Kazuhiko Takehara

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. ncbi request reprint Hypothesis: pathogenesis of systemic sclerosis
    Kazuhiko Takehara
    Department of Dermatology, Kanazawa University Graduate School of Medical Science and School of Medicine, Kanazawa, Japan
    J Rheumatol 30:755-9. 2003
  2. pmc Abnormal expression of intracellular cytokines and chemokine receptors in peripheral blood T lymphocytes from patients with systemic sclerosis
    H Fujii
    Department of Dermatology, Cancer Research Institute, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Clin Exp Immunol 130:548-56. 2002
  3. ncbi request reprint Longitudinal analysis of serum KL-6 levels in patients with systemic sclerosis: association with the activity of pulmonary fibrosis
    K Yanaba
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Clin Exp Rheumatol 21:429-36. 2003
  4. ncbi request reprint Augmented production of transforming growth factor-beta by cultured peripheral blood mononuclear cells from patients with systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Arch Dermatol Res 296:89-93. 2004
  5. ncbi request reprint Serum pulmonary and activation-regulated chemokine/CCL18 levels in patients with systemic sclerosis: a sensitive indicator of active pulmonary fibrosis
    Masanari Kodera
    Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Arthritis Rheum 52:2889-96. 2005
  6. ncbi request reprint A randomized, double-blind, placebo-controlled trial: intravenous immunoglobulin treatment in patients with diffuse cutaneous systemic sclerosis
    Kazuhiko Takehara
    Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    Clin Exp Rheumatol 31:151-6. 2013
  7. ncbi request reprint Growth regulation of skin fibroblasts
    K Takehara
    Department of Dermatology, Kanazawa University School of Medicine, 13 1 Takara machl, 920 8641, Kanazawa, Japan
    J Dermatol Sci 24:S70-7. 2000
  8. ncbi request reprint Treatment of early diffuse cutaneous systemic sclerosis patients in Japan by low-dose corticosteroids for skin involvement
    K Takehara
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa 920 8641, Japan
    Clin Exp Rheumatol 22:S87-9. 2004
  9. ncbi request reprint Localized scleroderma is an autoimmune disorder
    K Takehara
    Department of Dermatology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan
    Rheumatology (Oxford) 44:274-9. 2005
  10. ncbi request reprint Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice
    Yukiyo Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Immunol 179:698-707. 2007

Collaborators

Detail Information

Publications161 found, 100 shown here

  1. ncbi request reprint Hypothesis: pathogenesis of systemic sclerosis
    Kazuhiko Takehara
    Department of Dermatology, Kanazawa University Graduate School of Medical Science and School of Medicine, Kanazawa, Japan
    J Rheumatol 30:755-9. 2003
    ..Based on these data, we hypothesize that a 2-step process of fibrosis occurs in SSc: that is, TGF-beta induces fibrosis in the early stage and afterwards CTGF acts to maintain tissue fibrosis...
  2. pmc Abnormal expression of intracellular cytokines and chemokine receptors in peripheral blood T lymphocytes from patients with systemic sclerosis
    H Fujii
    Department of Dermatology, Cancer Research Institute, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Clin Exp Immunol 130:548-56. 2002
    ..Tc1 cells may be associated with pulmonary vascular damage in SSc...
  3. ncbi request reprint Longitudinal analysis of serum KL-6 levels in patients with systemic sclerosis: association with the activity of pulmonary fibrosis
    K Yanaba
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Clin Exp Rheumatol 21:429-36. 2003
    ..To determine whether changes in serum KL-6 levels reflect the activity of pulmonary fibrosis (PF) in patients with systemic sclerosis (SSc)...
  4. ncbi request reprint Augmented production of transforming growth factor-beta by cultured peripheral blood mononuclear cells from patients with systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Arch Dermatol Res 296:89-93. 2004
    ..Thus, the enhanced production of TGF-beta by PBMC may contribute to the disease process in SSc..
  5. ncbi request reprint Serum pulmonary and activation-regulated chemokine/CCL18 levels in patients with systemic sclerosis: a sensitive indicator of active pulmonary fibrosis
    Masanari Kodera
    Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Arthritis Rheum 52:2889-96. 2005
    ....
  6. ncbi request reprint A randomized, double-blind, placebo-controlled trial: intravenous immunoglobulin treatment in patients with diffuse cutaneous systemic sclerosis
    Kazuhiko Takehara
    Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    Clin Exp Rheumatol 31:151-6. 2013
    ....
  7. ncbi request reprint Growth regulation of skin fibroblasts
    K Takehara
    Department of Dermatology, Kanazawa University School of Medicine, 13 1 Takara machl, 920 8641, Kanazawa, Japan
    J Dermatol Sci 24:S70-7. 2000
    ..In the 21st century, we speculate that cocktails of various growth factors may permit subtle growth regulation of skin fibroblasts; such technology would have applications in the treatment of many skin diseases...
  8. ncbi request reprint Treatment of early diffuse cutaneous systemic sclerosis patients in Japan by low-dose corticosteroids for skin involvement
    K Takehara
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa 920 8641, Japan
    Clin Exp Rheumatol 22:S87-9. 2004
    ..8+/-7.0 after one year of treatment (p < 0.005) and to 8.7+/-6.1 at final evaluation (p < 0.001). Thus, we confirmed the usefulness of oral corticosteroid treatment for early dSSc in Japanese patients...
  9. ncbi request reprint Localized scleroderma is an autoimmune disorder
    K Takehara
    Department of Dermatology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan
    Rheumatology (Oxford) 44:274-9. 2005
    ..Here we summarize previous data on the autoimmunity of localized scleroderma, mostly published in the last two decades, because there has not been a review paper summarizing autoimmunity in this disorder...
  10. ncbi request reprint Intercellular adhesion molecule-1 deficiency attenuates the development of skin fibrosis in tight-skin mice
    Yukiyo Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Immunol 179:698-707. 2007
    ..Thus, our findings indicate that ICAM-1 expression contributes to the development of skin fibrosis in TSK/+ mice, especially via ICAM-1 expressed on skin fibroblasts...
  11. ncbi request reprint Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1
    Toru Yukami
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1, Takara machi, Kanazawa 920 8641, Japan
    J Leukoc Biol 82:519-31. 2007
    ..These results indicate that skin wound healing is regulated cooperatively by all selectins and ICAM-1 and may provide critical information for the therapy of skin wounds...
  12. pmc Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction
    Takayuki Ishii
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Am J Pathol 174:2225-33. 2009
    ..The IgE-mediated cutaneous reverse passive Arthus reaction may serve as an experimental model for cutaneous eosinophilic infiltration in vasculitis as well as in other diseases...
  13. pmc E- and P-selectins synergistically inhibit bleomycin-induced pulmonary fibrosis
    Mayuka Horikawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Am J Pathol 169:740-9. 2006
    ..These results suggest that E- and P-selectins synergistically inhibit lung fibrosis by promoting the recruitment of NKT cells...
  14. pmc B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Japan
    Am J Pathol 169:954-66. 2006
    ..Thereby, B-cell depletion during disease onset suppressed skin fibrosis, indicating that B cells contribute to the initiation of systemic sclerosis pathogenesis in tight-skin mice but are not required for disease maintenance...
  15. ncbi request reprint Ultraviolet light exposure suppresses contact hypersensitivity by abrogating endothelial intercellular adhesion molecule-1 up-regulation at the elicitation site
    Kazuhiro Komura
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Immunol 171:2855-62. 2003
    ..These results indicate that UV exposure inhibits CHS by abrogating up-regulation of endothelial ICAM-1 expression after Ag challenge at elicitation sites...
  16. ncbi request reprint Connective tissue growth factor causes persistent proalpha2(I) collagen gene expression induced by transforming growth factor-beta in a mouse fibrosis model
    Sonoko Chujo
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa, Ishikawa 920 8641, Japan
    J Cell Physiol 203:447-56. 2005
    ..The infiltrated mast cells and macrophages may also contribute to the maintenance of fibrosis...
  17. ncbi request reprint Intercellular adhesion molecule-1 and vascular cell adhesion molecule-1 cooperatively contribute to the cutaneous Arthus reaction
    Hidemitsu Orito
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    J Leukoc Biol 81:1197-204. 2007
    ..Thus, VCAM-1 plays a complementary role to ICAM-1 in the cutaneous Arthus reaction by regulating leukocyte accumulation and proinflammatory cytokine production...
  18. ncbi request reprint L-selectin or ICAM-1 deficiency reduces an immediate-type hypersensitivity response by preventing mast cell recruitment in repeated elicitation of contact hypersensitivity
    Yuka Shimada
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Immunol 170:4325-34. 2003
    ....
  19. doi request reprint Role of connective tissue growth factor and its interaction with basic fibroblast growth factor and macrophage chemoattractant protein-1 in skin fibrosis
    Sonoko Chujo
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    J Cell Physiol 220:189-95. 2009
    ..These results suggest that bFGF induces collagen production by stimulating skin fibroblasts and CTGF cooperates with bFGF. Our results indicate that the induction of MCP-1 is necessary for infiltration of inflammatory cells...
  20. ncbi request reprint BAFF antagonist attenuates the development of skin fibrosis in tight-skin mice
    Takashi Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Invest Dermatol 127:2772-80. 2007
    ..The results suggest that BAFF/BAFF receptor system is critical for the development of skin fibrosis in TSK/+ mice and could be a potent therapeutical target...
  21. pmc Phase-dependent roles of E-selectin during chronic contact hypersensitivity responses
    Tomoyuki Fujita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Am J Pathol 170:1649-58. 2007
    ..Collectively, P- and E-selectins cooperatively regulate CH response, although their roles may be different depending on the phase of the reaction...
  22. ncbi request reprint Antigen specificity of antihistone antibodies in connective tissue disease patients with anti-U1RNP antibodies
    Takamasa Wayaku
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Rheumatol Int 28:113-9. 2007
    ..The antigenic stimulus in SLE may be different from other connective tissue diseases and is more likely to be native chromatin...
  23. doi request reprint A novel inhibitor of Smad-dependent transcriptional activation suppresses tissue fibrosis in mouse models of systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Arthritis Rheum 60:3465-75. 2009
    ....
  24. doi request reprint Increased serum pentraxin 3 in patients with systemic sclerosis
    Yohei Iwata
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Rheumatol 36:976-83. 2009
    ..To determine serum concentrations of pentraxin 3 (PTX3) and its clinical associations in patients with systemic sclerosis (SSc)...
  25. ncbi request reprint Inducible costimulator ligand regulates bleomycin-induced lung and skin fibrosis in a mouse model independently of the inducible costimulator/inducible costimulator ligand pathway
    Chihiro Tanaka
    Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Arthritis Rheum 62:1723-32. 2010
    ..Although the ICOS/ICOSL pathway is known to play various roles in adaptive immunity, its roles in innate immunity and tissue fibrosis remain unknown...
  26. pmc Inhibitory role of CD19 in the progression of experimental autoimmune encephalomyelitis by regulating cytokine response
    Takashi Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Am J Pathol 168:812-21. 2006
    ..Thus, CD19 modulates the Th1/Th2 cytokine balance in B cells and plays a critical role as a suppressive molecule in the development of EAE...
  27. ncbi request reprint Both Th1 and Th2 chemokines are elevated in sera of patients with autoimmune blistering diseases
    Takeshi Echigo
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    Arch Dermatol Res 298:38-45. 2006
    ..These results suggest that both a Th1 chemoattractant MIG and Th2 chemoattractants, TARC and MDC, cooperatively play a role in the development of ABD...
  28. ncbi request reprint Increased serum soluble CD40 levels in patients with systemic sclerosis
    Kazuhiro Komura
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    J Rheumatol 34:353-8. 2007
    ..To determine serum levels of soluble CD40 (sCD40) and clinical association in patients with systemic sclerosis (SSc)...
  29. ncbi request reprint Decreased expression levels of CD22 and L-selectin on peripheral blood B lymphocytes from patients with bullous pemphigoid
    Makoto Inaoki
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Autoimmun 27:196-202. 2006
    ..These results suggest that a decrease in CD22 expression may not be associated with BP-specific antibody production...
  30. pmc Intercellular adhesion molecule-1 and L-selectin regulate bleomycin-induced lung fibrosis
    Yasuhito Hamaguchi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    Am J Pathol 161:1607-18. 2002
    ..This suggests that these adhesion molecules are potential therapeutic targets for inhibiting human pulmonary fibrosis...
  31. ncbi request reprint Serum levels of a Th1 chemoattractant IP-10 and Th2 chemoattractants, TARC and MDC, are elevated in patients with systemic sclerosis
    Hidetaka Fujii
    Department of Dermatology, Kyoto University Graduate School of Medicine, Kyoto, Japan
    J Dermatol Sci 35:43-51. 2004
    ..Although abnormalities of various chemokines are detected in systemic sclerosis (SSc), there are few findings concerning Th1 or Th2 chemoattractants...
  32. ncbi request reprint L-selectin and intercellular adhesion molecule-1 regulate the development of Concanavalin A-induced liver injury
    Ayako Kawasuji
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1, Takara machi, Kanazawa, 920 8641, Japan
    J Leukoc Biol 79:696-705. 2006
    ..These results indicate that L-selectin and ICAM-1 contribute cooperatively to the development of Con A-induced hepatitis by regulating leukocyte infiltration and subsequent cytokine production...
  33. doi request reprint Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease
    Doanh Le Huu
    Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920 8641, Japan
    Blood 121:3274-83. 2013
    ..Therefore, donor-derived B10 cells have a suppressive role in Scl-cGVHD development, warranting future investigation of regulatory B-cell-based therapy for treatment of Scl-cGVHD and SSc...
  34. doi request reprint FTY720 ameliorates murine sclerodermatous chronic graft-versus-host disease by promoting expansion of splenic regulatory cells and inhibiting immune cell infiltration into skin
    Doanh Le Huu
    Kanazawa University, Kanazawa, Japan
    Arthritis Rheum 65:1624-35. 2013
    ..Murine sclerodermatous chronic graft-versus-host disease (GVHD) is a model for human sclerodermatous chronic GVHD and SSc. We undertook this study to investigate the effects of FTY720 in murine sclerodermatous chronic GVHD...
  35. doi request reprint Basophils and mast cells play critical roles for leukocyte recruitment in IgE-mediated cutaneous reverse passive Arthus reaction
    Guihua Jin
    Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    J Dermatol Sci 67:181-9. 2012
    ..This uniquely provides a model of type III hypersensitivity in which Fc classes of Ig that forms immune complex differentially determine the disease manifestation...
  36. ncbi request reprint Elevated serum levels of APRIL, but not BAFF, in patients with atopic dermatitis
    Takashi Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Exp Dermatol 17:197-202. 2008
    ..These results suggest that elevated serum levels of APRIL are associated with disease severity and activity in AD, and APRIL may have an important role in the pathogenesis of AD...
  37. ncbi request reprint Neutralizing monoclonal antibody to human connective tissue growth factor ameliorates transforming growth factor-beta-induced mouse fibrosis
    Yuka Ikawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    J Cell Physiol 216:680-7. 2008
    ....
  38. doi request reprint Serum CXCL16 concentrations correlate with the extent of skin sclerosis in patients with systemic sclerosis
    Koichi Yanaba
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Rheumatol 36:1917-23. 2009
    ..To determine serum concentrations of soluble CXCL16 and its clinical associations in patients with systemic sclerosis (SSc)...
  39. doi request reprint Autoantibody against one of the antioxidant repair enzymes, methionine sulfoxide reductase A, in systemic sclerosis: association with pulmonary fibrosis and vascular damage
    Fumihide Ogawa
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Arch Dermatol Res 302:27-35. 2010
    ..These results suggest that elevated anti-MSRA autoantibody is associated with the disease severity of SSc and may enhance the oxidative stress by inhibiting MSRA enzymatic activity...
  40. doi request reprint Association between nail-fold capillary findings and disease activity in dermatomyositis
    Naoki Mugii
    Department of Rehabilitation, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan
    Rheumatology (Oxford) 50:1091-8. 2011
    ..Our objective was to assess the changes and red blood cell velocity in finger nail-fold capillaries using nail-fold video capillaroscopy (NVC) in patients with adult-onset DM...
  41. doi request reprint Chemokine receptors CCR2 and CX3CR1 regulate skin fibrosis in the mouse model of cytokine-induced systemic sclerosis
    Minako Arai
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    J Dermatol Sci 69:250-8. 2013
    ..Macrophages can be divided into two subsets, the first expressing CCR2, and the second expressing CX3CR1...
  42. pmc Common and distinct clinical features in adult patients with anti-aminoacyl-tRNA synthetase antibodies: heterogeneity within the syndrome
    Yasuhito Hamaguchi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    PLoS ONE 8:e60442. 2013
    ..To identify similarities and differences in the clinical features of adult Japanese patients with individual anti-aminoacyl-tRNA synthetase antibodies (anti-ARS Abs)...
  43. doi request reprint B-cell linker protein expression contributes to controlling allergic and autoimmune diseases by mediating IL-10 production in regulatory B cells
    Guihua Jin
    Department of Dermatology, Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Japan
    J Allergy Clin Immunol 131:1674-82. 2013
    ..B-cell linker protein (BLNK) is an essential component of the B-cell antigen receptor signaling pathway and is required for optimal B-cell development...
  44. ncbi request reprint Longitudinal analysis of serum cytokine concentrations in systemic sclerosis: association of interleukin 12 elevation with spontaneous regression of skin sclerosis
    Takashi Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Japan
    J Rheumatol 33:275-84. 2006
    ..We investigated the relationship between changes of the serum cytokine profile and changes in skin fibrosis in patients with SSc...
  45. ncbi request reprint Clinical evaluation of anti-aminoacyl tRNA synthetase antibodies in Japanese patients with dermatomyositis
    Takashi Matsushita
    Department of Dermatology and Division of Respiratory Medicine, Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Rheumatol 34:1012-8. 2007
    ..To investigate the distribution of anti-aminoacyl-tRNA synthetase (anti-ARS) antibodies among patients with autoimmune diseases, and to analyze the clinical features of patients with dermatomyositis (DM) with anti-ARS antibodies...
  46. ncbi request reprint Increased serum soluble OX40 in patients with systemic sclerosis
    Kazuhiro Komura
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
    J Rheumatol 35:2359-62. 2008
    ..To determine levels of serum soluble OX40 (also termed CD134, a member of the tumor necrosis factor receptor superfamily) and their clinical associations in patients with systemic sclerosis (SSc)...
  47. ncbi request reprint [Scleroderma]
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science
    Nihon Rinsho 63:295-9. 2005
  48. pmc Inducible costimulator (ICOS) and ICOS ligand signaling has pivotal roles in skin wound healing via cytokine production
    Shintaro Maeda
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Am J Pathol 179:2360-9. 2011
    ..Thus, our results indicate that ICOS-ICOSL costimulatory signaling has critical roles during wound healing, most likely by inducing IL-6 production...
  49. pmc Relative contributions of selectins and intercellular adhesion molecule-1 to tissue injury induced by immune complex deposition
    Koichi Yanaba
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Am J Pathol 162:1463-73. 2003
    ....
  50. ncbi request reprint Abnormal natural killer cell function in systemic sclerosis: altered cytokine production and defective killing activity
    Mayuka Horikawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Invest Dermatol 125:731-7. 2005
    ..These results suggested that altered NK cell function contributes to immunological abnormalities in SSc...
  51. ncbi request reprint Anti-DNA topoisomerase II alpha autoantibodies in Japanese patients with systemic sclerosis
    Ikuko Hayakawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Arch Dermatol Res 297:180-3. 2005
    ..The results of the present study indicate that anti-topo II alpha Ab represent one of the autoantibody specificities detected on SSc patients and may be regarded a serological marker of pulmonary fibrosis in Japanese patients with SSc...
  52. ncbi request reprint The loss of MCP-1 attenuates cutaneous ischemia-reperfusion injury in a mouse model of pressure ulcer
    Yuki Saito
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Invest Dermatol 128:1838-51. 2008
    ..We propose that this is a useful model for investigating the mechanism of pressure ulcer formation using various transgenic mice...
  53. doi request reprint Elevated circulating TWEAK levels in systemic sclerosis: association with lower frequency of pulmonary fibrosis
    Koichi Yanaba
    Department of Dermatology, Nagasaki University GraduateSchool of Biomedical Sciences, Nagasaki and Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Rheumatol 36:1657-62. 2009
    ..To determine serum levels of tumor necrosis factor-related weak inducer of apoptosis (TWEAK) and its clinical associations in patients with systemic sclerosis (SSc)...
  54. ncbi request reprint Antiphospholipid antibodies in patients with autoimmune blistering disease
    Takeshi Echigo
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Ishikawa 920 8641, Japan
    J Am Acad Dermatol 57:397-400. 2007
    ..Our purpose was to determine the serum levels and frequency of antiphospholipid antibodies (aPLs) and confirm the clinical importance of these antibodies in patients with autoimmune blistering disease (ABD)...
  55. doi request reprint Potential roles of interleukin-17A in the development of skin fibrosis in mice
    Yoshinobu Okamoto
    Kanazawa University Graduate School of Medical Science, Japan
    Arthritis Rheum 64:3726-35. 2012
    ..The aim of this study was to examine the roles of T helper cytokines in the development of skin fibrosis...
  56. ncbi request reprint Expression of fractalkine and its receptor, CX3CR1, in atopic dermatitis: possible contribution to skin inflammation
    Takeshi Echigo
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    J Allergy Clin Immunol 113:940-8. 2004
    ..Fractalkine (FKN) induces activation and adhesion of leukocytes expressing its receptor, CX(3)CR1. FKN is released from the cell surface through proteolytic cleavage as soluble FKN (sFKN)...
  57. ncbi request reprint Clinical significance of serum levels of soluble intercellular adhesion molecule-1 and soluble L-selectin in malignant melanoma
    Mizuki Yamada
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Arch Dermatol Res 297:256-60. 2005
    ..These results suggest that monitoring both sICAM-1 and sL-selectin is available to evaluate the progression of MM...
  58. ncbi request reprint The efficacy of self-administered stretching for finger joint motion in Japanese patients with systemic sclerosis
    Naoki Mugii
    Department of Dermatology and Division of Rehabilitation Science, Kanazawa University Hospital, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    J Rheumatol 33:1586-92. 2006
    ..To determine the efficacy of self-administered stretching of each finger in Japanese patients with systemic sclerosis (SSc)...
  59. ncbi request reprint Pathogenesis of systemic sclerosis: altered B cell function is the key linking systemic autoimmunity and tissue fibrosis
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Dermatol Sci 39:1-7. 2005
    ..Thus, altered B cell function may result in tissue fibrosis, as well as autoimmunity, in SSc...
  60. ncbi request reprint P-selectin glycoprotein ligand-1 is required for the development of cutaneous vasculitis induced by immune complex deposition
    Koichi Yanaba
    Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    J Leukoc Biol 76:374-82. 2004
    ....
  61. doi request reprint Elevated serum insulin-like growth factor (IGF-1) and IGF binding protein-3 levels in patients with systemic sclerosis: possible role in development of fibrosis
    Yasuhito Hamaguchi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Rheumatol 35:2363-71. 2008
    ..To examine serum concentrations of insulin-like growth factor (IGF-1) and IGF binding protein (IGFBP-3), a major carrier protein for IGF-1, in patients with systemic sclerosis (SSc); and to relate the results to clinical features in SSc...
  62. ncbi request reprint Elevated serum BAFF levels in patients with localized scleroderma in contrast to other organ-specific autoimmune diseases
    Takashi Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Exp Dermatol 16:87-93. 2007
    ..By contrast, serum BAFF levels were not significantly elevated in patients with pemphigus or pemphigoid. These results suggest that BAFF may be contributing to autoimmunity and disease development in localized scleroderma...
  63. doi request reprint Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis: a multicenter cross-sectional study
    Yasuhito Hamaguchi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Arch Dermatol 147:391-8. 2011
    ..To clarify the association of clinical and prognostic features with dermatomyositis (DM)-specific autoantibodies (Abs) in adult Japanese patients with DM...
  64. ncbi request reprint Serum levels of tumor necrosis factor and interleukin-13 are elevated in patients with localized scleroderma
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Dermatology 207:141-7. 2003
    ..The enhanced production of some cytokines may be related to the pathogenesis of localized scleroderma (LSc)...
  65. doi request reprint Myositis-specific anti-155/140 autoantibodies target transcription intermediary factor 1 family proteins
    Manabu Fujimoto
    Department of Dermatology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa, Japan
    Arthritis Rheum 64:513-22. 2012
    ....
  66. doi request reprint Host-derived MCP-1 and MIP-1α regulate protective anti-tumor immunity to localized and metastatic B16 melanoma
    Yuko Nakasone
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Am J Pathol 180:365-74. 2012
    ..These results indicate that host-derived MCP-1 and MIP-1α regulate protective anti-tumor immunity to B16 F10 melanoma by promoting lymphocyte infiltration into the tumor and subsequent cytokine production...
  67. ncbi request reprint Role of C-C chemokine receptors 1 and 5 and CCL3/macrophage inflammatory protein-1alpha in the cutaneous Arthus reaction: possible attenuation of their inhibitory effects by compensatory chemokine production
    Koichi Yanaba
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Eur J Immunol 34:3553-61. 2004
    ..These results indicate that CCR1, CCR5, and CCL3 cooperatively contribute to the cutaneous Arthus reaction, and also suggest that enhanced expression of CCL3 and CCL5 compensates for the loss of CCR1, CCR5, and CCL3 in the reaction...
  68. ncbi request reprint Anti-lipoprotein lipase antibody in systemic sclerosis: association with elevated serum triglyceride concentrations
    Masanari Kodera
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Rheumatol 32:629-36. 2005
    ..We investigated the prevalence and levels of anti-LPL antibodies, their clinical correlation, and their functional significance in patients with SSc...
  69. ncbi request reprint Elevated serum BAFF levels in patients with systemic sclerosis: enhanced BAFF signaling in systemic sclerosis B lymphocytes
    Takashi Matsushita
    Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Arthritis Rheum 54:192-201. 2006
    ..To determine serum levels of BAFF, a potent B cell survival factor, in patients with systemic sclerosis (SSc) and relate the results to the clinical features of SSc...
  70. ncbi request reprint Implications of popliteal lymph node detected by sentinel lymph node biopsy
    Naohito Hatta
    Department of Dermatology, Kanazawa University School of Medicine, Takara machi, Kanazawa, Japan
    Dermatol Surg 31:327-30. 2005
    ..Recently, sentinel lymph nodes outside traditional nodal basins have been identified. This study investigated the incidence of sentinel nodes in the popliteal region and the indication for biopsy...
  71. ncbi request reprint Elevated expression of CD23 on peripheral blood B lymphocytes from patients with bullous pemphigoid: correlation with increased serum IgE
    Makoto Inaoki
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Dermatol Sci 35:53-9. 2004
    ..CD23, a low affinity Fc receptor for IgE, is mainly expressed on mature B lymphocytes. Studies have suggested that serum levels of soluble CD23 (sCD23) correlate with serum IgE levels and disease severity in BP...
  72. doi request reprint Re-emergence of anti-topoisomerase I antibody with exacerbated development of skin sclerosis in a patient with systemic sclerosis
    Yasuhito Hamaguchi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Am Acad Dermatol 62:142-4. 2010
    ..This case suggests a role for anti-topo I in the pathogenesis of systemic sclerosis and an effect of corticosteroids on skin sclerosis and autoantibody production...
  73. pmc CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse
    Eriko Saito
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Clin Invest 109:1453-62. 2002
    ..CD19 deficiency also inhibited IL-6 production by TSK/+ B cells. Thus, chronic B cell activation resulting from augmented CD19 signaling in TSK/+ mice leads to skin sclerosis possibly through IL-6 overproduction as well as autoimmunity...
  74. ncbi request reprint Comparative study of serum surfactant protein-D and KL-6 concentrations in patients with systemic sclerosis as markers for monitoring the activity of pulmonary fibrosis
    Koichi Yanaba
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Rheumatol 31:1112-20. 2004
    ..To clarify the clinical significance of surfactant protein-D (SP-D) and KL-6 in the diagnosis and monitoring of pulmonary fibrosis (PF) in patients with systemic sclerosis (SSc), and to evaluate the differences between SP-D and KL-6...
  75. ncbi request reprint Expression and localization of tissue kallikrein mRNAs in human epidermis and appendages
    Nahoko Komatsu
    Department of Dermatology, Graduate School of Medical Science, School of Medicine, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641, Japan
    J Invest Dermatol 121:542-9. 2003
    ..Coexpression of various KLK and SPINK5 mRNA suggests that their proteins are the candidates to balance and maintain serine protease activities in both the skin and appendages...
  76. doi request reprint Usefulness of anti-cyclic citrullinated peptide antibody and rheumatoid factor to detect rheumatoid arthritis in patients with systemic sclerosis
    Ikuko Ueda-Hayakawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Rheumatology (Oxford) 49:2135-9. 2010
    ..The purpose of this study was to determine the prevalence of anti-CCP antibodies (anti-CCP Abs) and to assess associations between the presence of anti-CCP Ab and arthritis or arthralgia in SSc patients...
  77. pmc Autoantibody against matrix metalloproteinase-3 in patients with systemic sclerosis
    C Nishijima
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Clin Exp Immunol 138:357-63. 2004
    ..These results suggest that anti-MMP-3 antibody is a serological marker that reflects the severity of SSc and also suggest that it may contribute to the development of fibrosis by inhibiting MMP-3 activity and reducing the ECM turnover...
  78. doi request reprint CCL13 is a promising diagnostic marker for systemic sclerosis
    K Yanaba
    Department of Dermatology, Nagasaki University Graduate School of Biomedical Sciences, 1 7 1 Sakamoto, Nagasaki 852 8501, Japan
    Br J Dermatol 162:332-6. 2010
    ..Previous studies suggest that CCL13 may have some role in the pathogenesis of systemic sclerosis (SSc)...
  79. ncbi request reprint Increased cutaneous T-cell-attracting chemokine levels in sera from patients with systemic sclerosis
    I Hayakawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Rheumatology (Oxford) 44:873-8. 2005
    ....
  80. ncbi request reprint Antinucleosome antibody is a major autoantibody in localized scleroderma
    S Sato
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Br J Dermatol 151:1182-8. 2004
    ..Therefore, it has been hypothesized that antihistone antibody is induced by nucleosome or native chromatin as immunogens in LSc...
  81. ncbi request reprint Elevated levels of circulating CD44 in patients with systemic sclerosis: association with a milder subset
    K Komura
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Rheumatology (Oxford) 41:1149-54. 2002
    ..To determine serum levels of soluble CD44 (sCD44), one of the adhesion molecules that regulate the migration of leucocytes, and clinical associations of these levels in patients with systemic sclerosis (SSc)...
  82. ncbi request reprint Clinical significance of anti-topoisomerase I antibody levels determined by ELISA in systemic sclerosis
    S Sato
    Department of Dermatology, Kanazawa University School of Medicine, Kanazawa, Ishikawa, Japan
    Rheumatology (Oxford) 40:1135-40. 2001
    ..CONCLUSIONS: These results suggest the potential clinical significance of anti-topo I antibody levels in evaluating disease severity and the prognosis in SSc...
  83. ncbi request reprint Identification of a novel autoantibody reactive with 155 and 140 kDa nuclear proteins in patients with dermatomyositis: an association with malignancy
    K Kaji
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Rheumatology (Oxford) 46:25-8. 2007
    ..In this study, we identified a novel MSA reactive with 155 and 140 kDa nuclear proteins [anti-155/140 antibody (Ab)] and determined the clinical feature of DM patients positive for this autoantibody (autoAb)...
  84. pmc Regulation of local and metastatic host-mediated anti-tumour mechanisms by L-selectin and intercellular adhesion molecule-1
    M Yamada
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Clin Exp Immunol 143:216-27. 2006
    ..The results indicate that L-selectin and ICAM-1 contribute co-operatively to the anti-tumour reaction by regulating lymphocyte infiltration to the tumour...
  85. pmc Autoantibodies directed against the protease inhibitor calpastatin in psoriasis
    Y Matsushita
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Clin Exp Immunol 139:355-62. 2005
    ..Calpain II expression was up-regulated in psoriasis skin lesions compared with normal skin while calpastatin expression was normal. The results of this study reveal the presence of anti-calpastatin autoantibody in psoriasis...
  86. ncbi request reprint A clue for telangiectasis in systemic sclerosis: elevated serum soluble endoglin levels in patients with the limited cutaneous form of the disease
    M Fujimoto
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Japan
    Dermatology 213:88-92. 2006
    ..The role of endoglin in SSc is potentially intriguing since limited cutaneous SSc (lcSSc) and HHT share several symptoms, including telangiectasia...
  87. ncbi request reprint Role and interaction of connective tissue growth factor with transforming growth factor-beta in persistent fibrosis: A mouse fibrosis model
    T Mori
    Department of Dermatology, Kanazawa University School of Medicine, Kanazawa, Ishikawa, Japan
    J Cell Physiol 181:153-9. 1999
    ..The animal model on skin fibrosis by exogenous application of growth factors developed in this study may prove useful for future studies on fibrotic disorders...
  88. doi request reprint Intractable genital ulcers from herpes simplex virus reactivation in drug-induced hypersensitivity syndrome caused by allopurinol
    Yasuhito Hamaguchi
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Int J Dermatol 49:700-4. 2010
    ..Reactivation of HHV family members is generally characterized by increased serum antibody titers against the virus. By contrast, clinical symptoms caused by viral reactivation are relatively rare...
  89. doi request reprint Use of serum clara cell 16-kDa (CC16) levels as a potential indicator of active pulmonary fibrosis in systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa, Japan
    J Rheumatol 38:877-84. 2011
    ....
  90. doi request reprint Serum chemokine and cytokine levels as indicators of disease activity in patients with systemic sclerosis
    Minoru Hasegawa
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa, 920 8641, Japan
    Clin Rheumatol 30:231-7. 2011
    ..However, a longer-term prospective study in a larger population will be needed to confirm its clinical utility as predictors of outcomes...
  91. ncbi request reprint Myocardial damages in systemic sclerosis detected by gated myocardial perfusion SPECT and sympathetic imaging
    Kenichi Nakajima
    Department of Nuclear Medicine, Kanazawa University Hospital, Kanazawa 920 8641, Japan
    Circ J 70:1481-7. 2006
    ....
  92. ncbi request reprint The frequency of type 2 CD8+ T cells is increased in peripheral blood from patients with psoriasis vulgaris
    Makoto Inaoki
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Clin Immunol 23:269-78. 2003
    ..Our findings suggest an increase in Tc2 cell number in blood from psoriatic patients, and the association of Tc2 cells with inflammation in psoriasis...
  93. ncbi request reprint Novel autoantibody to Cu/Zn superoxide dismutase in patients with localized scleroderma
    Masaki Nagai
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Invest Dermatol 122:594-601. 2004
    ....
  94. ncbi request reprint The diagnostic value of oesophageal transit scintigraphy for evaluating the severity of oesophageal complications in systemic sclerosis
    Kenichi Nakajima
    Department of Nuclear Medicine, Kanazawa University Hospital, Japan
    Nucl Med Commun 25:375-81. 2004
    ..Oesophageal complications are common in systemic sclerosis (SSc). However, the ability to determine the severity of oesophageal complications according to SSc type and skin lesion has not been evaluated...
  95. ncbi request reprint Function blocking autoantibodies against matrix metalloproteinase-1 in patients with systemic sclerosis
    Shinichi Sato
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Japan
    J Invest Dermatol 120:542-7. 2003
    ....
  96. ncbi request reprint Sentinel lymph node biopsy in patients with extramammary Paget's disease
    Naohito Hatta
    Department of Dermatology, Kanazawa University School of Medicine, Takara machi, Kanazawa, Japan
    Dermatol Surg 30:1329-34. 2004
    ..Despite the poor prognosis for patients with lymph node metastasis, management of extramammary Paget's disease without clinical evidence of involved nodes is controversial...
  97. ncbi request reprint Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis
    Shinichi Sato
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Mol Immunol 41:1123-33. 2004
    ..Thus, chronic B cell activation resulting from augmented CD19 signaling leads to skin fibrosis possibly through IL-6 overproduction, as well as autoantibody production, in tight-skin mice and SSc patients...
  98. ncbi request reprint [A case of lepromatous type Hansen's disease]
    Fumiaki Shirasaki
    Kanazawa University Graduate School of Medical Science, Department of Dermatology, 15 1 Takara machi, Kanazawa 920 8641, Japan
    Nihon Hansenbyo Gakkai Zasshi 72:267-70. 2003
    ..Although a severe type 1 reaction developed after four months of treatment, he was treated with oral prednisolone at a dose of 40 mg/day...
  99. doi request reprint Esophageal transit scintigraphy and structured questionnaire in patients with systemic sclerosis with endoscopically proven reflux esophagitis
    Kenichi Nakajima
    Department of Nuclear Medicine, Kanazawa University Hospital, Kanazawa, Japan
    Ann Nucl Med 23:771-6. 2009
    ..The relationship between gastroesophageal reflux (GER) symptoms and dysmotility was examined in endoscopically confirmed patients suspected of having reflux esophagitis...
  100. ncbi request reprint Clinical significance of soluble CD31 in patients with systemic sclerosis (SSc): association with limited cutaneous SSc
    S Sato
    Department of Dermatology, Kanazawa University School of Medicine, Ishikawa, Japan
    J Rheumatol 28:2460-5. 2001
    ..To determine serum levels of soluble CD31 (sCD31) and its clinical associations in patients with systemic sclerosis (SSc)...
  101. pmc Antiphospholipid antibody in localised scleroderma
    S Sato
    Department of Dermatology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Ann Rheum Dis 62:771-4. 2003
    ..To investigate the prevalence and clinical correlation of antiphospholipid antibodies in localised scleroderma...