H Tsuchiya

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. ncbi request reprint Treatment of benign bone tumours using external fixation
    H Tsuchiya
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Japan
    J Bone Joint Surg Br 89:1077-83. 2007
  2. pmc Contralateral anterior cruciate ligament injury after anterior cruciate ligament reconstruction: a case controlled study
    Junsuke Nakase
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    Sports Med Arthrosc Rehabil Ther Technol 4:46. 2012
  3. pmc Innovative antimicrobial coating of titanium implants with iodine
    Hiroyuki Tsuchiya
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    J Orthop Sci 17:595-604. 2012
  4. ncbi request reprint Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-κB and MAPK pathways
    Shinji Miwa
    Department of Orthopedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Anticancer Res 32:3643-9. 2012
  5. ncbi request reprint Reconstruction using an autograft containing tumour treated by liquid nitrogen
    H Tsuchiya
    Kanazawa University, Kanazawa, Japan
    J Bone Joint Surg Br 87:218-25. 2005
  6. ncbi request reprint Effect of timing of pulmonary metastases identification on prognosis of patients with osteosarcoma: the Japanese Musculoskeletal Oncology Group study
    Hiroyuki Tsuchiya
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Clin Oncol 20:3470-7. 2002
  7. ncbi request reprint Effect of myocutaneous inflammatory changes caused by intra-arterial chemotherapy on the outcome of patients who undergo limb-saving surgery
    H Tsuchiya
    Department of Orthopedic Surgery, School of Medicine, Kanazawa University, Kanazawa, Japan
    Cancer 91:2447-53. 2001
  8. ncbi request reprint The natural limb is best: joint preservation and reconstruction by distraction osteogenesis for high-grade juxta-articular osteosarcomas
    Hiroyuki Tsuchiya
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Japan
    Anticancer Res 22:2373-6. 2002
  9. doi request reprint Safety of external fixation during postoperative chemotherapy
    H Tsuchiya
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa shi, Ishikawa Ken, 920 8641, Japan
    J Bone Joint Surg Br 90:924-8. 2008
  10. ncbi request reprint Biological reconstruction after excision of juxta-articular osteosarcoma around the knee: a new classification system
    Hiroyuki Tsuchiya
    Department of Orthopedic Surgery, Graduate School of Medical Science, Kanazawa University, Japan
    Anticancer Res 26:447-53. 2006

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. ncbi request reprint Treatment of benign bone tumours using external fixation
    H Tsuchiya
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Japan
    J Bone Joint Surg Br 89:1077-83. 2007
    ..At final follow-up all patients had returned to normal activities. Four patients required a second operation for recurrent deformity of further limb lengthening. Local recurrence occurred in one patient, requiring further surgery...
  2. pmc Contralateral anterior cruciate ligament injury after anterior cruciate ligament reconstruction: a case controlled study
    Junsuke Nakase
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    Sports Med Arthrosc Rehabil Ther Technol 4:46. 2012
    ..abstract:..
  3. pmc Innovative antimicrobial coating of titanium implants with iodine
    Hiroyuki Tsuchiya
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    J Orthop Sci 17:595-604. 2012
    ..In this study, a clinical trial was performed using an iodine-supported titanium that suppresses the microbial activities...
  4. ncbi request reprint Caffeine induces apoptosis of osteosarcoma cells by inhibiting AKT/mTOR/S6K, NF-κB and MAPK pathways
    Shinji Miwa
    Department of Orthopedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Anticancer Res 32:3643-9. 2012
    ..Caffeine inhibited proliferation of HOS cells and suppressed NF-κB, AKT, mTOR/S6K and ERK activities. Our results support those from previous studies relating to the use of caffeine in the treatment of osteosarcoma...
  5. ncbi request reprint Reconstruction using an autograft containing tumour treated by liquid nitrogen
    H Tsuchiya
    Kanazawa University, Kanazawa, Japan
    J Bone Joint Surg Br 87:218-25. 2005
    ..All were managed successfully. Our results suggest that this is a simple and effective method of biological reconstruction...
  6. ncbi request reprint Effect of timing of pulmonary metastases identification on prognosis of patients with osteosarcoma: the Japanese Musculoskeletal Oncology Group study
    Hiroyuki Tsuchiya
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Clin Oncol 20:3470-7. 2002
    ..The prognostic value of the time of identification of lung metastasis was investigated in 280 patients with metastatic lung osteosarcoma as a multi-institutional study of the Japanese Musculoskeletal Oncology Group...
  7. ncbi request reprint Effect of myocutaneous inflammatory changes caused by intra-arterial chemotherapy on the outcome of patients who undergo limb-saving surgery
    H Tsuchiya
    Department of Orthopedic Surgery, School of Medicine, Kanazawa University, Kanazawa, Japan
    Cancer 91:2447-53. 2001
    ..This study examined the effect of myocutaneous inflammatory changes caused by intra-arterial chemotherapy on the outcome of patients who undergo limb-saving surgery...
  8. ncbi request reprint The natural limb is best: joint preservation and reconstruction by distraction osteogenesis for high-grade juxta-articular osteosarcomas
    Hiroyuki Tsuchiya
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Japan
    Anticancer Res 22:2373-6. 2002
    ..3 months while seven patients remained free of disease with a mean follow-up of 55.4 months. Joint preservation and biological reconstruction through distraction osteogenesis can produce excellent and long-lasting functional results...
  9. doi request reprint Safety of external fixation during postoperative chemotherapy
    H Tsuchiya
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa shi, Ishikawa Ken, 920 8641, Japan
    J Bone Joint Surg Br 90:924-8. 2008
    ..Only one patient developed osteomyelitis which required further surgery...
  10. ncbi request reprint Biological reconstruction after excision of juxta-articular osteosarcoma around the knee: a new classification system
    Hiroyuki Tsuchiya
    Department of Orthopedic Surgery, Graduate School of Medical Science, Kanazawa University, Japan
    Anticancer Res 26:447-53. 2006
    ..Type V: Tumor extends to half or less of the epiphysis. Type VI: Extension of the tumor to more than half of the epiphysis...
  11. pmc Functional outcome in patients with osteosarcoma around the knee joint treated by minimised surgery
    K Hayashi
    Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Int Orthop 32:63-8. 2008
    ..No local tumour recurrence was seen at mean follow-up of 97 months. Marginal excision of the proximal fibula resulted in excellent function. Preservation of the epiphysis leads to better function than joint resection...
  12. ncbi request reprint Osteosarcoma around the knee. Intraepiphyseal excision and biological reconstruction with distraction osteogenesis
    H Tsuchiya
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Japan
    J Bone Joint Surg Br 84:1162-6. 2002
    ..8 months. Treatment of juxta-articular osteosarcomas around the knee with joint preservation and biological reconstruction using distraction osteogenesis can give excellent functional results...
  13. doi request reprint Influence of freezing with liquid nitrogen on whole-knee joint grafts and protection of cartilage from cryoinjury in rabbits
    M Hayashi
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Takara machi, Kanazawa, Japan
    Cryobiology 59:28-35. 2009
    ....
  14. ncbi request reprint Ilizarov technique for correction of the Shepherd's crook deformity: a report of two cases
    K Sakurakichi
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Kanazawa, Japan
    J Orthop Surg (Hong Kong) 16:254-6. 2008
    ..It is more important to achieve accurate alignment than resection of the lesion. The Ilizarov technique is effective for treating the Shepherd's crook deformity in patients with fibrous dysplasia...
  15. ncbi request reprint Bone transport using hydroxyapatite loaded with bone morphogenetic protein in rabbits
    K Watanabe
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa, Japan
    J Bone Joint Surg Br 89:1122-9. 2007
    ..We conclude that scaffold and proteins are essential for successful bone transport, and that bone substitute can be used to regenerate bone...
  16. doi request reprint Re-implantation of tumour tissue treated by cryotreatment with liquid nitrogen induces anti-tumour activity against murine osteosarcoma
    H Nishida
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    J Bone Joint Surg Br 90:1249-55. 2008
    ..Our results suggest that the treatment of malignant bone tumours by reconstruction using autografts containing tumours which have been treated by liquid nitrogen may be of clinical value...
  17. ncbi request reprint Total en bloc spondylectomy. A new surgical technique for primary malignant vertebral tumors
    K Tomita
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Japan
    Spine (Phila Pa 1976) 22:324-33. 1997
    ..The "total en bloc spondylectomy" offers one of the most aggressive modes of therapy for primary spinal malignancy...
  18. ncbi request reprint Ankle arthrodesis and tibial lengthening for congenital sensory neuropathy with anhidrosis
    K Uehara
    Department of Orthopaedic Surgery, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8641, Japan
    J Orthop Sci 6:430-4. 2001
    ..Distraction osteogenesis in patients with CSNA may lead to good results if rigid fixation, nonweight-bearing (i.e., adequate rest), and appropriate biological stimulation can be employed...
  19. ncbi request reprint Bilateral symmetrical cysts in the upper tibiae in a skeletally mature patient: might they be simple bone cysts?
    M E Abdel-Wanis
    Orthopaedic Department, Faculty of Medicine, Kanazawa University, Ishikawa, Japan
    J Orthop Sci 6:595-600. 2001
    ..Also, multiple and epiphyseal simple bone cysts have a better prognosis than the classic metaphyseal ones. Four clinicoanatomic varieties of simple bone cysts are recognized; classic metaphyseal, nontubular, epiphyseal, and multiple...
  20. doi request reprint Antibacterial iodine-supported titanium implants
    T Shirai
    Department of Orthopaedic Surgery, Kanazawa University, Takaramachi, Kanazawa, Japan
    Acta Biomater 7:1928-33. 2011
    ..These findings suggest that Ti-I(2) has antimicrobial activity and exhibits cytocompatibility. Therefore, Ti-I(2) substantially reduces the incidence of implant infection and shows particular promise as a biomaterial...
  21. ncbi request reprint Microtubular aggregates in the rough endoplasmic reticulum of sacrococcygeal chordoma
    Y Ueda
    Department of Pathology, School of Medicine, Kanazawa University, Ishikawa, Japan
    Ultrastruct Pathol 15:77-82. 1991
    ..Furthermore, the present electron microscopic and immunohistochemical findings suggest that tubulin is a constituent of the unusual structures...
  22. ncbi request reprint Ilizarov external fixator for burst fracture of the lumbar spine: a case report
    H Matsubara
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Kanazawa, Japan
    J Orthop Surg (Hong Kong) 15:380-3. 2007
    ..The external fixator was removed at 10 weeks. Six years and 10 months after surgery, the patient had a kyphosis of 19 degrees that did not affect his activities of daily living...
  23. ncbi request reprint Intense 201 Tl uptake in giant-cell tumour of bone
    T Higuchi
    Department of Nuclear Medicine, Kanazawa University School of Medicine, Japan
    Nucl Med Commun 23:595-9. 2002
    ..However, the Tl scintigraphy can be used for excluding GCT when no lesional Tl uptake is observed, and diagnosing recurrent lesions on post-operative follow-up...
  24. doi request reprint Tumor imaging with multicolor fluorescent protein expression
    Norio Yamamoto
    Department of Orthopedic Surgery, Graduate School of Medical Sciences, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Int J Clin Oncol 16:84-91. 2011
    ..Imaging with fluorescent proteins will reveal mechanisms of cancer progression and provide visual targets for novel therapeutics...
  25. doi request reprint Early prediction of histopathological tumor response to preoperative chemotherapy by Tc-99m MIBI imaging in bone and soft tissue sarcomas
    Junichi Taki
    Department of Nuclear Medicine, Kanazawa University Hospital, 13 1 Takara machi, Kanazawa, Japan
    Clin Nucl Med 35:154-9. 2010
    ....
  26. ncbi request reprint Histological examination of autoclaved bone removed 12 years after it was transplanted
    Katsuhiro Hayashi
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Japan
    J Orthop Sci 10:425-9. 2005
  27. doi request reprint The route of metastatic vertebral tumors extending to the adjacent vertebral body: a histological study
    Takeshi Sasagawa
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa, 920 8641, Japan
    J Orthop Sci 16:203-11. 2011
    ..The objective of this study was to investigate the route of vertical extension of metastatic vertebral tumors...
  28. doi request reprint Caffeine-potentiated chemotherapy for metastatic osteosarcoma
    Hiroaki Kimura
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan
    J Orthop Sci 14:556-65. 2009
    ..We report results of caffeine-potentiated chemotherapy for patients with osteosarcoma with pulmonary metastases...
  29. ncbi request reprint Prediction of final tumor response to preoperative chemotherapy by Tc-99m MIBI imaging at the middle of chemotherapy in malignant bone and soft tissue tumors: comparison with Tl-201 imaging
    Junichi Taki
    Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences, 13 1 Takara machi, Kanazawa, 920 8640, Japan
    J Orthop Res 26:411-8. 2008
    ..809, p = 0.35). 99mTc-MIBI imaging performed in the middle of chemotherapy well predicts the final tumor response to chemotherapy in patients with malignant bone and soft tissue tumors...
  30. ncbi request reprint Inhibitory effects on pulmonary metastases of low-dose consecutive administration of cisplatin on sarcoma-bearing mice
    Akira Takeda
    Department of Orthopedic Surgery, Fukushima Medical University, School of Medicine, 1 Hikarigaoka, Fukushima, 960 1295, Japan
    Anticancer Res 23:309-13. 2003
    ..Also, low-dose consecutive CDDP administrations may contribute to the attenuation of the adverse drug reactions expected by patients with bone and soft tissue tumors who are undergoing chemotherapy...
  31. ncbi request reprint Prediction of myocutaneous adverse side effect due to intra-arterial chemotherapy by intra-arterial (99m)Tc-macroaggregated albumin administration in patients with bone and soft-tissue tumors
    Junichi Taki
    Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences, Japan
    J Nucl Med 43:1452-6. 2002
    ..99m)Tc-macroaggregated albumin (MAA) imaging with intra-arterial tracer administration was performed to evaluate drug distribution, and the ability of (99m)Tc-MAA imaging to predict local side effects was assessed...
  32. ncbi request reprint Tumor growth potential after tumoral and instrumental contamination: an in-vivo comparative study of T-saw, Gigli saw, and scalpel
    M el-S Abdel-Wanis
    Orthopaedic Department, Faculty of Medicine, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa 920-8641, Japan
    J Orthop Sci 6:424-9. 2001
    ..8%, respectively. These findings show that tumor recurrence is less likely after intralesional tumor cutting with a T-saw than after such cutting with a Gigli saw or scalpel...
  33. ncbi request reprint Total sacrectomy and reconstruction for huge sacral tumors
    K Tomita
    Department of Orthopedic Surgery, School of Medicine, Kanazawa University, Japan
    Spine (Phila Pa 1976) 15:1223-7. 1990
    ..In spite of the serious structural and neurologic damage caused, total sacrectomy can be rewarding procedure in terms of improved morbidity and mortality...
  34. doi request reprint Pedicle frozen autograft reconstruction in malignant bone tumors
    Hiroyuki Tsuchiya
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    J Orthop Sci 15:340-9. 2010
    ..We report this newly modified technique using pedicle frozen autografts to save the continuity of anatomical structures...
  35. doi request reprint In vivo gene transfer between interacting human osteosarcoma cell lines is associated with acquisition of enhanced metastatic potential
    Yasunori Tome
    Department of Orthopedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920 8641, Japan
    J Cell Biochem 108:362-7. 2009
    ..The data also further demonstrated the power of color-coded imaging to visualize cancer-cell/cancer-cell interactions in vivo...
  36. ncbi request reprint Clinical outcomes of 54 pelvic osteosarcomas registered by Japanese musculoskeletal oncology group
    Toshihiro Matsuo
    Department of Orthopaedic Surgery, Hiroshima University, Hiroshima, Japan
    Oncology 68:375-81. 2005
    ..To determine the clinical outcomes in patients with pelvic osteosarcoma, we reviewed the experience with 54 pelvic osteosarcoma patients...
  37. ncbi request reprint Analysis of telomerase activity and telomere length in bone and soft tissue tumors
    Tadashi Terasaki
    Department of Orthopedic Surgery, Kanazawa University, School of Medicine, Kanazawa, Ishikawa 920 8641, Japan
    Oncol Rep 11:1307-11. 2004
    ..The present results indicate that telomerase activation is not prevalent in mesenchymal tumors and is not a critical determinant of telomere length, but it may be a prognostic indicator of mesenchymal tumors...
  38. ncbi request reprint Effects of liquid nitrogen treatment on the proliferation of osteosarcoma and the biomechanical properties of normal bone
    Norio Yamamoto
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    J Orthop Sci 8:374-80. 2003
    ..This might be one of the reasons for the discrepancy in compression strength...
  39. ncbi request reprint Cannulation of simple bone cysts
    H Tsuchiya
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Japan
    J Bone Joint Surg Br 84:245-8. 2002
    ..This technique seems to be a promising option for the treatment of simple bone cysts. The cannulated hydroxyapatite pin is recommended because of its higher success rate and the fact that it does not need to be removed...
  40. ncbi request reprint Lengthening of the normal tibia in a patient with hemihypertrophy caused by Klippel- Trenaunay-Weber syndrome: a case report
    Munetomo Takata
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Japan
    J Orthop Surg (Hong Kong) 19:359-63. 2011
    ..She underwent osteotomy and lengthening of the normal contralateral tibia using a Taylor spatial frame. Hip arthroplasty could be avoided as osteoarthritic changes of the hip joint had improved...
  41. pmc Anatomical aspects of biopsy of the proximal fibula
    A Takeda
    Department of Orthopedic Surgery, School of Medicine, Kanazawa, Japan
    Int Orthop 24:335-7. 2001
    ..5+/-3.5 degrees). We considered that biopsies should be performed with an anterolateral approach in the safe area formed by the fibular head and the deep peroneal nerve in the anterior compartment...
  42. ncbi request reprint Presacral tumor associated with the Currarino triad in an adolescent
    T Horii
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Japan
    Arch Orthop Trauma Surg 121:114-6. 2001
    ..The patient underwent excision of the presacral mass. Histologic examination of the resected specimen revealed features of an epidermoid cyst...
  43. ncbi request reprint Late radiographic findings after anterior cervical fusion for spondylotic myeloradiculopathy
    H Baba
    Department of Orthopaedic Surgery, Fukui Medical School, Japan
    Spine (Phila Pa 1976) 18:2167-73. 1993
    ..Results of salvage laminoplasty were not satisfactory. Unnecessarily extended longer fusion must be avoided...
  44. ncbi request reprint Differentiation of soft tissue haemangioma by 201Tl scintigraphy
    T Higuchi
    Department of Nuclear Medicine, Kanazawa University School of Medicine, Kanazawa Cardiovascular Hospital, Kanazawa, Japan
    Nucl Med Commun 24:327-30. 2003
    ..02). Deep soft tissue haemangiomas revealed Tl accumulation in early images; however, a rapid washout was observed in delayed images. This distinctive feature may facilitate the use of Tl scintigraphy in the diagnosis of haemangiomas...
  45. ncbi request reprint The antitumor effect of liposome-encapsulated cisplatin on rat osteosarcoma and its enhancement by caffeine
    Michiaki Karita
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Anticancer Res 28:1449-57. 2008
    ..Caffeine has been identified as belonging to the group of xanthines that enhances the action of cisplatin...
  46. ncbi request reprint Caffeine dose-dependently potentiates the antitumor effect of cisplatin on osteosarcomas
    Masami Kawahara
    Department of Hospital Pharmacy, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    Anticancer Res 28:1681-5. 2008
    ..However, there is little in vivo evidence for this treatment, and thus we sought to verify the dose and effect of caffeine in combination with cisplatin in osteosarcoma-bearing rats...
  47. doi request reprint Impact of serum caffeine monitoring on adverse effects and chemotherapeutic responses to caffeine-potentiated chemotherapy for osteosarcoma
    Katsuhiro Hayashi
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    J Orthop Sci 14:253-8. 2009
    ..The present study focused on monitoring and adjusting serum caffeine levels during caffeine-potentiated chemotherapy to reduce adverse effects...
  48. doi request reprint Histological examination of frozen autograft treated by liquid nitrogen removed after implantation
    Yoshikazu Tanzawa
    Department of Orthopaedic Surgery, Kanazawa University School of Medicine, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    J Orthop Sci 14:761-8. 2009
    ..To determine if frozen autografts exhibit early bone remodeling, we investigated the repair processes of the frozen bones...
  49. pmc Validation of radiographic response evaluation criteria of preoperative chemotherapy for bone and soft tissue sarcomas: Japanese Orthopaedic Association Committee on Musculoskeletal Tumors Cooperative Study
    Takafumi Ueda
    Department of Orthopaedic Surgery, Osaka National Hospital, Kinki Block Comprehensive Cancer Center, 2 1 14 Hoenzaka, Chuo Ku, Osaka, 540 0006, Japan
    J Orthop Sci 13:304-12. 2008
    ..Its prognostic correlation, however, has hardly been validated...
  50. ncbi request reprint Identification of novel genes involved in the synergistic antitumor effect of caffeine in osteosarcoma cells using cDNA macroarray
    Sadao Ii
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Anticancer Res 28:645-53. 2008
    ..Caffeine enhances the cytocidal effects of DNA-damaging agents. This study investigated genes involved in the synergistic effect of caffeine on osteosarcoma cells using gene-profiling analysis...
  51. ncbi request reprint Distraction osteogenesis for treatment of bone loss in the lower extremity
    Hiroyuki Tsuchiya
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Orthop Sci 8:116-24. 2003
    ..Joint preservation and reconstruction by means of distraction osteogenesis is the most conservative limb-saving surgery available at present. Furthermore, distraction osteogenesis can provide natural limb regeneration...
  52. ncbi request reprint Bone transport with frozen devitalized bone: an experimental study using rabbits and a clinical application
    Hiroyuki Tsuchiya
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Orthop Sci 9:619-24. 2004
    ..Therefore, bone transport using frozen devitalized bone can regenerate living bone. This experimental model represents the development of a new reconstruction technique of bone transport with devitalized bone...
  53. ncbi request reprint Successful management of complications from distraction osteogenesis after osteosarcoma resection: a case report
    Toshiharu Shirai
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Orthop Sci 9:638-42. 2004
    ..Distraction osteogenesis avoids some complications but may involve others, which require detection and appropriate management...
  54. ncbi request reprint Predicting the outcome of distraction osteogenesis by 3-phase bone scintigraphy
    Masaya Kawano
    Department of Biotracer Medicine, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa, Japan
    J Nucl Med 44:369-74. 2003
    ..In this study, we examined whether 3-phase bone scintigraphy can predict the outcome of distraction osteogenesis. We also investigated the effects of chemotherapy and surgical treatment on distraction osteogenesis...
  55. ncbi request reprint Intentional marginal excision of osteosarcoma of the proximal fibula to preserve limb function
    Yoshimitsu Kanazawa
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Orthop Sci 8:757-61. 2003
    ..For patients with osteosarcoma of the proximal fibula, this approach provides a better quality of life than conventional wide excision...
  56. ncbi request reprint Caffeine-potentiated chemotherapy for metastatic carcinoma and lymphoma of bone and soft tissue
    Masayuki Hayashi
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Anticancer Res 25:2399-405. 2005
    ..In that series, patients with metastatic carcinoma or lymphoma were treated with caffeine-potentiated chemotherapy...
  57. ncbi request reprint A glass foreign body migrating into the lumbar spinal canal: a case report
    Katsuhito Yoshioka
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Kanazawa, Japan
    J Orthop Surg (Hong Kong) 20:257-9. 2012
    ..Postoperatively, the pain resolved immediately. At the 9-year follow-up, the alignment of the lumbar spine and healing of L5 was good, with no features of aseptic necrosis...
  58. ncbi request reprint Melatonin deficiency and fibrous dysplasia: might a relation exist?
    M E Abdel-Wanis
    Orthopaedic Department, Faculty of Medicine, Kanazawa University, Kanazawa, Japan
    Med Hypotheses 59:552-4. 2002
    ..Further, melatonin deficiency might explain precocious puberty in cases of McCune-Albright syndrome. We might hypothesize that melatonin deficiency might play a role in development of fibrous dysplasia in some cases...
  59. ncbi request reprint Clinicopathological features of solitary fibrous tumours in the extremities: four case reports and a literature review
    S Wan
    Department of Orthopaedic Surgery, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China
    J Int Med Res 38:694-704. 2010
    ..Pathological and immunohistochemical studies are important in making the correct diagnosis...
  60. ncbi request reprint Pathological findings of an autograft containing osteosarcoma treated by liquid nitrogen retrieved 2 years after implantation
    Kenshi Sakayama
    Department of Orthopaedic Surgery, Ehime University School of Medicine, Shitsukawa, Toon, Ehime, 791 0295, Japan
    J Orthop Sci 11:655-6. 2006
  61. ncbi request reprint Down-regulation of plakoglobin in soft tissue sarcoma is associated with a higher risk of pulmonary metastasis
    Yoshimitsu Kanazawa
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13 1, Takara machi, Kanazawa, Ishikawa 920 8641, Japan
    Anticancer Res 28:655-64. 2008
    ..0001), and that STS cases with high plakoglobin gene expression had an excellent prognosis. These results suggest that plakoglobin gene expression level might be useful as a new biomarker for metastasis and prognosis of human STS...
  62. ncbi request reprint Osteofibrous dysplasia treated with distraction osteogenesis: a report of two cases
    Michiaki Karita
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13 1 Takara machi, 920 8641, Kanazawa, Japan
    J Orthop Sci 9:516-20. 2004
    ..We now prefer marginal excision of the lesion to avoid long-term failures, as in our first case. Distraction osteogenesis has proven useful for restoring structure and function in the affected limb...
  63. ncbi request reprint The relationship between distraction length and treatment indices during distraction osteogenesis
    Keisuke Sakurakichi
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Orthop Sci 7:298-303. 2002
    ..0 cm. When comparing the maturation and external fixation indices between different patients or studies, the length of the distraction must be taken into consideration...
  64. doi request reprint Correction of ankle ankylosis with deformity using the taylor spatial frame: a report of three cases
    Hidenori Matsubara
    Graduate School of Medical Science, Department of Orthopaedic Surgery, Kanazawa University, 13 1 Takara machi, Kanazawa, Japan
    Foot Ankle Int 28:1290-4. 2007
  65. ncbi request reprint Distraction osteogenesis of a previously irradiated femur with malignant lymphoma: a case report
    Hidenori Matsubara
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Japan
    J Orthop Sci 10:430-5. 2005
  66. ncbi request reprint Caffeine-potentiated chemotherapy for patients with high-grade soft tissue sarcoma: long-term clinical outcome
    Akihiko Takeuchi
    Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Anticancer Res 27:3489-95. 2007
    ..The present study was performed to assess the efficacy of caffeine-potentiated chemotherapy for high-grade soft tissue sarcoma (STS)...
  67. ncbi request reprint Ankle arthrodesis combined with tibial lengthening using the Ilizarov apparatus
    Keisuke Sakurakichi
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Orthop Sci 8:20-5. 2003
    ..The Ilizarov method may be practically applied for ankle arthrodesis, especially in complicated cases. The EFI and external fixation time tended to increase for patients with a length gain of 3 cm or less...
  68. ncbi request reprint Effects of timing of low-intensity pulsed ultrasound on distraction osteogenesis
    Keisuke Sakurakichi
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Orthop Res 22:395-403. 2004
    ..These results suggest the LIPUS effect is mediated via endochondral pathways. We concluded that LIPUS stimulates bone formation in distraction osteogenesis and is most effective during the lengthening phase...
  69. ncbi request reprint Distraction osteogenesis after irradiation in a rabbit model
    Hiroyuki Tsuchiya
    Department of Orthopedic Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    J Orthop Sci 10:627-33. 2005
    ..The present study was performed to investigate the effects of preoperative irradiation on distraction osteogenesis, as little is known about how preoperative irradiation delays distraction osteogenesis...
  70. ncbi request reprint Histological and radiological analysis of autoclaved bone 2 years after extirpation
    Norio Yamamoto
    Department of Orthopaedic Surgery, Graduate School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    J Orthop Sci 8:16-9. 2003
    ..We should be careful when applying autoclaved bone for weight-bearing parts...
  71. ncbi request reprint Endogenous secretory receptor for advanced glycation endproducts as a novel prognostic marker in chondrosarcoma
    Akihiko Takeuchi
    Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Cancer 109:2532-40. 2007
    ....
  72. doi request reprint Osteosarcoma in the elderly over 60 years: a multicenter study by the Japanese Musculoskeletal Oncology Group
    Yoshihiro Nishida
    Department of Orthopaedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Surg Oncol 100:48-54. 2009
    ..Few studies have described the characteristics and prognostic factors of osteosarcoma patients aged over 60 years...
  73. ncbi request reprint Correction of tibial deformity in adults
    Wakyo Sato
    Department of Orthopaedic Surgery, Faculty of Medicine, The University of Tokyo, 7 3 1 Hongo, Bunkyo ku, Tokyo 113 8655, Japan
    J Orthop Sci 8:306-12. 2003
    ..External fixation can correct not only the mechanical axis and joint inclination but also leg-length discrepancy simultaneously...
  74. doi request reprint Occlusive dressing for large soft tissue defects following soft tissue tumor excision
    Akihiko Takeuchi
    Department of Orthopaedic Surgery, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa, Japan
    J Orthop Sci 14:385-90. 2009
    ..The purpose of this study was to evaluate the effectiveness and safety of an occlusive dressing treatment method for soft tissue defects following soft tissue tumor excisions...
  75. ncbi request reprint An experimental study on the therapeutic effect of consecutive low-dose cisplatin with caffeine in sarcoma-bearing mice
    Akira Takeda
    Department of Orthopedic Surgery, Fukushima Medical University, School of Medicine, 1 Hikarigaoka, Fukushima 960 1295, Japan
    Anticancer Res 25:2777-84. 2005
    ..The aims of this study were to investigate the anti-tumor effects of consecutive low-dose cisplatin (LD-CDDP) in comparison with single high-dose CDDP (HD-CDDP) in combination with caffeine...
  76. ncbi request reprint Reconstruction with distraction osteogenesis for juxta-articular nonunions with bone loss
    Tamon Kabata
    Department of Orthopaedic Surgery, Kanazawa University School of Medicine, Kanazawa, Ishikawa 920 8641, Japan
    J Trauma 58:1213-22. 2005
    ..Nonunions of a juxta-articular lesion with bone loss, which represent a challenging therapeutic problem, were treated using external fixation and distraction osteogenesis...
  77. ncbi request reprint Adamantinoma of the proximal femur: a case report
    Sadao Ii
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Orthop Sci 9:152-6. 2004
    ..We finally diagnosed the patient with adamantinoma. In this report we describe the characteristics of this tumor and discuss the reasoning concerning the differential diagnosis and therapeutic plan...
  78. pmc Cryoimmunologic antitumor effects enhanced by dendritic cells in osteosarcoma
    Masanori Kawano
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    Clin Orthop Relat Res 468:1373-83. 2010
    ..We also reported systemic antitumor immunity was enhanced by cryotreatment in a murine osteosarcoma (LM8) model. We therefore combined the cryotreatment of tumor with dendritic cells to promote tumor-specific immune responses...
  79. doi request reprint Revision high tibial osteotomy with the Taylor spatial frame for failed opening-wedge high tibial osteotomy
    Koji Watanabe
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    J Orthop Sci 13:145-9. 2008
  80. ncbi request reprint Desmoplastic small round cell tumour successfully treated with caffeine-assisted chemotherapy: a case report and review of the literature
    Shinji Miwa
    Department of Orthopedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Anticancer Res 30:3769-74. 2010
    ..Four years after the initial diagnosis, no local relapse and no distant metastases have been observed. Therefore, it is concluded that caffeine-assisted chemotherapy should be one of the treatment options for DSRCT...
  81. ncbi request reprint Invasive features of spinal osteosarcoma obtained from whole-mount sections of total en bloc spondylectomy
    Hideki Murakami
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    J Orthop Sci 12:311-5. 2007
  82. ncbi request reprint Hip joint remodeling in an adult following excision of a giant cell tumor involving the acetabulum: a case report and literature review
    Hideji Nishida
    Department of Orthopedic Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    Arch Orthop Trauma Surg 126:458-63. 2006
    ..We performed intralesional curettage with phenol and ethanol adjuvant therapy for pelvic giant cell tumor without tumor recurrence, and good repair of a hip joint adaptation can be achieved even in an adult patient...
  83. ncbi request reprint Healing of autologous bone in a titanium mesh cage used in anterior column reconstruction after total spondylectomy
    Tomoyuki Akamaru
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Kanazawa, Japan
    Spine (Phila Pa 1976) 27:E329-33. 2002
    ..Autologous bone inside a titanium mesh cage, used as an anterior strut in a reconstruction after total spondylectomy, was histologically examined in a postmortem specimen...
  84. ncbi request reprint [Surgical treatment for metastatic bone tumor]
    Yoshiyasu Fujimaki
    Kanazawa University, School of Medicine, Department of Orthopaedic Surgery
    Clin Calcium 16:647- 54. 2006
    ..Radical resection and reconstruction are used for the patients with long life expectancy, though palliative surgery is for the patients with short life expectancy...
  85. pmc Deformity correction and lengthening of lower legs with an external fixator
    Hidenori Matsubara
    Department of Orthopedic Surgery, School of Medicine, Kanazawa University, Kanazawa, Japan
    Int Orthop 30:550-4. 2006
    ..Gradual correction may represent a better approach than acute correction with the use of external fixators to treat deformity combined with shortening...
  86. ncbi request reprint Tibial lengthening over an intramedullary nail
    Koji Watanabe
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Orthop Sci 10:480-5. 2005
    ..To minimize such problems, we have combined intramedullary nailing with external fixation. Using this technique, the external fixator can be removed more quickly after completing the lengthening...
  87. ncbi request reprint Distraction osteogenesis of a fresh fracture site using an external fixator
    Keisuke Sakurakichi
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Orthop Sci 11:390-3. 2006
  88. ncbi request reprint Osteoblast lineage properties in giant cell tumors of bone
    Atsushi Murata
    Department of Orthopaedic Surgery, Kanazawa University School of Medicine, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    J Orthop Sci 10:581-8. 2005
    ..This hypothesis suggests an osteoblast lineage origin of GCTs, although it has long been speculated about GCTs being of mesenchymal stem cell (MSC) origin...
  89. ncbi request reprint Deformity correction for vitamin D-resistant hypophosphatemic rickets of adults
    Hidenori Matsubara
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Arch Orthop Trauma Surg 128:1137-43. 2008
    ..However, the order of the corrections should be considered carefully depending on each patient...
  90. ncbi request reprint Ilizarov deformity correction of the lower limbs in Ellis-van Creveld syndrome
    Ahmad Morsy
    Department of Orthopaedic Surgery, Graduated School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    J Orthop Sci 12:505-9. 2007
  91. ncbi request reprint Clinical outcome of patients with Ewing sarcoma family of tumors of bone in Japan: the Japanese Musculoskeletal Oncology Group cooperative study
    Hideto Obata
    Department of Orthopedics, Osaka University Graduate School of Medicine, Osaka, Japan
    Cancer 109:767-75. 2007
    ..The objectives of the current study were to assess the clinical outcome and prognostic factors of patients with ESFT of bone in Japan and to compare them between Euro-American and Japanese populations...
  92. ncbi request reprint Treatment of lower limb deformities and limb-length discrepancies with the external fixator in Ollier's disease
    Koji Watanabe
    Department of Orthopaedic Surgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    J Orthop Sci 12:471-5. 2007
    ....
  93. ncbi request reprint Osteosarcoma arising from desmoplastic fibroma treated 16 years earlier: a case report
    Koutarou Takazawa
    Department of Orthopaedics Surgery, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Orthop Sci 8:864-8. 2003
    ..This extremely rare lesion is believed to be a desmoplastic fibroma transformed to osteosarcoma...
  94. ncbi request reprint Minimal curettage, multiple drilling, and continuous decompression through a cannulated screw for treatment of calcaneal simple bone cysts in children
    Mohamed E Abdel-Wanis
    Kanazawa University, Kanazawa, Japan
    J Pediatr Orthop 22:540-3. 2002
    ..Our technique of minimal curettage, drilling and continuous decompression with a cannulated screw insertion is considered to be a good option for management of simple bone cysts of the calcaneus...
  95. ncbi request reprint Determination of clonality of metastasis by cell-specific color-coded fluorescent-protein imaging
    Norio Yamamoto
    AntiCancer, Inc, San Diego, CA 92111, USA
    Cancer Res 63:7785-90. 2003
    ..The simple fluorescence method of determining clonality of metastases described here can allow large-scale clonal analysis in numerous types of metastatic models...
  96. ncbi request reprint Gradual closed correction of equinus contracture using the Ilizarov apparatus
    Hiroyuki Tsuchiya
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Orthop Sci 8:802-6. 2003
    ..However, particular care is needed during correction to avoid complications such as anterior subluxation of the talus and joint space narrowing. When complications do occur, intervention should be immediate...
  97. ncbi request reprint Rapid determination method of caffeine and application to monitoring of caffeine-assisted chemotherapy
    Masami Kawahara
    Department of Pharmacy, Kanazawa University Hospital, Ishikawa, Japan
    Biopharm Drug Dispos 25:61-7. 2004
    ..It is concluded that individual monitoring with this method for the purpose of dose adjustment is useful for avoiding the side effects of caffeine-assisted chemotherapy...
  98. ncbi request reprint Cellular dynamics visualized in live cells in vitro and in vivo by differential dual-color nuclear-cytoplasmic fluorescent-protein expression
    Norio Yamamoto
    AntiCancer, Inc, San Diego, California
    Cancer Res 64:4251-6. 2004
    ..The dual-color cells thus are a useful tool for visualizing living-cell dynamics in vivo as well as in vitro. Drugs that could specifically perturb these processes can now be readily screened in real time in vivo...
  99. ncbi request reprint Correction of juxtaarticular deformities in children using the Ilizarov apparatus
    Keisuke Sakurakichi
    Department of Orthopaedic Surgery, School of Medicine, Kanazawa University, Japan
    J Orthop Sci 10:360-6. 2005
    ..The amount of deformity correction, external fixation time, external fixation index, length gained, and incidence of complications were examined...
  100. ncbi request reprint Color coding cancer cells with fluorescent proteins to visualize in vivo cellular interaction in metastatic colonies
    Norio Yamamoto
    AntiCancer, Inc, 7917 Ostrow Street, San Diego, CA 92111, USA
    Anticancer Res 24:4067-72. 2004
    ..Fluorescence color coding of cancer cells enables visualization of the interaction of cancer cells and can be used to distinguish cancer cells of any genotype or phenotype...
  101. ncbi request reprint Clear cell sarcoma of tendons and aponeuroses: a study of 75 patients
    Akira Kawai
    Division of Orthopedic Surgery, National Cancer Center Hospital, Tokyo, Japan
    Cancer 109:109-16. 2007
    ..The objective of this study was to determine the clinical features, prognostic factors, and optimal treatment policy for patients with this rare disease...