Hiroshi Tanahashi

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. ncbi request reprint A novel beta-site amyloid precursor protein cleaving enzyme (BACE) isoform regulated by nonsense-mediated mRNA decay and proteasome-dependent degradation
    Hiroshi Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurosci Lett 428:103-8. 2007
  2. pmc Characterization of an amyloid precursor protein-binding protein Fe65L2 and its novel isoforms lacking phosphotyrosine-interaction domains
    Hiroshi Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Biochem J 367:687-95. 2002
  3. ncbi request reprint Association between tau polymorphism and male early-onset Alzheimer's disease
    Hiroshi Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neuroreport 15:175-9. 2004
  4. ncbi request reprint c954C-->T polymorphism in the Fe65L2 gene is associated with early-onset Alzheimer's disease
    Hiroshi Tanahashi
    Ann Neurol 52:691-3. 2002
  5. doi request reprint RNA interference silencing of DRAL affects processing of amyloid precursor protein
    Hiroshi Tanahashi
    Division of Molecular Cell Signaling, Cancer Research Institute, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920 0934, Japan
    Neurosci Lett 439:293-7. 2008

Detail Information

Publications5

  1. ncbi request reprint A novel beta-site amyloid precursor protein cleaving enzyme (BACE) isoform regulated by nonsense-mediated mRNA decay and proteasome-dependent degradation
    Hiroshi Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neurosci Lett 428:103-8. 2007
    ..Finally, I-127 was degraded in a proteasome-dependent manner. Thus, I-127 is regulated by both nonsense-mediated mRNA decay (NMD) and proteasome-dependent degradation...
  2. pmc Characterization of an amyloid precursor protein-binding protein Fe65L2 and its novel isoforms lacking phosphotyrosine-interaction domains
    Hiroshi Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Biochem J 367:687-95. 2002
    ..These results suggest that Fe65L2 affects Abeta production and a possible regulation of Fe65L2 function by alternative splicing...
  3. ncbi request reprint Association between tau polymorphism and male early-onset Alzheimer's disease
    Hiroshi Tanahashi
    Division of Demyelinating Disease and Aging, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4 1 1 Ogawahigashi, Kodaira, Tokyo 187 8502, Japan
    Neuroreport 15:175-9. 2004
    ..30-5.42), suggesting that age and gender modify the risk effect. However, we failed to replicate the reported association between the Saitohin gene located in the tau intron 9 and Japanese Alzheimer's disease...
  4. ncbi request reprint c954C-->T polymorphism in the Fe65L2 gene is associated with early-onset Alzheimer's disease
    Hiroshi Tanahashi
    Ann Neurol 52:691-3. 2002
  5. doi request reprint RNA interference silencing of DRAL affects processing of amyloid precursor protein
    Hiroshi Tanahashi
    Division of Molecular Cell Signaling, Cancer Research Institute, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920 0934, Japan
    Neurosci Lett 439:293-7. 2008
    ..We also found that in addition to a disintegrin and metalloprotease (ADAM)-17, DRAL binds to ADAM-10. Thus, DRAL may be involved in the processing of APP through the alpha-secretase pathway...