Research Topics
| K NobuharaSummaryAffiliation: Kansai Medical University Country: Japan Publications
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Detail Information
Publications
Frontal white matter anisotropy and symptom severity of late-life depression: a magnetic resonance diffusion tensor imaging studyK Nobuhara
Department of Neuropsychiatry, Kansai Medical University, Moriguchi, Japan
J Neurol Neurosurg Psychiatry 77:120-2. 2006....
SPET imaging of central muscarinic acetylcholine receptors with iodine-123 labelled E-IQNP and Z-IQNPK Nobuhara
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Hospital, Stockholm, Sweden
Eur J Nucl Med 28:13-24. 2001..123I]Z-IQNP has potential for exploration of M2 receptor binding in the cerebellum...- Successful electroconvulsive treatment of depression associated with a marked reduction in the symptoms of tardive dyskinesiaKenji Nobuhara
Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
J ECT 20:262-3. 2004..We discuss the possibility of improving TD by treating the depression with ECT... - Effects of electroconvulsive therapy on frontal white matter in late-life depression: a diffusion tensor imaging studyK Nobuhara
Department of Neuropsychiatry, Kansai Medical University, Moriguchi City, Japan
Neuropsychobiology 50:48-53. 2004..A course of bilateral ECT ameliorated white matter integrity in frontal brain regions. This suggests a strong relationship with the antidepressant action of ECT... - Z-IQNP: a potential radioligand for SPECT imaging of muscarinic acetylcholine receptors in Alzheimer's diseaseK Nobuhara
Karolinska Institutet, Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden
Psychopharmacology (Berl) 149:45-55. 2000..Z-(R,R)-1-azabicyclo[2.2.2]oct-3-yl alpha-hydroxy-alpha-(1-iodo1-propen-3-yl)-alpha-phenylacetat e (Z-IQNP) is a muscarinic antagonist with high affinity for the M2 subtype... - Diffusion tensor magnetic resonance imaging of disruption of regional white matter in schizophreniaT Minami
Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
Neuropsychobiology 47:141-5. 2003..Our findings also show the effects of antipsychotics on the white matter in the left frontal region in schizophrenia... - Effectiveness of treatment with donepezil hydrochloride and changes in regional cerebral blood flow in patients with Alzheimer's diseaseTsunetaka Yoshida
Department of Radiology, Kansai Medical University, Moriguchi, Osaka, Japan
Ann Nucl Med 21:257-65. 2007.... 
Corpus callosum in patients with obsessive-compulsive disorder: diffusion-tensor imaging studyYukiko Saito
Department of Neuropsychiatry, Kansai Medical University, 10 15 Fumizono cho, Moriguchi City, Osaka, 570 8506, Japan
Radiology 246:536-42. 2008....- Increased omega complexity and decreased microstate duration in nonmedicated schizophrenic patientsSatoshi Irisawa
Department of Neuropsychiatry, Kansai Medical University, 10 15 Fumizono cho, Moriguchi 570 8506, Japan
Neuropsychobiology 54:134-9. 2006..These results indicated looser cooperativity, or decreased connectivity of the active brain process and deviant brain information processing in schizophrenic patients... - Neural disorganization in the superior cerebellar peduncle and cognitive abnormality in patients with schizophrenia: A diffusion tensor imaging studyGaku Okugawa
Department of Neuropsychiatry, Kansai Medical University, 10 15 Fumizonocho Moriguchi, Osaka 570 8506, Japan
Prog Neuropsychopharmacol Biol Psychiatry 30:1408-12. 2006..These findings suggest that there is neural disruption in the superior cerebellar peduncle in patients with schizophrenia, which may be involved in the cognitive abnormalities found in schizophrenia... - Olanzapine increases grey and white matter volumes in the caudate nucleus of patients with schizophreniaGaku Okugawa
Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
Neuropsychobiology 55:43-6. 2007..These findings suggest that treatment with olanzapine may increase the grey and white matter volumes in the caudate nucleus in patients with schizophrenia... - Diffusion tensor imaging study of the middle cerebellar peduncles in patients with schizophreniaGaku Okugawa
Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
Cerebellum 4:123-7. 2005..This review provides current findings regarding DTI study on the cerebellar peduncle in patients with schizophrenia... - Controlled clinical comparison of paroxetine and fluvoxamine considering the serotonin transporter promoter polymorphismMasaki Kato
Department of Neuropsychiatry, Kansai Medical University, Moriguchi, Osaka, Japan
Int Clin Psychopharmacol 20:151-6. 2005..These findings suggest that the genetic test may be useful in investigating the efficacy of the two SSRIs, and that normalization by the 5HTTLPR genotypes may lead to improvement of the precision of comparative analysis... - Reduced white matter volume of the caudate nucleus in patients with schizophreniaKatsunori Takase
Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
Neuropsychobiology 50:296-300. 2004..Our result replicates a previous study reporting that there is a lack of negative correlation between age and caudate nucleus volume. We also suggest that the disease process of schizophrenia might interfere with normal aging... - Subtle disruption of the middle cerebellar peduncles in patients with schizophreniaGaku Okugawa
Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
Neuropsychobiology 50:119-23. 2004..The findings of the study suggest that antipsychotics may improve the subtle disruption in the middle cerebellar peduncles in patients with schizophrenia... - Global approach to multichannel electroencephalogram analysis for diagnosis and clinical evaluation in mild Alzheimer's diseaseMasafumi Yoshimura
Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
Neuropsychobiology 49:163-6. 2004..These results indicate an increase in spatial complexity of the brain electric field in mild AD, as well as a close relationship between slowing of the global frequency of field changes and the cognitive decline in mild AD... - Inter- and intraoperator reliability of brain tissue measures using magnetic resonance imagingGaku Okugawa
Dept of Neuropsychiatry, Kansai Medical University, 10 15 Fumizonocho Moriguchi, Osaka 570 8506, Japan
Eur Arch Psychiatry Clin Neurosci 253:301-6. 2003..971 and 0.999. The segmentation and measurement are useful for volumetric studies in the human brain using BRAINS... - Cerebellar posterior superior vermis and cognitive cluster scores in drug-naive patients with first-episode schizophreniaGaku Okugawa
Department of Neuropsychiatry, Kansai Medical University, Osaka, Japan
Neuropsychobiology 56:216-9. 2007..Smaller volumes of the posterior superior vermis were associated with worse cognitive cluster scores in patients with first-episode schizophrenia... - Effects of the serotonin type 2A, 3A and 3B receptor and the serotonin transporter genes on paroxetine and fluvoxamine efficacy and adverse drug reactions in depressed Japanese patientsMasaki Kato
Department of Neuropsychiatry, Kansai Medical University, Moriguchi, Japan
Neuropsychobiology 53:186-95. 2006..Furthermore, the effects of these polymorphisms varied from one SSRI to another and thus may depend on the characteristics of each SSRI... - Perospirone for treatment of dissociative identity disorderGaku Okugawa
Psychiatry Clin Neurosci 59:624. 2005 - Radioiodinated SB 207710 as a radioligand in vivo: imaging of brain 5-HT4 receptors with SPETVictor W Pike
MRC Cyclotron Unit, Imperial College School of Medicine, Hammersmith Hospital, DuCane Road, W12 0NN, London, UK
Eur J Nucl Med Mol Imaging 30:1520-8. 2003..Radioactivity in all brain regions was reduced almost to the level in cerebellum by 176 min after radioligand injection. These findings show that [(123)I]SB 207710 is an effective radioligand for imaging brain 5-HT(4) receptors in vivo...