Kazunori Hosoe

Summary

Affiliation: Kaneka Corporation
Country: Japan

Publications

  1. ncbi request reprint Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers
    Kazunori Hosoe
    Pharmacology and Toxicology Group, Life Science Research Laboratories, Kaneka Corporation, 1 8 Miyamae machi, Takasago Shi, Hyogo, Japan
    Regul Toxicol Pharmacol 47:19-28. 2007
  2. doi request reprint Subchronic oral toxicity of ubiquinol in rats and dogs
    Mitsuaki Kitano
    Life Science Research Laboratories, Kaneka Corporation, Hyogo, Japan
    Int J Toxicol 27:189-215. 2008
  3. ncbi request reprint Evaluation of the mutagenic and genotoxic potential of ubiquinol
    Mitsuaki Kitano
    Life Science Research Laboratories, Kaneka Corporation, Hyogo, Japan
    Int J Toxicol 26:533-44. 2007
  4. ncbi request reprint Low-temperature thermal decomposition of dioxin-like compounds in fly ash: combination of chemical analysis with in vitro bioassays (EROD and DR-CALUX)
    Peter A Behnisch
    Life Science Research Laboratories, Kaneka Corporation, 1 8 Miyamae machi, Takasago, Hyogo 676 8688, Japan
    Environ Sci Technol 36:5211-7. 2002
  5. ncbi request reprint Possible tumor development from double positive foci for TGF-alpha and GST-P observed in early stages on rat hepatocarcinogenesis
    Mitsuaki Kitano
    First Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Osaka 545 8585, Japan
    Cancer Sci 97:478-83. 2006
  6. ncbi request reprint Melting and incineration plants of municipal waste. Chemical and biochemical diagnosis of thermal processing samples (emission, residues)
    Peter A Behnisch
    Life Science Research Laboratories, Kaneka Corporation, Takasago, Japan
    Environ Sci Pollut Res Int 9:337-44. 2002
  7. doi request reprint Inhibition by licorice flavonoid oil of glutathione S-transferase-positive foci in the medium-term rat hepatocarcinogenesis bioassay
    Kaku Nakagawa
    QOL Division, Kaneka Corporation, Kita ku, Osaka, Japan
    Nutr Res 30:74-81. 2010
  8. ncbi request reprint Safety assessment of coenzyme Q10 (CoQ10)
    Takayoshi Hidaka
    Functional Food Ingredients Division, Healthcare Products Business Unit, Kaneka Corporation, Osaka, Japan
    Biofactors 32:199-208. 2008
  9. ncbi request reprint Screening of dioxin-like toxicity equivalents for various matrices with wildtype and recombinant rat hepatoma H4IIE cells
    Peter A Behnisch
    Life Science Research Laboratories, Kaneka Corporation, Takasago, Hyogo 676 8688, Japan
    Toxicol Sci 69:125-30. 2002
  10. ncbi request reprint Brominated dioxin-like compounds: in vitro assessment in comparison to classical dioxin-like compounds and other polyaromatic compounds
    Peter Alexander Behnisch
    Life Science Research Laboratories, Kaneka Corporation, 1 8 Miyamae machi, Hyogo Takasago 676 8688, Japan
    Environ Int 29:861-77. 2003

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Study on safety and bioavailability of ubiquinol (Kaneka QH) after single and 4-week multiple oral administration to healthy volunteers
    Kazunori Hosoe
    Pharmacology and Toxicology Group, Life Science Research Laboratories, Kaneka Corporation, 1 8 Miyamae machi, Takasago Shi, Hyogo, Japan
    Regul Toxicol Pharmacol 47:19-28. 2007
    ....
  2. doi request reprint Subchronic oral toxicity of ubiquinol in rats and dogs
    Mitsuaki Kitano
    Life Science Research Laboratories, Kaneka Corporation, Hyogo, Japan
    Int J Toxicol 27:189-215. 2008
    ..Based on these findings, a NOAEL for ubiquinol in male and female dogs was estimated to be more than 600 mg/kg/day under the conditions of this study...
  3. ncbi request reprint Evaluation of the mutagenic and genotoxic potential of ubiquinol
    Mitsuaki Kitano
    Life Science Research Laboratories, Kaneka Corporation, Hyogo, Japan
    Int J Toxicol 26:533-44. 2007
    ..Thus, ubiquinol was evaluated as negative in the bacterial reverse mutation, chromosomal aberration, and rat bone marrow micronucleus tests under the conditions of these assays...
  4. ncbi request reprint Low-temperature thermal decomposition of dioxin-like compounds in fly ash: combination of chemical analysis with in vitro bioassays (EROD and DR-CALUX)
    Peter A Behnisch
    Life Science Research Laboratories, Kaneka Corporation, 1 8 Miyamae machi, Takasago, Hyogo 676 8688, Japan
    Environ Sci Technol 36:5211-7. 2002
    ..4 times (range 0.9-1.8), for the H4IIE-EROD assay, and 5.1 times (range 1.2-12), for the DR-CALUX assay, higher than the I-TEQ values...
  5. ncbi request reprint Possible tumor development from double positive foci for TGF-alpha and GST-P observed in early stages on rat hepatocarcinogenesis
    Mitsuaki Kitano
    First Department of Pathology, Osaka City University Medical School, 1 4 3 Asahi machi, Osaka 545 8585, Japan
    Cancer Sci 97:478-83. 2006
    ..Our data suggest that double positive foci for GST-P and TGF-alpha in the early stages of rat hepatocarcinogenesis may develop into tumors with promotion...
  6. ncbi request reprint Melting and incineration plants of municipal waste. Chemical and biochemical diagnosis of thermal processing samples (emission, residues)
    Peter A Behnisch
    Life Science Research Laboratories, Kaneka Corporation, Takasago, Japan
    Environ Sci Pollut Res Int 9:337-44. 2002
    ..Furthermore, we showed that the levels of dioxins and co-PCBs contained in slag from melting processes and bottom ashes from incineration processes were lower by 1-2 orders of magnitude than that in fly ash...
  7. doi request reprint Inhibition by licorice flavonoid oil of glutathione S-transferase-positive foci in the medium-term rat hepatocarcinogenesis bioassay
    Kaku Nakagawa
    QOL Division, Kaneka Corporation, Kita ku, Osaka, Japan
    Nutr Res 30:74-81. 2010
    ..These results indicate that LFO concentrate solution has a significant inhibitory effect on liver carcinogenesis at 600 mg/kg...
  8. ncbi request reprint Safety assessment of coenzyme Q10 (CoQ10)
    Takayoshi Hidaka
    Functional Food Ingredients Division, Healthcare Products Business Unit, Kaneka Corporation, Osaka, Japan
    Biofactors 32:199-208. 2008
    ..Additionally, analysis of CoQ10 bioavailability or its pharmacokinetics provides the pertinent safety evaluation for CoQ10...
  9. ncbi request reprint Screening of dioxin-like toxicity equivalents for various matrices with wildtype and recombinant rat hepatoma H4IIE cells
    Peter A Behnisch
    Life Science Research Laboratories, Kaneka Corporation, Takasago, Hyogo 676 8688, Japan
    Toxicol Sci 69:125-30. 2002
    ..6, ranging from 1.0-3.9; for DR-CALUX/I-TEQ, 2.5; 0.61-8.3), respectively. This demonstrates that these bioassays can be used as alternative screening technology for monitoring I-TEQ values in various standards and matrices...
  10. ncbi request reprint Brominated dioxin-like compounds: in vitro assessment in comparison to classical dioxin-like compounds and other polyaromatic compounds
    Peter Alexander Behnisch
    Life Science Research Laboratories, Kaneka Corporation, 1 8 Miyamae machi, Hyogo Takasago 676 8688, Japan
    Environ Int 29:861-77. 2003
    ..These in vitro investigations indicate that further research is necessary to evaluate more Ah-receptor agonists for dioxin-like potency...
  11. ncbi request reprint Absorption of dietary licorice isoflavan glabridin to blood circulation in rats
    Chinatsu Ito
    Laboratory of Food and Nutritional Chemistry, Graduate School of Agriculture, Kobe University, Kobe, Japan
    J Nutr Sci Vitaminol (Tokyo) 53:358-65. 2007
    ..Thus, dietary glabridin was at least partly incorporated into the body in an unchanged form, though most dietary flavonoids are converted to non-active conjugate forms during intestinal absorption...
  12. ncbi request reprint Reduced coenzyme Q10 supplementation decelerates senescence in SAMP1 mice
    Jingmin Yan
    Department of Aging Biology, Institute on Aging and Adaptation, Shinshu University Graduate School of Medicine, 3 1 1, Asahi, Matsumoto 390 8621, Japan
    Exp Gerontol 41:130-40. 2006
    ..Urinary levels of acrolein (ACR)-lysine adduct increased significantly with age in SAMP1 mice; however, CoQH2 had no effect. Thus, lifelong dietary supplementation with CoQH2 decreased the degree of senescence in middle-aged SAMP1 mice...
  13. ncbi request reprint Intra- and interlaboratory calibration of the DR CALUX bioassay for the analysis of dioxins and dioxin-like chemicals in sediments
    Harrie T Besselink
    BioDetection Systems B V BDS, Badhuisweg 3, 1031 CM Amsterdam, The Netherlands
    Environ Toxicol Chem 23:2781-9. 2004
    ..The results of this study are intended as a starting point for implementing the integrated chemical-biological assessment strategy and for systematic monitoring of dredged materials and related materials in the coming years...