Taro Yamashita

Summary

Affiliation: Kanazawa University Graduate School of Medical Science
Country: Japan

Publications

  1. ncbi request reprint Orchestration of hepatocellular carcinoma development by diverse liver cancer stem cells
    Taro Yamashita
    Departments of General Medicine, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan
    J Gastroenterol 49:1105-10. 2014
  2. pmc Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma
    Masao Honda
    Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, 13 1Takara machi, Kanazawa 920 0934, Japan
    BMC Cancer 13:191. 2013
  3. pmc Cancer stem cells in the development of liver cancer
    Taro Yamashita
    Department of General Medicine, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan
    J Clin Invest 123:1911-8. 2013
  4. doi request reprint Discrete nature of EpCAM+ and CD90+ cancer stem cells in human hepatocellular carcinoma
    Taro Yamashita
    Liver Center, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan
    Hepatology 57:1484-97. 2013
  5. pmc Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma
    Junfang Ji
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Cell Biosci 1:4. 2011
  6. ncbi request reprint Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C
    Masao Honda
    Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Gastroenterology 139:499-509. 2010
  7. ncbi request reprint Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin-28B genotypes
    Masao Honda
    Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan Department of Advanced Medical Technology, Kanazawa University Graduate School of Health Medicine, Kanazawa, Japan
    Hepatology 59:828-38. 2014
  8. doi request reprint Malnutrition impairs interferon signaling through mTOR and FoxO pathways in patients with chronic hepatitis C
    Masao Honda
    Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Gastroenterology 141:128-40, 140.e1-2. 2011
  9. doi request reprint Association of interleukin-28B genotype and hepatocellular carcinoma recurrence in patients with chronic hepatitis C
    Yuji Hodo
    Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Clin Cancer Res 19:1827-37. 2013
  10. doi request reprint Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma
    Shunsuke Ura
    Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Hepatology 49:1098-112. 2009

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Orchestration of hepatocellular carcinoma development by diverse liver cancer stem cells
    Taro Yamashita
    Departments of General Medicine, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan
    J Gastroenterol 49:1105-10. 2014
    ..In this review article, we summarize the recent advances in understanding the pathogenesis and heterogeneity of liver CSCs. ..
  2. pmc Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma
    Masao Honda
    Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, 13 1Takara machi, Kanazawa 920 0934, Japan
    BMC Cancer 13:191. 2013
    ..However, little has been documented about the mechanism by which peretinoin exerts its inhibitory effects against recurrent HCC in humans in vivo...
  3. pmc Cancer stem cells in the development of liver cancer
    Taro Yamashita
    Department of General Medicine, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan
    J Clin Invest 123:1911-8. 2013
    ..This Review highlights recent advances in understanding the pathogenesis of liver CSCs and discusses unanswered questions about the concept of liver CSCs...
  4. doi request reprint Discrete nature of EpCAM+ and CD90+ cancer stem cells in human hepatocellular carcinoma
    Taro Yamashita
    Liver Center, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan
    Hepatology 57:1484-97. 2013
    ....
  5. pmc Wnt/beta-catenin signaling activates microRNA-181 expression in hepatocellular carcinoma
    Junfang Ji
    Liver Carcinogenesis Section, Laboratory of Human Carcinogenesis, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland, USA
    Cell Biosci 1:4. 2011
    ..abstract:..
  6. ncbi request reprint Hepatic ISG expression is associated with genetic variation in interleukin 28B and the outcome of IFN therapy for chronic hepatitis C
    Masao Honda
    Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Gastroenterology 139:499-509. 2010
    ..Multiple viral and host factors are related to the treatment response to pegylated-interferon and ribavirin combination therapy; however, the clinical relevance and relationship of these factors have not yet been fully evaluated...
  7. ncbi request reprint Hepatic interferon-stimulated genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin-28B genotypes
    Masao Honda
    Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan Department of Advanced Medical Technology, Kanazawa University Graduate School of Health Medicine, Kanazawa, Japan
    Hepatology 59:828-38. 2014
    ..This might be related to the high level of hepatic ISG expression in these patients and the treatment-resistant phenotype of the IL28B minor genotype...
  8. doi request reprint Malnutrition impairs interferon signaling through mTOR and FoxO pathways in patients with chronic hepatitis C
    Masao Honda
    Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Gastroenterology 141:128-40, 140.e1-2. 2011
    ..We assessed the importance of the nutritional state of the liver on IFN signaling and treatment response...
  9. doi request reprint Association of interleukin-28B genotype and hepatocellular carcinoma recurrence in patients with chronic hepatitis C
    Yuji Hodo
    Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Clin Cancer Res 19:1827-37. 2013
    ..However, such an association with hepatocellular carcinoma (HCC) is unkno3 we investigated the association between the IL-28B genotype and the biology and clinical outcome of patients with HCC receiving curative treatment...
  10. doi request reprint Differential microRNA expression between hepatitis B and hepatitis C leading disease progression to hepatocellular carcinoma
    Shunsuke Ura
    Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Hepatology 49:1098-112. 2009
    ....
  11. doi request reprint Gene expression profiling of hepatitis B- and hepatitis C-related hepatocellular carcinoma using graphical Gaussian modeling
    Teruyuki Ueda
    Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Takara machi 13 1, Kanazawa 920 8641, Japan
    Genomics 101:238-48. 2013
    ..Gene expression profiling of hepatocellular carcinoma (HCC) and background liver has been studied extensively; however, the relationship between the gene expression profiles of different lesions has not been assessed...
  12. ncbi request reprint Oncostatin m renders epithelial cell adhesion molecule-positive liver cancer stem cells sensitive to 5-Fluorouracil by inducing hepatocytic differentiation
    Taro Yamashita
    Center for Liver Diseases, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan
    Cancer Res 70:4687-97. 2010
    ....
  13. doi request reprint Randomized, phase II study comparing interferon combined with hepatic arterial infusion of fluorouracil plus cisplatin and fluorouracil alone in patients with advanced hepatocellular carcinoma
    Tatsuya Yamashita
    Department of Gastroenterology, Kanazawa University, Kanazawa, Japan
    Oncology 81:281-90. 2011
    ....
  14. doi request reprint Identification of a secretory protein c19orf10 activated in hepatocellular carcinoma
    Hajime Sunagozaka
    Department of Gastroenterology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan
    Int J Cancer 129:1576-85. 2011
    ..Taken together, these data suggest that c19orf10 might be one of the growth factors and potential molecular targets activated in HCC...
  15. doi request reprint Enhancement of tumor-associated antigen-specific T cell responses by radiofrequency ablation of hepatocellular carcinoma
    Eishiro Mizukoshi
    Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan
    Hepatology 57:1448-57. 2013
    ..The modification of T cell phenotype was observed after RFA. The number of TAA-specific T cells at 24 weeks after RFA was decreased...
  16. doi request reprint Comparative analysis of various tumor-associated antigen-specific t-cell responses in patients with hepatocellular carcinoma
    Eishiro Mizukoshi
    Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa, Japan
    Hepatology 53:1206-16. 2011
    ..Blocking cytotoxic T-lymphocyte antigen-4 (CTLA-4) resulted in unmasking of TAA-specific immune responses by changing cytokine and chemokine profiles of peripheral blood mononuclear cells stimulated by TAA-derived peptides...
  17. pmc MicroRNA-27a regulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells
    Takayoshi Shirasaki
    Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Virol 87:5270-86. 2013
    ..Thus, this negative feedback mechanism might contribute to the maintenance of a low viral load and would be beneficial to the virus by allowing it to escape host immune surveillance and establish a persistent chronic HCV infection...
  18. doi request reprint Differential gene expression profiling in blood from patients with digestive system cancers
    Masao Honda
    Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan
    Biochem Biophys Res Commun 400:7-15. 2010
    ..These results showed the potential relevance of peripheral blood gene expression profiling for the development of new diagnostic examination tools for cancer patients...
  19. ncbi request reprint Different signaling pathways in the livers of patients with chronic hepatitis B or chronic hepatitis C
    Masao Honda
    Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Hepatology 44:1122-38. 2006
    ..The results might be useful in guiding therapeutic strategies to prevent the development of hepatocellular carcinoma in cases of CH-B and CH-C...
  20. doi request reprint dUTP pyrophosphatase expression correlates with a poor prognosis in hepatocellular carcinoma
    Hajime Takatori
    Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    Liver Int 30:438-46. 2010
    ..To discover a novel molecular marker that is related to the efficacy of treatment for HCC and its biological nature, we performed serial analysis of gene expression (SAGE) in HCC, normal liver and cirrhotic liver tissues...
  21. doi request reprint Heterogeneous nuclear ribonucleoprotein A2/B1 in association with hTERT is a potential biomarker for hepatocellular carcinoma
    Hideki Mizuno
    Department of Gastroenterology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Liver Int 32:1146-55. 2012
    ....
  22. doi request reprint Differential interferon signaling in liver lobule and portal area cells under treatment for chronic hepatitis C
    Masao Honda
    Department of Gastroenterology, Kanazawa University, Graduate School of Medicine, Kanazawa, Japan
    J Hepatol 53:817-26. 2010
    ..This study aims to gain insight into these mechanisms by exploring hepatic gene expression before and during treatment...
  23. doi request reprint The transcription factor SALL4 regulates stemness of EpCAM-positive hepatocellular carcinoma
    Sha Sha Zeng
    Department of Gastroenterology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan
    J Hepatol 60:127-34. 2014
    ..We investigated the transcription program deregulated in hepatocellular carcinomas with stem cell features...
  24. doi request reprint Comprehensive gene expression analysis of 5'-end of mRNA identified novel intronic transcripts associated with hepatocellular carcinoma
    Yuji Hodo
    Department of Gastroentelorogy, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Genomics 95:217-23. 2010
    ..The present results indicate that the transcription initiation of a subset of genes may be distinctively altered in HCC, which may suggest the utility of intronic RNAs as surrogate tumor markers...
  25. ncbi request reprint Differential gene expression profiles in stage I primary biliary cirrhosis
    Masao Honda
    Department of Gastroenterology, Graduate School of Medicine, Kanazawa University, Kanazawa, Japan
    Am J Gastroenterol 100:2019-30. 2005
    ..Primary biliary cirrhosis (PBC) is a progressive disease. However, little is understood about the molecular mechanisms underlying its features...
  26. doi request reprint A liver-derived secretory protein, selenoprotein P, causes insulin resistance
    Hirofumi Misu
    Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    Cell Metab 12:483-95. 2010
    ..In summary, these results demonstrate a role of SeP in the regulation of glucose metabolism and insulin sensitivity and suggest that SeP may be a therapeutic target for type 2 diabetes...
  27. doi request reprint Nucleostemin in injury-induced liver regeneration
    Haruhiko Shugo
    Division of Molecular Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Stem Cells Dev 21:3044-54. 2012
    ..These data strongly suggest that NS plays a critical role in regeneration of both hepatic precursor cells and hepatocytes in response to liver injury...
  28. doi request reprint Frequency of CD45RO+ subset in CD4+CD25(high) regulatory T cells associated with progression of hepatocellular carcinoma
    Yoshiko Takata
    Disease Control and Homeostasis, Graduate School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa, Japan
    Cancer Lett 307:165-73. 2011
    ....
  29. doi request reprint Molecular mechanisms of hepatocarcinogenesis in chronic hepatitis C virus infection
    Taro Yamashita
    Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Gastroenterol Hepatol 26:960-4. 2011
    ..In this review, we summarize recent advances in knowledge about the mechanisms of hepatocarcinogenesis induced by HCV infection...
  30. ncbi request reprint Differential gene alteration among hepatoma cell lines demonstrated by cDNA microarray-based comparative genomic hybridization
    Kazunori Kawaguchi
    Department of Gastroenterology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Biochem Biophys Res Commun 329:370-80. 2005
    ..Differences in DNA copy alterations between AFP-producing and AFP-negative cells may lead to differential gene expression and may be related to the phenotype of these cells...
  31. ncbi request reprint SAGE application in the study of diabetes
    Toshinari Takamura
    Department of Disease Control and Homeostasis, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920 8641, Japan
    Curr Pharm Biotechnol 9:392-9. 2008
    ..Such SAGE-based approaches may lead to the identification of novel therapeutic targets for the treatment of type 2 diabetes and its complications...
  32. ncbi request reprint [Two cases of a nonfunctioning pancreatic endocrine tumor found on a medical checkup]
    Kouki Nio
    Department of Gastroenterology, Kanazawa University Hospital, Japan
    Nihon Shokakibyo Gakkai Zasshi 106:560-8. 2009
    ..Both cases showed FDG-PET accumulation in the tumors irrespective of their malignant or benign nature. Increased prevalence of FDG-PET checkup may increase the diagnosis of pancreatic neuroendocrine tumor in asymptomatic subjects...
  33. pmc Evaluation of eligibility criteria in living donor liver transplantation for hepatocellular carcinoma by α-SMA-positive cancer-associated fibroblasts
    Hiroyuki Takamura
    Department of Gastroenterologic Surgery, Graduate School of Medicine, Kanazawa University, Kanazawa, Ishikawa 920 8641, Japan
    Oncol Rep 30:1561-74. 2013
    ..LDLT should be limited to recipients within Up-to-7 criteria or without proliferation of α-SMA-positive CAFs...
  34. ncbi request reprint [Molecular pathogenesis of hepatocellular carcinoma]
    Taro Yamashita
    Department of Gastroenterology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan
    Gan To Kagaku Ryoho 37:14-7. 2010
    ..Development of novel classification systems based on the molecular profiles and drug sensitivities against molecularly targeted compounds is currently underway to facilitate novel strategies for effective eradication of HCC...