatisfactory compared to the clinical effect for pulmonary tuberculosis. The development of new companion drugs for MAC pulmonary diseases is needed...

..Then, the specificity of new MK assay was improved by using improved alkaline pretreatment reagent, without decreasing the sensitivity. Thus, the present findings indicate that the new MK assay is clinically quite useful...

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..Smear test of the resected tissue was positive for acid-fast bacilli and culture was positive for mycobacteria, which was identified as Mycobacterium kansasii. There are a few case reports of solitary nodule due to M. kansasii...

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..The study evaluated a newly developed ELISA (Hitazyme Chlamydophila pneumoniae) for detecting anti-C. pneumoniae-specific IgM antibody, by comparing the ELISA assay to a microimmunofluorescence (MIF) test and immunoblotting...

..pneumoniae pneumonia is rarely encountered, although self-limiting upper respiratory tract infections due to C. pneumoniae are common. Thus, most self-limiting C. pneumoniae pneumonia may be missed when symptoms are minimal...

..Finally, to measure plasma beta-glucan levels accurately, non-specific reactions should be excluded as possible by further improvement of measurement methods...

..Our results indicated that C. pneumoniae may not be the primary cause of community-acquired pneumonia but it might descript the normal clearance mechanisms, enabling other pathogens to invade...

..She is currently alive and ambulatory and has remained disease-free for two years. This multimodal treatment may be a good treatment option for locally advanced thymic carcinoma...

..Herein, we have reported a rare case of histological diagnosis of pulmonary adenosquamous cell carcinoma with cavity formation...

..In spite of influenza vaccination inoculation in 20% of patients with influenza in 2004-2005 and 2005-2006, influenza spread. The prognosis of these patients, however, was comparatively good...

..The aim of this study was to evaluate the clinicopathological features of lung cancer resembling malignant pleural mesothelioma...

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..Based on positive staining method with specific monoclonal antibodies against G-CSF, it was considered that the leukocytosis was caused by G-CSF producing tumor...

..Therefore, the development of new companion drugs for the disease with mycobacteria other than M. tuberculosis is needed...

..However, early diagnosis using bronchoscopy and early treatment seems to be useful, when Mycobacterium tuberculosis is not detected in the sputum...

..Therefore, treatment should be considered against resistant microoganisms such as MRSA...

..We report a rare case of the coexistence of metastatic lung cancer originating from tongue cancer and active pulmonary tuberculosis diagnosed in the same large cavitary lesion...

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..We consider this problem to be not so difficult considering the progress in diagnostic methods for M. tuberculosis...

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..The RFLP analysis revealed the same pattern in both mother and son, and confirmed that this was a case of mixed pulmonary infection passed from son to mother...

..The delayed administration of adequate antibiotics may contribute to the severity of M. pneumoniae pneumonia. Early corticosteroid therapy with adequate antibiotics should be considered...

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..We report this case because there have been no previous reports in the literature of infectious lung bulla caused by M. intracellulare although there have been several reports dealing with lung bulla caused by Mycobacterium tuberculosis...

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..We considered this a case of interest because 20 months after the diagnosis of pulmonary aspergillosis, a mixed pulmonary infection of Mycobacterium tuberculosis and Aspergillus sp. was identified...

..CONCLUSIONS We suggest that the existance and kind of underlying diseases significantly affect the method of treatment and the prognosis...

..By so doing, unnecessary initiation of anti fugal therapy in response to non-specific reactions can be avoided. Further prospective and radical studies of non-specific reactions in the alkaline-kinetic assay are necessary...

..Both endobronchial and endovascular stenting prior to antitumor therapy may be beneficial in the treatment of locally advanced cases of lung cancer...

..We have reported on this case of silicoproteinosis with pneumothorax which progressed for over one year and which showed unusual radiological findings dissimilar to those of primary pulmonary alveolar proteinosis...