Takuji Tanaka


Affiliation: Kanazawa Medical University
Country: Japan


  1. Tanaka T, Kawabata K, Kakumoto M, Hara A, Murakami A, Kuki W, et al. Citrus auraptene exerts dose-dependent chemopreventive activity in rat large bowel tumorigenesis: the inhibition correlates with suppression of cell proliferation and lipid peroxidation and with induction of phase II drug-metabolizing enzymes. Cancer Res. 1998;58:2550-6 pubmed
  2. Tanaka T, Sugiura H, Inaba R, Nishikawa A, Murakami A, Koshimizu K, et al. Immunomodulatory action of citrus auraptene on macrophage functions and cytokine production of lymphocytes in female BALB/c mice. Carcinogenesis. 1999;20:1471-6 pubmed
    ..These findings might suggest that oral administration of citrus auraptene effectively enhanced macrophage and lymphocyte functions in mice. ..
  3. Tanaka T, Kohno H, Murakami M, Shimada R, Kagami S, Sumida T, et al. Suppression of azoxymethane-induced colon carcinogenesis in male F344 rats by mandarin juices rich in beta-cryptoxanthin and hesperidin. Int J Cancer. 2000;88:146-50 pubmed
    ..In addition, treatment with MJ, MJ2, or MJ5 significantly increased apoptotic index in colonic adenocarcinoma. These findings might suggest effective chemopreventive ability of MJs, especially MJ5, in colon tumorigenesis. ..
  4. Tanaka T, Kohno H, Suzuki R, Sugie S. Lack of modifying effects of an estrogenic compound atrazine on 7,12-dimethylbenz(a)anthracene-induced ovarian carcinogenesis in rats. Cancer Lett. 2004;210:129-37 pubmed
    ..These results might suggest dietary feeding of a EDC atrazine did not affect DMBA-induced rat ovarian carcinogenesis. ..
  5. Tanaka T, Yasui Y, Tanaka M, Tanaka T, Oyama T, Rahman K. Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. Chem Biol Interact. 2009;177:128-36 pubmed publisher
    ..These results may indicate the beneficial effects of MEL on colitis-related colon carcinogenesis and a potential application for inhibiting colorectal cancer development in the inflamed colon. ..
  6. Tanaka T, Maeda M, Kohno H, Murakami M, Kagami S, Miyake M, et al. Inhibition of azoxymethane-induced colon carcinogenesis in male F344 rats by the citrus limonoids obacunone and limonin. Carcinogenesis. 2001;22:193-8 pubmed
    ..0002). Our results suggest that the citrus limonoids obacunone and limonin might be useful for the prevention of human colon cancers. ..
  7. Tanaka T, de Azevedo M, Duran N, Alderete J, Epifano F, Genovese S, et al. Colorectal cancer chemoprevention by 2 beta-cyclodextrin inclusion compounds of auraptene and 4'-geranyloxyferulic acid. Int J Cancer. 2010;126:830-40 pubmed publisher
  8. Tanaka T, Kohno H, Tsukio Y, Honjo S, Tanino M, Miyake M, et al. Citrus limonoids obacunone and limonin inhibit azoxymethane-induced colon carcinogenesis in rats. Biofactors. 2000;13:213-8 pubmed
    ..Thus, citrus bitter limonoids obacunone and limonin possess chemopreventive effects on chemically induced rat colon carcinogenesis. ..
  9. Tanaka T, Yasui Y, Ishigamori Suzuki R, Oyama T. Citrus compounds inhibit inflammation- and obesity-related colon carcinogenesis in mice. Nutr Cancer. 2008;60 Suppl 1:70-80 pubmed publisher
    ..1% CUSM, and 59% inhibition by 0.5% CUSM. CUSM treatment also decreased serum level of triglycerides. Our findings suggest that certain citrus materials are capable of inhibiting clitis- and obesity-related colon carcinogenesis. ..

More Information


  1. Shimizu M, Yasuda Y, Sakai H, Kubota M, Terakura D, Baba A, et al. Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice. BMC Cancer. 2011;11:281 pubmed publisher
    ..Pitavastatin is effective in inhibiting the early phase of obesity-related liver tumorigenesis and, therefore, may be useful in the chemoprevention of liver cancer in obese individuals. ..
  2. Suzuki R, Miyamoto S, Yasui Y, Sugie S, Tanaka T. Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate. BMC Cancer. 2007;7:84 pubmed
  3. Tanaka T, Shimizu M, Kohno H, Yoshitani S, Tsukio Y, Murakami A, et al. Chemoprevention of azoxymethane-induced rat aberrant crypt foci by dietary zerumbone isolated from Zingiber zerumbet. Life Sci. 2001;69:1935-45 pubmed