Research Topics
Genomes and GenesSpecies | Yutaka SeinoSummaryAffiliation: Kansai Denryoku Hospital Country: Japan Publications
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Publications
Efficacy and safety of the once-daily human GLP-1 analogue, liraglutide, vs glibenclamide monotherapy in Japanese patients with type 2 diabetesY Seino
Kansai Electric Power Hospital, Osaka, Japan
Curr Med Res Opin 26:1013-22. 2010....- Efficacy and safety of alogliptin added to metformin in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension studyY Seino
Kansai Electric Power Hospital, Osaka, Japan
Diabetes Obes Metab 14:927-36. 2012..To evaluate the efficacy and safety of alogliptin added to metformin versus metformin monotherapy in Japanese patients with type 2 diabetes who achieved inadequate glycaemic control on metformin (500 or 750 mg/day) + diet/exercise... 
Randomized, double-blind, placebo-controlled trial of the once-daily GLP-1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (GetGoal-L-Asia)Y Seino
Kansai Electric Power Hospital, Osaka, Japan
Diabetes Obes Metab 14:910-7. 2012..To assess the efficacy and safety of once-daily lixisenatide versus placebo in Asian patients with type 2 diabetes insufficiently controlled on basal insulin ± sulfonylurea...- Alogliptin plus voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extensionYutaka Seino
Kansai Electric Power Hospital, Osaka, Japan
Curr Med Res Opin 27:21-9. 2011..To compare the efficacy and safety of alogliptin and placebo as add-on therapy in Japanese patients with type 2 diabetes who experienced inadequate glycemic control on voglibose plus diet/exercise therapy... - Safety, tolerability, pharmacokinetics and pharmacodynamics of albiglutide, a long-acting GLP-1-receptor agonist, in Japanese subjects with type 2 diabetes mellitusYutaka Seino
Kansai Electric Power Hospital, Osaka, Japan
Curr Med Res Opin 25:3049-57. 2009..To investigate safety, pharmacokinetics and pharmacodynamics of albiglutide in Japanese subjects with type 2 diabetes mellitus... - Dose-dependent improvement in glycemia with once-daily liraglutide without hypoglycemia or weight gain: A double-blind, randomized, controlled trial in Japanese patients with type 2 diabetesY Seino
Kansai Electric Power Hospital, 2 1 7 Fukushima Fukushima ku Osaka shi, 553 0003 Osaka, Japan
Diabetes Res Clin Pract 81:161-8. 2008..To evaluate dose-response efficacy and safety of once-daily human GLP-1 analog liraglutide in Japanese subjects with type 2 diabetes... 
Platelet count is independently associated with insulin resistance in non-obese Japanese type 2 diabetic patientsAtaru Taniguchi
Division of Diabetes, Kansai-Denryoku Hospital, Osaka, Japan
Metabolism 52:1246-9. 2003..These results indicate that not only BMI, HbA(1c), and triglycerides levels but also platelet counts are independent predictor of insulin resistance in non-obese Japanese type 2 diabetic patients...- Efficacy and safety of alogliptin in Japanese patients with type 2 diabetes mellitus: a randomized, double-blind, dose-ranging comparison with placebo, followed by a long-term extension studyYutaka Seino
Kansai Electric Power Hospital, Osaka, Japan
Curr Med Res Opin 27:1781-92. 2011..In a subsequent open-label, long-term extension phase, patients continued on the same treatment for an additional 40 weeks (patients in the placebo group were reassigned equally to one of the four alogliptin dosages)... - Porphyromonas gingivalis infection is associated with carotid atherosclerosis in non-obese Japanese type 2 diabetic patientsAtaru Taniguchi
Division of Diabetes, Kansai-Denryoku Hospital, Osaka, Japan
Metabolism 52:142-5. 2003..4%, P =.009). From these results, it can be concluded that porphyromonas gingivalis infection, although still a subclinical infection, is associated with atherosclerotic vascular disease in non-obese Japanese type 2 diabetic patients... - The role of family nutritional support in Japanese patients with type 2 diabetes mellitusKoin Watanabe
Department of Medicine, Division of Diabetes, Clinical Nutrition and Endocrinology, Kansai Electric Power Hospital, Osaka, Japan
Intern Med 49:983-9. 2010..We investigated the role of family support in glycemic control by nutritional self-care behavior of Japanese patients with type 2 diabetes... - Circulating TNF receptor 2 is associated with the development of chronic kidney disease in non-obese Japanese patients with type 2 diabetesYoshio Izumi
Department of Internal Medicine, Osaka North Postal Services Agency Hospital, Osaka, Japan
Diabetes Res Clin Pract 99:145-50. 2013..This cross-sectional study was performed to investigate the relationship between inflammatory biomarkers and CKD in non-obese patients with type 2 diabetes... - Metabolic syndrome, insulin resistance, and atherosclerosis in Japanese type 2 diabetic patientsAtaru Taniguchi
Division of Diabetes and Clinical Nutrition, Kansai Denryoku Hospital, Osaka 553 0003, and Department of Endocrinology and Metabolism, Jichi Medical School of College, Tochigi, Japan
Metabolism 56:1099-103. 2007..15+/-0.01, P=.245) between the 2 groups. From these results, it can be suggested that metabolic syndrome, an insulin-resistant state, is not associated with carotid atherosclerosis, ba-PWV, or ABI in Japanese type 2 diabetic patients... - Interleukin 6, adiponectin, leptin, and insulin resistance in nonobese Japanese type 2 diabetic patientsAtaru Taniguchi
Division of Diabetes and Clinical Nutrition, Kansai Denryoku Hospital, Osaka 553 0003, Japan
Metabolism 55:258-62. 2006..300, P = .003) in our patients. From these results, it can be suggested that fasting serum IL-6 is not a major factor responsible for the evolution of insulin resistance in nonobese Japanese type 2 diabetic patients... - Abnormal regional left ventricular systolic and diastolic function in patients with coronary artery disease undergoing percutaneous coronary intervention: clinical significance of post-ischemic diastolic stunningKatsuhisa Ishii
Department of Cardiology, Kansai Electric Power Hospital, Osaka, Japan
J Am Coll Cardiol 54:1589-97. 2009..This study was designed to characterize both regional left ventricular (LV) systolic and diastolic function after percutaneous coronary intervention by using strain imaging (SI) derived from 2-dimensional speckle-tracking echocardiography... - Exercise-induced post-ischemic left ventricular delayed relaxation or diastolic stunning: is it a reliable marker in detecting coronary artery disease?Katsuhisa Ishii
Department of Cardiology, Kansai Electric Power Hospital, 2 1 7 Fukushima, Fukushima ku, Osaka, Japan
J Am Coll Cardiol 53:698-705. 2009.... - Factors responsible for the evolution of insulin resistance in Japanese type 2 diabetic patients: association with atherosclerosisAtaru Taniguchi
Division of Diabetes and Clinical Nutrition, Kansai Denryoku Hospital, 2 1 7 Fukushima, Osaka City, Osaka 553 0003, Japan
Diabetes Res Clin Pract 77:S213-9. 2007..In this section, we would like to focus on the factors contributing to insulin resistance and discuss the association of these factors with atherosclerosis in Japanese type 2 diabetic patients... - Soluble E-selectin, leptin, triglycerides, and insulin resistance in nonobese Japanese type 2 diabetic patientsAtaru Taniguchi
Division of Diabetes and Clinical Nutrition, Kansai Denryoku Hospital, Osaka 553 0003, Japan
Metabolism 54:376-80. 2005.... - A case of fulminant type 1 diabetes mellitus with exocrine pancreatic insufficiency and enhanced glucagon response to meal ingestionDaisuke Yabe
Division of Diabetes and Clinical Nutrition, Kansai Electric Power Hospital, 2 1 7 Fukushima, Osaka 553 0003, Japan
Diabetes Res Clin Pract 82:e1-4. 2008..Here, we report a FT1DM case with exocrine pancreatic insufficiency and enhanced glucagon response to meal ingestion... - C-reactive protein and insulin resistance in non-obese Japanese type 2 diabetic patientsAtaru Taniguchi
Division of Diabetes, Kansai-Denryoku Hospital, Osaka, Japan
Metabolism 51:1578-81. 2002..5% of the variability of CRP in our non-obese Japanese type 2 diabetic patients. These results indicate that insulin resistance and fibrinogen level are independent predictors of CRP in non-obese Japanese type 2 diabetic patients... - Effects of pitavastatin on lipid profiles and high-sensitivity CRP in Japanese subjects with hypercholesterolemia: Kansai Investigation of Statin for Hyperlipidemic Intervention in Metabolism and Endocrinology (KISHIMEN) investigatarsHiroyuki Koshiyama
Center for Diabetes and Endocrinology, The Tazuke Kofukai Foundation Medical Research Institute Kitano Hospital, Osaka, Japan
J Atheroscler Thromb 15:345-50. 2008..We, therefore, investigated the effects of pitavastatin on lipid profiles and hs-CRP in Japanese subjects with hypercholesterolemia... - Two incretin hormones GLP-1 and GIP: comparison of their actions in insulin secretion and β cell preservationDaisuke Yabe
The Division of Diabetes, Clinical Nutrition and Endocrinology, Kansai Electric Power Hospital, 2 1 7 Fukushima, Fukushima ku, Osaka 553 0003, Japan
Prog Biophys Mol Biol 107:248-56. 2011..We then try to discuss potential of GLP-1 and GIP in treatment of type 2 diabetes... - Liraglutide in adults with type 2 diabetes: global perspective on safety, efficacy and patient preferenceDaisuke Yabe
Division of Diabetes, Clinical Nutrition and Endocrinology, Kansai Electric Power Hospital, Osaka 553 0003, Japan
Clin Med Insights Endocrinol Diabetes 4:47-62. 2011..In this review, we summarize results from such clinical trials, and discuss efficacy and safety of liraglutide in management of type 2 diabetes in various countries, along with a pitfall of liraglutide usage in real clinical setting... - Insulin secretion and insulin sensitivity at different stages of glucose tolerance: a cross-sectional study of Japanese type 2 diabetesM Fukushima
Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Metabolism 53:831-5. 2004..Japanese type 2 diabetic patients are characterized by a larger decrease in insulin secretion and show less attribution of insulin resistance... - Normalization of cytoplasmic calcium response in pancreatic beta-cells of spontaneously diabetic GK rat by the treatment with T-1095, a specific inhibitor of renal Na+-glucose co-transportersK Yasuda
Laboratory of Metabolism, Faculty of Integrated Human Studies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
Horm Metab Res 34:217-21. 2002..1 +/- 15.3 sec, p < 0.01) compared to untreated GK rats (524.7 +/- 52.9 sec). Thus, improvement of hyperglycemia by T-1095 ameliorates beta-cell function by relieving [Ca(2+)]i response... - Soluble vascular cell adhesion molecule-1 is independently associated with soluble tumor necrosis factor receptor 2 in Japanese type 2 diabetic patientsD Nabeya
Diabetes Metab 33:81-2. 2007 - Which should we ADOPT: sulphonylureas or glitazones?H Koshiyama
Diabet Med 24:804. 2007 - Genetic variation in the hepatocyte nuclear factor (HNF)-3alpha gene does not contribute to maturity-onset diabetes of the young in JapaneseL Yu
Department of Cell Biology, Institute for Molecular and Cellular Regulation, Maebashi, Gunma, Japan
Horm Metab Res 33:163-6. 2001..However, their frequencies were not significantly different between MODY and control subjects, indicating that mutations in the HNF-3alpha gene are not a major cause of MODY in Japanese patients... - Is the concept of 'cardiometabolic risk' more useful than 'metabolic syndrome'?H Koshiyama
Diabet Med 24:571. 2007 - Association of serum resistin with TNF system activity in Japanese type 2 diabetic patientsN Kitatani
Diabetes Metab 33:156-7. 2007 - Factors responsible for glucose intolerance in Japanese subjects with impaired fasting glucoseM Izuka
Health Informatics Research Group, Translational Research Informatics Center, Foundation for Biomedical Research and Innovation, Kobe, Japan
Horm Metab Res 39:41-5. 2007..IFG is composed of three different categories in basal, early-phase insulin secretion, and insulin sensitivity... - Impairment of insulin-stimulated GLUT4 translocation in skeletal muscle and adipose tissue in the Tsumura Suzuki obese diabetic mouse: a new genetic animal model of type 2 diabetesT Miura
Department of Clinical Nutrition, Suzuka University of Medical Science, Faculty of Health Science, 1001 1 Kishioka cho, Suzuka, Mie 510 0293, Japan
Eur J Endocrinol 145:785-90. 2001..A defect in insulin stimulation of GLUT4 translocation also contributes to the characteristics of type 2 diabetes... - Human TSC-22 gene: no association with type 2 diabetesF Sugawara
Department of Metabolism and Clinical Nutrition, Graduate School of Medicine, Kyoto University
Intern Med 40:993-7. 2001.... - Synergistic effect of polymorphisms of uncoupling protein 1 and beta3-adrenergic receptor genes on autonomic nervous system activityN Shihara
The Laboratory of Metabolism, Graduate School of Human and Environmental Studies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
Int J Obes Relat Metab Disord 25:761-6. 2001.... - Genomic variation in pancreatic ion channel genes in Japanese type 2 diabetic patientsY Yamada
Department of Metabolism and Clinical Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan
Diabetes Metab Res Rev 17:213-6. 2001..Because type 2 diabetes is characterized by pancreatic beta-cell insensitivity to glucose, the genes responsible for glucose metabolism and calcium signaling in pancreatic beta-cells are candidate type 2 diabetes susceptibility genes... - Abnormal axonal inward rectifier in streptozocin-induced experimental diabetic neuropathyQ Yang
Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
Brain 124:1149-55. 2001..Reduced inward rectification potentiates conduction block caused by activity-dependent hyperpolarization and may underlie the decreased vibratory sensation seen in the early stage of diabetic neuropathy... - The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetesH Mori
Second Department of Internal Medicine, Kobe University School of Medicine, Japan
Diabetes 50:891-4. 2001.... - Novel mutation in the nephrin gene of a Japanese patient with congenital nephrotic syndrome of the Finnish typeK Aya
Department of Pediatrics, Okayama University Medical School, Okayama, Japan
Kidney Int 57:401-4. 2000..Most Finnish patients have one of two mutations. In this study, we described a Japanese CNS family associated with a novel missense point mutation in the nephrin gene... - Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout miceK Miyawaki
Department of Metabolism, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
Proc Natl Acad Sci U S A 96:14843-7. 1999.... - The threshold value for insulin resistance on homeostasis model assessment of insulin sensitivityY Nakai
Diabet Med 19:346-7. 2002 - The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genesY Yamada
Department of Metabolism and Clinical Nutrition, Kyoto University Faculty of Medicine, Japan
Genomics 27:312-9. 1995..The determination of the structures of the human CACNL1A2 and CACNLB3 genes should facilitate study of the role of these genes in the development of NIDDM and also other genetic diseases such as long QT syndrome... - Long-term therapeutic effects of voglibose, a potent intestinal alpha-glucosidase inhibitor, in spontaneous diabetic GK ratsK Yasuda
The Laboratory of Metabolism, Faculty of Integrated Human Studies, Kyoto University, Sakyo ku, Japan
Diabetes Res Clin Pract 59:113-22. 2003.... - Soluble TNF receptor and periodontal disease in non-obese Japanese type 2 diabetic patientsY Nomura
Horm Metab Res 38:688-9. 2006 - Synergistic effects of injection of bone marrow cells into both portal vein and bone marrow on tolerance induction in transplantation of allogeneic pancreatic isletsK Ikebukuro
First Department of Pathology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi City, Osaka 570-8506, Japan
Bone Marrow Transplant 38:657-64. 2006..PV+IBM)-BMT was found to be the most effective in inducing the acceptance of allogeneic PIs. These results suggest that allogeneic PI-transplantation in conjunction with (PV+IBM)-BMT could become a viable strategy... - Periodontal infection and dyslipidemia in type 2 diabetics: association with increased HMG-CoA reductase expressionF Nishimura
Department of Patho physiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, Japan
Horm Metab Res 38:530-5. 2006..It can be concluded that Pg infection is associated with increased LDL-cholesterol in diabetic subjects, which may be accompanied by increased cholesterol synthesis by inflammatory cytokines... - Effect of corosolic acid on postchallenge plasma glucose levelsM Fukushima
Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Diabetes Res Clin Pract 73:174-7. 2006..In this study, we have shown for the first time that CRA has a lowering effect on postchallenge plasma glucose levels in vivo in humans... - Soluble TNF receptors and albuminuria in non-obese Japanese type 2 diabetic patientsY Kawasaki
Department of Metabolism and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, and Division of Diabetes and Clinical Nutrition, Kansai-Denryoku Hospital, Osaka, Japan
Horm Metab Res 37:617-21. 2005..3% of the variability of urinary albumin concentration. From these results, it can be concluded that serum soluble TNF receptor is an important independent factor associated with albuminuria in non-obese Japanese type 2 diabetic patients... - Prevalence of periodontal bacterial infection in non-obese Japanese type 2 diabetic patients: relationship with C-reactive protein and albuminuriaA Kuroe
Division of Diabetes, Kansai-Denryoku Hospital, 2-1-7 Fukushima, Fukushima-ku, Osaka-city, Osaka 553-0003, Japan
Horm Metab Res 36:116-8. 2004..These results suggest that among periodontal bacteria, Porphyromonas gingivalis infection is associated with atherosclerosis in non-obese Japanese type 2 diabetic patients... - Effects of an aldose reductase inhibitor on gastroenteropathy in streptozotocin-diabetic ratsM Oya
Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, 54, Shogoin, Kawara-machi, Sakyo-ku, Kyoto 606-8507, Japan
Diabetes Res Clin Pract 62:69-77. 2003..These findings show that ARI partially prevented progression of impaired gastric emptying, ion transport, and water transport, and suggest that epalrestat might be useful in the treatment of diabetic gastroenteropathy... - Beneficial effect of pretreatment of islets with fibronectin on glucose tolerance after islet transplantationY Hamamoto
Department of Metabolism and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Japan
Horm Metab Res 35:460-5. 2003..These results indicate that cultivation with fibronectin might preserve islet cell viability, mass and insulin secretory function, which could improve glucose tolerance following islet transplantation... - Transcriptional repressors are increased in pancreatic islets of type 2 diabetic ratsA Inada
Department of Metabolism and Clinical Nutrition, Faculty of Medicine, Kyoto University, Japan
Biochem Biophys Res Commun 253:712-8. 1998....