Research Topics
Genomes and Genes | Takatoshi MuraseSummaryAffiliation: Kao Corporation Country: Japan Publications
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Publications
Coffee polyphenols modulate whole-body substrate oxidation and suppress postprandial hyperglycaemia, hyperinsulinaemia and hyperlipidaemiaTakatoshi Murase
Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai machi, Haga gun, Tochigi 321 3497, Japan
Br J Nutr 107:1757-65. 2012..These results suggest that CPP modulates whole-body substrate oxidation by suppressing postprandial hyperglycaemia and hyperinsulinaemia, and these effects are mediated by inhibiting digestive enzymes...- Tea catechin ingestion combined with habitual exercise suppresses the aging-associated decline in physical performance in senescence-accelerated miceTakatoshi Murase
Biological Science Laboratories, Kao Corporation, Ichikai machi, Haga gun, Tochigi, Japan
Am J Physiol Regul Integr Comp Physiol 295:R281-9. 2008.... - Nootkatone, a characteristic constituent of grapefruit, stimulates energy metabolism and prevents diet-induced obesity by activating AMPKTakatoshi Murase
Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai machi, Haga gun, Tochigi, Japan
Am J Physiol Endocrinol Metab 299:E266-75. 2010.... - Catechin-induced activation of the LKB1/AMP-activated protein kinase pathwayTakatoshi Murase
Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai machi, Haga gun, Tochigi 321 3497, Japan
Biochem Pharmacol 78:78-84. 2009.... - Suppression of the aging-associated decline in physical performance by a combination of resveratrol intake and habitual exercise in senescence-accelerated miceTakatoshi Murase
Biological Science Laboratories, Kao Corporation, Haga gun, Tochigi, Japan
Biogerontology 10:423-34. 2009.... - Coffee polyphenols suppress diet-induced body fat accumulation by downregulating SREBP-1c and related molecules in C57BL/6J miceTakatoshi Murase
Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai machi, Haga gun, Tochigi 321 3497, Japan
Am J Physiol Endocrinol Metab 300:E122-33. 2011..These findings indicate that CPP enhances energy metabolism and reduces lipogenesis by downregulating SREBP-1c and related molecules, which leads to the suppression of body fat accumulation... 
Green tea extract improves running endurance in mice by stimulating lipid utilization during exerciseTakatoshi Murase
Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai machi, Haga gun, Tochigi 321 3497, Japan
Am J Physiol Regul Integr Comp Physiol 290:R1550-6. 2006..These results suggest that the endurance-improving effects of GTE were mediated, at least partly, by increased metabolic capacity and utilization of fatty acid as a source of energy in skeletal muscle during exercise...- Reduction of diet-induced obesity by a combination of tea-catechin intake and regular swimmingT Murase
Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai machi, Haga gun, Japan
Int J Obes (Lond) 30:561-8. 2006..It is known to be a strong risk factor for lifestyle-related diseases. Here, we investigated the effects of long-term intake of tea catechins (Cat) in combination with regular exercise (Ex) on the development of obesity in C57BL/6 mice... - Green tea extract improves endurance capacity and increases muscle lipid oxidation in miceTakatoshi Murase
Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai machi, Haga gun, Tochigi 321 3497, Japan
Am J Physiol Regul Integr Comp Physiol 288:R708-15. 2005..These results indicate that GTE are beneficial for improving endurance capacity and support the hypothesis that the stimulation of fatty acid use is a promising strategy for improving endurance capacity... - Supplementation with alpha-linolenic acid-rich diacylglycerol suppresses fatty liver formation accompanied by an up-regulation of beta-oxidation in Zucker fatty ratsTakatoshi Murase
Biological Science Laboratories, Kao Corporation, Ichikai machi, Haga gun, Tochigi, Japan
Biochim Biophys Acta 1733:224-31. 2005..In addition, our findings suggest that both acylglycerol structure (that is, the structural difference between TG and DG) and fatty-acid species affect the nutritional behaviour of dietary lipids... - Differential regulation of intestinal lipid metabolism-related genes in obesity-resistant A/J vs. obesity-prone C57BL/6J miceHidehiko Kondo
Biological Science Laboratories, Kao Corporation, Tochigi, Japan
Am J Physiol Endocrinol Metab 291:E1092-9. 2006..These findings suggest that intestinal lipid metabolism is associated with susceptibility to obesity... - Different contribution of muscle and liver lipid metabolism to endurance capacity and obesity susceptibility of miceSatoshi Haramizu
Biological Science Laboratories, Kao Corporation, Ichikai machi, Haga gun, Tochigi, Japan
J Appl Physiol 106:871-9. 2009..These findings indicate that genetically determined basal muscle and liver lipid metabolism and responsiveness to exercise influence physical performance and obesity susceptibility... - Dietary alpha-linolenic acid-rich diacylglycerols reduce body weight gain accompanying the stimulation of intestinal beta-oxidation and related gene expressions in C57BL/KsJ-db/db miceTakatoshi Murase
Biological Science Laboratories, Kao Corporation, Ichikai, Haga, Tochigi 321-3497, Japan
J Nutr 132:3018-22. 2002..In addition, structural differences between DG and TG, not variations in the composition of fatty acids, are responsible for the different effects of the lipids... - Dietary fish oil upregulates intestinal lipid metabolism and reduces body weight gain in C57BL/6J miceTakuya Mori
Biological Science Laboratories, Kao Corporation, Akabane, Ichikai machi, Haga gun, Tochigi 321 3497, Japan
J Nutr 137:2629-34. 2007..2-, 1.6-, and 1.7-fold those in mice fed the 30% TG diet, respectively. These findings suggest that an upregulation of intestinal lipid metabolism is associated with the antiobesity effect of FO... - Tea catechins prevent contractile dysfunction in unloaded murine soleus muscle: a pilot studyNoriyasu Ota
Biological Science Laboratories, Kao Corporation, Tochigi, Japan
Nutrition 27:955-9. 2011..We investigated the effects of the intake of green tea catechins on unloading-induced muscle dysfunction in tail-suspended mice... - Exercise and green tea extract stimulate fat oxidation and prevent obesity in miceAkira Shimotoyodome
Biological Science Laboratories, Kao Corporation, Ichikai machi, Haga gun, Tochigi, Japan
Med Sci Sports Exerc 37:1884-92. 2005..The purpose of the present study was to explore the combined effects of dietary supplementation with green tea extract (GTE) and regular exercise on the development of obesity in high fat-fed C57BL/6J mice... - Catechins attenuate eccentric exercise-induced inflammation and loss of force production in muscle in senescence-accelerated miceSatoshi Haramizu
Biological Science Laboratories, Kao Corporation, Tochigi, Japan
J Appl Physiol 111:1654-63. 2011..These findings suggest that long-term catechin ingestion attenuates the aging-associated loss of force production, oxidative stress, and inflammation in muscle after exercise... - Dietary diacylglycerol reduces postprandial hyperlipidemia and ameliorates glucose intolerance in Otsuka Long-Evans Tokushima Fatty (OLETF) ratsYutaka Mori
Department of Internal Medicine, National Hospital Organization, Utsumomiya National Hospital, Tochigi, Japan
Nutrition 21:933-9. 2005..The aim of the present study was to determine the effects of dietary diacylglycerol (DG) on the metabolism of lipids and glucose in type II diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats... - Dietary diacylglycerol induces the regression of atherosclerosis in rabbitsNoriyasu Ota
Biological Science Laboratories, Kao Corporation, Tochigi 321 3497, Japan
J Nutr 137:1194-9. 2007.... - Aging-associated changes in physical performance and energy metabolism in the senescence-accelerated mouseSatoshi Haramizu
Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai machi, Haga gun, Tochigi 321 3497, Japan
J Gerontol A Biol Sci Med Sci 66:646-55. 2011..SAMP1 could thus be a useful accelerated functional depression model for studying physical performance and energy metabolism... - Hydroxypropylated distarch phosphate versus unmodified tapioca starch: fat oxidation and endurance in C57BL/6J miceSatoshi Haramizu
Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai machi, Haga gun, Tochigi, 321 3497, Japan
Eur J Appl Physiol 112:3409-16. 2012..These results suggest that acute oral administration of the RS4-type resistant starch, HPdTSP, maintained higher fat oxidation and reduced liver glycogen consumption during exercise and increased running endurance capacity in mice... - Red grape leaf extract improves endurance capacity by facilitating fatty acid utilization in skeletal muscle in miceYoshihiko Minegishi
Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai machi, Haga gun, Tochigi 321 3497, Japan
Eur J Appl Physiol 111:1983-9. 2011..5% RGLE group. Intake of RGLE upregulated Pgc1α expression and facilitated fatty acid oxidation in skeletal muscle, and these effects contributed, in part, to improve endurance capacity... - Digestion and assimilation features of dietary DAG in the rat small intestineHidehiko Kondo
Biological Science Laboratories, Kao Corporation, Haga, Tochigi 321-3497, Japan
Lipids 38:25-30. 2003..These findings suggest that features of 1,3-DAG digestion and assimilation in the intestine may be responsible for the reduction of the postprandial serum TAG level by dietary DAG... - Identification of diacylglycerol acyltransferase inhibitors from Rosa centifolia petalsHidehiko Kondo
Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai machi, Haga gun, Tochigi, 321 3497, Japan
Lipids 46:691-700. 2011..1 vs 345.3 ± 25.0 mg/dL, control vs rose extract group; P < 0.05). These results suggest that rose ellagitannins or rose extract could be beneficial in controlling lipid metabolism and used to improve metabolic disorders... - Dietary phospholipids ameliorate fructose-induced hepatic lipid and metabolic abnormalities in ratsTakuya Mori
Biological Science Laboratories, Kao Corporation, Tochigi, Japan
J Nutr 141:2003-9. 2011..These findings indicate that PL prevents fructose-induced metabolic abnormalities in association with alterations of the hepatic lipid profile by inhibiting de novo lipogenesis... - Anti-obesity effect of dietary diacylglycerol in C57BL/6J mice: dietary diacylglycerol stimulates intestinal lipid metabolismTakatoshi Murase
Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai-machi, Haga-gun, Tochigi 321-3497, Japan
J Lipid Res 43:1312-9. 2002..Thus, dietary DG reduces body weight gain that accompanies the stimulation of intestinal lipid metabolism, and these effects may be related to the characteristic metabolism of DG in the small intestine... - Expression of uncoupling proteins in human skin and skin-derived cellsShinobu Mori
Biological Science Laboratories, Kao Corporation, Tochigi, Japan
J Invest Dermatol 128:1894-900. 2008..This showed that UCPs exist in human skin, with their expression being under hormonal control. These findings are in stark contrast with the well-accepted view of UCP1 expression being exclusive to brown adipose tissue... - Effects of coumestrol on lipid and glucose metabolism as a farnesoid X receptor ligandMiki Takahashi
Biological Science Laboratories, Kao Corporation, 2606 Akabane, Ichikai machi, Haga gun, Tochigi 321 3497, Japan
Biochem Biophys Res Commun 372:395-9. 2008..Through these actions, coumestrol is expected to exert beneficial effects on lipid and glucose metabolism...