Research Topics
Genomes and Genes | Kazunari KanekoSummaryAffiliation: Kansai Medical University Country: Japan Publications
| Collaborators
|
Detail Information
Publications
Measurement of urinary 8-oxo-7,8-dihydro-2-deoxyguanosine in a novel point-of-care testing device to assess oxidative stress in childrenKazunari Kaneko
Department of Pediatrics, Kansai Medical University, Osaka, Japan
Clin Chim Acta 413:1822-6. 2012..Ltd., Japan) has been developed for point-of-care testing (POCT) to measure urinary 8-oxodG. We verified the reliability of the value of urinary 8-oxodG measured by this novel analyzer and to set the age-related reference intervals...- Intravenous immunoglobulin counteracts oxidative stress in Kawasaki diseaseKazunari Kaneko
Department of Pediatrics, Kansai Medical University, 2 3 l Shin machi, Hirakata shi, Osaka, 573 1191, Japan
Pediatr Cardiol 33:1086-8. 2012..Further study to elucidate this point would be worthwhile... - Serum albumin level accurately reflects antioxidant potentials in idiopathic nephrotic syndromeKazunari Kaneko
Department of Pediatrics, Kansai Medical University, Hirakata, Osaka, Japan
Clin Exp Nephrol 16:411-4. 2012..This study was conducted to investigate whether hypoalbuminemia contributes to a decreased biological antioxidant potentials (BAP) in idiopathic nephrotic syndrome (INS)... - Treatment for nocturnal enuresis: the current state in JapanKazunari Kaneko
Department of Pediatrics, Kansai Medical University, Osaka, Japan
Pediatr Int 54:8-13. 2012.... - Prediction of the risk of coronary arterial lesions in Kawasaki disease by brain natriuretic peptideKazunari Kaneko
Department of Pediatrics, Kansai Medical University, Osaka, Japan
Pediatr Cardiol 32:1106-9. 2011..4. In conclusion, NT-proBNP is increased in KD patients who are developing CAL, and patients with an elevated serum NT-proBNP >1,000 pg/ml have a risk of CAL ~10 times higher than that of patients with a modest increase... - A family with X-linked benign familial hematuriaKazunari Kaneko
Department of Pediatrics, Kansai Medical University, 2 3 1 Shin machi, Hirakata shi, Osaka 573 1191, Japan
Pediatr Nephrol 25:545-8. 2010..e. X-linked Alport syndrome or benign familial hematuria, remains unknown... - Oxidative imbalance in idiopathic renal hypouricemiaKazunari Kaneko
Department of Pediatrics, Kansai Medical University, 2 3 1 Shin machi, Hirakata shi, Osaka 573 1191, Japan
Pediatr Nephrol 24:869-71. 2009..Antioxidant properties may alter this imbalance by augmenting the antioxidant activity... - Immunoglobulin preparations affect hyponatremia in Kawasaki diseaseKazunari Kaneko
Department of Pediatrics, Kansai Medical University, 2 3 l Shin machi, Hirakata shi, Osaka 573 1191, Japan
Eur J Pediatr 169:957-60. 2010..In conclusion, we should keep it in mind that the IVIG products without Na have an adverse affect on hyponatremia in KD though their efficacy seems to be equivalent to those containing high Na... - Low calcium diet increases radical production of polymorphonuclear leukocytes from miceJunji Takaya
Department of Pediatrics, Kansai Medical University, Moriguchi Shi, Osaka, Japan
Int J Vitam Nutr Res 79:375-80. 2009..aureus-stimulated PMNs. A low-calcium diet increases ROS production from stimulated PMNs and decreases NO production at baseline. This finding suggests that calcium regulates ROS production from PMNs... 
GSTT1 gene abnormality in minimal change nephrotic syndrome with elevated serum immunoglobulin EKohei Miyazaki
Department of Pediatrics, Kinki University School of Medicine, Osaka, Japan
Clin Nephrol 77:261-6. 2012..Imbalance between T-helper 1 (Th1) and 2 (Th2) lymphocytes and effects of reactive oxygen species (ROS) upon glomerular capillary walls have been implicated in minimal change nephrotic syndrome (MCNS)...- A Novel Nuclear Factor κB Inhibitor, Dehydroxymethylepoxyquinomicin, Ameliorates Puromycin Aminonucleoside-Induced Nephrosis in MiceTomohiko Shimo
Department of Pediatrics, Kansai Medical University, Osaka, Japan
Am J Nephrol 37:302-9. 2013..Conclusions: These results suggest that DHMEQ can be a potential therapeutic agent for MCNS... - Production of nitric oxide is lower in Shiga toxin-stimulated neutrophils of infants compared to those of children or adultsShoji Tsuji
Department of Pediatrics, Kansai Medical University, Osaka, Japan
Tohoku J Exp Med 228:247-52. 2012..These results suggest that NO may contribute to the cellular defense mechanisms against Stx... - Increased production of nitric oxide by phagocytic stimulated neutrophils in patients with chronic granulomatous diseaseShoji Tsuji
Department of Pediatrics, Kansai Medical University, Hirakata shi, Osaka, Japan
J Pediatr Hematol Oncol 34:500-2. 2012.... - Hereditary renal hypouricemia: a cause of calcium oxalate urolithiasis in a young femaleNaoto Nishizaki
Division of Nephrology, Saitama Children s Medical Center, Saitama, Japan
Clin Nephrol 77:161-3. 2012..To the best of our knowledge, this is the youngest case of hereditary renal hypouricemia caused by URAT1 gene mutation, which was found by hematuria due to calcium oxalate urolithiasis... - Increased nitric oxide production by neutrophils in early stage of Kawasaki diseaseKen Yoshimura
Department of Pediatrics, Kansai Medical University, 2 3 1 Shin machi, Hirakata shi, Osaka 573 1191, Japan
Eur J Pediatr 168:1037-41. 2009..Abnormal immune system in KD might be characterized by an overproduction of NO, whereas the role of NO in endothelial damage remains to be elucidated... - Increased urinary calcium excretion caused by ceftriaxone: possible association with urolithiasisTakahisa Kimata
Department of Pediatrics, Kansai Medical University, 2 3 l Shin machi, Hirakata shi, Osaka 573 1191, Japan
Pediatr Nephrol 27:605-9. 2012..We therefore suggest that it is worthwhile monitoring the uCa/Cr levels in patients on ceftriaxone as they may be at greater risk for developing large stones and renal damage... - Upregulation of hepatic 11β-hydroxysteroid dehydrogenase-1 expression in calcium-deficient ratsJunji Takaya
Department of Pediatrics, Kansai Medical University, Moriguchi, Japan
Ann Nutr Metab 59:73-8. 2011..Many epidemiologic studies have reported a link between calcium (Ca) deficiency and metabolic syndrome. In this study, we examine Ca deficiency in rats and whether changes in glucocorticoid metabolism are induced... - Diagnosis of autoimmune neutropenia by neutrophil-bound IgG and IgM antibodiesTaichi Ito
Department of Pediatrics, Kansai Medical University, Moriguchi Shi, Osaka, Japan
J Pediatr Hematol Oncol 33:552-5. 2011..997, respectively) in the diagnosis of AIN. D-GIFT detecting both neutrophil-bound IgG autoantibodies and IgM autoantibodies has discriminatory power for identifying patients with AIN and, therefore, can be a useful diagnostic test... - Steroid pulse therapy for children with intravenous immunoglobulin therapy-resistant Kawasaki disease: a prospective studyMasayuki Teraguchi
Department of Pediatrics, Kansai Medical University, 2 3 1 Shin machi, Hirakatashi, Osaka, 573 1191, Japan
Pediatr Cardiol 34:959-63. 2013..MPT does not reduce the risk of development to CAL and does not seem to be beneficial as single agent therapy for IVIG resistant KD... - Effect of a novel free radical scavenger, edaravone, on puromycin aminonucleoside induced nephrosis in ratsTomonosuke Someya
Department of Pediatrics, School of Medicine, Juntendo University, Tokyo, Japan
Pediatr Nephrol 20:1430-4. 2005..In conclusion, EDA could delay and ameliorate the urinary protein excretion in accordance with the urinary 8-OHdG excretion in PAN-induced nephrosis... - Nephrotic syndrome associated with human parvovirus B19 infectionYoshiyuki Ohtomo
Department of Pediatrics, Juntendo University, School of Medicine, Tokyo, Japan
Pediatr Nephrol 18:280-2. 2003..A renal biopsy showed mesangiocapillary proliferative glomerulonephritis with immune complex deposits associated with PVB19 virus. His renal involvement improved spontaneously... 
Impact of obesity on childhood kidneyKazunari Kaneko
Department of Pediatrics, Kansai Medical University
Pediatr Rep 3:e27. 2011..BMI and systolic BP (mmHg) were significantly higher in the former than in the latter. As a result, obesity may be associated with the development of renal injury even in childhood...- Increased nitric oxide production by T- and B-cells in idiopathic nephrotic syndromeAnna Iharada
Department of Pediatrics, Kansai Medical University, Osaka, Japan
Pediatr Nephrol 24:1033-8. 2009..We conclude that an aberrant immune system may exist not only in T-cells but also in B-cells, and NO may play some role in INS... - A case of WHIM syndrome associated with diabetes and hypothyroidismJunji Takaya
Department of Pediatrics, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
Pediatr Diabetes 10:484-6. 2009..Taken into consideration the concurrent prevalence of the two disorders and the speculated common pathogenesis associated with the CXCR4, our patient may enable us to understand the genetic damage related to accelerated apoptosis... - Urinary sludge caused by ceftriaxone in a young boyTakahisa Kimata
Department of Pediatrics, Kansai Medical University
Pediatr Rep 4:e14. 2012..It is therefore worthwhile to monitor the levels of urinary calcium to creatinine ratio in patients on ceftriaxone, as they may be at greater risk for developing large stones and renal damage... - Two types of orthostatic dysregulation assessed by diameter of inferior vena cavaYuri Fujii
Department of Pediatrics, Kansai Medical University Nakano Children s Hospital Osaka University of Comprehensive Children Education, Osaka, Japan
Pediatr Int 53:162-7. 2011..Orthostatic dysregulation (OD) is common in adolescents. This study was conducted to evaluate the usefulness of the measurement of the diameter of the inferior vena cava (IVC) for objective assessment of patients with OD... - Phagocytosis of heat-killed Staphylococcus aureus by eosinophils: comparison with neutrophilsYasuko Hatano
Department of Pediatrics, Kansai Medical University, Osaka, Japan
APMIS 117:115-23. 2009..Whereas the mechanism of phagocytosis by neutrophils was mediated by CD16 and CD32, that of eosinophils was modulated by complement receptor 1 (CD35)... - Effects of human milk and spermine on hydrogen peroxide-induced oxidative damage in IEC-6 cellsHiromichi Shoji
Department of Pediatrics, Juntendo University School of Medicine, Hongo, Tokyo, Japan
J Pediatr Gastroenterol Nutr 41:460-5. 2005..Human milk (HM) contains various bioactive substances, some of which are known as antioxidants, including polyamines such as spermine (SPM). We examined the antioxidative properties of HM and SPM in an intestinal epithelial cell line... - Usefulness of an automated urinary flow cytometer in mass screening for nephritisKazunari Kaneko
Department of Pediatrics, Juntendo University Urayasu Hospital, 2 l l Tomioka, Urayasu shi, Chiba 279 0021, Japan
Pediatr Nephrol 19:499-502. 2004..It can precisely predict children with only transient hematuria who do not have any serious illness, and therefore can exclude further unnecessary examinations, resulting in the improvement of cost-effectiveness of the current program... - Methicillin-resistant Staphylococcus aureus-related glomerulonephritis in a childTakahisa Kimata
Department of Pediatrics, Kansai Medical University, 2 3 1 Shin machi, Hirakata shi, Osaka 573 1191, Japan
Pediatr Nephrol 27:2149-52. 2012..CONCLUSIONS: In summary, there should be a high index of suspicion for MRSA-GN, even in the very young, in order to avoid the unnecessary use of immune suppressants in this context... - Close association between proteinuria and regulatory T cells in patients with idiopathic nephrotic syndromeTakahisa Kimata
Department of Pediatrics, Kansai Medical University, 2 3 1 Shin machi, Hirakata shi, Osaka, 573 1191, Japan
Pediatr Nephrol 28:667-9. 2013..CONCLUSIONS: In summary, our case indicates an important role for Tregs in the development of the proteinuria associated with INS and sheds light on its pathogenesis. Further studies are warranted... - Antibiotic prophylaxis by low-dose cefaclor in children with vesicoureteral refluxKazunari Kaneko
Department of Pediatrics, Juntendo University School of Medicine, 2 l l Hongo, Bunkyo ku, 113 8421, Tokyo, Japan
Pediatr Nephrol 18:468-70. 2003..None withdrew from the study because of side effects. These results suggest that cefaclor can be an alternative choice for prophylactic treatment because of its safety, good compliance and low rates of resistant Escherichia coli... - Intracellular magnesium of obese and type 2 diabetes mellitus childrenJunji Takaya
Department of Pediatrics, Kansai Medical University, 10 15 Fumizonocho, Moriguchi, Osaka, 570 8506, Japan
Diabetes Ther 1:25-31. 2010..We studied the change of [Mg(2+)](i) in obese children and children with type 2 diabetes mellitus (DM2) after educational intervention or treatment... - Elevated intracellular calcium in neutrophils in patients with Down syndromeFumiko Yamato
Department of Pediatrics, Kansai Medical University, Osaka, Japan
Pediatr Int 51:474-7. 2009..The purpose of the present study was to compare the intracellular calcium concentration ([Ca(2+)]i) at baseline and stimulated conditions in DS patients and in normal subjects to investigate [Ca(2+)]i regulation in neutrophils... - Intracellular magnesium and adipokines in umbilical cord plasma and infant birth sizeJunji Takaya
Department of Pediatrics, Kansai Medical University, Moriguchi, Osaka 570 8506, Japan
Pediatr Res 62:700-3. 2007..Mg]i and adiponectin were correlated with QUICKI in all subjects. [Mg]i, as well as leptin and IGF-I, reflect the extent of fetal growth. Decreased [Mg2+]i may be involved in the underlying processes to insulin resistance... - [Electroencephalographic changes in sisters with infantile-onset dentatorubral-pallidoluysian atrophy (DRPLA)]Rika Hashi
Department of Pediatrics, Otokoyama Hospital, Kansai Medical University, Yawata, Kyoto
No To Hattatsu 39:445-9. 2007..Myoclonic seizures developed at 4 years and 7 months, but have been well controlled using sodium valproate. EEG showed diffuse 3-4 Hz spike-and-wave complexes that were rather different from the findings in her elder sister... - Cerebral edema in a child with diabetic ketoacidosis before initial treatmentJunji Takaya
Department of Pediatrics, Kansai Medical University, Moriguchi, Japan
Pediatr Int 49:395-6. 2007 - Down-regulation of hepatic phosphoenolpyruvate carboxykinase expression in magnesium-deficient ratsJunji Takaya
Department of Pediatrics, Kansai Medical University, 10 15 Fumizono cho, Moriguchi Shi, Osaka 570 8506, Japan
Magnes Res 25:131-9. 2012..Higher ADMA induces hypertension and insulin resistance. Hyperinsulinemia induces hepatic down-regulation of PEPCK, and is possibly a key mechanism inducing the metabolic complications of magnesium deficiency... - Simplified quantification of urinary protein excretion using a novel dipstick in childrenKazunari Kaneko
Department of Pediatrics, Juntendo University Urayasu Hospital, Chiba, Japan
Pediatr Nephrol 20:834-6. 2005..It is, therefore, a useful tool to monitor the urinary protein excretion in children with renal diseases at outpatient clinic... - Cerebral blood flow monitoring using a novel laser Doppler flowmeter in asphyxiated infantsAtsushi Ohashi
Department of Pediatrics, Kansai Medical University, Osaka, Japan
Pediatr Int 51:715-9. 2009..The aim of the present study was to investigate the role of early changes in cerebral blood flow (CBF) predicting the severity of neurological outcome in asphyxiated infants... - Low prevalence of hypercalciuria in Japanese childrenKazunari Kaneko
Department of Pediatrics, Juntendo University School of Medicine, 2 1 1 Hongo, Bunkyo ku, Tokyo 113 8421, Japan
Nephron 91:439-43. 2002..We hypothesize that the low prevalence of urolithiasis is associated with the urinary calcium excretion. The aim of our study was to investigate the prevalence of hypercalciuria in Japanese children... - [Effective and efficient method of painless venepuncture in children]Naoyuki Kitamura
Department of Pediatrics, Kansai Medical University, Hirakata
Rinsho Byori 55:257-61. 2007..To this end, several elements should be considered: preparation of procedural information, distraction during painful procedures, and local anesthesia. Current concepts to understand these elements are presented in this review... - Cyclosporine A for heavy proteinuria in a child with Henoch-Schönlein purpura nephritisTomonosuke Someya
Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan
Pediatr Int 46:111-3. 2004 - Management of intraventricular hemorrhage in preterm infants with low birth weightTakayuki Inagaki
Department of Neurosurgery, Kansai Medical University, Osaka, Japan
Acta Neurochir Suppl 113:173-5. 2012..After evaluating our series, we modified our protocol from reservoir placement to either cerebrospinal fluid (CSF) drainage or ventriculosubgaleal shunt directly. We will reevaluate this new protocol in the near future... - Effects of interview on mood status of pregnant women with high-risk deliveryNaoyuki Kitamura
Department of Pediatrics, Kansai Medical University, Osaka City University, Osaka, Japan
Pediatr Int 51:498-501. 2009..The purpose of the present study was to evaluate the effects of an interview by health professionals on their mood status... - Magnesium deficiency in pregnant rats alters methylation of specific cytosines in the hepatic hydroxysteroid dehydrogenase-2 promoter of the offspringJunji Takaya
Department of Pediatrics, Kansai Medical University, Osaka, Japan
Epigenetics 6:573-8. 2011..Therefore, a Mg-deficient diet alters glucocorticoid metabolism, predicting higher hepatic intracellular glucocorticoid concentrations, and is possibly a key mechanism that induces the metabolic complications of Mg deficiency... - Surgical repair of left ventricular noncompaction in a patient with a novel mutation of the Myosin heavy chain 7 geneTakamichi Uchiyama
Department of Pediatrics, Kansai Medical University
Tohoku J Exp Med 228:301-4. 2012..Although the postsurgical observational period was short, the findings indicate that LVNC mutation analyses may facilitate surgical decisions and help predict clinical courses... - Usefulness of magnetic resonance cholangiopancreatography in biliary structures in infants: a four-case reportJunji Takaya
Department of Pediatrics, Kansai Medical University, Moriguchi Shi, Osaka 570 8506, Japan
Eur J Pediatr 166:211-4. 2007..We conclude that MRCP can be used to depict the major biliary structures of neonates and small infants and to exclude BA as the cause of neonatal cholestasis by allowing visualisation of the biliary tract... - Usefulness of diffusion-weighted MRI in human herpesvirus-6 encephalitisJunji Takaya
Department of Pediatrics, Kansai Medical University, Moriguchi Shi, Osaka 570 8506, Japan
Acta Paediatr 96:137-8. 2007..CONCLUSION: DW-MRI may be a valuable tool for early detection and diagnosis of HHV-6 encephalitis and is more sensitive than conventional MRI to detect a subtle edematous change in the brain... - Caspase inhibitor ZVAD-fmk facilitates engraftment of donor hematopoietic stem cells in intra-bone marrow-bone marrow transplantationYuichiro Imai
First Department of Pathology, Kansai Medical University, Moriguchi City, Osaka, Japan
Stem Cells Dev 19:461-8. 2010..These results suggest that ZVAD-fmk can suppress apoptosis of hematopoietic stem cells and/or immature progenitor cells of the donor bone marrow cells, thereby accelerating the donor hematopoiesis... - Pentalogy of Cantrell with a double-outlet right ventricle: 3.5-year follow-up in a prenatally diagnosed patientJunji Takaya
Department of Pediatrics, Kansai Medical University, 10 15 Fumizonocho, Moriguchi, Osaka 570 8506, Japan
Eur J Pediatr 167:103-5. 2008..The patient is currently alive and well 3.5 years after surgery. It is concluded that a deliberate therapeutic strategy based on the intrauterine diagnosis may alter the natural history of this devastating disorder... - Small for gestational age and magnesium in cord blood platelets: intrauterine magnesium deficiency may induce metabolic syndrome in later lifeJunji Takaya
Department of Pediatrics, Kansai Medical University, 10 15 Fumizonocho, Moriguchi, Osaka 570 8506, Japan
J Pregnancy 2011:270474. 2011..In this review, we propose that intrauterine magnesium deficiency may induce metabolic syndrome in later life. We discuss the potential contribution of aberrant magnesium regulation to SGA and to the pathogenesis of metabolic syndrome... - [Fetus and magnesium]Junji Takaya
Department of Pediatrics, Kansai Medical University
Clin Calcium 15:105-10. 2005..Prospective study whether the children born with magnesium induced IUGR are at high-risk for metabolic syndrome in childhood or adulthood is currently undertaken... - Mechanisms underlying acceleration of blood flow recovery in ischemic limbs by macrophage colony-stimulating factorKeiji Nakano
First Department of Pathology, Kansai Medical University, 10-15 Moriguchi, Osaka, Japan
Stem Cells 24:1274-9. 2006.... - Granulocyte-colony stimulating factor increases donor mesenchymal stem cells in bone marrow and their mobilization into peripheral circulation but does not repair dystrophic heart after bone marrow transplantationKimiko Tatsumi
The Department of Pediatrics, Kansai Medical University, Moriguchi, Japan
Circ J 72:1351-8. 2008..Hereditary disordered cardiac muscle could be replaced with intact cardiomyocytes derived from genetically intact bone marrow (BM)-derived stem cells...