Gaku Okugawa

Summary

Affiliation: Kansai Medical University
Country: Japan

Publications

  1. ncbi request reprint Olanzapine increases grey and white matter volumes in the caudate nucleus of patients with schizophrenia
    Gaku Okugawa
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    Neuropsychobiology 55:43-6. 2007
  2. ncbi request reprint Diffusion tensor imaging study of the middle cerebellar peduncles in patients with schizophrenia
    Gaku Okugawa
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    Cerebellum 4:123-7. 2005
  3. ncbi request reprint Frontal and temporal volume size of grey and white matter in patients with schizophrenia: an MRI parcellation study
    Gaku Okugawa
    Department of Clinical Neuroscience, Human Brain Informatics, Karolinska Institutet, Stockholm 171 76, Sweden
    Eur Arch Psychiatry Clin Neurosci 257:304-7. 2007
  4. ncbi request reprint Subtle disruption of the middle cerebellar peduncles in patients with schizophrenia
    Gaku Okugawa
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    Neuropsychobiology 50:119-23. 2004
  5. ncbi request reprint Neural disorganization in the superior cerebellar peduncle and cognitive abnormality in patients with schizophrenia: A diffusion tensor imaging study
    Gaku Okugawa
    Department of Neuropsychiatry, Kansai Medical University, 10 15 Fumizonocho Moriguchi, Osaka 570 8506, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1408-12. 2006
  6. ncbi request reprint Inter- and intraoperator reliability of brain tissue measures using magnetic resonance imaging
    Gaku Okugawa
    Dept of Neuropsychiatry, Kansai Medical University, 10 15 Fumizonocho Moriguchi, Osaka 570 8506, Japan
    Eur Arch Psychiatry Clin Neurosci 253:301-6. 2003
  7. ncbi request reprint Reduced grey and white matter volumes in the temporal lobe of male patients with chronic schizophrenia
    Gaku Okugawa
    Department of Clinical Neuroscience, Human Brain Informatics HUBIN, Psychiatry Section, Karolinska Institute and Hospital, 17176 Stockholm, Sweden
    Eur Arch Psychiatry Clin Neurosci 252:120-3. 2002
  8. doi request reprint Antidepressant response and intolerance to SSRI is not influenced by G-protein beta3 subunit gene C825T polymorphism in Japanese major depressive patients
    Masaki Kato
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1041-4. 2008
  9. doi request reprint The alpha 2A-adrenergic receptor gene polymorphism modifies antidepressant responses to milnacipran
    Masataka Wakeno
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    J Clin Psychopharmacol 28:518-24. 2008
  10. doi request reprint Effect of 5-HT1A gene polymorphisms on antidepressant response in major depressive disorder
    Masaki Kato
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    Am J Med Genet B Neuropsychiatr Genet 150:115-23. 2009

Collaborators

Detail Information

Publications33

  1. ncbi request reprint Olanzapine increases grey and white matter volumes in the caudate nucleus of patients with schizophrenia
    Gaku Okugawa
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    Neuropsychobiology 55:43-6. 2007
    ..These findings suggest that treatment with olanzapine may increase the grey and white matter volumes in the caudate nucleus in patients with schizophrenia...
  2. ncbi request reprint Diffusion tensor imaging study of the middle cerebellar peduncles in patients with schizophrenia
    Gaku Okugawa
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    Cerebellum 4:123-7. 2005
    ..This review provides current findings regarding DTI study on the cerebellar peduncle in patients with schizophrenia...
  3. ncbi request reprint Frontal and temporal volume size of grey and white matter in patients with schizophrenia: an MRI parcellation study
    Gaku Okugawa
    Department of Clinical Neuroscience, Human Brain Informatics, Karolinska Institutet, Stockholm 171 76, Sweden
    Eur Arch Psychiatry Clin Neurosci 257:304-7. 2007
    ..Schizophrenic patients had a greater CSF volume in the frontal and temporal lobes. These results suggest that volume reduction in the cerebrum is prominent in the frontal and temporal lobes in both men and women with schizophrenia...
  4. ncbi request reprint Subtle disruption of the middle cerebellar peduncles in patients with schizophrenia
    Gaku Okugawa
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    Neuropsychobiology 50:119-23. 2004
    ..The findings of the study suggest that antipsychotics may improve the subtle disruption in the middle cerebellar peduncles in patients with schizophrenia...
  5. ncbi request reprint Neural disorganization in the superior cerebellar peduncle and cognitive abnormality in patients with schizophrenia: A diffusion tensor imaging study
    Gaku Okugawa
    Department of Neuropsychiatry, Kansai Medical University, 10 15 Fumizonocho Moriguchi, Osaka 570 8506, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 30:1408-12. 2006
    ..These findings suggest that there is neural disruption in the superior cerebellar peduncle in patients with schizophrenia, which may be involved in the cognitive abnormalities found in schizophrenia...
  6. ncbi request reprint Inter- and intraoperator reliability of brain tissue measures using magnetic resonance imaging
    Gaku Okugawa
    Dept of Neuropsychiatry, Kansai Medical University, 10 15 Fumizonocho Moriguchi, Osaka 570 8506, Japan
    Eur Arch Psychiatry Clin Neurosci 253:301-6. 2003
    ..971 and 0.999. The segmentation and measurement are useful for volumetric studies in the human brain using BRAINS...
  7. ncbi request reprint Reduced grey and white matter volumes in the temporal lobe of male patients with chronic schizophrenia
    Gaku Okugawa
    Department of Clinical Neuroscience, Human Brain Informatics HUBIN, Psychiatry Section, Karolinska Institute and Hospital, 17176 Stockholm, Sweden
    Eur Arch Psychiatry Clin Neurosci 252:120-3. 2002
    ..The volume of white matter in the whole brain also appears to be reduced. Among the different brains regions, grey matter reduction was significant only in the temporal region...
  8. doi request reprint Antidepressant response and intolerance to SSRI is not influenced by G-protein beta3 subunit gene C825T polymorphism in Japanese major depressive patients
    Masaki Kato
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:1041-4. 2008
    ..The result suggests that C825T variants of GNB3 cannot play a major role as a predictor of treatment response as well as intolerance to SSRIs in Japanese patients with major depression...
  9. doi request reprint The alpha 2A-adrenergic receptor gene polymorphism modifies antidepressant responses to milnacipran
    Masataka Wakeno
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    J Clin Psychopharmacol 28:518-24. 2008
    ..In this study, the effect of genetic variants of the ADRA2A gene on the response to selective serotonin reuptake inhibitors (SSRIs)/serotonin norepinephrine reuptake inhibitors (SNRIs) was examined in depressed patients...
  10. doi request reprint Effect of 5-HT1A gene polymorphisms on antidepressant response in major depressive disorder
    Masaki Kato
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    Am J Med Genet B Neuropsychiatr Genet 150:115-23. 2009
    ..This finding adds an important information for the pathway of detecting the genetics of antidepressant response even if results must be verified on larger samples...
  11. doi request reprint Effect of basic fibroblast growth factor (FGF2) gene polymorphisms on SSRIs treatment response and side effects
    Masaki Kato
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    Eur Neuropsychopharmacol 19:718-25. 2009
    ..This finding adds an important piece of information for the pathway of detecting the genetics of antidepressant response...
  12. ncbi request reprint ABCB1 (MDR1) gene polymorphisms are associated with the clinical response to paroxetine in patients with major depressive disorder
    Masaki Kato
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 32:398-404. 2008
    ..Furthermore, the wild variants haplotype (3435C-2677G-1236T) resulted associated with poor response (p=0.006). To our best knowledge, this study is the first suggestion of a possible association of ABCB1 variants with SSRIs response...
  13. ncbi request reprint Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patients
    Masaki Kato
    Department of Neuropsychiatry, Kansai Medical University, Moriguchi, Japan
    Neuropsychobiology 53:186-95. 2006
    ..Furthermore, the effects of these polymorphisms varied from one SSRI to another and thus may depend on the characteristics of each SSRI...
  14. ncbi request reprint Reduced white matter volume of the caudate nucleus in patients with schizophrenia
    Katsunori Takase
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    Neuropsychobiology 50:296-300. 2004
    ..Our result replicates a previous study reporting that there is a lack of negative correlation between age and caudate nucleus volume. We also suggest that the disease process of schizophrenia might interfere with normal aging...
  15. doi request reprint Cerebellar posterior superior vermis and cognitive cluster scores in drug-naive patients with first-episode schizophrenia
    Gaku Okugawa
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    Neuropsychobiology 56:216-9. 2007
    ..Smaller volumes of the posterior superior vermis were associated with worse cognitive cluster scores in patients with first-episode schizophrenia...
  16. ncbi request reprint Increased omega complexity and decreased microstate duration in nonmedicated schizophrenic patients
    Satoshi Irisawa
    Department of Neuropsychiatry, Kansai Medical University, 10 15 Fumizono cho, Moriguchi 570 8506, Japan
    Neuropsychobiology 54:134-9. 2006
    ..These results indicated looser cooperativity, or decreased connectivity of the active brain process and deviant brain information processing in schizophrenic patients...
  17. doi request reprint A 12-week randomized, open-label study of perospirone versus aripiprazole in the treatment of Japanese schizophrenia patients
    Yoshiteru Takekita
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    Prog Neuropsychopharmacol Biol Psychiatry 40:110-4. 2013
    ..To evaluate the efficacy and safety of aripiprazole and perospirone in Japanese patients with schizophrenia...
  18. ncbi request reprint Altered white matter/gray matter proportions in the striatum of patients with schizophrenia: a volumetric MRI study
    Chiharu Tamagaki
    Human Brain Informatics, Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden
    Am J Psychiatry 162:2315-21. 2005
    ..Anatomical structures of the striatum were studied in 58 patients with schizophrenia and 56 healthy comparison subjects of both genders matched for age and handedness...
  19. ncbi request reprint [5-HT1A gene polymorphisms contributed to antidepressant response in major depression]
    Masaki Kato
    Department of Neuropsychiatry, Kansai Medical University, 10 15 Fumizonocho, Moriguchi 570 8506, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 29:23-31. 2009
    ..001), week 2 (P < 0.0001), 4 (P = 0.007), and 6 (P = 0.048) as well as response rate (P = 0.0005) and remission rate (P = 0.004). We also pointed out the genotyping mis-definition of rs6295C/G in the previous four papers...
  20. ncbi request reprint Selective reduction of the posterior superior vermis in men with chronic schizophrenia
    Gaku Okugawa
    Department of Clinical Neuroscience, Human Brain Informatics Center HUBIN, Karolinska Institute and Hospital, SE 171 76 Stockholm, Sweden
    Schizophr Res 55:61-7. 2002
    ..The findings support the view that within the cerebellum the posterior superior vermis may be selectively reduced in men with chronic schizophrenia...
  21. ncbi request reprint Randomized clinical comparison of perospirone and risperidone in patients with schizophrenia: Kansai Psychiatric Multicenter Study
    Gaku Okugawa
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    Psychiatry Clin Neurosci 63:322-8. 2009
    ..To clarify the clinical traits of perospirone in the treatment of schizophrenia, the clinical efficacies and side-effects of perospirone and risperidone were compared in a randomized clinical multicenter trial...
  22. ncbi request reprint Global approach to multichannel electroencephalogram analysis for diagnosis and clinical evaluation in mild Alzheimer's disease
    Masafumi Yoshimura
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    Neuropsychobiology 49:163-6. 2004
    ..These results indicate an increase in spatial complexity of the brain electric field in mild AD, as well as a close relationship between slowing of the global frequency of field changes and the cognitive decline in mild AD...
  23. ncbi request reprint Smaller cerebellar vermis but not hemisphere volumes in patients with chronic schizophrenia
    Gaku Okugawa
    Department of Clinical Neuroscience, Human Brain Infomatics Center HUBIN, Karolinska Institute and Hospital, Stockholm, Sweden
    Am J Psychiatry 160:1614-7. 2003
    ..In this study, they tested whether posterior superior vermis reduction would be seen in a larger group of schizophrenia patients, both male and female...
  24. doi request reprint Corpus callosum in patients with obsessive-compulsive disorder: diffusion-tensor imaging study
    Yukiko Saito
    Department of Neuropsychiatry, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka, 570 8506, Japan
    Radiology 246:536-42. 2008
    ....
  25. pmc Genetic polymorphisms in dopamine- and serotonin-related genes and treatment responses to risperidone and perospirone
    Atsushi Tsutsumi
    Department of Neuropsychiatry, Osaka Medical College, Takatsuki, Osaka, Japan
    Psychiatry Investig 6:222-5. 2009
    ..043]. Although the small sample represents a serious limitation, these results suggest that variants in DRD4 are a predictor of whether treatment will be more effective with risperidone or with perospirone in individual patients...
  26. ncbi request reprint MR volumetry during acute alcohol withdrawal and abstinence: a descriptive study
    Ingrid Agartz
    Karolinska Institutet, Department of Clinical Neuroscience, Clinical Alcohol and Drug Addiction Research Section and Human Brain Informatics, Psychiatry Section, Karolinska Hospital, Stockholm SE 171 76, Sweden
    Alcohol Alcohol 38:71-8. 2003
    ....
  27. ncbi request reprint A pharmaco-EEG study on antipsychotic drugs in healthy volunteers
    Masafumi Yoshimura
    Department of Psychiatric Neurophysiology, University Hospital of Psychiatry, Bern, Switzerland
    Psychopharmacology (Berl) 191:995-1004. 2007
    ..Previous studies found that some psychotropic drugs had EEG effects opposite to the EEG effects of the mental disorders treated with these drugs (key-lock principle)...
  28. ncbi request reprint Controlled clinical comparison of paroxetine and fluvoxamine considering the serotonin transporter promoter polymorphism
    Masaki Kato
    Department of Neuropsychiatry, Kansai Medical University, Moriguchi, Osaka, Japan
    Int Clin Psychopharmacol 20:151-6. 2005
    ..These findings suggest that the genetic test may be useful in investigating the efficacy of the two SSRIs, and that normalization by the 5HTTLPR genotypes may lead to improvement of the precision of comparative analysis...
  29. ncbi request reprint Successful electroconvulsive treatment of depression associated with a marked reduction in the symptoms of tardive dyskinesia
    Kenji Nobuhara
    Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
    J ECT 20:262-3. 2004
    ..We discuss the possibility of improving TD by treating the depression with ECT...
  30. doi request reprint No association of TPH1 218A/C polymorphism with treatment response and intolerance to SSRIs in Japanese patients with major depression
    Masaki Kato
    Institute of Psychiatry, University of Bologna, Bologna, Italy
    Neuropsychobiology 56:167-71. 2007
    ..In the present study, we examined the possible association of the TPH1 218A/C polymorphism with response to SSRIs in a sample of Japanese patients with major depression...
  31. ncbi request reprint Perospirone for treatment of dissociative identity disorder
    Gaku Okugawa
    Psychiatry Clin Neurosci 59:624. 2005
  32. ncbi request reprint Cerebellar volumes in men with schizophrenia and alcohol dependence
    Katarina Varnas
    Institute of Psychiatry, University of Oslo, Oslo, Norway
    Psychiatry Clin Neurosci 61:326-9. 2007
    ..The results provide indications for differential morphological abnormalities of the cerebellar vermis in patients with schizophrenia and alcohol dependence...
  33. ncbi request reprint Paroxetine for treatment of somatization disorder
    Gaku Okugawa
    J Neuropsychiatry Clin Neurosci 14:464-5. 2002