Research Topics
| Yasuhiro MatsumuraSummaryAffiliation: Kansai Medical University Country: Japan Publications
| Collaborators
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Detail Information
Publications
Toxic effects of ultraviolet radiation on the skinYasuhiro Matsumura
Department of Dermatology, Kansai Medical University, Osaka 570 8507, Japan
Toxicol Appl Pharmacol 195:298-308. 2004..Although such therapy is beneficial, it is accompanied with undesirable side effects. Thus, UV radiation is like two sides of the same coin--on one side, it has detrimental effects, and on the other side, it has beneficial effects...- PIG7/LITAF gene mutation and overexpression of its gene product in extramammary Paget's diseaseYasuhiro Matsumura
Department of Dermatology, Graduate School of Medicine, Kyoto University, Kyoto, Japan
Int J Cancer 111:218-23. 2004..PIG7/LITAF mRNA expression is confined to tumor cells in in situ mRNA hybridization analysis. These results indicate that genetic disorder and overexpression of PIG7/LITAF may be involved in EMPD carcinogenesis... - Inverse relationship between increased apoptosis and decreased skin cancer in UV-irradiated CD1d-/- miceYasuhiro Matsumura
Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, TX, USA
Photochem Photobiol 81:46-51. 2005..These results indicate that the resistance of CD1d-/- mice to UV carcinogenesis may be due to increased cell death and elimination of keratinocytes and fibroblasts containing DNA damage and p53 mutations... - Development of a new mouse model (xeroderma pigmentosum a-deficient, stem cell factor-transgenic) of ultraviolet B-induced melanomaFumikazu Yamazaki
Department of Dermatology, Kansai Medical University, Moriguchi, Osaka, Japan
J Invest Dermatol 125:521-5. 2005..The newly generated model mouse might be useful for studying the photobiological aspects of human melanoma, because the mice developed melanoma from epidermal melanocytes only after UVR exposures... 
Resistance of CD1d-/- mice to ultraviolet-induced skin cancer is associated with increased apoptosisYasuhiro Matsumura
Department of Immunology, The University of Texas M D Anderson Cancer Center, Houston, TX, 77030, USA
Am J Pathol 165:879-87. 2004..Our findings identify an unexpected and novel function for CD1d as a critical molecule regulating UV carcinogenesis, by inhibiting apoptosis to prevent elimination of potentially malignant keratinocytes and fibroblasts...- Short-term and long-term cellular and molecular events following UV irradiation of skin: implications for molecular medicineYasuhiro Matsumura
Department of Immunology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Unit 178, Houston, TX 77030, USA
Expert Rev Mol Med 4:1-22. 2002..Further investigation and a better understanding of photocarcinogenesis are critical to the development of effective prevention and intervention strategies for human skin cancer... - Molecular analysis of DNA polymerase eta gene in Japanese patients diagnosed as xeroderma pigmentosum variant typeMiki Tanioka
Department of Dermatology, Graduate School of Medicine, Kobe University, Kobe, Japan
J Invest Dermatol 127:1745-51. 2007..Seven mutations in the POLH gene including three novel mutations were identified. Among the mutations detected, 11 alleles out of 28 (39%) were G490T mutations... - XPA gene-deficient, SCF-transgenic mice with epidermal melanin are resistant to UV-induced carcinogenesisFumikazu Yamazaki
Department of Dermatology, Kansai Medical University, Moriguchi, Osaka, Japan
J Invest Dermatol 123:220-8. 2004..These findings indicate that epidermal melanin has a high ability to protect DNA damage by UVB radiation, and thereby, prevent UV-induced inflammation, immunosuppression, and carcinogenesis... - Molecular mechanisms of photocarcinogenesisYasuhiro Matsumura
Department of Immunology, The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Box 178, Houston, TX, 77030, USA
Front Biosci 7:d765-83. 2002..The understanding and further investigation of photocarcinogenesis is critical to the development of effective prevention and intervention strategies for human skin cancer... - Expression profiling of fecal colonocytes for RNA-based screening of colorectal cancerSatoshi Yajima
Genetics Division, National Cancer Center Research Institute, Tsukiji 5 1 1, Chuo Ku, Tokyo 104 0045, Japan
Int J Oncol 31:1029-37. 2007..Our extensive gene list provides other markers for fecal RNA-based colorectal cancer screening... - A new method for isolating colonocytes from naturally evacuated feces and its clinical application to colorectal cancer diagnosisHisayuki Matsushita
Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, Japan
Gastroenterology 129:1918-27. 2005..The present study describes a promising procedure for future clinical evaluations and the early detection of colorectal cancers, including right-side colon cancer... - Platelet-activating factor is crucial in psoralen and ultraviolet A-induced immune suppression, inflammation, and apoptosisPeter Wolf
Research Unit for Photodermatology, Department of Dermatology, Medical University Graz, Auenbrugger Platz 8, A 8036 Graz, Austria
Am J Pathol 169:795-805. 2006.... - Fourteen novel genetic variations and haplotype structures of the TYMS gene encoding human thymidylate synthase (TS)Su Ryang Kim
Project Team for Pharmacogenetics, National Institute of Health Sciences, Tokyo, Japan
Drug Metab Pharmacokinet 21:509-16. 2006..In Blocks 1 and 3, 7 and 19 haplotypes were determined/inferred, respectively. Our findings provide fundamental and useful information for genotyping TYMS in the Japanese and probably other Asian populations... - Novel cisplatin-incorporated polymeric micelles can eradicate solid tumors in miceNobuhiro Nishiyama
Department of Materials Science and Engineering, Graduate School of Engineering, The University of Tokyo, Tokyo, Japan
Cancer Res 63:8977-83. 2003..These data suggest that CDDP/m could be a promising formulation of CDDP for the targeted therapy of solid tumors... - PCR-based assessment of the recovery rate of exfoliated colonocytes or cancer cells from fecal samples depends on the storage conditions after defecationShigeki Onouchi
Investigative Treatment Division, Research Center for Innovative Oncology, National Cancer Center Hospital East, Kashiwa, 6 5 1 Kashiwanoha, Kashiwa 277 8577, Japan
J Gastrointestin Liver Dis 16:369-72. 2007..The purpose of the present study was to determine how long after defecation and at what temperature the fecal samples should be stored to isolate the colonocytes successfully... 
Synergistic antitumor activity of the novel SN-38-incorporating polymeric micelles, NK012, combined with 5-fluorouracil in a mouse model of colorectal cancer, as compared with that of irinotecan plus 5-fluorouracilTakako Eguchi Nakajima
Gastrointestinal Oncology Division, National Cancer Center Hospital, Tokyo, Japan
Int J Cancer 122:2148-53. 2008..Optimal therapeutic synergy was observed between NK012 and 5FU, therefore, this regimen is considered to hold promise of clinical benefit, especially for patients with colorectal cancer...