H Tsuchiya

..At final follow-up all patients had returned to normal activities. Four patients required a second operation for recurrent deformity of further limb lengthening. Local recurrence occurred in one patient, requiring further surgery...

..In this study, a clinical trial was performed using an iodine-supported titanium that suppresses the microbial activities...

..Caffeine inhibited proliferation of HOS cells and suppressed NF-κB, AKT, mTOR/S6K and ERK activities. Our results support those from previous studies relating to the use of caffeine in the treatment of osteosarcoma...

..This study examined the effect of myocutaneous inflammatory changes caused by intra-arterial chemotherapy on the outcome of patients who undergo limb-saving surgery...

..No local tumour recurrence was seen at mean follow-up of 97 months. Marginal excision of the proximal fibula resulted in excellent function. Preservation of the epiphysis leads to better function than joint resection...

..The prognostic value of the time of identification of lung metastasis was investigated in 280 patients with metastatic lung osteosarcoma as a multi-institutional study of the Japanese Musculoskeletal Oncology Group...

..3 months while seven patients remained free of disease with a mean follow-up of 55.4 months. Joint preservation and biological reconstruction through distraction osteogenesis can produce excellent and long-lasting functional results...

..Only one patient developed osteomyelitis which required further surgery...

..All were managed successfully. Our results suggest that this is a simple and effective method of biological reconstruction...

..Type V: Tumor extends to half or less of the epiphysis. Type VI: Extension of the tumor to more than half of the epiphysis...

..8 months. Treatment of juxta-articular osteosarcomas around the knee with joint preservation and biological reconstruction using distraction osteogenesis can give excellent functional results...

..The "total en bloc spondylectomy" offers one of the most aggressive modes of therapy for primary spinal malignancy...

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..Our results suggest that the treatment of malignant bone tumours by reconstruction using autografts containing tumours which have been treated by liquid nitrogen may be of clinical value...

..It is more important to achieve accurate alignment than resection of the lesion. The Ilizarov technique is effective for treating the Shepherd's crook deformity in patients with fibrous dysplasia...

..We conclude that scaffold and proteins are essential for successful bone transport, and that bone substitute can be used to regenerate bone...

..Also, multiple and epiphyseal simple bone cysts have a better prognosis than the classic metaphyseal ones. Four clinicoanatomic varieties of simple bone cysts are recognized; classic metaphyseal, nontubular, epiphyseal, and multiple...

..Distraction osteogenesis in patients with CSNA may lead to good results if rigid fixation, nonweight-bearing (i.e., adequate rest), and appropriate biological stimulation can be employed...

..These findings suggest that Ti-I(2) has antimicrobial activity and exhibits cytocompatibility. Therefore, Ti-I(2) substantially reduces the incidence of implant infection and shows particular promise as a biomaterial...

..The external fixator was removed at 10 weeks. Six years and 10 months after surgery, the patient had a kyphosis of 19 degrees that did not affect his activities of daily living...

..Furthermore, the present electron microscopic and immunohistochemical findings suggest that tubulin is a constituent of the unusual structures...

..However, the Tl scintigraphy can be used for excluding GCT when no lesional Tl uptake is observed, and diagnosing recurrent lesions on post-operative follow-up...

..Imaging with fluorescent proteins will reveal mechanisms of cancer progression and provide visual targets for novel therapeutics...

..809, p = 0.35). 99mTc-MIBI imaging performed in the middle of chemotherapy well predicts the final tumor response to chemotherapy in patients with malignant bone and soft tissue tumors...

..The objective of this study was to investigate the route of vertical extension of metastatic vertebral tumors...

..We report results of caffeine-potentiated chemotherapy for patients with osteosarcoma with pulmonary metastases...

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..99m)Tc-macroaggregated albumin (MAA) imaging with intra-arterial tracer administration was performed to evaluate drug distribution, and the ability of (99m)Tc-MAA imaging to predict local side effects was assessed...

..Also, low-dose consecutive CDDP administrations may contribute to the attenuation of the adverse drug reactions expected by patients with bone and soft tissue tumors who are undergoing chemotherapy...

..8%, respectively. These findings show that tumor recurrence is less likely after intralesional tumor cutting with a T-saw than after such cutting with a Gigli saw or scalpel...

..In spite of the serious structural and neurologic damage caused, total sacrectomy can be rewarding procedure in terms of improved morbidity and mortality...

..This might be one of the reasons for the discrepancy in compression strength...

..To determine the clinical outcomes in patients with pelvic osteosarcoma, we reviewed the experience with 54 pelvic osteosarcoma patients...

..We report this newly modified technique using pedicle frozen autografts to save the continuity of anatomical structures...

..The data also further demonstrated the power of color-coded imaging to visualize cancer-cell/cancer-cell interactions in vivo...

..The present results indicate that telomerase activation is not prevalent in mesenchymal tumors and is not a critical determinant of telomere length, but it may be a prognostic indicator of mesenchymal tumors...

..This technique seems to be a promising option for the treatment of simple bone cysts. The cannulated hydroxyapatite pin is recommended because of its higher success rate and the fact that it does not need to be removed...

..The patient underwent excision of the presacral mass. Histologic examination of the resected specimen revealed features of an epidermoid cyst...

..Results of salvage laminoplasty were not satisfactory. Unnecessarily extended longer fusion must be avoided...

..She underwent osteotomy and lengthening of the normal contralateral tibia using a Taylor spatial frame. Hip arthroplasty could be avoided as osteoarthritic changes of the hip joint had improved...

..02). Deep soft tissue haemangiomas revealed Tl accumulation in early images; however, a rapid washout was observed in delayed images. This distinctive feature may facilitate the use of Tl scintigraphy in the diagnosis of haemangiomas...

..5+/-3.5 degrees). We considered that biopsies should be performed with an anterolateral approach in the safe area formed by the fibular head and the deep peroneal nerve in the anterior compartment...

..Distraction osteogenesis avoids some complications but may involve others, which require detection and appropriate management...

..However, there is little in vivo evidence for this treatment, and thus we sought to verify the dose and effect of caffeine in combination with cisplatin in osteosarcoma-bearing rats...

..To determine if frozen autografts exhibit early bone remodeling, we investigated the repair processes of the frozen bones...

..The present study focused on monitoring and adjusting serum caffeine levels during caffeine-potentiated chemotherapy to reduce adverse effects...

..Its prognostic correlation, however, has hardly been validated...

..Therefore, bone transport using frozen devitalized bone can regenerate living bone. This experimental model represents the development of a new reconstruction technique of bone transport with devitalized bone...

..CONCLUSION: Caffeine-potentiated chemotherapy may be of benefit for malignant tumors other than musculoskeletal sarcoma...

..Caffeine enhances the cytocidal effects of DNA-damaging agents. This study investigated genes involved in the synergistic effect of caffeine on osteosarcoma cells using gene-profiling analysis...

..In this study, we examined whether 3-phase bone scintigraphy can predict the outcome of distraction osteogenesis. We also investigated the effects of chemotherapy and surgical treatment on distraction osteogenesis...

..Joint preservation and reconstruction by means of distraction osteogenesis is the most conservative limb-saving surgery available at present. Furthermore, distraction osteogenesis can provide natural limb regeneration...

..Caffeine has been identified as belonging to the group of xanthines that enhances the action of cisplatin...

..For patients with osteosarcoma of the proximal fibula, this approach provides a better quality of life than conventional wide excision...

..Postoperatively, the pain resolved immediately. At the 9-year follow-up, the alignment of the lumbar spine and healing of L5 was good, with no features of aseptic necrosis...

..Pathological and immunohistochemical studies are important in making the correct diagnosis...

..Further, melatonin deficiency might explain precocious puberty in cases of McCune-Albright syndrome. We might hypothesize that melatonin deficiency might play a role in development of fibrous dysplasia in some cases...

..These results suggest the LIPUS effect is mediated via endochondral pathways. We concluded that LIPUS stimulates bone formation in distraction osteogenesis and is most effective during the lengthening phase...

..The present study was performed to assess the efficacy of caffeine-potentiated chemotherapy for high-grade soft tissue sarcoma (STS)...

..0001), and that STS cases with high plakoglobin gene expression had an excellent prognosis. These results suggest that plakoglobin gene expression level might be useful as a new biomarker for metastasis and prognosis of human STS...

..External fixation can correct not only the mechanical axis and joint inclination but also leg-length discrepancy simultaneously...

..The Ilizarov method may be practically applied for ankle arthrodesis, especially in complicated cases. The EFI and external fixation time tended to increase for patients with a length gain of 3 cm or less...

..We should be careful when applying autoclaved bone for weight-bearing parts...

..The purpose of this study was to evaluate the effectiveness and safety of an occlusive dressing treatment method for soft tissue defects following soft tissue tumor excisions...

..0 cm. When comparing the maturation and external fixation indices between different patients or studies, the length of the distraction must be taken into consideration...

..We now prefer marginal excision of the lesion to avoid long-term failures, as in our first case. Distraction osteogenesis has proven useful for restoring structure and function in the affected limb...

..CONCLUSION: Despite the length of postoperative external fixation, distraction osteogenesis can be a valuable alternative for the treatment of juxta-articular nonunions...

..CONCLUSIONS: Preoperative irradiation interferes with distraction osteogenesis by inducing a state of poor angiogenesis...

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..The aims of this study were to investigate the anti-tumor effects of consecutive low-dose cisplatin (LD-CDDP) in comparison with single high-dose CDDP (HD-CDDP) in combination with caffeine...

..Few studies have described the characteristics and prognostic factors of osteosarcoma patients aged over 60 years...

..We performed intralesional curettage with phenol and ethanol adjuvant therapy for pelvic giant cell tumor without tumor recurrence, and good repair of a hip joint adaptation can be achieved even in an adult patient...

..We finally diagnosed the patient with adamantinoma. In this report we describe the characteristics of this tumor and discuss the reasoning concerning the differential diagnosis and therapeutic plan...

..Radical resection and reconstruction are used for the patients with long life expectancy, though palliative surgery is for the patients with short life expectancy...

..These observations may provide some insight into the mechanisms of disease progression and the origin of GCTs...

..Four years after the initial diagnosis, no local relapse and no distant metastases have been observed. Therefore, it is concluded that caffeine-assisted chemotherapy should be one of the treatment options for DSRCT...

..Furthermore, this combined procedure decreases the external fixation time and is associated with fewer complications...

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..We also reported systemic antitumor immunity was enhanced by cryotreatment in a murine osteosarcoma (LM8) model. We therefore combined the cryotreatment of tumor with dendritic cells to promote tumor-specific immune responses...

..Gradual correction may represent a better approach than acute correction with the use of external fixators to treat deformity combined with shortening...

..However, the order of the corrections should be considered carefully depending on each patient...

..The objectives of the current study were to assess the clinical outcome and prognostic factors of patients with ESFT of bone in Japan and to compare them between Euro-American and Japanese populations...

..This extremely rare lesion is believed to be a desmoplastic fibroma transformed to osteosarcoma...

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..Our technique of minimal curettage, drilling and continuous decompression with a cannulated screw insertion is considered to be a good option for management of simple bone cysts of the calcaneus...

..The simple fluorescence method of determining clonality of metastases described here can allow large-scale clonal analysis in numerous types of metastatic models...

..However, particular care is needed during correction to avoid complications such as anterior subluxation of the talus and joint space narrowing. When complications do occur, intervention should be immediate...

..It is concluded that individual monitoring with this method for the purpose of dose adjustment is useful for avoiding the side effects of caffeine-assisted chemotherapy...

..The dual-color cells thus are a useful tool for visualizing living-cell dynamics in vivo as well as in vitro. Drugs that could specifically perturb these processes can now be readily screened in real time in vivo...

..CONCLUSIONS: Accurate limb alignment was obtained for all cases. A focal dome osteotomy by maximizing the area of bony contact was more effective than a transverse osteotomy for acute deformity correction...

..Fluorescence color coding of cancer cells enables visualization of the interaction of cancer cells and can be used to distinguish cancer cells of any genotype or phenotype...

..The objective of this study was to determine the clinical features, prognostic factors, and optimal treatment policy for patients with this rare disease...

..We demonstrate in this report, using powerful color-coded fluorescent imageable tumor-host models, the onset of angiogenesis of these sarcomas and its inhibition...