Kiyofumi Yamada

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. ncbi The rewards of nicotine: regulation by tissue plasminogen activator-plasmin system through protease activated receptor-1
    Taku Nagai
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 1192, Japan
    J Neurosci 26:12374-83. 2006
  2. ncbi [Regulation by tissue plasminogen activator of rewarding effects of drugs of abuse]
    Taku Nagai
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, 466 8560 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 28:1-6. 2008
  3. ncbi Endogenous modulators for drug dependence
    Kiyofumi Yamada
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Biol Pharm Bull 31:1635-8. 2008
  4. ncbi Drug dependence, synaptic plasticity, and tissue plasminogen activator
    Kiyofumi Yamada
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Japan
    J Pharmacol Sci 97:157-61. 2005
  5. ncbi Brain-derived neurotrophic factor/TrkB signaling in memory processes
    Kiyofumi Yamada
    Laboratory of Experimental Therapeutics, Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa 920 0934, Japan
    J Pharmacol Sci 91:267-70. 2003
  6. ncbi [Pro- and anti-addictive factors related to drug addiction]
    Kiyofumi Yamada
    Nippon Yakurigaku Zasshi 126:49-53. 2005
  7. ncbi Interaction of BDNF/TrkB signaling with NMDA receptor in learning and memory
    Kiyofumi Yamada
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    Drug News Perspect 17:435-8. 2004
  8. ncbi Possible involvement of protease-activated receptor-1 in the regulation of morphine-induced dopamine release and hyperlocomotion by the tissue plasminogen activator-plasmin system
    Mina Ito
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    J Neurochem 101:1392-9. 2007
  9. ncbi Role of tissue plasminogen activator in the sensitization of methamphetamine-induced dopamine release in the nucleus accumbens
    Ayumi Fukakusa
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    J Neurochem 105:436-44. 2008
  10. ncbi Involvement of pallidotegmental neurons in methamphetamine- and MK-801-induced impairment of prepulse inhibition of the acoustic startle reflex in mice: reversal by GABAB receptor agonist baclofen
    Sawako Arai
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    Neuropsychopharmacology 33:3164-75. 2008

Collaborators

Detail Information

Publications82

  1. ncbi The rewards of nicotine: regulation by tissue plasminogen activator-plasmin system through protease activated receptor-1
    Taku Nagai
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 1192, Japan
    J Neurosci 26:12374-83. 2006
    ..Targeting the tPA-plasmin-PAR1 system would provide new therapeutic approaches to the treatment of nicotine dependence...
  2. ncbi [Regulation by tissue plasminogen activator of rewarding effects of drugs of abuse]
    Taku Nagai
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya, 466 8560 Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 28:1-6. 2008
    ..Our findings suggest that targeting the tPA-plasmin-PAR1 system would provide new therapeutic approaches to the treatment of drug dependence...
  3. ncbi Endogenous modulators for drug dependence
    Kiyofumi Yamada
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Biol Pharm Bull 31:1635-8. 2008
    ..Furthermore, targeting these endogenous modulators would provide new therapeutic approaches to the treatment of drug dependence...
  4. ncbi Drug dependence, synaptic plasticity, and tissue plasminogen activator
    Kiyofumi Yamada
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Japan
    J Pharmacol Sci 97:157-61. 2005
    ..These results support our hypothesis that tPA plays a role in long-lasting neuronal changes related to drug dependence...
  5. ncbi Brain-derived neurotrophic factor/TrkB signaling in memory processes
    Kiyofumi Yamada
    Laboratory of Experimental Therapeutics, Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa 920 0934, Japan
    J Pharmacol Sci 91:267-70. 2003
    ..A Src-family tyrosine kinase, Fyn plays a role in this interaction by linking TrkB with NR2B. These findings suggest that BDNF/TrkB signaling in the hippocampus plays a crucial role in learning and memory...
  6. ncbi [Pro- and anti-addictive factors related to drug addiction]
    Kiyofumi Yamada
    Nippon Yakurigaku Zasshi 126:49-53. 2005
  7. ncbi Interaction of BDNF/TrkB signaling with NMDA receptor in learning and memory
    Kiyofumi Yamada
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    Drug News Perspect 17:435-8. 2004
    ..The interaction of BDNF/TrkB signaling with N-methyl-D-aspartate receptors is important for spatial learning and memory, and an Src-family tyrosine kinase Fyn may play a key role in this interaction by linking TrkB with NR2B...
  8. ncbi Possible involvement of protease-activated receptor-1 in the regulation of morphine-induced dopamine release and hyperlocomotion by the tissue plasminogen activator-plasmin system
    Mina Ito
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    J Neurochem 101:1392-9. 2007
    ..These results suggest that PAR-1 is a target for the tPA-plasmin system in the regulation of acute morphine-induced dopamine release in the NAc...
  9. ncbi Role of tissue plasminogen activator in the sensitization of methamphetamine-induced dopamine release in the nucleus accumbens
    Ayumi Fukakusa
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    J Neurochem 105:436-44. 2008
    ....
  10. ncbi Involvement of pallidotegmental neurons in methamphetamine- and MK-801-induced impairment of prepulse inhibition of the acoustic startle reflex in mice: reversal by GABAB receptor agonist baclofen
    Sawako Arai
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    Neuropsychopharmacology 33:3164-75. 2008
    ..GABA(B) receptor may constitute a putative target in treating neuropsychiatric disorders with sensorimotor gating deficits, such as schizophrenia and METH psychosis...
  11. ncbi Therapeutic potential of nicotine for methamphetamine-induced impairment of sensorimotor gating: involvement of pallidotegmental neurons
    Hiroyuki Mizoguchi
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, 920 1192, Japan
    Psychopharmacology (Berl) 207:235-43. 2009
    ....
  12. ncbi Repeated methamphetamine treatment impairs spatial working memory in rats: reversal by clozapine but not haloperidol
    Taku Nagai
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Psychopharmacology (Berl) 194:21-32. 2007
    ..Although chronic use of methamphetamine (METH) leads to long-lasting cognitive dysfunction in humans, there are few reports about an animal model that reflects METH-induced impairment of working memory...
  13. ncbi Improvement by minocycline of methamphetamine-induced impairment of recognition memory in mice
    Hiroyuki Mizoguchi
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 1192, Japan
    Psychopharmacology (Berl) 196:233-41. 2008
    ..Recent studies indicate that minocycline, a second-generation tetracycline, has potent neuroprotective effects in various animal models of neurological diseases...
  14. ncbi Activation of post-synaptic dopamine D₁ receptors promotes the release of tissue plasminogen activator in the nucleus accumbens via PKA signaling
    Mina Ito
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    J Neurochem 103:2589-96. 2007
    ..Furthermore, dopamine D(2) receptors are also involved in the release of tPA induced by morphine and methamphetamine...
  15. ncbi Ovariectomy increases neuronal amyloid-beta binding alcohol dehydrogenase level in the mouse hippocampus
    Emiko Fukuzaki
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa, Japan
    Neurochem Int 52:1358-64. 2008
    ....
  16. ncbi Dopamine D1 receptors regulate protein synthesis-dependent long-term recognition memory via extracellular signal-regulated kinase 1/2 in the prefrontal cortex
    Taku Nagai
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    Learn Mem 14:117-25. 2007
    ..These results suggest that the activation of ERK1/2 following the stimulation of dopamine D1 receptors is necessary for the protein synthesis-dependent long-term retention of recognition memory in the PFC...
  17. ncbi Social isolation rearing-induced impairment of the hippocampal neurogenesis is associated with deficits in spatial memory and emotion-related behaviors in juvenile mice
    Daisuke Ibi
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    J Neurochem 105:921-32. 2008
    ....
  18. ncbi Tissue plasminogen activator is not involved in methamphetamine-induced neurotoxicity
    Ayumi Fukakusa
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Japan
    J Pharmacol Sci 106:321-4. 2008
    ..No difference in METH-induced abnormal behavior and hyperthermia was observed among the three types of mice. These results suggest that neither tPA nor PAR-1 is involved in METH-induced dopaminergic neurotoxicity in vivo...
  19. ncbi Repeated methamphetamine treatment impairs recognition memory through a failure of novelty-induced ERK1/2 activation in the prefrontal cortex of mice
    Hiroyuki Kamei
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University
    Biol Psychiatry 59:75-84. 2006
    ..CONCLUSIONS: These results suggest that repeated METH treatment induces cognitive impairment, which is associated with the dysfunction of the ERK1/2 pathway in the prefrontal cortex...
  20. ncbi Involvement of tissue plasminogen activator-plasmin system in depolarization-evoked dopamine release in the nucleus accumbens of mice
    Mina Ito
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Mol Pharmacol 70:1720-5. 2006
    ..Our findings suggest that the tPA-plasmin system is involved in the regulation of depolarization-evoked DA release in the NAc...
  21. ncbi GABAB receptor agonist baclofen improves methamphetamine-induced cognitive deficit in mice
    Sawako Arai
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 1192, Japan
    Eur J Pharmacol 602:101-4. 2009
    ..GABA(B) receptors may constitute a putative new target in treating cognitive deficits in patients suffering from schizophrenia, as well as methamphetamine psychosis...
  22. ncbi A novel azaindolizinone derivative ZSET1446 (spiro[imidazo[1,2-a]pyridine-3,2-indan]-2(3H)-one) improves methamphetamine-induced impairment of recognition memory in mice by activating extracellular signal-regulated kinase 1/2
    Yukio Ito
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 1192, Japan
    J Pharmacol Exp Ther 320:819-27. 2007
    ..ZSET1446 would be a potential candidate for further preclinical study aimed at the treatment of cognitive deficits in Alzheimer's disease and schizophrenia, as well as METH psychosis...
  23. ncbi [Role of tissue plasminogen activator in the rewarding effect of morphine]
    Taku Nagai
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
    Nihon Arukoru Yakubutsu Igakkai Zasshi 41:23-30. 2006
    ..Our findings demonstrate a novel function of the tPA-plasmin system in regulating dopamine release in the NAc, which is involved in the morphine reward...
  24. ncbi Involvement of hippocampal extracellular signal-regulated kinase 1/2 in spatial working memory in rats
    Taku Nagai
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    Neuroreport 17:1453-7. 2006
    ..These results suggest that extracellular signal-regulated kinase 1/2 activation in the hippocampus plays a crucial role in spatial working memory...
  25. ncbi Neural circuits containing pallidotegmental GABAergic neurons are involved in the prepulse inhibition of the startle reflex in mice
    Kenji Takahashi
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    Biol Psychiatry 62:148-57. 2007
    ..We attempted to clarify the neuronal circuits underlying the control of PPI of the startle reflex in mice...
  26. ncbi Enhanced activity of hippocampal BACE1 in a mouse model of postmenopausal memory deficits
    Emiko Fukuzaki
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa 920 1192, Japan
    Neurosci Lett 433:141-5. 2008
    ..These findings suggest that a stressful life after menopause can influence the levels of AD-related molecules and that BACE1 is the most sensitive molecule for such a situation...
  27. ncbi Placental extract improves hippocampal neuronal loss and fear memory impairment resulting from chronic restraint stress in ovariectomized mice
    Kazuhiro Takuma
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Japan
    J Pharmacol Sci 120:89-97. 2012
    ..These results have important implications for the neuroprotective and cognition-enhancing effects of placental extract in postmenopausal women...
  28. ncbi Involvement of matrix metalloproteinase-9 in the development of morphine tolerance
    Kazuo Nakamoto
    Department of Clinical Pharmacy, Kobe Gakuin University, School of Pharmaceutical Sciences, 1 1 3 Minatojima, Chuo Ku, Kobe, Hyogo 650 8586, Japan
    Eur J Pharmacol 683:86-92. 2012
    ..Our findings suggest that persistent MMP-9 activation observed after the transient increment in MMP-9 expression from the early phase of morphine treatment may contribute to the development of morphine tolerance...
  29. ncbi Possible protection by notoginsenoside R1 against glutamate neurotoxicity mediated by N-methyl-D-aspartate receptors composed of an NR1/NR2B subunit assembly
    Bin Gu
    Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kanazawa, Japan
    J Neurosci Res 87:2145-56. 2009
    ..These results suggest that NTR1 may preferentially protect neurons from Glu excitotoxicity mediated by NMDA receptor composed of an NR1/NR2B subunit assembly in the brain...
  30. ncbi Modification by the tissue plasminogen activator-plasmin system of morphine-induced dopamine release and hyperlocomotion, but not anti-nociceptive effect in mice
    Taku Nagai
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    J Neurochem 93:1272-9. 2005
    ..These results suggest that the tPA-plasmin system is involved in the regulation of morphine-induced dopamine release and dopamine-dependent behaviors but not the anti-nociceptive effects of morphine...
  31. ncbi Clozapine prevents a decrease in neurogenesis in mice repeatedly treated with phencyclidine
    Kenji Maeda
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    J Pharmacol Sci 103:299-308. 2007
    ..These results suggest that chronic dysfunction of NMDA receptors causes a decrease in neurogenesis in the dentate gyrus...
  32. ncbi Transient suppression of progenitor cell proliferation through NMDA receptors in hippocampal dentate gyrus of mice with traumatic stress experience
    Keisuke Tamaki
    Laboratories of Molecular Pharmacology, Kanazawa University Graduate School of Natural Science and Technology, Kakuma machi, Kanazawa, Ishikawa, Japan
    J Neurochem 105:1642-55. 2008
    ....
  33. ncbi Matrix metalloprotease-9 inhibition improves amyloid beta-mediated cognitive impairment and neurotoxicity in mice
    Hiroyuki Mizoguchi
    Kanazawa University, Japan
    J Pharmacol Exp Ther 331:14-22. 2009
    ..Our findings suggest that, as opposed to expectations based on previous findings, MMP-9 plays a causal role in Abeta-induced cognitive impairment and neurotoxicity...
  34. ncbi Transcriptional induction and translational inhibition of Arc and Cugbp2 in mice hippocampus after transient global ischemia under normothermic condition
    Noboru Otsuka
    Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kakuma machi, Kanazawa, Ishikawa 920 1192, Japan
    Brain Res 1287:136-45. 2009
    ..Thus, translational inhibition might play an important role in the progress of neuronal injury after transient global ischemia...
  35. ncbi Synergistic effects of adenosine A2A antagonist and L-DOPA on rotational behaviors in 6-hydroxydopamine-induced hemi-Parkinsonian mouse model
    Takahiro Matsuya
    Laboratory of Neuropsychopharmacology, Division of Life Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa, Japan
    J Pharmacol Sci 103:329-32. 2007
    ..These findings suggest that adenosine A(2A) antagonists are extremely useful for pharmacotherapy of L-DOPA in Parkinson's disease patients...
  36. ncbi Cytokine receptor-like factor 1 is highly expressed in damaged human knee osteoarthritic cartilage and involved in osteoarthritis downstream of TGF-beta
    Katsuki Tsuritani
    Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University Graduate School of Natural Science and Technology, Kakuma machi, Kanazawa, Japan
    Calcif Tissue Int 86:47-57. 2010
    ..A component of the complex, CRLF1, may be useful as a biomarker of OA; and the corresponding receptor is a potential new drug target for OA...
  37. ncbi Effects of memantine and donepezil on amyloid beta-induced memory impairment in a delayed-matching to position task in rats
    Kiyofumi Yamada
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma-machi, Kanazawa 920-1192, Japan
    Behav Brain Res 162:191-9. 2005
    ..Moreover, it is suggested that memantine is effective for preventing Abeta-induced short-term memory impairment...
  38. ncbi Mitochondrial dysfunction, endoplasmic reticulum stress, and apoptosis in Alzheimer's disease
    Kazuhiro Takuma
    Laboratory of Neuropsychopharmacology, Graduate School of Natural Science and Technology, Kanazawa University, Kanazawa
    J Pharmacol Sci 97:312-6. 2005
    ..This review summarizes recent progress of research in this field focused on the molecular mechanisms involved in neuronal apoptosis mediated by organelle dysfunction...
  39. ncbi [Objective evaluation of clinical pharmacy lectures and experience in a master program using visual analog scale method]
    Kazumasa Naruhashi
    Division of Pharmacy and Health Sciences, Graduate School of Natural Science and Technology, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Yakugaku Zasshi 123:973-80. 2003
    ....
  40. ncbi [Behavioral analyses for learning and memory in mice and rats]
    Kazuhiro Takuma
    Nippon Yakurigaku Zasshi 130:112-6. 2007
  41. ncbi [Behavioral approaches for analyzing emotionality in mutant mice]
    Taku Nagai
    Nippon Yakurigaku Zasshi 125:71-6. 2005
  42. ncbi Efficacy of the herbal medicine Unkei-to as an adjunctive treatment to hormone replacement therapy for postmenopausal women with depressive symptoms
    Koji Koike
    Department of Obstetrics and Gynecology, School of Medicine, Graduate School of Medical Science, Knazawa University, Ishikawa, Japan
    Clin Neuropharmacol 27:157-62. 2004
    ..The aim of this study was to assess whether the herbal medicine Unkei-to has an impact on HRT-resistant menopausal depressive symptoms as an effective adjunctive therapy combined with HRT...
  43. ncbi Involvement of matrix metalloproteinase-mediated proteolysis of neural cell adhesion molecule in the development of cerebral ischemic neuronal damage
    Kanako Shichi
    Department of Clinical Pharmacy, Kobe Gakuin University School of Pharmaceutical Sciences, 1 1 3 Minatojima, Chuo Ku, Kobe 650 8586, Japan
    J Pharmacol Exp Ther 338:701-10. 2011
    ..The present findings clearly suggest that MMP-2/MMP-9-mediated NCAM proteolysis is implicated in the exacerbation of ischemic neuronal damage...
  44. ncbi The magnetism responsive gene Ntan1 in mouse brain
    Yasuaki Goto
    Laboratory of Molecular Pharmacology, Division of Pharmaceutical Sciences, Kanazawa University, Graduate School of Natural Science and Technology, Kakuma machi, Kanazawa, Ishikawa 920 1192, Japan
    Neurochem Int 49:334-41. 2006
    ..The mice exposed to magnetic fields under the same condition showed significantly decreased locomotor activity. These results suggest that magnetic exposure affects higher order neural functions through modulation of genes expression...
  45. ncbi Pro- and anti-addictive neurotrophic factors and cytokines in psychostimulant addiction: mini review
    Kiyofumi Yamada
    Laboratory of Neuropsychopharmacology, Faculty of Pharmaceutical Sciences, Kanazawa University, Japan
    Ann N Y Acad Sci 1025:198-204. 2004
    ..In this article, a role of neurotrophic factors and cytokines in psychostimulant addiction is discussed...
  46. ncbi [Effects of sigma receptor ligands on psychiatric disorders]
    Hiroyuki Kamei
    Laboratory of Neuropsychopharmacology, Faculty of Pharmaceutical Sciences, Kanazawa University, 13-1, Takara-machi, Kanazawa, 920-0934, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 23:187-96. 2003
    ..These findings suggest that sigma receptors are novel potential targets for the treatment of psychiatric disorders such as schizophrenia, drug abuse, depression and dementia...
  47. ncbi Therapeutic approaches to the treatment of Alzheimer's disease
    Kiyofumi Yamada
    Laboratory of Experimental Therapeutics, Department of Clinical Pharmacy, Faculty of Pharmaceutical Sciences, Kanazawa University, Kanazawa, Japan
    Drugs Today (Barc) 38:631-7. 2002
    ..Inhibitors of tau hyperphosphorylation may also modulate the development and progress of the disease...
  48. ncbi A dibenzoylmethane derivative protects dopaminergic neurons against both oxidative stress and endoplasmic reticulum stress
    Katsura Takano
    Department of Neuroanatomy, Kanazawa University Graduate School of Medical Science, Kanazawa City, Ishikawa, Japan
    Am J Physiol Cell Physiol 293:C1884-94. 2007
    ..These results suggest that 14-26 is an antioxidant that protects dopaminergic neurons against both oxidative stress and ER stress and could be a therapeutic candidate for the treatment of PD...
  49. ncbi Neuropsychotoxicity of abused drugs: involvement of matrix metalloproteinase-2 and -9 and tissue inhibitor of matrix metalloproteinase-2 in methamphetamine-induced behavioral sensitization and reward in rodents
    Hiroyuki Mizoguchi
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Pharmacol Sci 106:9-14. 2008
    ..The MMP/TIMP system may be involved in METH-induced sensitization and reward by regulating extracellular dopamine levels...
  50. ncbi Role of matrix metalloproteinase and tissue inhibitor of MMP in methamphetamine-induced behavioral sensitization and reward: implications for dopamine receptor down-regulation and dopamine release
    Hiroyuki Mizoguchi
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Neurochem 102:1548-60. 2007
    ..These results suggest that the MMP/TIMP system is involved in METH-induced behavioral sensitization and reward, by regulating dopamine release and receptor signaling...
  51. ncbi The roles of glial cell line-derived neurotrophic factor, tumor necrosis factor-alpha, and an inducer of these factors in drug dependence
    Minae Niwa
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    J Pharmacol Sci 104:116-21. 2007
    ..These findings suggest that Leu-Ile could be a novel therapeutic agent for drug dependence...
  52. ncbi Restraining tumor necrosis factor-alpha by thalidomide prevents the amyloid beta-induced impairment of recognition memory in mice
    Tursun Alkam
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Behav Brain Res 189:100-6. 2008
    ..These results suggested the practicability of targeting TNF-alpha as a preventive strategy against Abeta-mediated cognitive impairments...
  53. ncbi Reduction of methamphetamine-induced sensitization and reward in matrix metalloproteinase-2 and -9-deficient mice
    Hiroyuki Mizoguchi
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Neurochem 100:1579-88. 2007
    ..These results suggest that both MMP-2 and MMP-9 play a crucial role in METH-induced behavioural sensitization and reward by regulating METH-induced dopamine release and uptake in the NAc...
  54. ncbi [Candidate genes or compounds for therapeutic tools against methamphetamine and/or morphine-induced dependence]
    Atsumi Nitta
    Department of Neuropsychopharmacology, Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan
    Nippon Yakurigaku Zasshi 122:81P-83P. 2003
    ..Leu-Ile protected blocked the methamphetamine induced rewarding effects. These results suggest that a stimulator of TNF-alpha synthesis may be one of therapeutic tools against drug dependence...
  55. ncbi Role of tumor necrosis factor-alpha in methamphetamine-induced drug dependence and neurotoxicity
    Akira Nakajima
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    J Neurosci 24:2212-25. 2004
    ....
  56. ncbi The tissue plasminogen activator-plasmin system participates in the rewarding effect of morphine by regulating dopamine release
    Taku Nagai
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    Proc Natl Acad Sci U S A 101:3650-5. 2004
    ..Our findings demonstrate a previously undescribed function of the tPA-plasmin system in regulating dopamine release, which is involved in the rewarding effects of morphine...
  57. ncbi The role of tissue plasminogen activator in methamphetamine-related reward and sensitization
    Taku Nagai
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8560, Japan
    J Neurochem 92:660-7. 2005
    ..Our findings suggest that tPA is involved in the rewarding effects as well as the sensitization of the locomotor-stimulating effect of METH...
  58. ncbi Involvement of BDNF receptor TrkB in spatial memory formation
    Makoto Mizuno
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya 466-8560, Japan
    Learn Mem 10:108-15. 2003
    ..The phosphorylation of Fyn and NR2B, but not TrkB, was diminished by PP2 treatment. Our findings suggest the importance of interaction between BDNF/TrkB signaling and NMDA receptors for spatial memory in the hippocampus...
  59. ncbi Behavioural adaptations to addictive drugs in mice lacking the NMDA receptor epsilon1 subunit
    Yoshiaki Miyamoto
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma cho, Showa Ku, Nagoya 466 8560, Japan
    Eur J Neurosci 19:151-8. 2004
    ..These findings provide genetic evidence that GluRepsilon1 subunit-containing NMDA receptors are involved in certain aspects of drug addiction...
  60. ncbi Lower sensitivity to stress and altered monoaminergic neuronal function in mice lacking the NMDA receptor epsilon 4 subunit
    Yoshiaki Miyamoto
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8560, Japan
    J Neurosci 22:2335-42. 2002
    ..These findings suggest that GluRepsilon4 mutant mice have dysfunctional NMDA receptors and altered emotional behavior probably caused by changes in monoaminergic neuronal activities in adulthood...
  61. ncbi Role for brain-derived neurotrophic factor in learning and memory
    Kiyofumi Yamada
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan
    Life Sci 70:735-44. 2002
    ..It is concluded that BDNF/TrkB signaling plays an important role in learning and memory...
  62. ncbi Transient drug-primed but persistent cue-induced reinstatement of extinguished methamphetamine-seeking behavior in mice
    Yijin Yan
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University, Graduate School of Medicine, Nagoya 466 8560, Japan
    Behav Brain Res 177:261-8. 2007
    ..In conclusion, our findings suggest that the present reinstatement procedure for mouse model of relapse is useful and reliable, and different neural mechanisms may be involved in drug-primed and cue-induced METH-seeking behavior...
  63. ncbi [Role of cytokines in drug dependence]
    Akira Nakajima
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya 466-8560, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 23:179-82. 2003
    ..Thus, it is suggested that these communications play an important role in drug dependence. Here we review the role of cytokines in drug dependence...
  64. ncbi Role of the mesotelencephalic dopamine system in learning and memory processes in the rat
    Vasile Hefco
    Department of Physiology, AlI Cuza University, Blv Carol I, NR 11, 6600 Iasi, Romania
    Eur J Pharmacol 475:55-60. 2003
    ..As compared to short-term memory, long-term memory is more susceptible to the decreased dopamine level in nervous structures involved in processing and storage of information...
  65. ncbi Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress
    Taku Nagai
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466 8560, Japan
    FASEB J 17:50-2. 2003
    ..These results suggest that oxidative stress has a crucial role in the aging-associated cognition impairment in klotho mutant mice. Klotho protein may be involved in the regulation of antioxidative defense...
  66. ncbi Memory impairment induced by chronic intracerebroventricular infusion of beta-amyloid (1-40) involves downregulation of protein kinase C
    Ana Olariu
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya, Japan
    Brain Res 957:278-86. 2002
    ..Our data indicate that chronic accumulation of beta-amyloid (1-40) into the rat brain reduced activation of PKC, effect that would substantially contribute to the memory deficit found in these animals...
  67. ncbi Learning and memory in two different reward tasks in a radial arm maze in rats
    Jue He
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8560, Japan
    Behav Brain Res 134:139-48. 2002
    ..These results suggest that different strategies are used between the FPRT and VPRT but the hippocampus plays an important role in performance of rats trained for the VPRT as well as FPRT...
  68. ncbi Effect of dietary fiber on morphine-induced constipation in rats
    Takashi Niwa
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan
    Biosci Biotechnol Biochem 66:1233-40. 2002
    ..These results suggest that dietary fiber has a preventative effect on morphine-induced constipation by increasing SCFAs in the cecum, and thereby promoting colon motility in rats...
  69. ncbi CREB phosphorylation as a molecular marker of memory processing in the hippocampus for spatial learning
    Makoto Mizuno
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Japan
    Behav Brain Res 133:135-41. 2002
    ..These results suggest that activation of the PKA/CREB signaling pathway in the hippocampus plays an important role in spatial memory formation...
  70. ncbi Enduring vulnerability to reinstatement of methamphetamine-seeking behavior in glial-cell-line-derived neurotrophic factor mutant mice
    Yijin Yan
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Showa Ku, Nagoya 466 8560, Japan
    FASEB J 21:1994-2004. 2007
    ..These findings suggest that GDNF may be associated with enduring vulnerability to reinstatement of METH-seeking behavior and a potential target in the development of therapies to control relapse...
  71. ncbi [Cognition impairment in the klotho gene mutant mice and oxidative stress]
    Taku Nagai
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan
    Nihon Shinkei Seishin Yakurigaku Zasshi 23:211-7. 2003
    ..These results suggest that oxidative stress has a crucial role in the aging-associated cognition impairment in klotho mutant mice. Klotho protein may be involved in the regulation of antioxidative defense...
  72. ncbi Enhanced antidepressant efficacy of sigma1 receptor agonists in rats after chronic intracerebroventricular infusion of beta-amyloid-(1-40) protein
    Alexandre Urani
    INSERM U 336, Behavioural Neuropharmacology Group, Institut de Biologie, 4, bvd Henri IV, 34060 Montpellier, France
    Eur J Pharmacol 486:151-61. 2004
    ..The present study suggests that sigma(1) receptor agonists, due to their enhanced efficacy in a nontransgenic animal model, may alleviate Alzheimer's disease-associated depressive symptoms...
  73. ncbi High fat and high fructose diet induced intracranial atherosclerosis and enhanced vasoconstrictor responses in non-human primate
    Masakazu Suzuki
    HAMRI Co, Ltd, 2638 2 Ozaki, Koga City, Ibaraki, Japan 306 0101
    Life Sci 80:200-4. 2006
    ....
  74. ncbi Discriminative-stimulus effects of methamphetamine and morphine in rats are attenuated by cAMP-related compounds
    Yijin Yan
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan
    Behav Brain Res 173:39-46. 2006
    ..These findings suggest that the cAMP signaling cascade may play a key role in the discriminative-stimulus effects of METH and morphine and may be a potential target for the development of therapeutics to counter drugs of abuse...
  75. ncbi Relapse of methamphetamine-seeking behavior in C57BL/6J mice demonstrated by a reinstatement procedure involving intravenous self-administration
    Yijin Yan
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Showa-ku, Nagoya 466-8560, Japan
    Behav Brain Res 168:137-43. 2006
    ..These results suggest that the mouse model of relapse in our study might provide a new stage for the exploration of genetic factors involved in relapse of drug dependence and of the underlying mechanisms of drugs of abuse...
  76. ncbi Effects of single and repeated administration of methamphetamine or morphine on neuroglycan C gene expression in the rat brain
    Kazuhiro Ishikawa
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, 65 Tsuruma-cho, Showa-ku, Nagoya 466-8560, Japan
    Int J Neuropsychopharmacol 9:407-15. 2006
    ..These results suggest that the sensitization to MAP is associated with up-regulation of NGC gene expression, while the tolerance to the morphine-induced analgesic effect is associated with the down-regulation of NGC gene expression...
  77. ncbi Fos expression associated with the discriminative stimulus effects of methamphetamine in rats
    Nan Zeng
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya 466-8560, Japan
    Ann N Y Acad Sci 1025:236-41. 2004
    ..These results suggest that the VTA and the NAc play an important role in the discriminative stimulus effects of methamphetamine...
  78. ncbi Anatomical substrates for the discriminative stimulus effects of methamphetamine in rats
    Akira Nakajima
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Neurochem 91:308-17. 2004
    ..The present findings suggest a role for the VTA and NAc as possible neuronal substrates in the discriminative stimulus effects of methamphetamine...
  79. ncbi Production and functions of IL-17 in microglia
    Jun Kawanokuchi
    Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Furo cho, Chikusaku, Nagoya 464 8601, Japan
    J Neuroimmunol 194:54-61. 2008
    ..Because microglia produce IL-1beta and IL-23, these cytokines may act in an autocrine manner to induce IL-17 expression in microglia, and thereby contribute to autoimmune diseases, such as MS, in the central nervous system...
  80. ncbi Beta-amyloid (1-42)-induced learning and memory deficits in mice: involvement of oxidative burdens in the hippocampus and cerebral cortex
    Jin Hyeong Jhoo
    Department of Psychiatry, Pundang Jesaeng Hospital, Daejin Medical Center, Seongnam, South Korea
    Behav Brain Res 155:185-96. 2004
    ..Therefore, our results suggest that the oxidative stress contributes to the Abeta (1-42)-induced learning and memory deficits in mice...
  81. ncbi Regulations of methamphetamine reward by extracellular signal-regulated kinase 1/2/ets-like gene-1 signaling pathway via the activation of dopamine receptors
    Hiroyuki Mizoguchi
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Japan
    Mol Pharmacol 65:1293-301. 2004
    ..These results suggest the importance of the ERK1/2 signaling pathway through activation of dopamine D1 and D2 receptors in the expression of CPP induced by MAP...
  82. ncbi Exposure to extremely low frequency magnetic fields enhances locomotor activity via activation of dopamine D1-like receptors in mice
    Eun Joo Shin
    Neuropsychopharmacology and Toxicology Program, College of Pharmacy, Kangwon National University, Chunchon, Korea
    J Pharmacol Sci 105:367-71. 2007
    ..Thus, our results suggest that ELF-MF-induced behavioral responses are, at least in part, mediated by activation of dopamine D(1)-like receptors...