Yutaka Seino

Summary

Affiliation: Kansai Denryoku Hospital
Country: Japan

Publications

  1. doi request reprint Efficacy and safety of the once-daily human GLP-1 analogue, liraglutide, vs glibenclamide monotherapy in Japanese patients with type 2 diabetes
    Y Seino
    Kansai Electric Power Hospital, Osaka, Japan
    Curr Med Res Opin 26:1013-22. 2010
  2. doi request reprint Alogliptin benzoate for the treatment of type 2 diabetes
    Yutaka Seino
    Kansai Electric Power Hospital, Center for Diabetes, Endocrinology and Metabolism, 1 7, Fukushima 2 chome, Fukushima ku, Osaka, 553 0003, Japan 81 6 6458 5821 81 6 7501 1403
    Expert Opin Pharmacother 15:851-63. 2014
  3. ncbi request reprint Efficacy and safety of alogliptin added to metformin in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension study
    Y Seino
    Kansai Electric Power Hospital, Osaka, Japan
    Diabetes Obes Metab 14:927-36. 2012
  4. pmc Randomized, double-blind, placebo-controlled trial of the once-daily GLP-1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (GetGoal-L-Asia)
    Y Seino
    Kansai Electric Power Hospital, Osaka, Japan
    Diabetes Obes Metab 14:910-7. 2012
  5. doi request reprint Alogliptin plus voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension
    Yutaka Seino
    Kansai Electric Power Hospital, Osaka, Japan
    Curr Med Res Opin 27:21-9. 2011
  6. doi request reprint Safety, tolerability, pharmacokinetics and pharmacodynamics of albiglutide, a long-acting GLP-1-receptor agonist, in Japanese subjects with type 2 diabetes mellitus
    Yutaka Seino
    Kansai Electric Power Hospital, Osaka, Japan
    Curr Med Res Opin 25:3049-57. 2009
  7. doi request reprint Dose-dependent improvement in glycemia with once-daily liraglutide without hypoglycemia or weight gain: A double-blind, randomized, controlled trial in Japanese patients with type 2 diabetes
    Y Seino
    Kansai Electric Power Hospital, 2 1 7 Fukushima Fukushima ku Osaka shi, 553 0003 Osaka, Japan
    Diabetes Res Clin Pract 81:161-8. 2008
  8. ncbi request reprint Platelet count is independently associated with insulin resistance in non-obese Japanese type 2 diabetic patients
    Ataru Taniguchi
    Division of Diabetes, Kansai Denryoku Hospital, Osaka, Japan
    Metabolism 52:1246-9. 2003
  9. doi request reprint Efficacy and safety of alogliptin in Japanese patients with type 2 diabetes mellitus: a randomized, double-blind, dose-ranging comparison with placebo, followed by a long-term extension study
    Yutaka Seino
    Kansai Electric Power Hospital, Osaka, Japan
    Curr Med Res Opin 27:1781-92. 2011
  10. doi request reprint Circulating TNF receptor 2 is associated with the development of chronic kidney disease in non-obese Japanese patients with type 2 diabetes
    Yoshio Izumi
    Department of Internal Medicine, Osaka North Postal Services Agency Hospital, Osaka, Japan
    Diabetes Res Clin Pract 99:145-50. 2013

Collaborators

Detail Information

Publications57

  1. doi request reprint Efficacy and safety of the once-daily human GLP-1 analogue, liraglutide, vs glibenclamide monotherapy in Japanese patients with type 2 diabetes
    Y Seino
    Kansai Electric Power Hospital, Osaka, Japan
    Curr Med Res Opin 26:1013-22. 2010
    ....
  2. doi request reprint Alogliptin benzoate for the treatment of type 2 diabetes
    Yutaka Seino
    Kansai Electric Power Hospital, Center for Diabetes, Endocrinology and Metabolism, 1 7, Fukushima 2 chome, Fukushima ku, Osaka, 553 0003, Japan 81 6 6458 5821 81 6 7501 1403
    Expert Opin Pharmacother 15:851-63. 2014
    ..Dipeptidyl peptidase (DPP)-4 inhibitor is one of the newer classes of oral antidiabetic drug, and alogliptin is the most recently approved drug in this class...
  3. ncbi request reprint Efficacy and safety of alogliptin added to metformin in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension study
    Y Seino
    Kansai Electric Power Hospital, Osaka, Japan
    Diabetes Obes Metab 14:927-36. 2012
    ..To evaluate the efficacy and safety of alogliptin added to metformin versus metformin monotherapy in Japanese patients with type 2 diabetes who achieved inadequate glycaemic control on metformin (500 or 750 mg/day) + diet/exercise...
  4. pmc Randomized, double-blind, placebo-controlled trial of the once-daily GLP-1 receptor agonist lixisenatide in Asian patients with type 2 diabetes insufficiently controlled on basal insulin with or without a sulfonylurea (GetGoal-L-Asia)
    Y Seino
    Kansai Electric Power Hospital, Osaka, Japan
    Diabetes Obes Metab 14:910-7. 2012
    ..To assess the efficacy and safety of once-daily lixisenatide versus placebo in Asian patients with type 2 diabetes insufficiently controlled on basal insulin ± sulfonylurea...
  5. doi request reprint Alogliptin plus voglibose in Japanese patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial with an open-label, long-term extension
    Yutaka Seino
    Kansai Electric Power Hospital, Osaka, Japan
    Curr Med Res Opin 27:21-9. 2011
    ..To compare the efficacy and safety of alogliptin and placebo as add-on therapy in Japanese patients with type 2 diabetes who experienced inadequate glycemic control on voglibose plus diet/exercise therapy...
  6. doi request reprint Safety, tolerability, pharmacokinetics and pharmacodynamics of albiglutide, a long-acting GLP-1-receptor agonist, in Japanese subjects with type 2 diabetes mellitus
    Yutaka Seino
    Kansai Electric Power Hospital, Osaka, Japan
    Curr Med Res Opin 25:3049-57. 2009
    ..To investigate safety, pharmacokinetics and pharmacodynamics of albiglutide in Japanese subjects with type 2 diabetes mellitus...
  7. doi request reprint Dose-dependent improvement in glycemia with once-daily liraglutide without hypoglycemia or weight gain: A double-blind, randomized, controlled trial in Japanese patients with type 2 diabetes
    Y Seino
    Kansai Electric Power Hospital, 2 1 7 Fukushima Fukushima ku Osaka shi, 553 0003 Osaka, Japan
    Diabetes Res Clin Pract 81:161-8. 2008
    ..To evaluate dose-response efficacy and safety of once-daily human GLP-1 analog liraglutide in Japanese subjects with type 2 diabetes...
  8. ncbi request reprint Platelet count is independently associated with insulin resistance in non-obese Japanese type 2 diabetic patients
    Ataru Taniguchi
    Division of Diabetes, Kansai Denryoku Hospital, Osaka, Japan
    Metabolism 52:1246-9. 2003
    ..These results indicate that not only BMI, HbA(1c), and triglycerides levels but also platelet counts are independent predictor of insulin resistance in non-obese Japanese type 2 diabetic patients...
  9. doi request reprint Efficacy and safety of alogliptin in Japanese patients with type 2 diabetes mellitus: a randomized, double-blind, dose-ranging comparison with placebo, followed by a long-term extension study
    Yutaka Seino
    Kansai Electric Power Hospital, Osaka, Japan
    Curr Med Res Opin 27:1781-92. 2011
    ..In a subsequent open-label, long-term extension phase, patients continued on the same treatment for an additional 40 weeks (patients in the placebo group were reassigned equally to one of the four alogliptin dosages)...
  10. doi request reprint Circulating TNF receptor 2 is associated with the development of chronic kidney disease in non-obese Japanese patients with type 2 diabetes
    Yoshio Izumi
    Department of Internal Medicine, Osaka North Postal Services Agency Hospital, Osaka, Japan
    Diabetes Res Clin Pract 99:145-50. 2013
    ..This cross-sectional study was performed to investigate the relationship between inflammatory biomarkers and CKD in non-obese patients with type 2 diabetes...
  11. ncbi request reprint Porphyromonas gingivalis infection is associated with carotid atherosclerosis in non-obese Japanese type 2 diabetic patients
    Ataru Taniguchi
    Division of Diabetes, Kansai Denryoku Hospital, Osaka, Japan
    Metabolism 52:142-5. 2003
    ..4%, P =.009). From these results, it can be concluded that porphyromonas gingivalis infection, although still a subclinical infection, is associated with atherosclerotic vascular disease in non-obese Japanese type 2 diabetic patients...
  12. ncbi request reprint Early and late onset side effects of short-acting insulin analogue in seven Japanese diabetic patients
    Akira Kuroe
    Division of Diabetes and Clinical Nutrition, Kansai Denryoku Hospital, 2 1 7 Fukushima, Fukushima ku, Osaka City, Osaka 553 0003, Japan
    Diabetes Res Clin Pract 77:412-3. 2007
    ..We should monitor the early and late onset side effects as diligently as possible when we use short-acting insulin analogue on diabetic patients...
  13. doi request reprint A case of fulminant type 1 diabetes mellitus with exocrine pancreatic insufficiency and enhanced glucagon response to meal ingestion
    Daisuke Yabe
    Division of Diabetes and Clinical Nutrition, Kansai Electric Power Hospital, 2 1 7 Fukushima, Osaka 553 0003, Japan
    Diabetes Res Clin Pract 82:e1-4. 2008
    ..Here, we report a FT1DM case with exocrine pancreatic insufficiency and enhanced glucagon response to meal ingestion...
  14. ncbi request reprint The role of family nutritional support in Japanese patients with type 2 diabetes mellitus
    Koin Watanabe
    Department of Medicine, Division of Diabetes, Clinical Nutrition and Endocrinology, Kansai Electric Power Hospital, Osaka, Japan
    Intern Med 49:983-9. 2010
    ..We investigated the role of family support in glycemic control by nutritional self-care behavior of Japanese patients with type 2 diabetes...
  15. ncbi request reprint Enhanced glucagon-like peptide-1 secretion in a patient with glucagonoma: implications for glucagon-like peptide-1 secretion from pancreatic α cells in vivo
    Daisuke Yabe
    Division of Diabetes, Clinical Nutrition and Endocrinology, Kansai Electric Power Hospital, 2 1 7 Fukushima ku, Osaka 553 0003, Japan Division of Metabolism and Clinical Nutrition, Kansai Electric Power Hospital, 2 1 7 Fukushima ku, Osaka 553 0003, Japan Electronic address
    Diabetes Res Clin Pract 102:e1-4. 2013
    ..Our findings support the notion that GLP-1 is secreted from pancreatic α cells in humans. ..
  16. pmc Drug-induced generalized skin eruption in a diabetes mellitus patient receiving a dipeptidyl peptidase-4 inhibitor plus metformin
    Kaori Nakatani
    Division of Diabetes, Clinical Nutrition and Endocrinology, Department of Internal Medicine, Kasai Electric Power Hospital, 2 1 7 Fukushima, Fukushima Ward, Osaka City, 553 0003, Japan
    Diabetes Ther 3:14. 2012
    ..Close attention should be paid to patients receiving this drug with a history of urticaria, and to the development of photosensitivity...
  17. doi request reprint Improvement of fasting plasma glucose level after ingesting moderate amount of dietary fiber in Japanese men with mild hyperglycemia and visceral fat obesity
    Akira Kobayakawa
    Research and Development Department, MIKI Corporation, Kita ku, Osaka, Japan
    J Diet Suppl 10:129-41. 2013
    ....
  18. ncbi request reprint Exercise-induced post-ischemic left ventricular delayed relaxation or diastolic stunning: is it a reliable marker in detecting coronary artery disease?
    Katsuhisa Ishii
    Department of Cardiology, Kansai Electric Power Hospital, 2 1 7 Fukushima, Fukushima ku, Osaka, Japan
    J Am Coll Cardiol 53:698-705. 2009
    ....
  19. doi request reprint Abnormal regional left ventricular systolic and diastolic function in patients with coronary artery disease undergoing percutaneous coronary intervention: clinical significance of post-ischemic diastolic stunning
    Katsuhisa Ishii
    Department of Cardiology, Kansai Electric Power Hospital, Osaka, Japan
    J Am Coll Cardiol 54:1589-97. 2009
    ..This study was designed to characterize both regional left ventricular (LV) systolic and diastolic function after percutaneous coronary intervention by using strain imaging (SI) derived from 2-dimensional speckle-tracking echocardiography...
  20. ncbi request reprint Factors responsible for the evolution of insulin resistance in Japanese type 2 diabetic patients: association with atherosclerosis
    Ataru Taniguchi
    Division of Diabetes and Clinical Nutrition, Kansai Denryoku Hospital, 2 1 7 Fukushima, Osaka City, Osaka 553 0003, Japan
    Diabetes Res Clin Pract 77:S213-9. 2007
    ..In this section, we would like to focus on the factors contributing to insulin resistance and discuss the association of these factors with atherosclerosis in Japanese type 2 diabetic patients...
  21. ncbi request reprint Metabolic syndrome, insulin resistance, and atherosclerosis in Japanese type 2 diabetic patients
    Ataru Taniguchi
    Division of Diabetes and Clinical Nutrition, Kansai Denryoku Hospital, Osaka 553 0003, and Department of Endocrinology and Metabolism, Jichi Medical School of College, Tochigi, Japan
    Metabolism 56:1099-103. 2007
    ..15+/-0.01, P=.245) between the 2 groups. From these results, it can be suggested that metabolic syndrome, an insulin-resistant state, is not associated with carotid atherosclerosis, ba-PWV, or ABI in Japanese type 2 diabetic patients...
  22. ncbi request reprint Interleukin 6, adiponectin, leptin, and insulin resistance in nonobese Japanese type 2 diabetic patients
    Ataru Taniguchi
    Division of Diabetes and Clinical Nutrition, Kansai Denryoku Hospital, Osaka 553 0003, Japan
    Metabolism 55:258-62. 2006
    ..300, P = .003) in our patients. From these results, it can be suggested that fasting serum IL-6 is not a major factor responsible for the evolution of insulin resistance in nonobese Japanese type 2 diabetic patients...
  23. ncbi request reprint Soluble E-selectin, leptin, triglycerides, and insulin resistance in nonobese Japanese type 2 diabetic patients
    Ataru Taniguchi
    Division of Diabetes and Clinical Nutrition, Kansai Denryoku Hospital, Osaka 553 0003, Japan
    Metabolism 54:376-80. 2005
    ....
  24. ncbi request reprint C-reactive protein and insulin resistance in non-obese Japanese type 2 diabetic patients
    Ataru Taniguchi
    Division of Diabetes, Kansai Denryoku Hospital, Osaka, Japan
    Metabolism 51:1578-81. 2002
    ..5% of the variability of CRP in our non-obese Japanese type 2 diabetic patients. These results indicate that insulin resistance and fibrinogen level are independent predictors of CRP in non-obese Japanese type 2 diabetic patients...
  25. ncbi request reprint Effects of pitavastatin on lipid profiles and high-sensitivity CRP in Japanese subjects with hypercholesterolemia: Kansai Investigation of Statin for Hyperlipidemic Intervention in Metabolism and Endocrinology (KISHIMEN) investigatars
    Hiroyuki Koshiyama
    Center for Diabetes and Endocrinology, The Tazuke Kofukai Foundation Medical Research Institute Kitano Hospital, Osaka, Japan
    J Atheroscler Thromb 15:345-50. 2008
    ..We, therefore, investigated the effects of pitavastatin on lipid profiles and hs-CRP in Japanese subjects with hypercholesterolemia...
  26. ncbi request reprint Incretin actions beyond the pancreas: lessons from knockout mice
    Daisuke Yabe
    Division of Diabetes, Clinical Nutrition and Endocrinology, Kansai Electric Power Hospital, 2 1 7 Fukushima ku, Osaka 553 0003, Japan Division of Metabolism and Clinical Nutrition, Kansai Electric Power Hospital, 2 1 7 Fukushima ku, Osaka 553 0003, Japan
    Curr Opin Pharmacol 13:946-53. 2013
    ..We review here recent findings on the extra-pancreatic effects of GIP and GLP-1 from the perspective of diabetes treatment. ..
  27. ncbi request reprint A randomized dose-finding study demonstrating the efficacy and tolerability of albiglutide in Japanese patients with type 2 diabetes mellitus
    Yutaka Seino
    Kansai Electric Power Hospital, Osaka, Japan
    Curr Med Res Opin 30:1095-106. 2014
    ..To investigate the optimal dosage/regimen and to evaluate the efficacy and safety of albiglutide in Japanese patients with type 2 diabetes mellitus...
  28. doi request reprint Two incretin hormones GLP-1 and GIP: comparison of their actions in insulin secretion and β cell preservation
    Daisuke Yabe
    The Division of Diabetes, Clinical Nutrition and Endocrinology, Kansai Electric Power Hospital, 2 1 7 Fukushima, Fukushima ku, Osaka 553 0003, Japan
    Prog Biophys Mol Biol 107:248-56. 2011
    ..We then try to discuss potential of GLP-1 and GIP in treatment of type 2 diabetes...
  29. pmc Liraglutide in adults with type 2 diabetes: global perspective on safety, efficacy and patient preference
    Daisuke Yabe
    Division of Diabetes, Clinical Nutrition and Endocrinology, Kansai Electric Power Hospital, Osaka 553 0003, Japan
    Clin Med Insights Endocrinol Diabetes 4:47-62. 2011
    ..In this review, we summarize results from such clinical trials, and discuss efficacy and safety of liraglutide in management of type 2 diabetes in various countries, along with a pitfall of liraglutide usage in real clinical setting...
  30. ncbi request reprint Soluble vascular cell adhesion molecule-1 is independently associated with soluble tumor necrosis factor receptor 2 in Japanese type 2 diabetic patients
    D Nabeya
    Diabetes Metab 33:81-2. 2007
  31. ncbi request reprint Normalization of cytoplasmic calcium response in pancreatic beta-cells of spontaneously diabetic GK rat by the treatment with T-1095, a specific inhibitor of renal Na+-glucose co-transporters
    K Yasuda
    Laboratory of Metabolism, Faculty of Integrated Human Studies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Horm Metab Res 34:217-21. 2002
    ..1 +/- 15.3 sec, p < 0.01) compared to untreated GK rats (524.7 +/- 52.9 sec). Thus, improvement of hyperglycemia by T-1095 ameliorates beta-cell function by relieving [Ca(2+)]i response...
  32. ncbi request reprint Insulin secretion and insulin sensitivity at different stages of glucose tolerance: a cross-sectional study of Japanese type 2 diabetes
    M Fukushima
    Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Metabolism 53:831-5. 2004
    ..Japanese type 2 diabetic patients are characterized by a larger decrease in insulin secretion and show less attribution of insulin resistance...
  33. ncbi request reprint Synergistic effects of injection of bone marrow cells into both portal vein and bone marrow on tolerance induction in transplantation of allogeneic pancreatic islets
    K Ikebukuro
    First Department of Pathology, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka 570 8506, Japan
    Bone Marrow Transplant 38:657-64. 2006
    ..PV+IBM)-BMT was found to be the most effective in inducing the acceptance of allogeneic PIs. These results suggest that allogeneic PI-transplantation in conjunction with (PV+IBM)-BMT could become a viable strategy...
  34. ncbi request reprint Genetic variation in the hepatocyte nuclear factor (HNF)-3alpha gene does not contribute to maturity-onset diabetes of the young in Japanese
    L Yu
    Department of Cell Biology, Institute for Molecular and Cellular Regulation, Maebashi, Gunma, Japan
    Horm Metab Res 33:163-6. 2001
    ..However, their frequencies were not significantly different between MODY and control subjects, indicating that mutations in the HNF-3alpha gene are not a major cause of MODY in Japanese patients...
  35. ncbi request reprint Abnormal axonal inward rectifier in streptozocin-induced experimental diabetic neuropathy
    Q Yang
    Department of Neurology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Brain 124:1149-55. 2001
    ..Reduced inward rectification potentiates conduction block caused by activity-dependent hyperpolarization and may underlie the decreased vibratory sensation seen in the early stage of diabetic neuropathy...
  36. ncbi request reprint The Pro12 -->Ala substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes
    H Mori
    Second Department of Internal Medicine, Kobe University School of Medicine, Japan
    Diabetes 50:891-4. 2001
    ....
  37. ncbi request reprint Genomic variation in pancreatic ion channel genes in Japanese type 2 diabetic patients
    Y Yamada
    Department of Metabolism and Clinical Nutrition, Kyoto University Graduate School of Medicine, Kyoto, Japan
    Diabetes Metab Res Rev 17:213-6. 2001
    ..Because type 2 diabetes is characterized by pancreatic beta-cell insensitivity to glucose, the genes responsible for glucose metabolism and calcium signaling in pancreatic beta-cells are candidate type 2 diabetes susceptibility genes...
  38. ncbi request reprint Novel mutation in the nephrin gene of a Japanese patient with congenital nephrotic syndrome of the Finnish type
    K Aya
    Department of Pediatrics, Okayama University Medical School, Okayama, Japan
    Kidney Int 57:401-4. 2000
    ..Most Finnish patients have one of two mutations. In this study, we described a Japanese CNS family associated with a novel missense point mutation in the nephrin gene...
  39. pmc Glucose intolerance caused by a defect in the entero-insular axis: a study in gastric inhibitory polypeptide receptor knockout mice
    K Miyawaki
    Department of Metabolism, Graduate School of Medicine, Kyoto University, Kyoto 606 8507, Japan
    Proc Natl Acad Sci U S A 96:14843-7. 1999
    ....
  40. ncbi request reprint Transcriptional repressors are increased in pancreatic islets of type 2 diabetic rats
    A Inada
    Department of Metabolism and Clinical Nutrition, Faculty of Medicine, Kyoto University, Japan
    Biochem Biophys Res Commun 253:712-8. 1998
    ....
  41. ncbi request reprint The structures of the human calcium channel alpha 1 subunit (CACNL1A2) and beta subunit (CACNLB3) genes
    Y Yamada
    Department of Metabolism and Clinical Nutrition, Kyoto University Faculty of Medicine, Japan
    Genomics 27:312-9. 1995
    ..The determination of the structures of the human CACNL1A2 and CACNLB3 genes should facilitate study of the role of these genes in the development of NIDDM and also other genetic diseases such as long QT syndrome...
  42. ncbi request reprint Periodontal infection and dyslipidemia in type 2 diabetics: association with increased HMG-CoA reductase expression
    F Nishimura
    Department of Patho physiology Periodontal Science, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2 5 1 Shikata cho, Okayama, Japan
    Horm Metab Res 38:530-5. 2006
    ..It can be concluded that Pg infection is associated with increased LDL-cholesterol in diabetic subjects, which may be accompanied by increased cholesterol synthesis by inflammatory cytokines...
  43. ncbi request reprint Effect of corosolic acid on postchallenge plasma glucose levels
    M Fukushima
    Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, Japan
    Diabetes Res Clin Pract 73:174-7. 2006
    ..In this study, we have shown for the first time that CRA has a lowering effect on postchallenge plasma glucose levels in vivo in humans...
  44. ncbi request reprint Synergistic effect of polymorphisms of uncoupling protein 1 and beta3-adrenergic receptor genes on autonomic nervous system activity
    N Shihara
    The Laboratory of Metabolism, Graduate School of Human and Environmental Studies, Kyoto University, Sakyo ku, Kyoto 606 8501, Japan
    Int J Obes Relat Metab Disord 25:761-6. 2001
    ....
  45. ncbi request reprint Human TSC-22 gene: no association with type 2 diabetes
    F Sugawara
    Department of Metabolism and Clinical Nutrition, Graduate School of Medicine, Kyoto University
    Intern Med 40:993-7. 2001
    ....
  46. ncbi request reprint Prevalence of periodontal bacterial infection in non-obese Japanese type 2 diabetic patients: relationship with C-reactive protein and albuminuria
    A Kuroe
    Division of Diabetes, Kansai Denryoku Hospital, 2 1 7 Fukushima, Fukushima ku, Osaka City, Osaka 553 0003, Japan
    Horm Metab Res 36:116-8. 2004
    ..These results suggest that among periodontal bacteria, Porphyromonas gingivalis infection is associated with atherosclerosis in non-obese Japanese type 2 diabetic patients...
  47. ncbi request reprint Association of serum resistin with TNF system activity in Japanese type 2 diabetic patients
    N Kitatani
    Diabetes Metab 33:156-7. 2007
  48. ncbi request reprint Is the concept of 'cardiometabolic risk' more useful than 'metabolic syndrome'?
    H Koshiyama
    Diabet Med 24:571. 2007
  49. ncbi request reprint Effects of an aldose reductase inhibitor on gastroenteropathy in streptozotocin-diabetic rats
    M Oya
    Department of Diabetes and Clinical Nutrition, Graduate School of Medicine, Kyoto University, 54, Shogoin, Kawara machi, Sakyo ku, Kyoto 606 8507, Japan
    Diabetes Res Clin Pract 62:69-77. 2003
    ..These findings show that ARI partially prevented progression of impaired gastric emptying, ion transport, and water transport, and suggest that epalrestat might be useful in the treatment of diabetic gastroenteropathy...
  50. ncbi request reprint Which should we ADOPT: sulphonylureas or glitazones?
    H Koshiyama
    Diabet Med 24:804. 2007
  51. ncbi request reprint Factors responsible for glucose intolerance in Japanese subjects with impaired fasting glucose
    M Izuka
    Health Informatics Research Group, Translational Research Informatics Center, Foundation for Biomedical Research and Innovation, Kobe, Japan
    Horm Metab Res 39:41-5. 2007
    ..IFG is composed of three different categories in basal, early-phase insulin secretion, and insulin sensitivity...
  52. ncbi request reprint Beneficial effect of pretreatment of islets with fibronectin on glucose tolerance after islet transplantation
    Y Hamamoto
    Department of Metabolism and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Japan
    Horm Metab Res 35:460-5. 2003
    ..These results indicate that cultivation with fibronectin might preserve islet cell viability, mass and insulin secretory function, which could improve glucose tolerance following islet transplantation...
  53. ncbi request reprint Long-term therapeutic effects of voglibose, a potent intestinal alpha-glucosidase inhibitor, in spontaneous diabetic GK rats
    K Yasuda
    The Laboratory of Metabolism, Faculty of Integrated Human Studies, Kyoto University, Sakyo ku, Japan
    Diabetes Res Clin Pract 59:113-22. 2003
    ....
  54. ncbi request reprint Soluble TNF receptor and periodontal disease in non-obese Japanese type 2 diabetic patients
    Y Nomura
    Horm Metab Res 38:688-9. 2006
  55. ncbi request reprint The threshold value for insulin resistance on homeostasis model assessment of insulin sensitivity
    Y Nakai
    Diabet Med 19:346-7. 2002
  56. ncbi request reprint Impairment of insulin-stimulated GLUT4 translocation in skeletal muscle and adipose tissue in the Tsumura Suzuki obese diabetic mouse: a new genetic animal model of type 2 diabetes
    T Miura
    Department of Clinical Nutrition, Suzuka University of Medical Science, Faculty of Health Science, 1001 1 Kishioka cho, Suzuka, Mie 510 0293, Japan
    Eur J Endocrinol 145:785-90. 2001
    ..A defect in insulin stimulation of GLUT4 translocation also contributes to the characteristics of type 2 diabetes...
  57. ncbi request reprint Soluble TNF receptors and albuminuria in non-obese Japanese type 2 diabetic patients
    Y Kawasaki
    Department of Metabolism and Clinical Nutrition, Graduate School of Medicine, Kyoto University, Kyoto, and Division of Diabetes and Clinical Nutrition, Kansai Denryoku Hospital, Osaka, Japan
    Horm Metab Res 37:617-21. 2005
    ..3% of the variability of urinary albumin concentration. From these results, it can be concluded that serum soluble TNF receptor is an important independent factor associated with albuminuria in non-obese Japanese type 2 diabetic patients...