Taizo Wada

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. doi request reprint Sustained elevation of serum interleukin-18 and its association with hemophagocytic lymphohistiocytosis in XIAP deficiency
    Taizo Wada
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan Electronic address
    Cytokine 65:74-8. 2014
  2. ncbi request reprint Down-regulation of CD5 expression on activated CD8+ T cells in familial hemophagocytic lymphohistiocytosis with perforin gene mutations
    Taizo Wada
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan Electronic address
    Hum Immunol 74:1579-85. 2013
  3. doi request reprint Cytokine profiles in children with primary Epstein-Barr virus infection
    Taizo Wada
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    Pediatr Blood Cancer 60:E46-8. 2013
  4. doi request reprint Rapid detection of intracellular p47phox and p67phox by flow cytometry; useful screening tests for chronic granulomatous disease
    Taizo Wada
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13 1 Takaramachi, Kanazawa, 920 8641, Japan
    J Clin Immunol 33:857-64. 2013
  5. doi request reprint Clonal expansion of Epstein-Barr virus (EBV)-infected γδ T cells in patients with chronic active EBV disease and hydroa vacciniforme-like eruptions
    Taizo Wada
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    Int J Hematol 96:443-9. 2012
  6. doi request reprint A case of acute encephalopathy with hemophagocytic lymphohistiocytosis and clonal T-cell expansion
    Taizo Wada
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    Brain Dev 34:376-9. 2012
  7. doi request reprint Flow cytometric analysis of skin blister fluid induced by mosquito bites in a patient with chronic active Epstein-Barr virus infection
    Taizo Wada
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920 8641, Japan
    Int J Hematol 90:611-5. 2009
  8. ncbi request reprint [Monitoring of Epstein-Barr virus-infected cells by flow cytometer permits early diagnosis and evaluation of disease progression in EBV-associated hemophagocytic lymphohistiocytosis]
    Masaki Fukuda
    Department of Pediatrics, Kanazawa University
    Rinsho Ketsueki 53:337-41. 2012
  9. doi request reprint Successful bone marrow transplantation with reduced intensity conditioning in a patient with delayed-onset adenosine deaminase deficiency
    Hirokazu Kanegane
    Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Pediatr Transplant 17:E29-32. 2013
  10. ncbi request reprint Skin infiltration of CD56(bright) CD16(-) natural killer cells in a case of X-SCID with Omenn syndrome-like manifestations
    Fumie Shibata
    Department of Pediatrics, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Eur J Haematol 79:81-5. 2007

Collaborators

Detail Information

Publications30

  1. doi request reprint Sustained elevation of serum interleukin-18 and its association with hemophagocytic lymphohistiocytosis in XIAP deficiency
    Taizo Wada
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan Electronic address
    Cytokine 65:74-8. 2014
    ..These findings may suggest the association between HLH susceptibility and high serum IL-18 levels in XIAP deficiency. ..
  2. ncbi request reprint Down-regulation of CD5 expression on activated CD8+ T cells in familial hemophagocytic lymphohistiocytosis with perforin gene mutations
    Taizo Wada
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan Electronic address
    Hum Immunol 74:1579-85. 2013
    ..These findings suggest that down-regulation of CD5 on activated CD8(+) T cells may serve as a useful marker of dysregulated T cell activation and proliferation in FHL2. ..
  3. doi request reprint Cytokine profiles in children with primary Epstein-Barr virus infection
    Taizo Wada
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    Pediatr Blood Cancer 60:E46-8. 2013
    ..TNF-α levels were elevated in both diseases. Elevation of those mediators may contribute to the disease pathogenesis of EBV-HLH by activating and inhibiting host immune responses...
  4. doi request reprint Rapid detection of intracellular p47phox and p67phox by flow cytometry; useful screening tests for chronic granulomatous disease
    Taizo Wada
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13 1 Takaramachi, Kanazawa, 920 8641, Japan
    J Clin Immunol 33:857-64. 2013
    ..These techniques will be useful to rapidly assess the expression of the cytosolic components, p47phox and p67phox, and represents important secondary screening tests for CGD...
  5. doi request reprint Clonal expansion of Epstein-Barr virus (EBV)-infected γδ T cells in patients with chronic active EBV disease and hydroa vacciniforme-like eruptions
    Taizo Wada
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    Int J Hematol 96:443-9. 2012
    ..These results suggest the pathogenic roles of clonally expanded γδ T cells infected by EBV in patients with CAEBV and HV-like eruptions...
  6. doi request reprint A case of acute encephalopathy with hemophagocytic lymphohistiocytosis and clonal T-cell expansion
    Taizo Wada
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    Brain Dev 34:376-9. 2012
    ..Our findings suggest that his acute encephalopathy was likely a clinical manifestation of HLH, and that immunophenotypic analysis may be helpful for early recognition of HLH in such rare encephalopathy...
  7. doi request reprint Flow cytometric analysis of skin blister fluid induced by mosquito bites in a patient with chronic active Epstein-Barr virus infection
    Taizo Wada
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, 920 8641, Japan
    Int J Hematol 90:611-5. 2009
    ..These results suggest that CD203c(+) cells as well as NK cells may play pathogenic roles in the severe skin reactions to mosquito bites in NK-CAEBV...
  8. ncbi request reprint [Monitoring of Epstein-Barr virus-infected cells by flow cytometer permits early diagnosis and evaluation of disease progression in EBV-associated hemophagocytic lymphohistiocytosis]
    Masaki Fukuda
    Department of Pediatrics, Kanazawa University
    Rinsho Ketsueki 53:337-41. 2012
    ..Easy monitoring of EBV-infected cells by using flow cytometry over time may provide useful information to choose an appropriate treatment for each individual patient with EBV-HLH...
  9. doi request reprint Successful bone marrow transplantation with reduced intensity conditioning in a patient with delayed-onset adenosine deaminase deficiency
    Hirokazu Kanegane
    Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, Toyama, Japan
    Pediatr Transplant 17:E29-32. 2013
    ..These results suggest that BMT with RIC may sufficiently restore immune regulation in delayed-onset ADA deficiency. A longer follow-up period is needed to confirm these observations...
  10. ncbi request reprint Skin infiltration of CD56(bright) CD16(-) natural killer cells in a case of X-SCID with Omenn syndrome-like manifestations
    Fumie Shibata
    Department of Pediatrics, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Eur J Haematol 79:81-5. 2007
    ..This may be the first human case to demonstrate that close cell-to-cell contact between DC and NK cells provides an effective alternative pathway for NK cell differentiation/activation in vivo...
  11. doi request reprint Clinical significance of cloned expansion and CD5 down-regulation in Epstein-Barr Virus (EBV)-infected CD8+ T lymphocytes in EBV-associated hemophagocytic lymphohistiocytosis
    Akiko Toga
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    J Infect Dis 201:1923-32. 2010
    ..All together, our findings reveal the immunophenotypic characteristics of EBV-infected CD8(+) T cells and may provide a valuable tool for the diagnosis of EBV-HLH...
  12. doi request reprint Urinary heme oxygenase-1 as a sensitive indicator of tubulointerstitial inflammatory damage in various renal diseases
    Tadafumi Yokoyama
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    Am J Nephrol 33:414-20. 2011
    ..We examined urinary HO-1 (uHO-1) levels to assess whether uHO-1 acts as a sensitive biomarker for detecting tubulointerstitial inflammatory damage in renal diseases...
  13. doi request reprint Clinical and immunophenotypic features of atypical complete DiGeorge syndrome
    Quang Van Vu
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    Pediatr Int 55:2-6. 2013
    ..This rare condition is known as atypical complete DiGeorge syndrome, resembles Omenn syndrome, and has not been fully characterized...
  14. doi request reprint Agranulocytosis after infectious mononucleosis
    Tadafumi Yokoyama
    Department of Pediatrics, Fukuiken Saiseikai Hospital, Wadanaka machi, 7 1 Funahashi, Fukui, Fukui 918 8503, Japan
    J Clin Virol 56:271-3. 2013
    ..A literature review on agranulocytosis after IM and our case suggest that anti-HNA-1 antibodies play important roles in agranulocytosis associated with IM...
  15. ncbi request reprint Immunophenotypic analysis of Epstein-Barr virus (EBV)-infected CD8(+) T cells in a patient with EBV-associated hemophagocytic lymphohistiocytosis
    Taizo Wada
    Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Eur J Haematol 79:72-5. 2007
    ..These findings suggest that lacking expression of CD5 on CD8(+) T cells with specific TCR VB may serve as a useful marker of dysregulated T-cell activation and proliferation in EBV-HLH...
  16. doi request reprint Enhanced exon 2 skipping caused by c.910G>A variant and alternative splicing of MEFV genes in two independent cases of familial Mediterranean fever
    Yumi Tone
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    Mod Rheumatol 22:45-51. 2012
    ..This is the first report to show that an MEFV variant other than missense mutation is responsible for the FMF phenotype...
  17. doi request reprint Analysis of mutations and recombination activity in RAG-deficient patients
    Erika Asai
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    Clin Immunol 138:172-7. 2011
    ..These findings suggest that functional evaluation together with molecular analysis contributes to our broader understanding of RAG deficiency...
  18. ncbi request reprint Detection of T lymphocytes with a second-site mutation in skin lesions of atypical X-linked severe combined immunodeficiency mimicking Omenn syndrome
    Taizo Wada
    Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Japan
    Blood 112:1872-5. 2008
    ..These findings suggest that the clinical spectrum of XSCID is quite broad and includes atypical cases mimicking Omenn syndrome, and highlight the importance of revertant mosaicism as a possible cause for variable phenotypic expression...
  19. doi request reprint Distinct cytokine profiles of systemic-onset juvenile idiopathic arthritis-associated macrophage activation syndrome with particular emphasis on the role of interleukin-18 in its pathogenesis
    Masaki Shimizu
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    Rheumatology (Oxford) 49:1645-53. 2010
    ....
  20. ncbi request reprint Oligoclonal expansion of T lymphocytes with multiple second-site mutations leads to Omenn syndrome in a patient with RAG1-deficient severe combined immunodeficiency
    Taizo Wada
    Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    Blood 106:2099-101. 2005
    ..These findings suggest that his revertant T-cell mosaicism is responsible for OS phenotype switched from T-B- SCID...
  21. ncbi request reprint Reactive peripheral blood plasmacytosis in a patient with acute hepatitis A
    Taizo Wada
    Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Int J Hematol 85:191-4. 2007
    ..The patient's plasma cells had almost disappeared from the blood by hospital day 16. This report may represent the first described case of reactive peripheral blood plasmacytosis in acute hepatitis A...
  22. ncbi request reprint Somatic revertant mosaicism in a patient with leukocyte adhesion deficiency type 1
    Yumi Tone
    Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Japan
    Blood 109:1182-4. 2007
    ..These findings suggest that spontaneous in vivo reversion was responsible for the somatic mosaicism in our patient...
  23. ncbi request reprint Paradoxical enhancement of oxidative cell injury by overexpression of heme oxygenase-1 in an anchorage-dependent cell ECV304
    Keiko Maruhashi
    Department of Pediatrics, Angiogenesis and Vascular Development, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    J Cell Biochem 93:552-62. 2004
    ..However, HO-1 reduces the oxidative cell injury and protects the endothelial cells, if its expression is appropriately controlled...
  24. ncbi request reprint Intermittent X-linked thrombocytopenia with a novel WAS gene mutation
    Taizo Wada
    Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    Pediatr Blood Cancer 61:746-8. 2014
    ..Our findings further support the importance of analysis of Wiskott-Aldrich syndrome protein in male patients who exhibit fluctuating courses of thrombocytopenia...
  25. doi request reprint Multiple reversions of an IL2RG mutation restore T cell function in an X-linked severe combined immunodeficiency patient
    Tomoki Kawai
    Department of Pediatrics, Kyoto University Graduate School of Medicine, 54 Kawahara cho, Shogoin, Sakyo ku, Kyoto, 606 8507, Japan
    J Clin Immunol 32:690-7. 2012
    ..This case demonstrates that multiple but restricted somatic reversions in T cell progenitors can improve the clinical phenotype of SCID-X1...
  26. doi request reprint Successful cord blood transplantation after repeated transfusions of unmobilized neutrophils in addition to antifungal treatment in an infant with chronic granulomatous disease complicated by invasive pulmonary aspergillosis
    Tomonari Shigemura
    Department of Pediatrics, Shinshu University School of Medicine, Matsumoto, Japan Division of Hematology, Oncology, and Immunology, Nagano Children s Hospital, Azumino, Japan Department of Pediatrics, School of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan Division of Transfusion Medicine, Cell Processing Center, Shinshu University Hospital Department of Infection and Host Defense, Shinshu University, Graduate School of Medicine, Matsumoto, Japan
    Transfusion 54:516-21. 2014
    ..The management of life-threatening Aspergillus infections in CGD is particularly difficult because some infections cannot be eradicated with standard antifungal treatments and, hence, result in death...
  27. pmc Characterization of Epstein-Barr virus (EBV)-infected cells in EBV-associated hemophagocytic lymphohistiocytosis in two patients with X-linked lymphoproliferative syndrome type 1 and type 2
    Xi Yang
    Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Science, University of Toyama, Toyama, Japan
    Herpesviridae 3:1. 2012
    ..abstract:..
  28. doi request reprint Delayed onset adenosine deaminase deficiency associated with acute disseminated encephalomyelitis
    Hideyuki Nakaoka
    Department of Pediatrics, Graduate School of Medicine and Pharmaceutical Sciences, University of Toyama, 2630 Sugitani, Toyama, Toyama 930 0194, Japan
    Int J Hematol 95:692-6. 2012
    ..The ADEM in this patient may be a presentation of delayed onset adenosine deaminase deficiency...
  29. doi request reprint Somatic mosaicism in primary immune deficiencies
    Taizo Wada
    Department of Pediatrics, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Curr Opin Allergy Clin Immunol 8:510-4. 2008
    ..Here we summarize the several cases that have been reported thus far with particular focus on the most recent observations...
  30. ncbi request reprint A case series of CAEBV of children and young adults treated with reduced-intensity conditioning and allogeneic bone marrow transplantation: a single-center study
    Yuko Watanabe
    Department of Pediatrics, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan
    Eur J Haematol 91:242-8. 2013
    ..Allogeneic hematopoietic stem cell transplantation (HSCT) is curative treatment for CAEBV patients. However, chemotherapy prior to HSCT and optimal conditioning regimen for allogeneic HSCT are still controversial...