Tomohiro Katsuya

Summary

Country: Japan

Publications

  1. ncbi Gene polymorphism of angiotensin II type 1 and type 2 receptors
    Tomohiro Katsuya
    Katsuya Clinic, Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, 2 17 21 Nanamatsu cho, Amagasaki, Hyogo 660 0052, Japan
    Curr Pharm Des 19:2996-3001. 2013
  2. ncbi Genetic basis of hypertension for the development of tailored medicine
    Tomohiro Katsuya
    Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 32:643-8. 2009
  3. ncbi Association between hepatocyte growth factor gene polymorphism and essential hypertension
    Masaharu Motone
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 27:247-51. 2004
  4. doi Variation in OSBPL10 is associated with dyslipidemia
    Hiroshi Koriyama
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Yamada oka, Suita, Japan
    Hypertens Res 33:511-4. 2010
  5. ncbi A common polymorphism of uncoupling protein 2 gene is associated with hypertension
    Quihe Ji
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Hypertens 22:97-102. 2004
  6. doi Gene polymorphism of myospryn (cardiomyopathy-associated 5) is associated with left ventricular wall thickness in patients with hypertension
    Hironori Nakagami
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Hypertens Res 30:1239-46. 2007
  7. ncbi Hypoadiponectinemia is an independent risk factor for hypertension
    Yoshio Iwashima
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertension 43:1318-23. 2004
  8. ncbi Association between angiotensin II type 1 receptor gene polymorphism and essential hypertension: the Ohasama Study
    Ken Sugimoto
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 27:551-6. 2004
  9. doi -374 T/A polymorphism in RAGE gene is associated with onset of diabetes mellitus, atherosclerosis, and renal dysfunction in patients with hypertension
    Tatsuo Kawai
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Clin Exp Hypertens 35:236-41. 2013
  10. ncbi Single nucleotide polymorphisms in the interleukin-6 gene associated with blood pressure and atherosclerosis in a Japanese general population
    Chihiro Tanaka
    Research Institute, National Cardiovascular Center, Suita, Japan
    Hypertens Res 28:35-41. 2005

Collaborators

Detail Information

Publications52

  1. ncbi Gene polymorphism of angiotensin II type 1 and type 2 receptors
    Tomohiro Katsuya
    Katsuya Clinic, Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, 2 17 21 Nanamatsu cho, Amagasaki, Hyogo 660 0052, Japan
    Curr Pharm Des 19:2996-3001. 2013
    ..In this review, we summarized previous investigations concerning the genetic aspects of AGTR1 and AGTR2 to consider the clinical utility of SNPs of these receptors...
  2. ncbi Genetic basis of hypertension for the development of tailored medicine
    Tomohiro Katsuya
    Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 32:643-8. 2009
    ..In this review, we reaffirm the genetic basis of hypertension and outline recent progress in genomics. In addition, we discuss both the possibility and usefulness of genomic information in the development of tailored medicine...
  3. ncbi Association between hepatocyte growth factor gene polymorphism and essential hypertension
    Masaharu Motone
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 27:247-51. 2004
    ..In conclusion, our data suggested that C/A polymorphism in intron 13 of the HGF gene is associated with susceptibility to essential hypertension in lean or female subjects...
  4. doi Variation in OSBPL10 is associated with dyslipidemia
    Hiroshi Koriyama
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Yamada oka, Suita, Japan
    Hypertens Res 33:511-4. 2010
    ..003), with an odds ratio of 0.35 (95% confidence interval=0.17-0.76). Overall, the rs2290532 (D254N) polymorphism in OSBPL10 may predispose individuals with this SNP to hyper-LDL cholesterolemia...
  5. ncbi A common polymorphism of uncoupling protein 2 gene is associated with hypertension
    Quihe Ji
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Hypertens 22:97-102. 2004
    ..To clarify the contribution of this polymorphism to obesity and related conditions, we studied the association of the -866 G/A polymorphism of the UCP2 gene with obesity, hypertension and type 2 diabetes mellitus...
  6. doi Gene polymorphism of myospryn (cardiomyopathy-associated 5) is associated with left ventricular wall thickness in patients with hypertension
    Hironori Nakagami
    Division of Gene Therapy Science, Graduate School of Medicine, Osaka University, Suita, Japan
    Hypertens Res 30:1239-46. 2007
    ..Our results suggest that the polymorphism of myospryn is associated with left ventricular hypertrophy, and an association between a Z-disc protein and cardiac adaptation in response to pressure overload...
  7. ncbi Hypoadiponectinemia is an independent risk factor for hypertension
    Yoshio Iwashima
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertension 43:1318-23. 2004
    ..01), and most of them had hypertension. In contrast, the G276T polymorphism was not associated with adiponectin concentration or hypertension. In conclusion, hypoadiponectinemia is a marker for predisposition to hypertension in men...
  8. ncbi Association between angiotensin II type 1 receptor gene polymorphism and essential hypertension: the Ohasama Study
    Ken Sugimoto
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 27:551-6. 2004
    ..Our data suggested that the AT1R/A1166C polymorphism is not a major genetic predisposing factor for hypertension in Japanese...
  9. doi -374 T/A polymorphism in RAGE gene is associated with onset of diabetes mellitus, atherosclerosis, and renal dysfunction in patients with hypertension
    Tatsuo Kawai
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Clin Exp Hypertens 35:236-41. 2013
    ..These significant correlations were only seen in male subjects. Carriers of the A allele of -374 T/A RAGE show an independent risk of atherosclerosis and reduced renal function in male hypertensive patients with DM...
  10. ncbi Single nucleotide polymorphisms in the interleukin-6 gene associated with blood pressure and atherosclerosis in a Japanese general population
    Chihiro Tanaka
    Research Institute, National Cardiovascular Center, Suita, Japan
    Hypertens Res 28:35-41. 2005
    ..Thus, these two SNPs in the promoter region and intron 3 of the IL-6 gene might play a role in the blood pressure regulation and progression of atherosclerosis in the Japanese...
  11. ncbi G2736A polymorphism of thiazide-sensitive Na-Cl cotransporter gene predisposes to hypertension in young women
    Akiko Matsuo
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    J Hypertens 22:2123-7. 2004
    ..We examined the genetic involvement of the TSC gene in essential hypertension in Japanese...
  12. doi A polymorphism regulates CYP4A11 transcriptional activity and is associated with hypertension in a Japanese population
    Ken Sugimoto
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Hypertension 52:1142-8. 2008
    ..We have identified a functional variant (-845A/G) of CYP4A11 that is significantly associated with hypertension and that appears to be a novel candidate for a predisposing factor for hypertension...
  13. ncbi Relationship of bradykinin B2 receptor gene polymorphism with essential hypertension and left ventricular hypertrophy
    Yuxiao Fu
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Yamada oka, Suita, Japan
    Hypertens Res 27:933-8. 2004
    ....
  14. ncbi Renal protective effect in hypertensive patients: the high doses of angiotensin II receptor blocker (HARB) study
    Mitsuru Ohishi
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 30:1187-92. 2007
    ..0011) prior to changeover were independently correlated with reduction in UPE. Our results suggest that the maximum dose of valsartan is more effective than the maximum dose of candesartan for reducing BP and proteinuria...
  15. ncbi beta2- and beta3-Adrenoceptor polymorphisms relate to subsequent weight gain and blood pressure elevation in obese normotensive individuals
    Hideki Kawaguchi
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 29:951-9. 2006
    ..beta2- and beta3-adrenoceptor polymorphisms could predict the future BP elevation and further weight gain-induced BP elevation in originally obese subjects...
  16. doi Association of gene polymorphism of the fat-mass and obesity-associated gene with insulin resistance in Japanese
    Izumi Shimaoka
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Hypertens Res 33:214-8. 2010
    ..One SNP, rs1121980, and a haplotype of three SNPs in FTO that contains this SNP, might be important in the progression of insulin resistance in Japanese subjects...
  17. doi Association of carotid atherosclerosis with genetic polymorphisms of the klotho gene in patients with hypertension
    Ryosuke Oguro
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Geriatr Gerontol Int 10:311-8. 2010
    ..Here, we studied whether klotho single nucleotide polymorphisms (SNP) were associated with carotid atherosclerosis...
  18. ncbi Analyses of differential gene expression in genetic hypertensive rats by microarray
    Tomohiko Okuda
    Research Institute, National Cardiovascular Center, Suita, Osaka, Japan
    Hypertens Res 25:249-55. 2002
    ..Based on these results, the identification of differentially expressed genes may not be an efficient method for selecting candidate genes for hypertension in the SHR-WKY system...
  19. ncbi Epsilon 4 allele of apolipoprotein E gene associates with lower blood pressure in young Japanese subjects: the Suita Study
    Tomohiro Katsuya
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    J Hypertens 20:2017-21. 2002
    ..However, the correlation between hypertension and APOE/epsilon 4 has not yet been clarified. To examine the APOE/epsilon 4 effect in the general population of Japan, we performed a large genetic epidemiological survey (the Suita Study)...
  20. ncbi alpha-Adducin Gly460Trp polymorphism is associated with low renin hypertension in younger subjects in the Ohasama study
    Ken Sugimoto
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    J Hypertens 20:1779-84. 2002
    ..However, we failed to detect a positive association between the Gly460Trp polymorphism of ADD-1 and hypertension in a small series of Japanese subjects...
  21. ncbi Identification of 21 single nucleotide polymorphisms in human hepatocyte growth factor gene and association with blood pressure and carotid atherosclerosis in the Japanese population
    Shin Takiuchi
    Division of Hypertension and Nephrology, Department of Medicine, National Cardiovascular Center, 5 7 1, Fujishirodai, Suita, Osaka 565 8565, Japan
    Atherosclerosis 173:301-7. 2004
    ..This study provides the first evidence that HGF may be a candidate susceptibility loci that affects the progression of atherosclerosis in Japanese subjects...
  22. doi Effect of tablets with a combination of telmisartan and amlodipine on patients with hypertension: the Cotalo study
    Mitsuru Ohishi
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan
    Hypertens Res 36:620-6. 2013
    ..We conclude that T40/A5 FDC therapy significantly decreased the 24-h mean and clinical BP, independent of administration time, in patients whose hypertension was not controlled by 5 mg of amlodipine...
  23. doi Effect of interleukin-6 receptor blockage on renal injury in apolipoprotein E-deficient mice
    Mari Tomiyama-Hanayama
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Am J Physiol Renal Physiol 297:F679-84. 2009
    ....
  24. doi CVD-associated non-coding RNA, ANRIL, modulates expression of atherogenic pathways in VSMC
    Ada Congrains
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Japan
    Biochem Biophys Res Commun 419:612-6. 2012
    ....
  25. doi A single nucleotide polymorphism of the adenosine deaminase, RNA-specific gene is associated with the serum triglyceride level, abdominal circumference, and serum adiponectin concentration
    Ryosuke Oguro
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565, Japan
    Exp Gerontol 47:183-7. 2012
    ..There are possibilities that ADAR is associated with major risk factors of atherosclerotic cardiovascular diseases (CVD), such as hypertension, diabetes, dyslipidemia, and obesity...
  26. ncbi Renal-protective effect of T-and L-type calcium channel blockers in hypertensive patients: an Amlodipine-to-Benidipine Changeover (ABC) study
    Mitsuru Ohishi
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 30:797-806. 2007
    ..0284) were correlated with reduction of urinary proteins during changeover. Taken together, our results suggest that benidipine may have greater efficacy than amlodipine in reducing blood pressure and proteinuria...
  27. ncbi Effects of angiotensin II type 1 receptor gene polymorphisms on insulin resistance in a Japanese general population: the Tanno-Sobetsu study
    Hiroshi Akasaka
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 29:961-7. 2006
    ..Further study is required to confirm these findings in a larger, multi-ethnic population...
  28. ncbi Genetic influences of beta-adrenoceptor polymorphisms on arterial functional changes and cardiac remodeling in hypertensive patients
    Ming Yuan
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 29:875-81. 2006
    ..05). These data suggested that two polymorphisms of different beta-adrenoreceptor subtypes are the genetic influences on the development of arterial stiffness and left ventricular hypertrophy in essential hypertension...
  29. pmc Potential role of CYLD (Cylindromatosis) as a deubiquitinating enzyme in vascular cells
    Yoichi Takami
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
    Am J Pathol 172:818-29. 2008
    ..In conclusion, these data demonstrate that the deubiquitinating enzyme CYLD may inhibit inflammation and proliferation in vascular cells and may represent a novel target for the treatment or prevention of atherosclerosis...
  30. ncbi Association of methylenetetrahydrofolate reductase gene polymorphism with carotid atherosclerosis depending on smoking status in a Japanese general population
    Nozomu Inamoto
    Department of Geriatric Medicine, National Cardiovascular Center, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Stroke 34:1628-33. 2003
    ..This may be due to small sample size and inappropriate analysis. We investigated the association of C677T/MTHFR with blood pressure and carotid atherosclerosis in a Japanese general population...
  31. pmc Decrease in blood pressure and regression of cardiovascular complications by angiotensin II vaccine in mice
    Futoshi Nakagami
    Department of Clinical Gene Therapy, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan
    PLoS ONE 8:e60493. 2013
    ..Taken together, these data indicate that vaccines targeting Ang II might be effective to decrease high BP and prevent cardiovascular complications without severe side effects...
  32. doi Genetic variants at the 9p21 locus contribute to atherosclerosis through modulation of ANRIL and CDKN2A/B
    Ada Congrains
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Japan
    Atherosclerosis 220:449-55. 2012
    ..It is still not clear which of or how these transcripts are involved in the pathogenesis of atherosclerosis...
  33. doi Fas promoter region gene polymorphism is associated with an increased risk for myocardial infarction
    Hiroko Hanasaki
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan
    Hypertens Res 32:261-4. 2009
    ..We conclude that the Fas promoter gene, SNP (-670G/A), may be a risk factor of MI occurrence...
  34. doi Macrophage inflammatory protein-1beta induced cell adhesion with increased intracellular reactive oxygen species
    Yuji Tatara
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita 565 0871, Japan
    J Mol Cell Cardiol 47:104-11. 2009
    ..In conclusion, MIP-1beta directly induced cell adhesion to endothelial cells through oxidative stress via PI3k-Rac1 cascades. Serum MIP-1beta level might be a useful predictor for cerebro-cardiovascular events in hypertensive patients...
  35. ncbi Leptin gene polymorphism is associated with hypertension independent of obesity
    Maki Shintani
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    J Clin Endocrinol Metab 87:2909-12. 2002
    ....
  36. ncbi Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population
    Hiroshi Koriyama
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita, Japan
    J Atheroscler Thromb 17:1054-62. 2010
    ..However, little is known about the genetic basis of PAD. To elucidate this, we performed a two-staged genome-wide association study in Japanese individuals...
  37. ncbi Salt sensitivity of Japanese from the viewpoint of gene polymorphism
    Tomohiro Katsuya
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Yamada oka, Suita, Japan
    Hypertens Res 26:521-5. 2003
    ..This interesting finding might suggest a feasible explanation for the huge interracial differences in the frequency of salt-sensitive hypertension...
  38. doi Akt activation prevents Apop-1-induced death of cells
    Xin Sun
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita, Osaka 565 0871, Japan
    Biochem Biophys Res Commun 377:1097-101. 2008
    ..Furthermore, our data indicate that the inhibition of Apop-1-induced death by IGF-1 is mediated by the activation of the PI3K/Akt signaling pathway...
  39. ncbi Association of hypoadiponectinemia with smoking habit in men
    Yoshio Iwashima
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamadaoka, Suita 565 0871, Japan
    Hypertension 45:1094-100. 2005
    ..Smoking habit is associated with adiponectin concentration in men, and its suppressive effect is mediated in part through direct inhibition of smoking on adiponectin expression in adipocytes...
  40. doi Klotho suppresses TNF-alpha-induced expression of adhesion molecules in the endothelium and attenuates NF-kappaB activation
    Yoshihiro Maekawa
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Osaka 565 0871, Japan
    Endocrine 35:341-6. 2009
    ..These results suggest that Klotho suppresses TNF-alpha-induced expression of adhesion molecules and NF-kappaB activation. Klotho may have a role in the modulation of endothelial inflammation...
  41. pmc Promoter Polymorphism of RGS2 Gene Is Associated with Change of Blood Pressure in Subjects with Antihypertensive Treatment: The Azelnidipine and Temocapril in Hypertensive Patients with Type 2 Diabetes Study
    Ken Sugimoto
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, 2 2 B6, Yamada oka, Suita, Osaka 565 0871, Japan
    Int J Hypertens 2010:196307. 2010
    ..There was no gene whose expression was associated with BP phenotypes or the polymorphisms of each gene. Conclusions. A-638G polymorphism of the RGS-2 gene could be a predictive factor for therapeutic performance of Ca channel blockers...
  42. pmc Inhibition of neointima formation through DNA vaccination for apolipoprotein(a): a new therapeutic strategy for lipoprotein(a)
    Mariko Kyutoku
    Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, 2 2 Yamada Oka Suita, Japan
    Sci Rep 3:1600. 2013
    ....
  43. ncbi Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease
    Koji Ohashi
    Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Suita, Japan
    J Am Coll Cardiol 43:1195-200. 2004
    ..This study examined the association of mutations in adiponectin gene with the prevalence of coronary artery disease (CAD)...
  44. ncbi Deletion of angiotensin-converting enzyme 2 accelerates pressure overload-induced cardiac dysfunction by increasing local angiotensin II
    Koichi Yamamoto
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertension 47:718-26. 2006
    ..Disruption of this regulatory function may accelerate cardiac hypertrophy and shorten the transition period from compensated hypertrophy to cardiac failure...
  45. ncbi Genome-wide response to antihypertensive medication using home blood pressure measurements: a pilot study nested within the HOMED-BP study
    Kei Kamide
    Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, Osaka, Japan and Department of Health Sciences, Osaka University Graduate School of Medicine, Osaka, Japan and Research Institute, National Cerebro and Cardiovascular Research Center, Osaka, Japan and Studies Coordinating Centre, Research Unit Hypertension and Cardiovascular Epidemiology, Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium
    Pharmacogenomics 14:1709-21. 2013
    ....
  46. ncbi Low-dose doxazosin improved aortic stiffness and endothelial dysfunction as measured by noninvasive evaluation
    Norio Komai
    Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan
    Hypertens Res 25:5-10. 2002
    ..7+/-15.7 micromol/l; p<0.005). These data suggest that a low dose of doxazosin may play an important role in improving arterial stiffness and endothelial dysfunction without changing cardiac hemodynamics...
  47. ncbi Kynureninase is a novel candidate gene for hypertension in spontaneously hypertensive rats
    Ken ichi Mizutani
    Research Institute, National Cardiovascular Center, Suita, Japan
    Hypertens Res 25:135-40. 2002
    ..The increased expression of KYNU in SHR is thought to decrease the KYN level. KYNU seems to be one of the genes that contributes to hypertension in SHR...
  48. ncbi Association of a mast cell chymase gene variant with HDL cholesterol, but not with blood pressure in the Ohasama study
    Masayuki Fukuda
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    Hypertens Res 25:179-84. 2002
    ..In conclusion, G3255A polymorphism of MCC is not directly associated with blood pressure but may modulate the prevalence of hypertensive complications via alteration of lipid metabolism...
  49. ncbi Ubiquitin carboxyl-terminal hydrolase L1, a novel deubiquitinating enzyme in the vasculature, attenuates NF-kappaB activation
    Yoichi Takami
    Department of Geriatric Medicine, Osaka University Graduate School of Medicine, 2 2 Yamada oka, Suita 565 0871, Japan
    Arterioscler Thromb Vasc Biol 27:2184-90. 2007
    ..Therefore, the goal of present study was to clarify the role of the UCHL1 gene in vascular remodeling by evaluating nuclear factor-kappaB (NF-kappaB) inactivation in ECs and vascular smooth muscle cells (VSMCs)...
  50. ncbi Association between SAH, an acyl-CoA synthetase gene, and hypertriglyceridemia, obesity, and hypertension
    Naoharu Iwai
    Department of Epidemiology, Research Institute, National Cardiovascular Center, 5 7 1 Fujishirodai, Suita, Osaka 565 8565, Japan
    Circulation 105:41-7. 2002
    ..Recently, the SA protein has been reported to be highly homologous to bovine xenobiotic-metabolizing medium-chain fatty acid:CoA ligase...
  51. ncbi [WRN gene]
    Tomohiro Katsuya
    Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine
    Nihon Rinsho 67:1277-82. 2009
    ..In this review, we introduce the clinical characteristics of Werner's syndrome and recent topics concerning WRN in comparison with other progeroid syndromes...