Tomokazu Yoshizaki

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. pmc Role of activation-induced cytidine deaminase in the development of oral squamous cell carcinoma
    Yosuke Nakanishi
    Division of Otolaryngology, Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan
    PLoS ONE 8:e62066. 2013
  2. doi request reprint Pathogenic role of Epstein-Barr virus latent membrane protein-1 in the development of nasopharyngeal carcinoma
    Tomokazu Yoshizaki
    Division of Otolaryngology Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8640, Japan
    Cancer Lett 337:1-7. 2013
  3. doi request reprint Current understanding and management of nasopharyngeal carcinoma
    Tomokazu Yoshizaki
    Division of Otolaryngology Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa, Japan
    Auris Nasus Larynx 39:137-44. 2012
  4. ncbi request reprint Malignant myoepithelioma arising from recurrent pleomorphic adenoma of minor salivary gland
    Tomokazu Yoshizaki
    Department of Otolaryngology, School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 0934, Japan
    Auris Nasus Larynx 29:91-4. 2002
  5. ncbi request reprint Matrix metalloproteinase 9 is induced by the Epstein-Barr virus BZLF1 transactivator
    T Yoshizaki
    Department of Otolaryngology, Cancer Research Institute, Kanazawa University, Japan
    Clin Exp Metastasis 17:431-6. 1999
  6. ncbi request reprint Oncogenic role of Epstein-Barr virus-encoded small RNAs (EBERs) in nasopharyngeal carcinoma
    Tomokazu Yoshizaki
    Division of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    Auris Nasus Larynx 34:73-8. 2007
  7. ncbi request reprint Leiomyosarcoma of the larynx
    T Yoshizaki
    Department of Otolaryngology, School of Medicine, Kanazawa University, Japan
    J Laryngol Otol 113:167-9. 1999
  8. ncbi request reprint Expression of tissue inhibitor of matrix metalloproteinase-2 correlates with activation of matrix metalloproteinase-2 and predicts poor prognosis in tongue squamous cell carcinoma
    T Yoshizaki
    Department of Otolaryngology, School of Medicine, Kanazawa University, Kanazawa, Japan
    Int J Cancer 95:44-50. 2001
  9. doi request reprint Treatment of locally recurrent Epstein-Barr virus-associated nasopharyngeal carcinoma using the anti-viral agent cidofovir
    Tomokazu Yoshizaki
    Division of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan
    J Med Virol 80:879-82. 2008
  10. ncbi request reprint Elevation of antibody against Epstein-Barr virus genes BRLF1 and BZLF1 in nasopharyngeal carcinoma
    T Yoshizaki
    Department of Otolaryngology, School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 0934, Japan
    J Cancer Res Clin Oncol 126:69-73. 2000

Collaborators

Detail Information

Publications86

  1. pmc Role of activation-induced cytidine deaminase in the development of oral squamous cell carcinoma
    Yosuke Nakanishi
    Division of Otolaryngology, Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan
    PLoS ONE 8:e62066. 2013
    ..The aim of this study is to investigate the correlation between AID expression and the clinical classification of oral cancer tissues...
  2. doi request reprint Pathogenic role of Epstein-Barr virus latent membrane protein-1 in the development of nasopharyngeal carcinoma
    Tomokazu Yoshizaki
    Division of Otolaryngology Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8640, Japan
    Cancer Lett 337:1-7. 2013
    ..Here we reviewed the contribution of EBV gene products to NPC pathogenesis in relation with LMP1. ..
  3. doi request reprint Current understanding and management of nasopharyngeal carcinoma
    Tomokazu Yoshizaki
    Division of Otolaryngology Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa, Japan
    Auris Nasus Larynx 39:137-44. 2012
    ..Finally, molecular targeting therapy, including targeting EBV gene product, has been developing and on the way to the clinical use...
  4. ncbi request reprint Malignant myoepithelioma arising from recurrent pleomorphic adenoma of minor salivary gland
    Tomokazu Yoshizaki
    Department of Otolaryngology, School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 0934, Japan
    Auris Nasus Larynx 29:91-4. 2002
    ..With adequate surgical margin, the patient has been free from tumor recurrence for 20 months...
  5. ncbi request reprint Matrix metalloproteinase 9 is induced by the Epstein-Barr virus BZLF1 transactivator
    T Yoshizaki
    Department of Otolaryngology, Cancer Research Institute, Kanazawa University, Japan
    Clin Exp Metastasis 17:431-6. 1999
    ..Proc. Natl. Acad. Sci. 1998; 95: 3621-6). Thus, Z together with LMP1 may contribute to invasion and metastasis of NPC by inducing expression of MMP9...
  6. ncbi request reprint Oncogenic role of Epstein-Barr virus-encoded small RNAs (EBERs) in nasopharyngeal carcinoma
    Tomokazu Yoshizaki
    Division of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    Auris Nasus Larynx 34:73-8. 2007
    ..However, the role of EBERs still remains unclear. This study was designed to investigate the relevance of EBERs to the oncogenesis of NPC...
  7. ncbi request reprint Leiomyosarcoma of the larynx
    T Yoshizaki
    Department of Otolaryngology, School of Medicine, Kanazawa University, Japan
    J Laryngol Otol 113:167-9. 1999
    ..Here, we report a case of well-differentiated laryngeal leiomyosarcoma that showed rapid local growth but no metastasis. Diagnosis and treatment of leiomyosarcoma are discussed...
  8. ncbi request reprint Expression of tissue inhibitor of matrix metalloproteinase-2 correlates with activation of matrix metalloproteinase-2 and predicts poor prognosis in tongue squamous cell carcinoma
    T Yoshizaki
    Department of Otolaryngology, School of Medicine, Kanazawa University, Kanazawa, Japan
    Int J Cancer 95:44-50. 2001
    ..779, p < 0.0001), MT1-MMP (r = 0.674, p < 0.0022) and TIMP-2 (r = 0.858, p < 0.0001). Increased expression of TIMP-2, as well as MMP-2 and MT1-MMP, was an important prognostic factor in patients with tongue SCC...
  9. doi request reprint Treatment of locally recurrent Epstein-Barr virus-associated nasopharyngeal carcinoma using the anti-viral agent cidofovir
    Tomokazu Yoshizaki
    Division of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan
    J Med Virol 80:879-82. 2008
    ..Although the anti-tumor mechanism remains unclear, these results suggest that cidofovir is actually an effective and safe agent for the treatment of NPC...
  10. ncbi request reprint Elevation of antibody against Epstein-Barr virus genes BRLF1 and BZLF1 in nasopharyngeal carcinoma
    T Yoshizaki
    Department of Otolaryngology, School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 0934, Japan
    J Cancer Res Clin Oncol 126:69-73. 2000
    ..This study was performed to analyze antibody titers against Z and R in Japan...
  11. doi request reprint A novel immune evasion mechanism of LMP-1, an EBV-primary oncogene, in nasopharyngeal carcinoma
    Tomokazu Yoshizaki
    Division of Otolaryngology, Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Takaramachi, Kanazawa, Japan
    Adv Otorhinolaryngol 72:157-9. 2011
    ..These results delineate a novel mechanism of immune evasion, which renders a virally encoded oncogene inaccessible to the conventional MHC class I pathway limiting its cis-presentation...
  12. ncbi request reprint Induction of interleukin-8 by Epstein-Barr virus latent membrane protein-1 and its correlation to angiogenesis in nasopharyngeal carcinoma
    T Yoshizaki
    Department of Otolaryngology, School of Medicine, Kanazawa University, Kanazawa 920 8641, Japan
    Clin Cancer Res 7:1946-51. 2001
    ..Angiogenesis is a key step for metastasis. Thus, the association of LMP-1 to neovascularization of NPC was examined in this study...
  13. ncbi request reprint Concurrent intra-arterial chemotherapy and radiotherapy for advanced laryngeal cancer
    Tomokazu Yoshizaki
    Division of Otolaryngology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Ann Otol Rhinol Laryngol 118:172-8. 2009
    ..An intra-arterial chemoradiotherapy regimen (RADPLAT) provides remarkable local control for head and neck cancer. This study evaluates the efficacy of a reduced RADPLAT protocol in patients who are candidates for total laryngectomy...
  14. doi request reprint Expression of seven-in-absentia homologue 1 and hypoxia-inducible factor 1 alpha: novel prognostic factors of nasopharyngeal carcinoma
    Noriko Kitagawa
    Division of Otolaryngology Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Takara machi 13 1, Kanazawa, Ishikawa 920 8640, Japan
    Cancer Lett 331:52-7. 2013
    ..This is the first study to evaluate the pattern and clinical significance of Siah1 and HIF1α expression in NPC, and such an evaluation is valuable for identifying those patients at a high risk for a poor prognosis...
  15. doi request reprint A single nucleotide polymorphism in the matrix metalloproteinase-1 and interleukin-8 gene promoter predicts poor prognosis in tongue cancer
    Yoshinori Shimizu
    Department of Otolaryngology, School of Medicine, Kanazawa University, Takaramachi 13 1, Ishikawa, Japan
    Auris Nasus Larynx 35:381-9. 2008
    ..MMP-1 -1607 2G/2G and IL-8 -251 A/A genotypes enhance transcriptional activity and may be associated with increased risk in malignant tumors. We therefore evaluated the impact of these SNPs in tongue squamous cell carcinoma (SCC)...
  16. ncbi request reprint Epstein-Barr virus (EBV) latent membrane protein 1 induces interleukin-8 through the nuclear factor-kappa B signaling pathway in EBV-infected nasopharyngeal carcinoma cell line
    Qingchun Ren
    Division of Otolaryngology, Graduate School of Medicine, and Department of Molecular Oncology and Virology, Cancer Research Institute, Kanazawa University, Takaramachi, Kanazawa, Japan
    Laryngoscope 114:855-9. 2004
    ..Our previous studies have indicated that interleukin (IL)-8 was over-expressed in many NPC tissues and was found to be significantly correlated with angiogenesis by immunohistochemistry...
  17. ncbi request reprint Immunoglobulin class switching to IgG4 in Warthin tumor and analysis of serum IgG4 levels and IgG4-positive plasma cells in the tumor
    Mitsuharu Aga
    Division of Otolaryngology, Graduate School of Medicine, Kanazawa University, Kanazawa 920 8641, Japan
    Hum Pathol 45:793-801. 2014
    ....
  18. ncbi request reprint Intra-arterial chemotherapy less intensive than RADPLAT with concurrent radiotherapy for resectable advanced head and neck squamous cell carcinoma: a prospective study
    Tomokazu Yoshizaki
    Division of Otolaryngology, Graduate School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    Ann Otol Rhinol Laryngol 116:754-61. 2007
    ....
  19. doi request reprint Lymphangiogenesis in regional lymph nodes predicts nodal recurrence in pathological N0 squamous cell carcinoma of the tongue
    Kyoko Hirota
    Division of Otolaryngology Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Histopathology 61:1065-71. 2012
    ..The aim of this study was to retrospectively evaluate lymph node lymphangiogenesis before the establishment of nodal recurrence in squamous cell carcinoma (SCC) of the tongue...
  20. doi request reprint An extremely rare case of large Delphian node metastasis preceding primary laryngeal cancer
    Shigeyuki Murono
    Department of Otolaryngology, Head and Neck Surgery, Kanazawa University, Takaramachi, Japan
    Auris Nasus Larynx 36:614-7. 2009
    ..To present an extremely rare case of large Delphian node metastasis preceding primary laryngeal cancer...
  21. doi request reprint Induction of receptor for advanced glycation end products by EBV latent membrane protein 1 and its correlation with angiogenesis and cervical lymph node metastasis in nasopharyngeal carcinoma
    Akira Tsuji
    Division of Otolaryngology Head and Neck Surgery, Graduate School of Medicine, Kanazawa University, Ishikawa, Japan
    Clin Cancer Res 14:5368-75. 2008
    ..Moreover, some papers have suggested the association of RAGE overexpression with tumor metastasis; thus, the associations of RAGE with LMP1 and angiogenesis in NPC were examined...
  22. doi request reprint Induction of lymphangiogenesis through vascular endothelial growth factor-C/vascular endothelial growth factor receptor 3 axis and its correlation with lymph node metastasis in nasopharyngeal carcinoma
    Naohiro Wakisaka
    Division of Otolaryngology, and Head and Neck Surgery, Graduate School of Medicine, Kanazawa University, Takara machi 13 1, Kanazawa, Ishikawa, Japan
    Oral Oncol 48:703-8. 2012
    ..These results suggest the involvement of the VEGF-C/VEGFR3 axis in the induction of lymphangiogenesis which results in lymphatic spread of NPC. However, EBV-LMP1 was not associated with the mechanism...
  23. ncbi request reprint Concurrent superselective intra-arterial chemotherapy and radiotherapy for late-stage squamous cell carcinoma of the temporal bone
    Hisashi Sugimoto
    Department of Otolaryngology Head and Neck Surgery, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Ann Otol Rhinol Laryngol 120:372-6. 2011
    ..This study evaluated the efficacy of concurrent superselective intra-arterial chemotherapy and radiotherapy without surgery for late-stage squamous cell carcinoma of the temporal bone, which typically has a poor prognosis...
  24. doi request reprint Pseudoaneurysm of the lingual artery after concurrent intra-arterial chemotherapy with radiotherapy for advanced tongue cancer
    Shigeyuki Murono
    Department of Otolaryngology, Head and Neck Surgery, School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
    Head Neck 33:1230-2. 2011
    ..Aneurysms of the external carotid artery and its branches are rare...
  25. ncbi request reprint Prognostic value of cell motility activation factors in patients with tongue squamous cell carcinoma
    Kazuhira Endo
    Department of Otolaryngology, Kouseiren Takaoka Hospital, Toyama, Japan
    Hum Pathol 37:1111-6. 2006
    ..The evaluation of AMFR and c-Met in tongue SCC is valuable in identifying patients at high risk for recurrences and who should be treated as more advanced cases...
  26. pmc Epstein-Barr virus latent membrane protein 1 induces cancer stem/progenitor-like cells in nasopharyngeal epithelial cell lines
    Satoru Kondo
    Division of Otolaryngology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa 920 8640, Japan
    J Virol 85:11255-64. 2011
    ..Our findings indicate that LMP1 can induce a CPC-like rather than a CSC-like phenotype in epithelial cells and suggest that LMP1-induced phenotypic changes contribute to the development of NPC...
  27. doi request reprint Efficacy and safety of garenoxacin in the treatment of upper respiratory tract infections
    Makoto Ito
    Department of Otolaryngology Head and Neck Surgery, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Auris Nasus Larynx 39:512-8. 2012
    ..To determine the efficacy and safety of garenoxacin, a new generation of quinolone antimicrobial agent, in the treatment of adult upper respiratory tract infections...
  28. doi request reprint Tumor-targeted chemotherapy with the nanopolymer-based drug NC-6004 for oral squamous cell carcinoma
    Kazuhira Endo
    Division of Otolaryngology, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan
    Cancer Sci 104:369-74. 2013
    ....
  29. ncbi request reprint Adjuvant chemotherapy with an oral fluoropyrimidine, S-1, following reduced RADPLAT in advanced laryngeal cancer
    Naohiro Wakisaka
    Division of Otolaryngology Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Ann Otol Rhinol Laryngol 121:555-62. 2012
    ..However, distant metastases were more frequent. Our study retrospectively evaluated the efficacy and feasibility of adjuvant chemotherapy with S-1, an oral fluoropyrimidine, for distant metastases following reduced RADPLAT...
  30. ncbi request reprint Impact of MDM2 single nucleotide polymorphism on tumor onset in head and neck squamous cell carcinoma
    Masashi Nakashima
    Division of Otolaryngology, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan
    Acta Otolaryngol 128:808-13. 2008
    ..SNP309 may be a key factor in the tumorigenesis of HNSCC as well as other hereditary or sporadic tumors...
  31. ncbi request reprint Cleavage of syndecan-1 by membrane type matrix metalloproteinase-1 stimulates cell migration
    Kazuhira Endo
    Department of Molecular Virology and Oncology, Cancer Research Institute, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    J Biol Chem 278:40764-70. 2003
    ..These results suggest that the shedding of syndecan-1 promoted by MT1-MMP through the preferential cleavage of Gly245-Leu246 peptide bond stimulates cell migration...
  32. ncbi request reprint Post-operative pharyngocutaneous fistula after laryngectomy
    Naohiro Wakisaka
    Division of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 8640, Japan
    Auris Nasus Larynx 35:203-8. 2008
    ..Here, we evaluated the cause of PCF after laryngectomy, with special emphasis on radiotherapy and/or chemotherapy...
  33. ncbi request reprint Modulation of cell growth and matrix metalloproteinase-2 activation of oral squamous cell carcinoma as a function of culture condition with type I collagen
    Hidenori Kinsenn
    Department of Otolaryngology, School of Medicine, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Acta Otolaryngol 123:987-93. 2003
    ..This study was designed to analyze the effect of type I collagen on tumor growth and MMP-2 activation of OSCC cell lines as a function of culture conditions...
  34. ncbi request reprint A case report: Epstein-Barr virus-associated undifferentiated carcinoma of the tongue base
    Naohiro Wakisaka
    Department of Otolaryngology, School of Medicine, Kanazawa University, Takara machi 13 1, Kanazawa, Ishikawa, Japan
    Auris Nasus Larynx 33:487-91. 2006
    ..Although it is unclear whether our case is recurrent or newly developed EBV-latently infected undifferentiated carcinoma, we propose that EBV-associated tumors should be carefully observed after treatment at least for more than 10 years...
  35. doi request reprint Epidemiological analysis of nasopharyngeal carcinoma in the central region of Japan during the period from 1996 to 2005
    Yuichi Kimura
    Department of Otorhinolaryngology, Head and Neck Surgery, University of Fukui, Japan
    Auris Nasus Larynx 38:244-9. 2011
    ..The aim of this study was to analyze the epidemiology and current incidence of NPC in the Chubu region of Japan during the period from 1996 to 2005...
  36. ncbi request reprint Assessment of antitumor activity and acute peripheral neuropathy of 1,2-diaminocyclohexane platinum (II)-incorporating micelles (NC-4016)
    Takayoshi Ueno
    Division of Otolaryngology Head and Neck Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Int J Nanomedicine 9:3005-12. 2014
    ..In addition, NC-4016-treated rats did not develop acute cold hypersensitivity, which is frequently experienced by patients after oxaliplatin administration. ..
  37. doi request reprint Warthin's tumor associated with IgG4-related disease
    Mitsuharu Aga
    Division of Otolaryngology, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan
    Auris Nasus Larynx 40:514-7. 2013
    ..This case shows the possible involvement of Warthin's tumor with IgG4-RD...
  38. ncbi request reprint Endoscopic nasopharyngectomy for patients with recurrent nasopharyngeal carcinoma at the primary site
    Tomokazu Yoshizaki
    Division of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    Laryngoscope 115:1517-9. 2005
  39. doi request reprint Clonal spread of beta-lactamase-producing amoxicillin-clavulanate-resistant (BLPACR) strains of non-typeable Haemophilus influenzae among young children attending a day care in Japan
    Makoto Ito
    Department of Otolaryngology Head and Neck Surgery, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa 920 8640, Japan
    Int J Pediatr Otorhinolaryngol 74:901-6. 2010
    ..We investigated the nasopharyngeal carriage status of these resistant strains among children attending a same day care center during a 10-year period...
  40. doi request reprint A case of chronic otitis media caused by Mycobacterium abscessus
    Hisashi Sugimoto
    Department of Otolaryngology Head and Neck Surgery, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8640, Japan
    Auris Nasus Larynx 37:636-9. 2010
    ..After surgery the symptoms resolved and remained well without evidence of infection recurrence 12 months after the operation...
  41. doi request reprint Immunohistochemical detection of SATB1 is independent of thyroid cancer differentiation
    Shigeyuki Murono
    Department of Otolaryngology, Head and Neck Surgery, School of Medicine, Kanazawa University, Japan
    Laryngoscope 123:2909-12. 2013
    ..However, this association is controversial. SATB1 expression in aggressive types of thyroid cancer has not been reported to date...
  42. doi request reprint Roles of epithelial-mesenchymal transition in squamous cell carcinoma of the temporal bone
    Hisashi Sugimoto
    Department of Otolaryngology Head and Neck Surgery, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Otol Neurotol 32:483-7. 2011
    ..The present objective was to investigate the expressions and the roles of epithelial-mesenchymal transition (EMT) in SCC of the temporal bone...
  43. ncbi request reprint Recent advances in the regulation of matrix metalloproteinase 2 activation: from basic research to clinical implication (Review)
    Tomokazu Yoshizaki
    Department of Otolaryngology, Graduate School of Medicine, Kanazawa 920 8641, Japan
    Oncol Rep 9:607-11. 2002
    ..MMPs are especially important in the early stage of cancer progression, and thus strategies for future MMPI trials should be reconsidered...
  44. doi request reprint A solitary fibrous tumor arising in the parapharyngeal space, with MRI and FDG-PET findings
    Naohiro Wakisaka
    Department of Otolaryngology, School of Medicine, Kanazawa University, Japan
    Auris Nasus Larynx 36:367-71. 2009
    ..This is the first report of FDG-PET finding of SFT arising in the head and neck. More cases are needed to achieve diagnostic significance from FDG-PET findings of parapharyngeal SFTs...
  45. ncbi request reprint Diagnostic value of serum EBV-DNA quantification and antibody to viral capsid antigen in nasopharyngeal carcinoma patients
    Satoru Kondo
    Division of Otolaryngology, Graduate School of Medicine, Cancer Research Institute, Kanazawa University, Ishikawa, Kanazawa 920 8640, Japan
    Cancer Sci 95:508-13. 2004
    ..ROC analysis again revealed a higher diagnostic value of EBV-DNA than EBV-VCA. These results suggest EBV-DNA is a more reliable tumor marker than EBV-VCA in both high-incidence and low-incidence areas of NPC...
  46. ncbi request reprint Inhibition of cervical lymph node metastasis by marimastat (BB-2516) in an orthotopic oral squamous cell carcinoma implantation model
    Ken ichi Maekawa
    Department of Otolaryngology, School of Medicine, Kanazawa University, Japan
    Clin Exp Metastasis 19:513-8. 2002
    ..Improvement of survival in patients with OSCC could be expected using adjuvant therapy with marimastat...
  47. ncbi request reprint Intraoperative free jejunum flap monitoring with indocyanine green near-infrared angiography
    Shigeyuki Murono
    Department of Otolaryngology, Head and Neck Surgery, School of Medicine, Kanazawa University, Kanazawa, Ishikawa, 920 8640, Japan
    Eur Arch Otorhinolaryngol 271:1335-8. 2014
    ..Our preliminary results implicate that this novel technique offers secure intraoperative monitoring of a free jejunum graft. This technique will provide us with advantages over regular patency test in selected cases. ..
  48. doi request reprint Evaluation of the olfactory nerve transport function by SPECT-MRI fusion image with nasal thallium-201 administration
    Hideaki Shiga
    Department of Otorhinolaryngology Head and Neck Surgery, Kanazawa Medical University, Kahokugun, Ishikawa, Japan
    Mol Imaging Biol 13:1262-6. 2011
    ..The aim of this study was to visualize the human olfactory transport pathway to the brain by performing imaging after nasal thallium-201 ((201)Tl) administration...
  49. doi request reprint Oncological and functional outcome after transoral 532-nm pulsed potassium-titanyl-phosphate laser surgery for T1a glottic carcinoma
    Shigeyuki Murono
    Department of Otolaryngology, Head and Neck Surgery, School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa, 920 8640, Japan
    Lasers Med Sci 28:615-9. 2013
    ....
  50. ncbi request reprint EGFR and HER2-Akt-mTOR signaling pathways are activated in subgroups of salivary gland carcinomas
    Shioto Suzuki
    Department of Molecular and Cellular Pathology, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa, Ishikawa 920 8640, Japan
    Virchows Arch 461:271-82. 2012
    ..These findings indicate that phosphoprotein mapping of components in the EGFR/HER2-Akt-mTOR pathways may be a useful guide to select appropriate targeting regimens...
  51. doi request reprint Malignant phosphaturic mesenchymal tumor, mixed connective tissue variant of the tongue
    Naoki Uramoto
    Division of Otolaryngology, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    Auris Nasus Larynx 36:104-5. 2009
    ..These results suggest clinical feature of malignant PMTMCT could be changed by radiation therapy. Thus, this report could add an insight to the nature of PMTMCT...
  52. doi request reprint Prognostic factors for squamous cell carcinoma of the temporal bone: extensive bone involvement or extensive soft tissue involvement?
    Makoto Ito
    Department of Otolaryngology Head and Neck Surgery, Kanazawa University Graduate School of Medical Science, Kanazawa University Hospital, 13 1 Takaramachi, Kanazawa, Ishikawa, Japan
    Acta Otolaryngol 129:1313-9. 2009
    ..Resectability of the tumor seems to be major prognostic factor of temporal bone SCC...
  53. ncbi request reprint Expression of interleukin-8 receptor A predicts poor outcome in patients with nasopharyngeal carcinoma
    Toshiyuki Horikawa
    Department of Otolaryngology, Fukui Saiseikai Hospital, Fukui, Japan
    Laryngoscope 115:62-7. 2005
    ..The present objective was to investigate the expressions and the roles of IL-8 receptors in nasopharyngeal carcinoma...
  54. pmc Vascular endothelial growth factor and lymph node metastasis in primary lung cancer
    Y Ohta
    Department of Surgery I, School of Medicine, Kanazawa University, Japan
    Br J Cancer 76:1041-5. 1997
    ....
  55. ncbi request reprint Cleavage of amyloid-beta precursor protein (APP) by membrane-type matrix metalloproteinases
    Munirah Ahmad
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Takara machi, Ishikawa
    J Biochem 139:517-26. 2006
    ..These results suggest that MT1-MMP, MT3-MMP and MT5-MMP should play an important role in the regulation of APP functions in tissues including the central nervous system...
  56. ncbi request reprint Metastasizing mixed tumour of the parotid gland presenting as multiple lung metastases
    Tomokazu Yoshizaki
    Division of Otolaryngology, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan
    J Laryngol Otol 118:724-6. 2004
    ..Thus, it is important for the head and neck surgeon to be aware of the concept of pathologically benign metastasizing mixed tumour and the importance of adequate surgical procedure...
  57. ncbi request reprint Hepatic hilar inflammatory pseudotumor mimicking cholangiocarcinoma with cholangitis and phlebitis--a variant of primary sclerosing cholangitis?
    A Nonomura
    Department of Surgery, Kanazawa University Hospital, School of Medicine, Kanazawa University
    Pathol Res Pract 193:519-25; discussion 526. 1997
    ....
  58. ncbi request reprint Diffuse biliary tract involvement mimicking primary sclerosing cholangitis in an experimental model of chronic graft-versus-host disease in mice
    A Nonomura
    Pathology Section, Kanazawa University Hospital, Ishikawa, Japan
    Pathol Int 48:421-7. 1998
    ..This histologic feature resembled that of primary sclerosing cholangitis (PSC). These results suggest that PSC lesions might develop as a result of chronic cellular immunologic mechanisms in GVHD across minor histocompatibility barriers...
  59. ncbi request reprint Intense 201 Tl uptake in giant-cell tumour of bone
    T Higuchi
    Department of Nuclear Medicine, Kanazawa University School of Medicine, Japan
    Nucl Med Commun 23:595-9. 2002
    ..However, the Tl scintigraphy can be used for excluding GCT when no lesional Tl uptake is observed, and diagnosing recurrent lesions on post-operative follow-up...
  60. ncbi request reprint Mapping sentinel nodes in patients with early-stage gastric carcinoma
    K Miwa
    Department of Gastroenterological Surgery, Division of Cancer Medicine, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Br J Surg 90:178-82. 2003
    ..However, a method for accurate assessment of nodal status during operation has not been established. This study aimed to map the sentinel nodes of gastric carcinoma and to estimate the clinical usefulness of sentinel node biopsy...
  61. ncbi request reprint Differentiation of soft tissue haemangioma by 201Tl scintigraphy
    T Higuchi
    Department of Nuclear Medicine, Kanazawa University School of Medicine, Kanazawa Cardiovascular Hospital, Kanazawa, Japan
    Nucl Med Commun 24:327-30. 2003
    ..02). Deep soft tissue haemangiomas revealed Tl accumulation in early images; however, a rapid washout was observed in delayed images. This distinctive feature may facilitate the use of Tl scintigraphy in the diagnosis of haemangiomas...
  62. ncbi request reprint Thymic lesions in patients with myasthenia gravis: characterization with thallium 201 scintigraphy
    T Higuchi
    Department of Nuclear Medicine, Kanazawa University School of Medicine, Takaramachi 13 1, Kanazawa, Ishikawa, Japan
    Radiology 221:201-6. 2001
    ..To assess thallium 201 ((201)Tl) single photon emission computed tomography (SPECT) for evaluation of thymic lesions associated with myasthenia gravis (MG), including lymphoid follicular hyperplasia (LFH) and thymoma...
  63. ncbi request reprint Can tumor size be a guide for limited surgical intervention in patients with peripheral non-small cell lung cancer? Assessment from the point of view of nodal micrometastasis
    Y Ohta
    Department of Thoracic Surgery, Kanazawa University, School of Medicine, Japan
    J Thorac Cardiovasc Surg 122:900-6. 2001
    ..We sought to determine the critical diameter of a peripheral non-small cell lung cancer tumor less than which no evidence of nodal micrometastasis is present...
  64. ncbi request reprint Intraluminal duodenal diverticulum: MR findings
    S Takamatsu
    Department of Radiology, Kanazawa University, School of Medicine, 13 1 Takara machi, Kanazawa City, Ishikawa, 920 8641, Japan
    Abdom Imaging 31:39-42. 2006
    ....
  65. ncbi request reprint Intraoperative lymphatic mapping and sentinel lymph node biopsy in patients with papillary carcinoma of the thyroid gland
    K Tsugawa
    Department of Surgical Oncology Surgery II, Kanazawa University Graduate School of Medical Science, 13 1, Takara machi, Kanazawa City, Ishikawa 920 8641, Japan
    Biomed Pharmacother 56:100s-103s. 2002
    ..Our preliminary study indicated that sentinel lymph node biopsy was available on detection of non-palpable nodal metastasis in the patients with thyroid cancer; however, further experience and refinement are needed...
  66. ncbi request reprint Extent of mediastinal node metastasis in clinical stage I non-small-cell lung cancer: the role of systematic nodal dissection
    M Oda
    First Department of Surgery, Kanazawa University School of Medicine, Ishikawa, Japan
    Lung Cancer 22:23-30. 1998
    ..To determine the extent of lymph node metastasis in clinical stage I non-small-cell lung cancer (NSCLC)...
  67. ncbi request reprint Fatal cardiac beta2-microglobulin amyloidosis in patients on long-term hemodialysis
    M Kawano
    Pathology Section, Kanazawa University Hospital, Kanazawa, and Naruwa Hospital, Kanazawa, Japan
    Am J Kidney Dis 31:E4. 1998
    ..We conclude that cardiac dialysis-related amyloidosis should also be considered in long-term hemodialysis patients with congestive heart failure as a life-threatening complication...
  68. ncbi request reprint Retrograde approach and soft wall reconstruction in surgery for congenital cholesteatoma
    Hisashi Sugimoto
    Department of Otolaryngology Head and Neck Surgery, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Acta Otolaryngol 133:1142-7. 2013
    ..A retrograde approach and soft wall reconstruction is thought to be an effective surgical approach for patients with good eustachian tube function and good mastoid development such as in congenital cholesteatoma...
  69. doi request reprint Cochlear implantation in a patient with superficial siderosis
    Hisashi Sugimoto
    Department of Otolaryngology Head and Neck Surgery, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Auris Nasus Larynx 39:623-6. 2012
    ..We report the case of a 65-year-old woman with bilateral progressive sensorineural hearing loss caused by superficial siderosis who benefited significantly from cochlear implantation...
  70. ncbi request reprint Nasopharyngeal penicillin-resistant Streptococcus pneumoniae strains among young children in Japan
    Makoto Ito
    Department of Otolaryngology Head and Neck Surgery, Kanazawa University School of Medicine, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8640, Japan
    Otol Neurotol 23:349-52. 2002
    ..Penicillin-resistant S. pneumoniae was examined so that we could investigate the bacteriologic and clinical interpretations of nasopharyngeal flora from healthy children...
  71. ncbi request reprint Expression of intercellular adhesion molecule (ICAM)-1 in adenoid cystic carcinoma of the head and neck
    Akiko Shirai
    Division of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kanazawa University, Japan
    Laryngoscope 113:1955-60. 2003
    ..To investigate the relationship between the clinical features of ACCHN and host immune surveillance, the expression of ICAM-1 and infiltration of T/natural killer (NK) cells and macrophages were immunohistochemically examined...
  72. ncbi request reprint Biological Safety of Nasal Thallium-201 Administration: A Preclinical Study for Olfacto-scintigraphy
    Kohshin Washiyama
    Department of Quantum Medical Technology, Graduate School of Medical Science, Kanazawa University
    J Radiat Res (Tokyo) 52:450-5. 2011
    ..Thus, nasal administration of (201)Tl for the diagnosis of traumatic olfactory impairment did not produce harmful biological effects in vivo...
  73. ncbi request reprint Feeding artery of laryngeal and hypopharyngeal cancers: role of the superior thyroid artery in superselective intraarterial chemotherapy
    Noboru Terayama
    Department of Radiology, Kanazawa University Graduate School of Medical Science, Kanazawa, 920 8641, Japan
    Cardiovasc Intervent Radiol 29:536-43. 2006
    ..To accomplish contrast enhancement of the entire tumor, additional intra-arterial infusion from other arteries such as the inferior thyroid artery is often necessary...
  74. ncbi request reprint [Limitations in intra-arterial infusions of chemotherapy for head and neck cancer]
    Tomokazu Yoshizaki
    Dept of Otolaryngology, School of Medicine, Kanazawa University, Kanazawa, Japan
    Gan To Kagaku Ryoho 35:1106-9. 2008
  75. ncbi request reprint Histological changes of bile duct in experimental graft-versus-host disease across minor histocompatibility barriers. II. Electron microscopic observations
    A Nonomura
    Department of Pathology, School of Medicine, Kanazawa University, Japan
    Liver 8:32-41. 1988
    ..From our previous finding that a large majority of the infiltrating lymphocytes had a phenotype of helper/inducer T cells, a putative role of these lymphocytes in the induction of the bile duct lesions is discussed...
  76. doi request reprint Retrograde mastoidectomy on demand with soft-wall reconstruction in pediatric cholesteatoma
    Miyako Hatano
    Department of Otolaryngology Head and Neck Surgery, Kanazawa University Hospital, Ishikawa, Japan
    Acta Otolaryngol 130:1113-8. 2010
    ..Retrograde mastoidectomy with soft-wall reconstruction is an effective technique that can be used to lower the recurrence rate of cholesteatoma in the pediatric population...
  77. ncbi request reprint Respiratory epithelial adenomatoid hamartoma of the maxillary sinus
    Yuji Himi
    Departments of Plastic and Reconstructive Surgery, Kanazawa Medical College, Kanazawa, Japan
    J Laryngol Otol 116:317-8. 2002
    ..The differential diagnosis of adenomatoid hamartoma includes schneiderian papilloma of the inverted type and adenocarcinoma. Limited but complete surgical resection is the treatment of choice...
  78. ncbi request reprint [Primary small cell carcinoma of the kidney: a case report]
    T Miyagi
    Department of Urology, Kanazawa University, School of Medicine
    Hinyokika Kiyo 47:411-4. 2001
    ..He died 6 months after the diagnosis. Autopsy specimen revealed primary small cell carcinoma of the right kidney. To our knowledge, this is the seventh case as primary renal small cell carcinoma in the world literature...
  79. ncbi request reprint Surgical management of early stage central (hilar) and peripheral nonsmall cell lung carcinoma
    Y Watanabe
    Department of Surgery, Kanazawa University, School of Medicine, Japan
    Cancer 89:2438-44. 2000
    ..In the current study the diagnostic methods, pathology, and results of the surgical treatment of early hilar and peripheral nonsmall cell lung carcinoma cases defined by Japanese criteria are presented...
  80. ncbi request reprint Retinoblastoma protein and proliferating-cell nuclear antigen expression as predictors of recurrence in well-differentiated papillary thyroid carcinoma
    K Omura
    Department of Surgery 1, Kanazawa University Faculty of Medicine, School of Medicine, Japan
    J Clin Oncol 15:3458-63. 1997
    ....
  81. ncbi request reprint Simultaneous detection of epidermal growth factor receptor (EGF-R), epidermal growth factor (EGF) and ras p21 in cholangiocarcinoma by an immunocytochemical method
    A Nonomura
    Department of Pathology, School of Medicine, Kanazawa University, Japan
    Liver 8:157-66. 1988
    ..Furthermore, the data also indicate that an autocrine model for tumor growth, as suggested by a combination of EGF and EGF-R, may be applicable only to very limited cases of CCs...
  82. ncbi request reprint Invasive growth of hepatic angiomyolipoma; a hitherto unreported ominous histological feature
    A Nonomura
    Department of Diagnostic Pathology, Nara Medical University, School of Medicine, Kashihara, Nara, Japan
    Histopathology 48:831-5. 2006
    ..The aim was to review the histological features of invasive growth and clinical outcomes in 39 cases of hepatic AML...
  83. ncbi request reprint The psychological and cosmetic aspects of breast conserving therapy compared with radical mastectomy
    M Noguchi
    Operation Center, Kanazawa University Hospital, School of Medicine, Japan
    Surg Today 23:598-602. 1993
    ..Sexual adjustment was the same in both groups. Body image was thus concluded to have been improved by BCT rather than RM, but psychological morbidity was essentially the same in both groups...
  84. ncbi request reprint Intra-abdominal and retroperitoneal liposarcomas
    T Sato
    Department of Second Surgery, School of Medicine, Kanazawa University, Japan
    Int Surg 84:163-7. 1999
    ..Labelling index of Ki-67 of recurrent tumors increased in two cases. The tumor size affected prognoses of patients with intra-abdominal or retroperitoneal liposarcoma. Combined resection was important to get a tumor-free margin...
  85. ncbi request reprint Infantile disease with microvesicular fatty infiltration of viscera spontaneously occurring in the C3H-H-2(0) strain of mouse with similarities to Reye's syndrome
    T Koizumi
    Institute for Experimental Animals, School of Medicine, Kanazawa University, Japan
    Lab Anim 22:83-7. 1988
    ..The clinical, biochemical and histopathological findings of an infantile disease occurring in the C3H-H-2 degree strain of mice, which has similarities with Reye's syndrome in children, is described...
  86. ncbi request reprint [Treatment for bilateral multiple lung cancers]
    K Iino
    First Department of Surgery, Kanazawa University School of Medicine, Kanazawa, Japan
    Kyobu Geka 55:443-8; discussion 448-50. 2002
    ..A long-term detailed follow-up is necessary to detect second lung carcinoma after the first operation as soon as possible...