Satoshi Orimo

Summary

Affiliation: Kanto Central Hospital
Country: Japan

Publications

  1. doi request reprint Unmyelinated axons are more vulnerable to degeneration than myelinated axons of the cardiac nerve in Parkinson's disease
    S Orimo
    Department of Neurology, Kanto Central Hospital, Tokyo, Japan
    Neuropathol Appl Neurobiol 37:791-802. 2011
  2. doi request reprint 123I-MIBG myocardial scintigraphy for differentiating Parkinson's disease from other neurodegenerative parkinsonism: a systematic review and meta-analysis
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital, 6 25 1 Kami Yoga, Setagaya ku 158 8531, Tokyo, Japan
    Parkinsonism Relat Disord 18:494-500. 2012
  3. ncbi request reprint Degeneration of cardiac sympathetic nerve can occur in multiple system atrophy
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital, 6 25 1 Kami Yoga, Setagaya Ku, Tokyo, 158 8531, Japan
    Acta Neuropathol 113:81-6. 2007
  4. ncbi request reprint Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital, 6 25 1 Kami Yoga, Setagaya Ku, 158 8531 Tokyo, Japan
    Brain 131:642-50. 2008
  5. ncbi request reprint Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital, Tokyo, Japan
    Mov Disord 20:1350-3. 2005
  6. ncbi request reprint Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital, 6 25 1 Kami Yoga, Setagaya Ku, 158 8531, Tokyo, Japan
    Acta Neuropathol 109:583-8. 2005
  7. ncbi request reprint Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital, Tokyo, Japan
    Brain Pathol 17:24-30. 2007
  8. ncbi request reprint [A useful marker for differential diagnosis of Parkinson's disease--MIBG myocardial scintigraphy]
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital
    Rinsho Shinkeigaku 44:827-9. 2004
  9. ncbi request reprint Profound cardiac sympathetic denervation occurs in Parkinson disease
    Takeshi Amino
    Department of Neurology, Kanto Central Hospital, Tokyo, Japan
    Brain Pathol 15:29-34. 2005
  10. ncbi request reprint [Clinical and pathological study on early diagnosis of Parkinson's disease and dementia with Lewy bodies]
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital
    Rinsho Shinkeigaku 48:831-4. 2008

Collaborators

Detail Information

Publications27

  1. doi request reprint Unmyelinated axons are more vulnerable to degeneration than myelinated axons of the cardiac nerve in Parkinson's disease
    S Orimo
    Department of Neurology, Kanto Central Hospital, Tokyo, Japan
    Neuropathol Appl Neurobiol 37:791-802. 2011
    ..The aim of this study is to determine whether there is a difference in the degenerative process between unmyelinated and myelinated axons of the cardiac nerve...
  2. doi request reprint 123I-MIBG myocardial scintigraphy for differentiating Parkinson's disease from other neurodegenerative parkinsonism: a systematic review and meta-analysis
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital, 6 25 1 Kami Yoga, Setagaya ku 158 8531, Tokyo, Japan
    Parkinsonism Relat Disord 18:494-500. 2012
    ....
  3. ncbi request reprint Degeneration of cardiac sympathetic nerve can occur in multiple system atrophy
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital, 6 25 1 Kami Yoga, Setagaya Ku, Tokyo, 158 8531, Japan
    Acta Neuropathol 113:81-6. 2007
    ..Moreover, concurrent Lewy body pathology in the sympathetic ganglia might accelerate cardiac sympathetic denervation even in MSA...
  4. ncbi request reprint Axonal alpha-synuclein aggregates herald centripetal degeneration of cardiac sympathetic nerve in Parkinson's disease
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital, 6 25 1 Kami Yoga, Setagaya Ku, 158 8531 Tokyo, Japan
    Brain 131:642-50. 2008
    ....
  5. ncbi request reprint Preserved cardiac sympathetic nerve accounts for normal cardiac uptake of MIBG in PARK2
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital, Tokyo, Japan
    Mov Disord 20:1350-3. 2005
    ..Moreover, normal cardiac uptake of MIBG might be of potential diagnostic value to indicate the absence of Lewy body pathology, even in patients with levodopa-responsive Parkinsonism, as in PARK2...
  6. ncbi request reprint Cardiac sympathetic denervation precedes neuronal loss in the sympathetic ganglia in Lewy body disease
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital, 6 25 1 Kami Yoga, Setagaya Ku, 158 8531, Tokyo, Japan
    Acta Neuropathol 109:583-8. 2005
    ..Decreased cardiac uptake of MIBG in Lewy body disease reflects actual cardiac sympathetic denervation, which precedes the neuronal loss in the sympathetic ganglia...
  7. ncbi request reprint Degeneration of cardiac sympathetic nerve begins in the early disease process of Parkinson's disease
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital, Tokyo, Japan
    Brain Pathol 17:24-30. 2007
    ..These findings suggest that degeneration of the cardiac sympathetic nerve begins in the early disease process of PD and that it occurs before neuronal cell loss in the dorsal vagal nucleus...
  8. ncbi request reprint [A useful marker for differential diagnosis of Parkinson's disease--MIBG myocardial scintigraphy]
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital
    Rinsho Shinkeigaku 44:827-9. 2004
    ..These findings suggest that postganglionic cardiac sympathetic nerve denervation occurs in PD and DLB but not in MSA, PSP, CBD and AD, which accounts for the decreased cardiac uptake of MIBG in PD and DLB, but not in the other diseases...
  9. ncbi request reprint Profound cardiac sympathetic denervation occurs in Parkinson disease
    Takeshi Amino
    Department of Neurology, Kanto Central Hospital, Tokyo, Japan
    Brain Pathol 15:29-34. 2005
    ..PD affects the cardiac sympathetic nervous system profoundly as well as nigrostriatal dopaminergic system...
  10. ncbi request reprint [Clinical and pathological study on early diagnosis of Parkinson's disease and dementia with Lewy bodies]
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital
    Rinsho Shinkeigaku 48:831-4. 2008
    ..This chronological and dynamic relationship between alpha-synuclein aggregates and degeneration of the cardiac sympathetic nervous system may represent the pathological mechanism underlying a common degenerative process in PD...
  11. ncbi request reprint [Clinical and pathological study on early diagnosis of Parkinson's disease and dementia with Lewy bodies]
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital
    Rinsho Shinkeigaku 48:11-24. 2008
    ....
  12. doi request reprint Pale neurites, premature α-synuclein aggregates with centripetal extension from axon collaterals
    Toshiro Kanazawa
    Laboratory of Strucutural Neuropathology, Tokyo Metropolitan Institute of Medical Science, Setagaya, Tokyo, Japan
    Brain Pathol 22:67-78. 2012
    ..This branching-oriented extension of αS is related to its selective predisposition to systems with highly divergent axons, preferentially affected in PD, which may explain barely somatotopic manifestations of PD...
  13. doi request reprint Three-layered structure shared between Lewy bodies and lewy neurites-three-dimensional reconstruction of triple-labeled sections
    Toshiro Kanazawa
    Department of Neurology, Kanto Central Hospital, Tokyo, Japan
    Brain Pathol 18:415-22. 2008
    ..Besides progression from pale bodies to LBs, structural evolution from LNs into LBs may provide an alternative explanation for the variability of alphaS deposits and their interrelation...
  14. ncbi request reprint Preserved myocardial [123I]metaiodobenzylguanidine uptake in autosomal recessive juvenile parkinsonism: first case report
    Masahiko Suzuki
    Department of Neurology, The Jikei University School of Medicine, Tokyo, Japan
    Mov Disord 20:634-6. 2005
    ..Although the clinical features of AR-JP are sometimes quite similar to those of late-onset idiopathic PD, 123I-MIBG myocardial scintigraphy may be a powerful tool to differentiate PD from other parkinsonian syndromes, including AR-JP...
  15. doi request reprint Myocardial nerve fibers are preserved in MPTP-treated mice, despite cardiac sympathetic dysfunction
    Takeshi Amino
    Department of Neurology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashidai, Fuchu, Tokyo 183 8526, Japan
    Neurosci Res 60:314-8. 2008
    ..Western blot analyses also showed no difference in the amounts of these proteins. Myocardial nerve fibers were well preserved in MPTP-treated mice, despite apparent cardiac sympathetic dysfunction...
  16. ncbi request reprint [123I] meta-iodobenzylguanidine myocardial scintigraphy differentiates corticobasal degeneration from Parkinson's disease
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital, Tokyo
    Intern Med 42:127-8. 2003
  17. doi request reprint Limbic and nigral Lewy bodies and Alzheimer's disease pathology mimicking progressive supranuclear palsy in a 75-year-old man with preserved cardiac uptake of MIBG
    Naoki Kasahata
    Department of Neurology, Makita General Hospital, Tokyo, Japan n
    J Alzheimers Dis 32:889-94. 2012
    ..Tuft-shaped astrocytes were not apparent. Although decreased myocardial uptake of MIBG is a rule in patients harboring Lewy bodies, its normal uptake may be related to their absence in lower brainstem nuclei...
  18. ncbi request reprint [The clinical significance of MIBG myocardial scintigraphy in Parkinson disease]
    Satoshi Orimo
    Department of Neurology, Kanto Central Hospital, Setagaya Ku, Tokyo, Japan
    Brain Nerve 64:403-12. 2012
    ..Thus, we conclude that reduced cardiac MIBG uptake is a potential biomarker for the presence of Lewy bodies in the nervous system. We infer that MIBG myocardial scintigraphy is a noninvasive tool for detecting Lewy bodies during life...
  19. ncbi request reprint [MIBG myocardial scintigraphy of Parkinson's disease and related diseases]
    Satoshi Orimo
    Departmentof Neurology, Kanto Central Hospital, 6 25 1 Kamiyoga, Setagaya Ku, Tokyo 158 8531, Japan
    No To Shinkei 56:543-57. 2004
  20. ncbi request reprint Quantitative assessment of gait bradykinesia in Parkinson's disease using a portable gait rhythmogram
    Hiroya Utsumi
    Department of Neurology, Tokyo Medical University, Shinjuku ku, Japan
    Acta Med Okayama 66:31-40. 2012
    ..e., a range of floor reaction forces. The results suggest that assessment of the combination of changes in gait cycle and gait acceleration can quantitatively define the severity of gait bradykinesia...
  21. doi request reprint Cognitive status correlates with white matter alteration in Parkinson's disease
    Takaaki Hattori
    Department of Neurology and Neurological Sciences, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    Hum Brain Mapp 33:727-39. 2012
    ....
  22. doi request reprint Spreading of amyotrophic lateral sclerosis lesions--multifocal hits and local propagation?
    Teruhiko Sekiguchi
    Department of Neurology and Neurological Science, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan
    J Neurol Neurosurg Psychiatry 85:85-91. 2014
    ....
  23. ncbi request reprint 24-hour recording of parkinsonian gait using a portable gait rhythmogram
    Hiroshi Mitoma
    Department of Medical Education, Tokyo Medical University, Tokyo, Japan
    Intern Med 49:2401-8. 2010
    ..Despite its importance, motor fluctuation has received little scientific analysis probably due to limitation in objective assessment. Here, we focused on gait disorders to estimate motor fluctuation in daily activities...
  24. ncbi request reprint Pituitary abscess with panhypopituitarism showing T1 signal hyperintensity of the marginal pituitary area: a non-invasive differential diagnosis of pituitary abscess and pituitary apoplexy
    Jun Shirakawa
    Department of Endocrinology and Metabolism, Kanto Central Hospital, Tokyo
    Intern Med 48:441-6. 2009
    ..In this report, we propose a new diagnostic approach of pituitary abscess, using a combination of CT, MR imaging and clinical manifestations, without either pituitary surgery or pituitary biopsy...
  25. ncbi request reprint Silver stainings distinguish Lewy bodies and glial cytoplasmic inclusions: comparison between Gallyas-Braak and Campbell-Switzer methods
    Toshiki Uchihara
    Department of Neuropathology, Tokyo Metropolitan Institute for Neuroscience, 2 6 Musashi dai, Fuchu, 183 8526 Tokyo, Japan
    Acta Neuropathol 110:255-60. 2005
    ..Even though these empirical differences still remain to be explained, awareness of this clear distinction is potentially of diagnostic and pathological relevance...
  26. ncbi request reprint [A case of 51-year-old woman demonstrating akinetic mutism with seven years course of Parkinsonism]
    Hideji Hashida
    No To Shinkei 57:425-39. 2005
  27. ncbi request reprint [An autopsy case of 54-year-old man with progressive dementia]
    Kenji Ishihara
    No To Shinkei 56:439-50. 2004