Kazuhiro Kawamura

Summary

Country: Japan

Publications

  1. pmc Suppression of choriocarcinoma invasion and metastasis following blockade of BDNF/TrkB signaling
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, St Marianna University School of Medicine, Kanagawa, 216 8511, Japan Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, 010 8543, Japan
    Cancer Med 2:849-61. 2013
  2. pmc Inhibition of uterine sarcoma cell growth through suppression of endogenous tyrosine kinase B signaling
    Kenichi Makino
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita, Japan
    PLoS ONE 7:e41049. 2012
  3. doi Suppression of hydatidiform molar growth by inhibiting endogenous brain-derived neurotrophic factor/tyrosine kinase B signaling
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Endocrinology 153:3972-81. 2012
  4. doi Pre-ovulatory LH/hCG surge decreases C-type natriuretic peptide secretion by ovarian granulosa cells to promote meiotic resumption of pre-ovulatory oocytes
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita 010 8543, Japan
    Hum Reprod 26:3094-101. 2011
  5. doi Brain-derived neurotrophic factor/tyrosine kinase B signaling regulates human trophoblast growth in an in vivo animal model of ectopic pregnancy
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Endocrinology 152:1090-100. 2011
  6. ncbi Gonadotropin-releasing hormone I analog acts as an antiapoptotic factor in mouse blastocysts
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Hondo 1 1 1, Akita 010 8543, Japan
    Endocrinology 146:4105-16. 2005
  7. doi Brain-derived neurotrophic factor promotes implantation and subsequent placental development by stimulating trophoblast cell growth and survival
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita 010 8543 Japan
    Endocrinology 150:3774-82. 2009
  8. ncbi Tumor necrosis factor regulation of apoptosis in mouse preimplantation embryos and its antagonism by transforming growth factor alpha/phosphatidylionsitol 3-kinase signaling system
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita, 010 8543 Japan
    Biol Reprod 76:611-8. 2007
  9. ncbi Regulation of preimplantation embryo development by brain-derived neurotrophic factor
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita, 010 8543, Japan
    Dev Biol 311:147-58. 2007
  10. doi Completion of Meiosis I of preovulatory oocytes and facilitation of preimplantation embryo development by glial cell line-derived neurotrophic factor
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita 010 8543, Japan
    Dev Biol 315:189-202. 2008

Collaborators

Detail Information

Publications37

  1. pmc Suppression of choriocarcinoma invasion and metastasis following blockade of BDNF/TrkB signaling
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, St Marianna University School of Medicine, Kanagawa, 216 8511, Japan Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita, 010 8543, Japan
    Cancer Med 2:849-61. 2013
    ..Inhibition of this signaling could serve as the basis to develop a novel therapy for patients with choriocarcinoma. ..
  2. pmc Inhibition of uterine sarcoma cell growth through suppression of endogenous tyrosine kinase B signaling
    Kenichi Makino
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita, Japan
    PLoS ONE 7:e41049. 2012
    ..Our findings indicated that endogenous signaling of the TrkB pathway contributed to uterine sarcoma cell growth, and inhibition of TrkB signaling in these tumors could provide a novel medical therapy for patients with uterine sarcomas...
  3. doi Suppression of hydatidiform molar growth by inhibiting endogenous brain-derived neurotrophic factor/tyrosine kinase B signaling
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Endocrinology 153:3972-81. 2012
    ..Inhibition of BDNF/TrkB signaling could provide a novel medical treatment for hydatidiform mole...
  4. doi Pre-ovulatory LH/hCG surge decreases C-type natriuretic peptide secretion by ovarian granulosa cells to promote meiotic resumption of pre-ovulatory oocytes
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University Graduate School of Medicine, Akita 010 8543, Japan
    Hum Reprod 26:3094-101. 2011
    ..However, regulation of NPPC/CNP expression during the pre-ovulatory period and their regulation by the LH surge have not been investigated...
  5. doi Brain-derived neurotrophic factor/tyrosine kinase B signaling regulates human trophoblast growth in an in vivo animal model of ectopic pregnancy
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Endocrinology 152:1090-100. 2011
    ....
  6. ncbi Gonadotropin-releasing hormone I analog acts as an antiapoptotic factor in mouse blastocysts
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Hondo 1 1 1, Akita 010 8543, Japan
    Endocrinology 146:4105-16. 2005
    ..These results indicate that GnRH-I, acting as an antiapoptotic factor, is an important growth factor in development of mouse blastocysts...
  7. doi Brain-derived neurotrophic factor promotes implantation and subsequent placental development by stimulating trophoblast cell growth and survival
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita 010 8543 Japan
    Endocrinology 150:3774-82. 2009
    ..Our findings suggested important autocrine/paracrine roles of the BDNF/TrkB signaling system during implantation, subsequent placental development, and fetal growth by increasing trophoblast cell growth and survival...
  8. ncbi Tumor necrosis factor regulation of apoptosis in mouse preimplantation embryos and its antagonism by transforming growth factor alpha/phosphatidylionsitol 3-kinase signaling system
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita, 010 8543 Japan
    Biol Reprod 76:611-8. 2007
    ....
  9. ncbi Regulation of preimplantation embryo development by brain-derived neurotrophic factor
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita, 010 8543, Japan
    Dev Biol 311:147-58. 2007
    ..Our findings suggested that BDNF signaling plays important paracrine roles during blastocyst development by promoting the development of preimplantation embryos...
  10. doi Completion of Meiosis I of preovulatory oocytes and facilitation of preimplantation embryo development by glial cell line-derived neurotrophic factor
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita 010 8543, Japan
    Dev Biol 315:189-202. 2008
    ..Our findings suggest potential paracrine roles of GDNF in the promotion of completion of meiosis I and the development of early embryos...
  11. ncbi Survivin contributes to the anti-apoptotic activities of transforming growth factor alpha in mouse blastocysts through phosphatidylinositol 3'-kinase pathway
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Japan
    Biol Reprod 73:1094-101. 2005
    ..Thus, TGFA inhibits apoptosis in mouse blastocysts through upregulation of survivin expression via the PI3K pathway...
  12. doi Paracrine regulation of the resumption of oocyte meiosis by endothelin-1
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita 010 8543, Japan
    Dev Biol 327:62-70. 2009
    ....
  13. ncbi Ghrelin inhibits the development of mouse preimplantation embryos in vitro
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita 010 8543, Japan
    Endocrinology 144:2623-33. 2003
    ..Thus, ghrelin may act as a peripheral factor to avoid the excess metabolic demands imposed by pregnancy during malnutritional states...
  14. ncbi The role of leptin during the development of mouse preimplantation embryos
    K Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Hondo 1 1 1, Akita 010 8543, Japan
    Mol Cell Endocrinol 202:185-9. 2003
    ..These findings raise the possibility that leptin regulates the development of mouse preimplantation embryo through a paracrine pathway...
  15. ncbi Leptin promotes the development of mouse preimplantation embryos in vitro
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Hondo 1 1 1, Akita 010 8543, Japan
    Endocrinology 143:1922-31. 2002
    ..These findings raise the possibility of a paracrine/autocrine leptin signaling system regulating the development of mouse preimplantation embryo...
  16. pmc Kit ligand promotes first polar body extrusion of mouse preovulatory oocytes
    Yinghui Ye
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita, Japan
    Reprod Biol Endocrinol 7:26. 2009
    ..The purpose of this study is to investigate the roles of KITL in the nuclear and cytoplasmic maturation of preovulatory mouse oocytes...
  17. ncbi Survivin acts as an antiapoptotic factor during the development of mouse preimplantation embryos
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita, 010 8543, Japan
    Dev Biol 256:331-41. 2003
    ..These results indicate that survivin is an essential antiapoptotic gene expressed in preimplantation embryos and could protect the embryos from apoptosis by inhibiting an apoptotic pathway involving caspases...
  18. ncbi Expression of Smac/DIABLO in mouse preimplantation embryos and its correlation to apoptosis and fragmentation
    Yoko Honda
    Division of Obstetrics and Gynecology, Department of Reproductive and Developmental Medicine, Akita University School of Medicine, 1 1 1, Hondo, Akita 010 8543, Japan
    Mol Hum Reprod 11:183-8. 2005
    ..These observations indicate that the Smac/DIABLO is involved in the fragmentation and apoptosis of preimplantation embryos...
  19. doi Inhibition of brain-derived neurotrophic factor/tyrosine kinase B signaling suppresses choriocarcinoma cell growth
    Nanami Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, 1 1 1 Hondo, Akita 010 8543, Japan
    Endocrinology 151:3006-14. 2010
    ..Thus, autocrine signaling of the BDNF/TrkB system is important for human choriocarcinoma cell growth, and inhibition of BDNF/TrkB signaling in these cells could provide a novel therapy for patients with choriocarcinoma...
  20. ncbi Leptin and ObRa/MEK signalling in mouse oocyte maturation and preimplantation embryo development
    Yinghui Ye
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Akita, Japan
    Reprod Biomed Online 19:181-90. 2009
    ....
  21. ncbi HCG up-regulates survivin mRNA in human granulosa cells
    Yukiyo Kumazawa
    Division of Obstetrics and Gynecology, Department of Reproductive and Developmental Medicine, Akita University School of Medicine, 1 1 1 Hondo, Akita, 010 8543, Japan
    Mol Hum Reprod 11:161-6. 2005
    ..These results suggest that survivin is involved in supporting luteal function, and that HCG contributes to this role...
  22. pmc Hippo signaling disruption and Akt stimulation of ovarian follicles for infertility treatment
    Kazuhiro Kawamura
    Department of Obstetrics and Gynecology and Department of Advanced Reproductive Medicine, St Marianna University School of Medicine, Kawasaki, Kanagawa 216 8511, Japan
    Proc Natl Acad Sci U S A 110:17474-9. 2013
    ....
  23. ncbi Xanthine oxidase inhibitors suppress testicular germ cell apoptosis induced by experimental cryptorchidism
    Akiko Kumagai
    Department of Obstetrics and Gynecology, Akita University School of Medicine, 1 1 1 Hondo, Akita City, 010 0041 Japan
    Mol Hum Reprod 8:118-23. 2002
    ..In conclusion, xanthine oxidase inhibitors can inhibit germ cell apoptosis induced by experimental cryptorchidism, and may be considered for treatment of male infertility associated with heat stress...
  24. ncbi Expression of LDL receptor and uptake of LDL in mouse preimplantation embryos
    N Sato
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Hondo 1 1 1, Akita 010 8543, Japan
    Mol Cell Endocrinol 202:191-4. 2003
    ..The aim of this study is to address the role of low-density lipoprotein (LDL) on mouse preimplantation embryos...
  25. doi Does presence of prostate cancer affect serum testosterone levels in clinically localized prostate cancer patients?
    T Imamoto
    Department of Urology, Graduate School of Medicine, Chiba University, Chuo Ku, Chiba, Japan
    Prostate Cancer Prostatic Dis 12:78-82. 2009
    ..This study suggests that serum T levels are altered by the presence of PCa, supporting the possibility that PCa may inhibit serum T levels with negative feedback in the hypothalamic-pituitary axis...
  26. pmc Analysis of late-onset ovarian insufficiency after ovarian surgery: retrospective study with 75 patients of post-surgical ovarian insufficiency
    Seido Takae
    Department of Obstetrics and Gynecology, St Marianna University School of Medicine, Kawasaki City, Kanagawa Prefecture, Japan
    PLoS ONE 9:e98174. 2014
    ..It is particularly important to monitor ovarian reserve long-term for patients who wish to conceive in the future and to suggest a variety of infertility treatments appropriate for their ovarian reserve. ..
  27. ncbi Chaperonin 10 in the rat oocytes and early embryos: its expression and activity for early pregnancy factor
    K Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine, Japan
    Am J Reprod Immunol 44:242-8. 2000
    ..The aim of this study was to investigate the expression of chaperonin (cpn) 10 and cpn 60 mRNA in oocytes or embryos, and to further explore the possibility that early pregnancy factor (EPF) is identical with cpn 10...
  28. pmc Promotion of human early embryonic development and blastocyst outgrowth in vitro using autocrine/paracrine growth factors
    Kazuhiro Kawamura
    Program of Reproductive and Stem Cell Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California, United States of America
    PLoS ONE 7:e49328. 2012
    ..This approach is valuable for infertility treatment and future derivation of patient-specific embryonic stem cells...
  29. ncbi Expression of Fas and Fas ligand mRNA in rat and human preimplantation embryos
    K Kawamura
    Department of Obstetrics and Gynecology, Akita University School of Medicine and Akita University College of Allied Medical Science, Akita, 010 0041 Japan
    Mol Hum Reprod 7:431-6. 2001
    ..Because simultaneous expression of Fas and Fas L mRNA occurred in 2-cell rat embryos and in 4-cell human embryos, the Fas-Fas L system might be involved in the apoptotic pathway in the early embryos of these species...
  30. ncbi Paracrine regulation of ovarian granulosa cell differentiation by stanniocalcin (STC) 1: mediation through specific STC1 receptors
    Ching Wei Luo
    Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    Mol Endocrinol 18:2085-96. 2004
    ..The observed STC1 suppression of progesterone, but not estradiol, production further suggests the potential role of this paracrine hormone as a luteinization inhibitor...
  31. ncbi Intraovarian tumor necrosis factor-related weak inducer of apoptosis/fibroblast growth factor-inducible-14 ligand-receptor system limits ovarian preovulatory follicles from excessive luteinization
    Ananya De
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    Mol Endocrinol 20:2528-38. 2006
    ..The present findings demonstrate a suppressive role of the TWEAK/Fn14 signaling system in the ovary. Following gonadotropin induction of ovulation, Fn14 is induced and could protect preovulatory follicles from excessive luteinization...
  32. ncbi N-WASP and WAVE2 acting downstream of phosphatidylinositol 3-kinase are required for myogenic cell migration induced by hepatocyte growth factor
    Kazuhiro Kawamura
    Department of Biology, Faculty of Science, Graduate School of Science and Technology, Chiba University, Yayoicho, Inageku, Chiba 263 8522, Japan
    J Biol Chem 279:54862-71. 2004
    ..These results imply that both N-WASP and WAVE2, which are activated downstream of phosphati-dylinositol 3-kinase, are required for the migration through the lamellipodial formation of C2C12 cells induced by HGF...
  33. pmc Ovarian brain-derived neurotrophic factor (BDNF) promotes the development of oocytes into preimplantation embryos
    Kazuhiro Kawamura
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Proc Natl Acad Sci U S A 102:9206-11. 2005
    ..Treatment with BDNF could condition the cultured oocytes for optimal progression into the totipotent blastocysts...
  34. pmc Neonatal lethality of LGR5 null mice is associated with ankyloglossia and gastrointestinal distension
    Hiroki Morita
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Mol Cell Biol 24:9736-43. 2004
    ....
  35. ncbi Relaxin research in the postgenomic era
    Kazuhiro Kawamura
    Division of Reproductive Health, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Ann N Y Acad Sci 1041:1-7. 2005
    ..Our data demonstrate the importance of the INSL3-LGR8 paracrine system in mediating gonadotropic actions in both ovary and testis...
  36. pmc Paracrine regulation of mammalian oocyte maturation and male germ cell survival
    Kazuhiro Kawamura
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94305 5317, USA
    Proc Natl Acad Sci U S A 101:7323-8. 2004
    ....
  37. ncbi Leucine-rich repeat-containing, G protein-coupled receptor 4 null mice exhibit intrauterine growth retardation associated with embryonic and perinatal lethality
    Sabine Mazerbourg
    Division of Reproductive Biology, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, California 94305 5317, USA
    Mol Endocrinol 18:2241-54. 2004
    ..The observed pre- and postnatal lethality of LGR4 null mice illustrates the importance of the LGR4 signaling system for the survival and growth of animals during the perinatal stage...