Richard W Wong
Affiliation: Kanazawa University
Wong R. An update on cohesin function as a 'molecular glue' on chromosomes and spindles. Cell Cycle. 2010;9:1754-8 pubmed
Wong R, Mamede J, Hope T. Impact of Nucleoporin-Mediated Chromatin Localization and Nuclear Architecture on HIV Integration Site Selection. J Virol. 2015;89:9702-5 pubmed publisher
Lim K, Mohamed M, Wang H, Hartono -, Hazawa M, Kobayashi A, et al
. Direct visualization of avian influenza H5N1 hemagglutinin precursor and its conformational change by high-speed atomic force microscopy. Biochim Biophys Acta Gen Subj. 2019;: pubmed publisher
..Understanding this acidic behavior is imperative for designing therapeutic strategies against H5N1. This article reports a sophisticated new tool for studying the spatiotemporal dynamics of the HA precursor protein. ..
Lim K, Wong R. Targeting Nucleoporin POM121-Importin ? Axis in Prostate Cancer. Cell Chem Biol. 2018;25:1056-1058 pubmed publisher
..Treatment with Importazole, an importin ? inhibitor, impeded tumor aggressiveness, presenting a potential therapeutic strategy. ..
Wong R. Nuclear Pore Complex: From Structural View to Chemical Tools. Chem Biol. 2015;22:1285-7 pubmed publisher
..Here, I highlight several recent findings on NPC architectures, and briefly discuss how chemical biologists might use this information to design synthetic devices and improve strategies for nuclear drug delivery. ..
Wong R, D Angelo M. Linking Nucleoporins, Mitosis, and Colon Cancer. Cell Chem Biol. 2016;23:537-539 pubmed publisher
..Treatment with vinorelbine, a microtubule-depolymerizing drug that inhibits mitosis, might be a potential treatment for these CCs. ..
Wong R, Blobel G. Cohesin subunit SMC1 associates with mitotic microtubules at the spindle pole. Proc Natl Acad Sci U S A. 2008;105:15441-5 pubmed publisher
..Imbalances in these assembly pathways caused formation of multipolar spindles. Our data suggest that cohesin's known bundling function for chromatids in mitotic and interphase cells extends to microtubules at the spindle pole. ..