Rikako Suzuki

Summary

Affiliation: Kanazawa Medical University
Country: Japan

Publications

  1. ncbi request reprint Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Carcinogenesis 27:162-9. 2006
  2. pmc Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    BMC Cancer 7:84. 2007
  3. ncbi request reprint Dietary protocatechuic acid during the progression phase exerts chemopreventive effects on chemically induced rat tongue carcinogenesis
    Rikako Suzuki
    The First Departments of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Asian Pac J Cancer Prev 4:319-26. 2003
  4. ncbi request reprint Dose-dependent promoting effect of dextran sodium sulfate on mouse colon carcinogenesis initiated with azoxymethane
    R Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Histol Histopathol 20:483-92. 2005
  5. ncbi request reprint Preventive effects of extract of leaves of ginkgo (Ginkgo biloba) and its component bilobalide on azoxymethane-induced colonic aberrant crypt foci in rats
    Rikako Suzuki
    The First Department of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Cancer Lett 210:159-69. 2004
  6. ncbi request reprint Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats
    Rikako Suzuki
    The First Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Biofactors 22:111-4. 2004
  7. ncbi request reprint 9trans,11trans conjugated linoleic acid inhibits the development of azoxymethane-induced colonic aberrant crypt foci in rats
    Yumiko Yasui
    Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
    Nutr Cancer 59:82-91. 2007
  8. ncbi request reprint Diet supplemented with citrus unshiu segment membrane suppresses chemically induced colonic preneoplastic lesions and fatty liver in male db/db mice
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
    Int J Cancer 120:252-8. 2007
  9. ncbi request reprint Catalpa seed oil rich in 9t,11t,13c-conjugated linolenic acid suppresses the development of colonic aberrant crypt foci induced by azoxymethane in rats
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Oncol Rep 16:989-96. 2006
  10. ncbi request reprint Dietary supplementation with silymarin inhibits 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in male F344 rats
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
    Clin Cancer Res 11:4962-7. 2005

Detail Information

Publications40

  1. ncbi request reprint Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in mice
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Carcinogenesis 27:162-9. 2006
    ..These differences may have been directly influenced by the response to nitrosation stress due to the inflammation caused by DSS...
  2. pmc Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfate
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    BMC Cancer 7:84. 2007
    ....
  3. ncbi request reprint Dietary protocatechuic acid during the progression phase exerts chemopreventive effects on chemically induced rat tongue carcinogenesis
    Rikako Suzuki
    The First Departments of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Asian Pac J Cancer Prev 4:319-26. 2003
    ..001) during progression phase. Our results suggest that dietary PCA inhibits progression of 4-NQO-induced oral carcinogenesis, and such inhibition might be related to suppression of cell proliferation by PCA...
  4. ncbi request reprint Dose-dependent promoting effect of dextran sodium sulfate on mouse colon carcinogenesis initiated with azoxymethane
    R Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Histol Histopathol 20:483-92. 2005
    ..Thus, our findings indicate that a tumor-promoting effect of DSS was dose-dependent (1% or more) and the effect might occur under the condition of inflammation and nitrosation stress...
  5. ncbi request reprint Preventive effects of extract of leaves of ginkgo (Ginkgo biloba) and its component bilobalide on azoxymethane-induced colonic aberrant crypt foci in rats
    Rikako Suzuki
    The First Department of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Cancer Lett 210:159-69. 2004
    ..These findings might suggest possible chemopreventive ability of EGb or bilobalide, through alterations in cryptal cell proliferation activity and drug metabolizing enzymes' activities, in colon tumorigenesis...
  6. ncbi request reprint Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in rats
    Rikako Suzuki
    The First Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Biofactors 22:111-4. 2004
    ..These findings might suggest that citrus nobiletin has chemopreventive ability against AOM-induced rat colon carcinogenesis...
  7. ncbi request reprint 9trans,11trans conjugated linoleic acid inhibits the development of azoxymethane-induced colonic aberrant crypt foci in rats
    Yumiko Yasui
    Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
    Nutr Cancer 59:82-91. 2007
    ..Our findings thus provide some novel insight into the chemopreventive effect of 9t,11t-CLA against preinitiation as well as postinitiation stages of colorectal carcinogenesis...
  8. ncbi request reprint Diet supplemented with citrus unshiu segment membrane suppresses chemically induced colonic preneoplastic lesions and fatty liver in male db/db mice
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
    Int J Cancer 120:252-8. 2007
    ....
  9. ncbi request reprint Catalpa seed oil rich in 9t,11t,13c-conjugated linolenic acid suppresses the development of colonic aberrant crypt foci induced by azoxymethane in rats
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Oncol Rep 16:989-96. 2006
    ..These findings suggest the possible chemopreventive activity of CPO in the early phase of colon carcinogenesis...
  10. ncbi request reprint Dietary supplementation with silymarin inhibits 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in male F344 rats
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
    Clin Cancer Res 11:4962-7. 2005
    ..Here, we investigated the modifying effects of dietary feeding with a naturally occurring polyphenolic antioxidant flavonoid silymarin on 3,2'-dimethyl-4-aminobiphenyl (DMAB)-induced prostatic carcinogenesis in male F344 rats...
  11. ncbi request reprint Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Cancer Sci 96:69-76. 2005
    ....
  12. ncbi request reprint Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPARgamma expression and alteration of lipid composition
    Hiroyuki Kohno
    First Departments of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Int J Cancer 110:896-901. 2004
    ....
  13. ncbi request reprint A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfate
    Takuji Tanaka
    The First Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293
    Cancer Sci 94:965-73. 2003
    ....
  14. ncbi request reprint A lipophilic statin, pitavastatin, suppresses inflammation-associated mouse colon carcinogenesis
    Yumiko Yasui
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 121:2331-9. 2007
    ..Our findings thus show that pitavastatin is effective in inhibiting colitis-related colon carcinogenesis through modulation of mucosal inflammation, oxidative/nitrosative stress, and cell proliferation...
  15. ncbi request reprint Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess beta-catenin gene mutations and increases immunoreactivity for beta-catenin, cycloox
    Takuji Tanaka
    The Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Carcinogenesis 26:229-38. 2005
    ..The findings suggest that DSS exerts powerful tumor-promoting effects on PhIP-initiated colon carcinogenesis in mice and this mouse model is useful for investigating environment-related colon carcinogenesis within a short-term period...
  16. ncbi request reprint Citrus auraptene suppresses azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db mice
    Kei Hayashi
    Department of Surgical Oncology, Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Oshikawaa 020 0903, Japan
    Nutr Cancer 58:75-84. 2007
    ....
  17. ncbi request reprint A specific inducible nitric oxide synthase inhibitor, ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) mice
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 121:506-13. 2007
    ..Our findings may suggest that ONO-1714 could therefore serve as an effective agent for suppression of colitis-related colon cancer development in the Apc(Min/+) mice...
  18. ncbi request reprint An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studies
    Rikako Suzuki
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Carcinogenesis 27:619-30. 2006
    ....
  19. pmc Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligands
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    BMC Cancer 5:46. 2005
    ....
  20. ncbi request reprint Dietary beta-cryptoxanthin inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice
    Katsuhito Miyazawa
    Department of Urogenital Surgery, Kanazawa Medical University, Ishikawa 920 0293, Japan
    Oncol Rep 17:297-304. 2007
    ..These findings suggest that beta-cryptoxanthin is able to prevent OH-BBN-induced bladder carcinogenesis in mice...
  21. ncbi request reprint Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in rats
    Hiroyuki Kohno
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Cancer Sci 95:481-6. 2004
    ....
  22. ncbi request reprint Dextran sodium sulfate strongly promotes colorectal carcinogenesis in Apc(Min/+) mice: inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasms
    Takuji Tanaka
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 118:25-34. 2006
    ..The findings also suggest that strong oxidative/nitrosative stress caused by DSS-induced inflammation may contribute to the colonic neoplasms development...
  23. ncbi request reprint Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in mice
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
    Clin Cancer Res 13:2519-25. 2007
    ..Inflammation influences carcinogenesis. In the current study, we investigated whether ursodeoxycholic acid (UDCA) can inhibit colitis-related mouse colon carcinogenesis and compared it with the effects of sulfasalazine...
  24. ncbi request reprint Tumor-initiating potency of a novel heterocyclic amine, aminophenylnorharman in mouse colonic carcinogenesis model
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
    Int J Cancer 121:1659-64. 2007
    ..These findings indicate that APNH has an initiating activity in inflamed mouse colon and the APNH-DNA adduct formation correlates with its tumorigenic potential...
  25. ncbi request reprint Dietary administration with prenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in mice
    Hiroyuki Kohno
    Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 118:2936-42. 2006
    ..Our findings may suggest that certain prenyloxycoumarins, such as auraptene and collinin, could serve as an effective agent against colitis-related colon cancer development in rodents...
  26. ncbi request reprint Suppressive effect of 1,4-phenylene diisothiocyanate on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR mice
    Shigeyuki Sugie
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 117:524-30. 2005
    ..These results suggest that dietary DITC could be a preventive agent against BBN-induced bladder carcinogenesis in mice when fed during the initiation phase...
  27. ncbi request reprint Lack of modifying effects of 4-ter t-octylphenol and benzyl butyl phthalate on 3,2-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in rats
    Hiroyuki Kohno
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Cancer Sci 95:300-5. 2004
    ..These results might suggest that dietary feeding of the estrogenic compounds tOP and BBP did not modulate DMAB-induced prostatic carcinogenesis in rats...
  28. ncbi request reprint Effect of alpha-naphthyl isothiocyanate on 2-amino-3-methylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in rats
    Shigeyuki Sugie
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Int J Cancer 115:346-50. 2005
    ..These results imply that the isothiocyanate compound ANIT shows potent inhibitory effects on mammary carcinogenesis induced by PhIP in female SD rats when administered during the initiation stage...
  29. ncbi request reprint Dietary conjugated linolenic acid inhibits azoxymethane-induced colonic aberrant crypt foci in rats
    Hiroyuki Kohno
    Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Jpn J Cancer Res 93:133-42. 2002
    ..These findings might suggest possible chemopreventive activity of CLN in the early phase of colon tumorigenesis through modulation of cryptal cell proliferation activity and/or apoptosis...
  30. ncbi request reprint Lack of modifying effects of an estrogenic compound atrazine on 7,12-dimethylbenz(a)anthracene-induced ovarian carcinogenesis in rats
    Takuji Tanaka
    The First Department of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    Cancer Lett 210:129-37. 2004
    ..These results might suggest dietary feeding of a EDC atrazine did not affect DMBA-induced rat ovarian carcinogenesis...
  31. ncbi request reprint Preventive effects of chrysin on the development of azoxymethane-induced colonic aberrant crypt foci in rats
    Shingo Miyamoto
    Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
    Oncol Rep 15:1169-73. 2006
    ..These findings might suggest a possible chemopreventive activity of chrysin in the early step of colon tumorigenesis through modulation of cryptal cell proliferation activity and apoptosis...
  32. ncbi request reprint Sequential observations on the occurrence of preneoplastic and neoplastic lesions in mouse colon treated with azoxymethane and dextran sodium sulfate
    Rikako Suzuki
    Research Fellow of the Japan Society for the Promotion of Science, Chiyoda ku, Tokyo 102 8471, Japan
    Cancer Sci 95:721-7. 2004
    ..Our results suggest that combined treatment of mice with AOM and DSS generates neoplasms in the colonic mucosa via dysplastic lesions induced by nitrosative stress...
  33. ncbi request reprint Prevention of rat hepatocarcinogenesis by acyclic retinoid is accompanied by reduction in emergence of both TGF-alpha-expressing oval-like cells and activated hepatic stellate cells
    Tetsuro Sano
    Pharmaceutical Research Laboratories, Nikken Chemicals Co, Saitama, Japan
    Nutr Cancer 51:197-206. 2005
    ..These results suggest that NIK-333 is a promising drug for the chemoprevention of HCC by uniquely suppressing the early events of hepatocarcinogenesis, that is, development of both oval-like cells and fibrogenesis...
  34. ncbi request reprint Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARgamma in human colon cancer Caco-2 cells
    Yumiko Yasui
    Graduate School of Fisheries Sciences, Hokkaido University, 3 1 1 Minato, Hakodate, Hokkaido 041 8611, Japan
    Prostaglandins Leukot Essent Fatty Acids 73:113-9. 2005
    ..These results suggest that BGO-FFA rich in 9c,11t,13t-CLN may induce apoptosis in Caco-2 cells through up-regulation of GADD45, p53 and PPARgamma...
  35. ncbi request reprint Lack of enhancing effects of degraded lambda-carrageenan on the development of beta-catenin-accumulated crypts in male DBA/2J mice initiated with azoxymethane
    Kazuya Hata
    BMR Laboratories, Sunplanet Co, Ltd, 4388 Hagiwara, Kamiishidu, Yoro gun, Gifu 503 1602, Japan
    Cancer Lett 238:69-75. 2006
    ..Our results may indicate no enhancing or promoting effects of degraded lambda-carrageenan on colon carcinogenesis in mice initiated with AOM...
  36. ncbi request reprint beta-Catenin-accumulated crypts in the colonic mucosa of juvenile ApcMin/+ mice
    Kazuya Hata
    BMR Laboratories, Sunplanet Co, Ltd, 4388 Hagiwara, Kamiishidu, Yourou, Gifu 503 1602, Japan
    Cancer Lett 239:123-8. 2006
    ..Also, a few microadenomas were detected in Apc(Min/+) mice of 5-week old. Our results may indicate need of further investigation of the colorectal mucosa of Apc(Min/+) mice for examining colorectal carcinogenesis using Apc(Min/+) mice...
  37. ncbi request reprint An acyclic retinoid, NIK-333, inhibits N-diethylnitrosamine-induced rat hepatocarcinogenesis through suppression of TGF-alpha expression and cell proliferation
    Masataka Kagawa
    Pharmaceutical Research Laboratories, Nikken Chemicals Co Ltd, 1 346 Kitabukuro cho, Omiya ku, Saitama shi, Saitama 330 0835, Japan
    Carcinogenesis 25:979-85. 2004
    ..01). Our results suggest that NIK-333 inhibits DEN-induced hepatocarcinogenesis through suppression of TGF-alpha expression and cell proliferation...
  38. ncbi request reprint A prostaglandin E2 receptor subtype EP1-selective antagonist, ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis
    Hiroki Makita
    Department of Oral and Maxillofacial Sciences, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
    Carcinogenesis 28:677-84. 2007
    ....
  39. ncbi request reprint Indole-3-carbinol inhibits the growth of human colon carcinoma cells but enhances the tumor multiplicity and volume of azoxymethane-induced rat colon carcinogenesis
    Masumi Suzui
    Tumor Pathology Division, Faculty of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
    Int J Oncol 27:1391-9. 2005
    ..Therefore, the present study may provide further evidence for the ambivalent modulatory activity of I3C and this information may be useful when including I3C in cancer chemoprevention and/or extensive clinical therapy trials...
  40. ncbi request reprint Clinical evaluation of circulating interleukin-6 and interleukin-10 levels after surgery-induced inflammation
    Kenichi Miyaoka
    Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry, Tokyo, Japan
    J Surg Res 125:144-50. 2005
    ..This prospective study assessed the risk of SIRS and MODS after orthognathic surgery by measuring the circulating levels of inflammatory cytokines such as IL-6 and IL-10 as well as the neutrophil functions as a marker of organ failure...