Research Topics
Species | Seiji YanoSummaryAffiliation: Kanazawa University Country: Japan Publications
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Detail Information
Publications
Ligand-triggered resistance to molecular targeted drugs in lung cancer: roles of hepatocyte growth factor and epidermal growth factor receptor ligandsSeiji Yano
Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Ishikawa
Cancer Sci 103:1189-94. 2012..This review focuses specifically on receptor activation by ligand stimulation and discusses novel therapeutic strategies that are under development for overcoming resistance to molecular targeted drugs in lung cancer...
Antiangiogenic therapies for malignant pleural mesotheliomaSeiji Yano
Division of Medical Oncology, Cancer Research Institute, Kanazawa University Kanazawa, Ishikawa 920 0934, Japan
Front Biosci 16:740-8. 2011..In this review, we introduce current status of clinical strategies and novel therapeutic approaches against angiogenesis in MPM...- Hepatocyte growth factor induces gefitinib resistance of lung adenocarcinoma with epidermal growth factor receptor-activating mutationsSeiji Yano
Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
Cancer Res 68:9479-87. 2008..Therefore, inhibition of HGF-MET signaling may be a considerable strategy for more successful treatment with gefitinib... - Hepatocyte growth factor expression in EGFR mutant lung cancer with intrinsic and acquired resistance to tyrosine kinase inhibitors in a Japanese cohortSeiji Yano
Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Takara machi, Kanazawa, Japan
J Thorac Oncol 6:2011-7. 2011.... - Paracrine receptor activation by microenvironment triggers bypass survival signals and ALK inhibitor resistance in EML4-ALK lung cancer cellsTadaaki Yamada
Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
Clin Cancer Res 18:3592-602. 2012..We determined whether microenvironmental factors trigger ALK inhibitor resistance in EML4-ALK lung cancer cells... - Dual inhibition of Met kinase and angiogenesis to overcome HGF-induced EGFR-TKI resistance in EGFR mutant lung cancerShinji Takeuchi
Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Japan
Am J Pathol 181:1034-43. 2012..These results indicate the therapeutic rationale of dual targeting of HGF-Met and VEGF-VEGF receptor 2 for overcoming HGF-induced EGFR-TKI resistance in EGFR mutant lung cancer... - Crosstalk to stromal fibroblasts induces resistance of lung cancer to epidermal growth factor receptor tyrosine kinase inhibitorsWei Wang
Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
Clin Cancer Res 15:6630-8. 2009..We have therefore assessed the effect of crosstalk between stromal cells and lung cancer cells harboring EGFR mutations on susceptibility to EGFR-TKIs... - Hsp90 inhibition overcomes HGF-triggering resistance to EGFR-TKIs in EGFR-mutant lung cancer by decreasing client protein expression and angiogenesisHitomi Koizumi
Division of Medical Oncology, Division of Tumor Dynamics and Regulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
J Thorac Oncol 7:1078-85. 2012..Here, we determined whether inhibition of Hsp90 could overcome HGF-triggered EGFR-TKI resistance in EGFR mutant lung cancer cells... - Met kinase inhibitor E7050 reverses three different mechanisms of hepatocyte growth factor-induced tyrosine kinase inhibitor resistance in EGFR mutant lung cancerWei Wang
Kanazawa University, Kanazawa, Ishikawa, Japan
Clin Cancer Res 18:1663-71. 2012..We assayed whether a new Met kinase inhibitor, E7050, which is currently being evaluated in clinical trials, could overcome these three mechanisms of resistance to EGFR-TKIs... - Hepatocyte growth factor induces resistance to anti-epidermal growth factor receptor antibody in lung cancerTadaaki Yamada
Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
J Thorac Oncol 7:272-80. 2012..We therefore determined whether HGF could induce resistance to the anti-EGFR antibody (EGFR Ab) cetuximab in lung cancer cells, regardless of EGFR gene status... - Hepatocyte growth factor reduces susceptibility to an irreversible epidermal growth factor receptor inhibitor in EGFR-T790M mutant lung cancerTadaaki Yamada
Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Ishikawa, Japan
Clin Cancer Res 16:174-83. 2010..Here, we investigated whether HGF induced resistance to the irreversible EGFR-TKI, CL-387,785, in lung cancer cells (H1975) harboring both L858R activating mutation and T790M secondary mutation in EGFR... - Transient PI3K inhibition induces apoptosis and overcomes HGF-mediated resistance to EGFR-TKIs in EGFR mutant lung cancerIvan S Donev
Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
Clin Cancer Res 17:2260-9. 2011..The purpose of this study was to determine whether inhibition of PI3K, a downstream molecule of both EGFR and MET, could overcome HGF-mediated EGFR-TKI resistance in EGFR mutant lung cancer cells PC-9 and HCC827... 
Pleural mesothelioma instigates tumor-associated fibroblasts to promote progression via a malignant cytokine networkQi Li
Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
Am J Pathol 179:1483-93. 2011..These findings indicate that MPM instigates tumor-associated fibroblasts, promoting tumor progression via a malignant cytokine network. Regulation of this cytokine network may be therapeutically useful for controlling MPM...- [Cancer of unknown primary site with epidermal growth factor receptor mutation for which gefitinib proved effective]Tadaaki Yamada
Kanazawa University, Japan
Gan To Kagaku Ryoho 39:1291-4. 2012..Subsequently, multiple metastatic tumors gradually reduced and clinical benefit was observed for a long time... - The EGFR ligands amphiregulin and heparin-binding egf-like growth factor promote peritoneal carcinomatosis in CXCR4-expressing gastric cancerKazuo Yasumoto
Divisions of Surgical Oncology and Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
Clin Cancer Res 17:3619-30. 2011..Here, we investigated whether epidermal growth factor receptor (EGFR) ligands are also involved in the development of peritoneal carcinomatosis from gastric cancer... - Combined therapy with mutant-selective EGFR inhibitor and Met kinase inhibitor for overcoming erlotinib resistance in EGFR-mutant lung cancerTakayuki Nakagawa
Division of Medical Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
Mol Cancer Ther 11:2149-57. 2012..Further evaluations in clinical trials are warranted... - Genetically engineered humanized anti-ganglioside GM2 antibody against multiple organ metastasis produced by GM2-expressing small-cell lung cancer cellsTadaaki Yamada
Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Ishikawa, Japan
Cancer Sci 102:2157-63. 2011..These findings suggest that humanized anti-GM2 antibodies could be therapeutically useful for controlling multiple organ metastases of GM2-expressing SCLC... - Cancer of unknown primary site in which tumor marker-oriented chemotherapy was effective and pancreatic cancer was finally confirmed at autopsyKoushiro Ohtsubo
Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
Intern Med 48:1651-6. 2009..Microscopic examination at autopsy revealed poorly differentiated adenocarcinoma in the pancreatic head, although a pancreatic mass was not clear macroscopically... - [PI3K inhibitor]Seiji Yano
Division of Medical Oncology Cancer Research Institute, Kanazawa University, Japan
Gan To Kagaku Ryoho 38:23-6. 2011..Therefore, PI3K is thought to be an ideal therapeutic target. A large number of PI3K inhibitors are being developed and evaluated in clinical trials... - Endoscopic findings of upper gastrointestinal lesions in patients with pancreatic cancerKoushiro Ohtsubo
Division of Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
JOP 13:420-6. 2012..However, there have been few endoscopic studies in pancreatic cancer patients. We retrospectively investigated the upper gastrointestinal lesions in patients with pancreatic cancer who underwent upper gastrointestinal endoscopy... - Metastatic renal cell carcinoma complicated with diffuse alveolar hemorrhage: a rare adverse effect of sunitinibTadaaki Yamada
Cancer Center, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
Int J Clin Oncol 15:638-41. 2010..Care should be taken with pulmonary hemorrhage in the use of anti-angiogenesis agents in not only squamous cell lung cancer, but also metastatic lung tumors... - Combined chemotherapy with carboplatin plus irinotecan showed favorable efficacy in a patient with relapsed small cell carcinoma of the prostate complicated with meningeal carcinomatosisTadaaki Yamada
Kanazawa University Hospital Cancer Center, Kanazawa, Japan
Int J Clin Oncol 14:468-72. 2009..Because this clinical condition is extremely rare, a gold standard treatment has yet to be established... - The role of percutaneous needle biopsy in differentiation of renal tumorsKouji Izumi
Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
Jpn J Clin Oncol 40:1081-6. 2010..In this study, we examined the background, accuracy, adverse events and patient prognosis associated with such biopsies...