Research Topics
Genomes and Genes | Rikako SuzukiSummaryAffiliation: Kanazawa Medical University Country: Japan Publications
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Publications
Strain differences in the susceptibility to azoxymethane and dextran sodium sulfate-induced colon carcinogenesis in miceRikako Suzuki
Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
Carcinogenesis 27:162-9. 2006..These differences may have been directly influenced by the response to nitrosation stress due to the inflammation caused by DSS...
Global gene expression analysis of the mouse colonic mucosa treated with azoxymethane and dextran sodium sulfateRikako Suzuki
Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
BMC Cancer 7:84. 2007....- Dietary protocatechuic acid during the progression phase exerts chemopreventive effects on chemically induced rat tongue carcinogenesisRikako Suzuki
The First Departments of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
Asian Pac J Cancer Prev 4:319-26. 2003..001) during progression phase. Our results suggest that dietary PCA inhibits progression of 4-NQO-induced oral carcinogenesis, and such inhibition might be related to suppression of cell proliferation by PCA... - Dose-dependent promoting effect of dextran sodium sulfate on mouse colon carcinogenesis initiated with azoxymethaneR Suzuki
Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
Histol Histopathol 20:483-92. 2005..Thus, our findings indicate that a tumor-promoting effect of DSS was dose-dependent (1% or more) and the effect might occur under the condition of inflammation and nitrosation stress... - Preventive effects of extract of leaves of ginkgo (Ginkgo biloba) and its component bilobalide on azoxymethane-induced colonic aberrant crypt foci in ratsRikako Suzuki
The First Department of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
Cancer Lett 210:159-69. 2004..These findings might suggest possible chemopreventive ability of EGb or bilobalide, through alterations in cryptal cell proliferation activity and drug metabolizing enzymes' activities, in colon tumorigenesis... - Citrus nobiletin inhibits azoxymethane-induced large bowel carcinogenesis in ratsRikako Suzuki
The First Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
Biofactors 22:111-4. 2004..These findings might suggest that citrus nobiletin has chemopreventive ability against AOM-induced rat colon carcinogenesis... - 9trans,11trans conjugated linoleic acid inhibits the development of azoxymethane-induced colonic aberrant crypt foci in ratsYumiko Yasui
Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
Nutr Cancer 59:82-91. 2007..Our findings thus provide some novel insight into the chemopreventive effect of 9t,11t-CLA against preinitiation as well as postinitiation stages of colorectal carcinogenesis... - Diet supplemented with citrus unshiu segment membrane suppresses chemically induced colonic preneoplastic lesions and fatty liver in male db/db miceRikako Suzuki
Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
Int J Cancer 120:252-8. 2007.... - Catalpa seed oil rich in 9t,11t,13c-conjugated linolenic acid suppresses the development of colonic aberrant crypt foci induced by azoxymethane in ratsRikako Suzuki
Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920-0293, Japan
Oncol Rep 16:989-96. 2006..These findings suggest the possible chemopreventive activity of CPO in the early phase of colon carcinogenesis... - Dietary supplementation with silymarin inhibits 3,2'-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in male F344 ratsHiroyuki Kohno
Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
Clin Cancer Res 11:4962-7. 2005..Here, we investigated the modifying effects of dietary feeding with a naturally occurring polyphenolic antioxidant flavonoid silymarin on 3,2'-dimethyl-4-aminobiphenyl (DMAB)-induced prostatic carcinogenesis in male F344 rats... - Beta-Catenin mutations in a mouse model of inflammation-related colon carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfateHiroyuki Kohno
Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
Cancer Sci 96:69-76. 2005.... - Dietary seed oil rich in conjugated linolenic acid from bitter melon inhibits azoxymethane-induced rat colon carcinogenesis through elevation of colonic PPARgamma expression and alteration of lipid compositionHiroyuki Kohno
First Departments of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
Int J Cancer 110:896-901. 2004.... - A novel inflammation-related mouse colon carcinogenesis model induced by azoxymethane and dextran sodium sulfateTakuji Tanaka
The First Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293
Cancer Sci 94:965-73. 2003.... - A lipophilic statin, pitavastatin, suppresses inflammation-associated mouse colon carcinogenesisYumiko Yasui
Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
Int J Cancer 121:2331-9. 2007..Our findings thus show that pitavastatin is effective in inhibiting colitis-related colon carcinogenesis through modulation of mucosal inflammation, oxidative/nitrosative stress, and cell proliferation... - Colonic adenocarcinomas rapidly induced by the combined treatment with 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and dextran sodium sulfate in male ICR mice possess beta-catenin gene mutations and increases immunoreactivity for beta-catenin, cyclooxTakuji Tanaka
The Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
Carcinogenesis 26:229-38. 2005..The findings suggest that DSS exerts powerful tumor-promoting effects on PhIP-initiated colon carcinogenesis in mice and this mouse model is useful for investigating environment-related colon carcinogenesis within a short-term period... - Citrus auraptene suppresses azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db miceKei Hayashi
Department of Surgical Oncology, Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Oshikawaa 020 0903, Japan
Nutr Cancer 58:75-84. 2007.... - A specific inducible nitric oxide synthase inhibitor, ONO-1714 attenuates inflammation-related large bowel carcinogenesis in male Apc(Min/+) miceHiroyuki Kohno
Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
Int J Cancer 121:506-13. 2007..Our findings may suggest that ONO-1714 could therefore serve as an effective agent for suppression of colitis-related colon cancer development in the Apc(Min/+) mice... - An animal model for the rapid induction of tongue neoplasms in human c-Ha-ras proto-oncogene transgenic rats by 4-nitroquinoline 1-oxide: its potential use for preclinical chemoprevention studiesRikako Suzuki
Department of Oncologic Pathology, Kanazawa Medical University, 1-1 Daigaku, Uchinada, Ishikawa 920-0293, Japan
Carcinogenesis 27:619-30. 2006.... - Suppression of colitis-related mouse colon carcinogenesis by a COX-2 inhibitor and PPAR ligandsHiroyuki Kohno
Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
BMC Cancer 5:46. 2005.... - Dietary beta-cryptoxanthin inhibits N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR miceKatsuhito Miyazawa
Department of Urogenital Surgery, Kanazawa Medical University, Ishikawa 920 0293, Japan
Oncol Rep 17:297-304. 2007..These findings suggest that beta-cryptoxanthin is able to prevent OH-BBN-induced bladder carcinogenesis in mice... - Pomegranate seed oil rich in conjugated linolenic acid suppresses chemically induced colon carcinogenesis in ratsHiroyuki Kohno
Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
Cancer Sci 95:481-6. 2004.... - Dextran sodium sulfate strongly promotes colorectal carcinogenesis in Apc(Min/+) mice: inflammatory stimuli by dextran sodium sulfate results in development of multiple colonic neoplasmsTakuji Tanaka
Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
Int J Cancer 118:25-34. 2006..The findings also suggest that strong oxidative/nitrosative stress caused by DSS-induced inflammation may contribute to the colonic neoplasms development... - Ursodeoxycholic acid versus sulfasalazine in colitis-related colon carcinogenesis in miceHiroyuki Kohno
Department of Oncologic Pathology, Kanazawa Medical University, Ishikawa, Japan
Clin Cancer Res 13:2519-25. 2007..Inflammation influences carcinogenesis. In the current study, we investigated whether ursodeoxycholic acid (UDCA) can inhibit colitis-related mouse colon carcinogenesis and compared it with the effects of sulfasalazine... - Tumor-initiating potency of a novel heterocyclic amine, aminophenylnorharman in mouse colonic carcinogenesis modelHiroyuki Kohno
Department of Oncologic Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa, Japan
Int J Cancer 121:1659-64. 2007..These findings indicate that APNH has an initiating activity in inflamed mouse colon and the APNH-DNA adduct formation correlates with its tumorigenic potential... - Dietary administration with prenyloxycoumarins, auraptene and collinin, inhibits colitis-related colon carcinogenesis in miceHiroyuki Kohno
Department of Oncologic Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
Int J Cancer 118:2936-42. 2006..Our findings may suggest that certain prenyloxycoumarins, such as auraptene and collinin, could serve as an effective agent against colitis-related colon cancer development in rodents... - Suppressive effect of 1,4-phenylene diisothiocyanate on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in male ICR miceShigeyuki Sugie
Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
Int J Cancer 117:524-30. 2005..These results suggest that dietary DITC could be a preventive agent against BBN-induced bladder carcinogenesis in mice when fed during the initiation phase... - Lack of modifying effects of 4-ter t-octylphenol and benzyl butyl phthalate on 3,2-dimethyl-4-aminobiphenyl-induced prostate carcinogenesis in ratsHiroyuki Kohno
Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
Cancer Sci 95:300-5. 2004..These results might suggest that dietary feeding of the estrogenic compounds tOP and BBP did not modulate DMAB-induced prostatic carcinogenesis in rats... - Effect of alpha-naphthyl isothiocyanate on 2-amino-3-methylimidazo[4,5-b]pyridine (PhIP)-induced mammary carcinogenesis in ratsShigeyuki Sugie
Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa, Japan
Int J Cancer 115:346-50. 2005..These results imply that the isothiocyanate compound ANIT shows potent inhibitory effects on mammary carcinogenesis induced by PhIP in female SD rats when administered during the initiation stage... - Dietary conjugated linolenic acid inhibits azoxymethane-induced colonic aberrant crypt foci in ratsHiroyuki Kohno
Department of Pathology, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
Jpn J Cancer Res 93:133-42. 2002..These findings might suggest possible chemopreventive activity of CLN in the early phase of colon tumorigenesis through modulation of cryptal cell proliferation activity and/or apoptosis... - Lack of modifying effects of an estrogenic compound atrazine on 7,12-dimethylbenz(a)anthracene-induced ovarian carcinogenesis in ratsTakuji Tanaka
The First Department of Pathology, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
Cancer Lett 210:129-37. 2004..These results might suggest dietary feeding of a EDC atrazine did not affect DMBA-induced rat ovarian carcinogenesis... - Preventive effects of chrysin on the development of azoxymethane-induced colonic aberrant crypt foci in ratsShingo Miyamoto
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto 606 8502, Japan
Oncol Rep 15:1169-73. 2006..These findings might suggest a possible chemopreventive activity of chrysin in the early step of colon tumorigenesis through modulation of cryptal cell proliferation activity and apoptosis... - Sequential observations on the occurrence of preneoplastic and neoplastic lesions in mouse colon treated with azoxymethane and dextran sodium sulfateRikako Suzuki
Research Fellow of the Japan Society for the Promotion of Science, Chiyoda-ku, Tokyo 102-8471, Japan
Cancer Sci 95:721-7. 2004..Our results suggest that combined treatment of mice with AOM and DSS generates neoplasms in the colonic mucosa via dysplastic lesions induced by nitrosative stress... - Prevention of rat hepatocarcinogenesis by acyclic retinoid is accompanied by reduction in emergence of both TGF-alpha-expressing oval-like cells and activated hepatic stellate cellsTetsuro Sano
Pharmaceutical Research Laboratories, Nikken Chemicals Co, Saitama, Japan
Nutr Cancer 51:197-206. 2005..These results suggest that NIK-333 is a promising drug for the chemoprevention of HCC by uniquely suppressing the early events of hepatocarcinogenesis, that is, development of both oval-like cells and fibrogenesis... - Bitter gourd seed fatty acid rich in 9c,11t,13t-conjugated linolenic acid induces apoptosis and up-regulates the GADD45, p53 and PPARgamma in human colon cancer Caco-2 cellsYumiko Yasui
Graduate School of Fisheries Sciences, Hokkaido University, 3-1-1 Minato, Hakodate, Hokkaido 041-8611, Japan
Prostaglandins Leukot Essent Fatty Acids 73:113-9. 2005..These results suggest that BGO-FFA rich in 9c,11t,13t-CLN may induce apoptosis in Caco-2 cells through up-regulation of GADD45, p53 and PPARgamma... - Lack of enhancing effects of degraded lambda-carrageenan on the development of beta-catenin-accumulated crypts in male DBA/2J mice initiated with azoxymethaneKazuya Hata
BMR Laboratories, Sunplanet Co, Ltd, 4388 Hagiwara, Kamiishidu, Yoro-gun, Gifu 503-1602, Japan
Cancer Lett 238:69-75. 2006..Our results may indicate no enhancing or promoting effects of degraded lambda-carrageenan on colon carcinogenesis in mice initiated with AOM... - beta-Catenin-accumulated crypts in the colonic mucosa of juvenile ApcMin/+ miceKazuya Hata
BMR Laboratories, Sunplanet Co, Ltd, 4388 Hagiwara, Kamiishidu, Yourou, Gifu 503 1602, Japan
Cancer Lett 239:123-8. 2006..Also, a few microadenomas were detected in Apc(Min/+) mice of 5-week old. Our results may indicate need of further investigation of the colorectal mucosa of Apc(Min/+) mice for examining colorectal carcinogenesis using Apc(Min/+) mice... - An acyclic retinoid, NIK-333, inhibits N-diethylnitrosamine-induced rat hepatocarcinogenesis through suppression of TGF-alpha expression and cell proliferationMasataka Kagawa
Pharmaceutical Research Laboratories, Nikken Chemicals Co. Ltd, 1-346 Kitabukuro-cho, Omiya-ku, Saitama-shi, Saitama 330-0835, Japan
Carcinogenesis 25:979-85. 2004..01). Our results suggest that NIK-333 inhibits DEN-induced hepatocarcinogenesis through suppression of TGF-alpha expression and cell proliferation... - A prostaglandin E2 receptor subtype EP1-selective antagonist, ONO-8711, suppresses 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesisHiroki Makita
Department of Oral and Maxillofacial Sciences, Gifu University Graduate School of Medicine, 1 1 Yanagido, Gifu 501 1194, Japan
Carcinogenesis 28:677-84. 2007.... - Indole-3-carbinol inhibits the growth of human colon carcinoma cells but enhances the tumor multiplicity and volume of azoxymethane-induced rat colon carcinogenesisMasumi Suzui
Tumor Pathology Division, Faculty of Medicine, University of the Ryukyus, Okinawa 903 0215, Japan
Int J Oncol 27:1391-9. 2005..Therefore, the present study may provide further evidence for the ambivalent modulatory activity of I3C and this information may be useful when including I3C in cancer chemoprevention and/or extensive clinical therapy trials... - Clinical evaluation of circulating interleukin-6 and interleukin-10 levels after surgery-induced inflammationKenichi Miyaoka
Department of Oral and Maxillofacial Surgery, Showa University School of Dentistry, Tokyo, Japan
J Surg Res 125:144-50. 2005..We conclude that the ratio of IL-6 to IL-10 may be a predictive factor in SIRS...