Nobuo Suzuki

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. ncbi request reprint Cloning of a calcitonin gene-related peptide receptor and a novel calcitonin receptor-like receptor from the gill of flounder, Paralichthys olivaceus
    N Suzuki
    Noto Marine Laboratory, Faculty of Science, Kanazawa University, Ishikawa, Japan
    Gene 244:81-8. 2000
  2. ncbi request reprint Both mercury and cadmium directly influence calcium homeostasis resulting from the suppression of scale bone cells: the scale is a good model for the evaluation of heavy metals in bone metabolism
    Nobuo Suzuki
    Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, 927 0553, Ishikawa, Uchiura, Japan
    J Bone Miner Metab 22:439-46. 2004
  3. ncbi request reprint Bisphenol A suppresses osteoclastic and osteoblastic activities in the cultured scales of goldfish
    Nobuo Suzuki
    Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Uchiura, Ishikawa 927 0553, Japan
    Life Sci 73:2237-47. 2003
  4. ncbi request reprint Bisphenol A influences the plasma calcium level and inhibits calcitonin secretion in goldfish
    Nobuo Suzuki
    Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Japan
    Zoolog Sci 20:745-8. 2003
  5. ncbi request reprint Melatonin suppresses osteoclastic and osteoblastic activities in the scales of goldfish
    Nobuo Suzuki
    Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Uchiura, Ishikawa 927 0553, Japan
    J Pineal Res 33:253-8. 2002
  6. ncbi request reprint Tributyltin inhibits osteoblastic activity and disrupts calcium metabolism through an increase in plasma calcium and calcitonin levels in teleosts
    Nobuo Suzuki
    Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Ishikawa 927 0553, Japan
    Life Sci 78:2533-41. 2006
  7. doi request reprint Novel bromomelatonin derivatives as potentially effective drugs to treat bone diseases
    Nobuo Suzuki
    Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Housu gun, Ishikawa, Japan
    J Pineal Res 45:229-34. 2008
  8. doi request reprint Monohydroxylated polycyclic aromatic hydrocarbons inhibit both osteoclastic and osteoblastic activities in teleost scales
    Nobuo Suzuki
    Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Noto cho, Ishikawa 927 0553, Japan
    Life Sci 84:482-8. 2009
  9. ncbi request reprint Cloning of a calcitonin gene-related peptide from genomic DNA and its mRNA expression in flounder, Paralichthys olivaceus
    N Suzuki
    Noto Marine Laboratory, Faculty of Science, Kanazawa University, Uchiura, 927 0553, Ishikawa, Japan
    Peptides 22:1435-8. 2001
  10. ncbi request reprint Calcitonin-like substance in the plasma of Cyclostomata and its putative role
    N Suzuki
    Noto Marine Laboratory, Faculty of Science, Kanazawa University, Ishikawa 927 0553, Uchiura, Japan
    Comp Biochem Physiol B Biochem Mol Biol 129:319-26. 2001

Collaborators

Detail Information

Publications29

  1. ncbi request reprint Cloning of a calcitonin gene-related peptide receptor and a novel calcitonin receptor-like receptor from the gill of flounder, Paralichthys olivaceus
    N Suzuki
    Noto Marine Laboratory, Faculty of Science, Kanazawa University, Ishikawa, Japan
    Gene 244:81-8. 2000
    ..2% at the amino-acid level, indicating that the receptor is not likely to be an isoform of CGRPR. The receptor, but not fCGRPR, is expressed in bones, suggesting the possibility that this receptor corresponds to the flounder CTR...
  2. ncbi request reprint Both mercury and cadmium directly influence calcium homeostasis resulting from the suppression of scale bone cells: the scale is a good model for the evaluation of heavy metals in bone metabolism
    Nobuo Suzuki
    Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, 927 0553, Ishikawa, Uchiura, Japan
    J Bone Miner Metab 22:439-46. 2004
    ..This study demonstrates that mercury directly acts on the bone cells and influences calcium homeostasis and indicates that, in a short-term exposure, mercury has a different action from that of cadmium and induces hypercalcemia...
  3. ncbi request reprint Bisphenol A suppresses osteoclastic and osteoblastic activities in the cultured scales of goldfish
    Nobuo Suzuki
    Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Uchiura, Ishikawa 927 0553, Japan
    Life Sci 73:2237-47. 2003
    ....
  4. ncbi request reprint Bisphenol A influences the plasma calcium level and inhibits calcitonin secretion in goldfish
    Nobuo Suzuki
    Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Japan
    Zoolog Sci 20:745-8. 2003
    ..Therefore, bisphenol A influences plasma calcium levels, but its action is different from that of estrogen, which indicates that bisphenol A affects the calcium homeostasis and might bring about abnormal conditions in teleosts...
  5. ncbi request reprint Melatonin suppresses osteoclastic and osteoblastic activities in the scales of goldfish
    Nobuo Suzuki
    Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Uchiura, Ishikawa 927 0553, Japan
    J Pineal Res 33:253-8. 2002
    ..This is the first report on the function of melatonin in osteoclasts and on the suppressive effect of melatonin in osteoblasts among vertebrates...
  6. ncbi request reprint Tributyltin inhibits osteoblastic activity and disrupts calcium metabolism through an increase in plasma calcium and calcitonin levels in teleosts
    Nobuo Suzuki
    Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Ishikawa 927 0553, Japan
    Life Sci 78:2533-41. 2006
    ..The current data are the first to demonstrate that, in teleosts, TBTA inhibits osteoblastic activity without affecting osteoclastic activity and disrupts the calcium metabolism, including the calcemic hormone, in goldfish...
  7. doi request reprint Novel bromomelatonin derivatives as potentially effective drugs to treat bone diseases
    Nobuo Suzuki
    Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Housu gun, Ishikawa, Japan
    J Pineal Res 45:229-34. 2008
    ..These studies identified a melatonin derivative that may have potential use in the treatment of bone diseases, such as osteoporosis...
  8. doi request reprint Monohydroxylated polycyclic aromatic hydrocarbons inhibit both osteoclastic and osteoblastic activities in teleost scales
    Nobuo Suzuki
    Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Noto cho, Ishikawa 927 0553, Japan
    Life Sci 84:482-8. 2009
    ..As a negative control, 1-hydroxypyrene (1-OHPy), which has no binding activity to human ER, was used...
  9. ncbi request reprint Cloning of a calcitonin gene-related peptide from genomic DNA and its mRNA expression in flounder, Paralichthys olivaceus
    N Suzuki
    Noto Marine Laboratory, Faculty of Science, Kanazawa University, Uchiura, 927 0553, Ishikawa, Japan
    Peptides 22:1435-8. 2001
    ..Since we have previously shown that the CGRP receptor is expressed in these tissues, it is suggested that CGRP secreted from each tissue functions in a paracrine or autocrine manner...
  10. ncbi request reprint Calcitonin-like substance in the plasma of Cyclostomata and its putative role
    N Suzuki
    Noto Marine Laboratory, Faculty of Science, Kanazawa University, Ishikawa 927 0553, Uchiura, Japan
    Comp Biochem Physiol B Biochem Mol Biol 129:319-26. 2001
    ..In both fishes, moreover, the molecular weight of these substances was equal to that of salmon CT, which strongly suggests that these substances detected here are their CTs...
  11. ncbi request reprint Suppression of osteoclastic activities by calcitonin in the scales of goldfish (freshwater teleost) and nibbler fish (seawater teleost)
    N Suzuki
    Noto Marine Laboratory, Faculty of Science, Kanazawa University, Ishikawa, Japan
    Peptides 21:115-24. 2000
    ..In fish reproduction, this function of CT may be useful to protect scales from excess degradation of calcium at vitellogenesis...
  12. ncbi request reprint Possible direct induction by estrogen of calcitonin secretion from ultimobranchial cells in the goldfish
    Nobuo Suzuki
    Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Uchiura, Ishikawa 927 0553, Japan
    Gen Comp Endocrinol 138:121-7. 2004
    ..This is the first report on the existence of ERs in a teleost UBG and the occurrence of CT secretion caused by estrogen...
  13. ncbi request reprint Effects of inorganic mercury and methylmercury on osteoclasts and osteoblasts in the scales of the marine teleost as a model system of bone
    Koji Yachiguchi
    1 Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Housu gun, Ishikawa 927 0553, Japan
    Zoolog Sci 31:330-7. 2014
    ..To our knowledge, this is the first report of the effects of mercury on osteoclasts and osteoblasts using marine teleost scale as a model system of bone. ..
  14. doi request reprint Parathyroid hormone 1 (1-34) acts on the scales and involves calcium metabolism in goldfish
    Nobuo Suzuki
    Institute of Nature and Environmental Technology, Kanazawa University, Housu gun, Ishikawa, Japan
    Bone 48:1186-93. 2011
    ..Thus, we concluded that PTH acts on osteoblasts and osteoclasts in the scales and regulates calcium metabolism in goldfish...
  15. doi request reprint Osteoblast activity in the goldfish scale responds sensitively to mechanical stress
    Kei Ichiro Kitamura
    Department of Clinical Laboratory Science, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa 920 0942, Japan
    Comp Biochem Physiol A Mol Integr Physiol 156:357-63. 2010
    ..01) but TRAP activity did not change. These in vitro and in vivo results strongly suggest that osteoblasts in the goldfish scale respond sensitively to mechanical stress and may be important in promoting bone formation...
  16. doi request reprint Novel bromomelatonin derivatives suppress osteoclastic activity and increase osteoblastic activity: implications for the treatment of bone diseases
    Nobuo Suzuki
    Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Housu gun, Ishikawa, Japan
    J Pineal Res 44:326-34. 2008
    ..Taken together, the present results strongly suggest that these novel melatonin derivatives have significant potential for use as beneficial drug for bone diseases such as osteoporosis...
  17. ncbi request reprint Osteoblastic activity and estrogenic response in the regenerating scale of goldfish, a good model of osteogenesis
    Hiroaki Yoshikubo
    Division of Health Sciences, Graduate School of Medical Science, Faculty of Medicine, Kanazawa University, Kodatsuno, Ishikawa 920 0942, Japan
    Life Sci 76:2699-709. 2005
    ..Our findings strongly suggest that regenerating scales can be used as a model of osteogenesis in vertebrates...
  18. doi request reprint Zebrafish scales respond differently to in vitro dynamic and static acceleration: analysis of interaction between osteoblasts and osteoclasts
    Kei Ichiro Kitamura
    Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa, Ishikawa 920 0942, Japan
    Comp Biochem Physiol A Mol Integr Physiol 166:74-80. 2013
    ..The results of the present study indicated that osteoclasts have predominant control over bone metabolism via semaphorin 4D expression induced by static acceleration at 3.0√óg. ..
  19. ncbi request reprint [Physiological significance of calcitonin in fish]
    Nobuo Suzuki
    Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University
    Clin Calcium 15:139-46. 2005
    ..In cartilaginous fish and cyclostomes as well as teleosts, CT has some roles in the reproductive period. These results suggest that CT in fish has a more important role in the reproductive physiology than in the Ca metabolism...
  20. doi request reprint Cloning of two members of the calcitonin-family receptors from stingray, Dasyatis akajei: possible physiological roles of the calcitonin family in osmoregulation
    Nobuo Suzuki
    Noto Marine Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Housu gun, Ishikawa 927 0553, Japan
    Gene 499:326-31. 2012
    ..Thus, our cloning and isolation of both receptors in the stingray will be helpful for elucidation of their physiological role(s) such as osmoregulation including calcium metabolism of cartilaginous fish...
  21. ncbi request reprint Increase of cGMP, cADP-ribose and inositol 1,4,5-trisphosphate preceding Ca(2+) transients in fertilization of sea urchin eggs
    R Kuroda
    Department of Environmental Biology and Chemistry, Faculty of Science, Toyama University, 3190 Gofuku, Toyama 930-8555, Japan
    Development 128:4405-14. 2001
    ....
  22. ncbi request reprint Two osteoclastic markers expressed in multinucleate osteoclasts of goldfish scales
    Kyoichi Azuma
    Department of Biology, Faculty of Education and Integrated Arts and Sciences, Waseda University, Tokyo 169 8050, Japan
    Biochem Biophys Res Commun 362:594-600. 2007
    ..Thus, both of these molecular markers should be useful for the study of osteoclasts in the teleost scale...
  23. ncbi request reprint Effects of 3-D clino-rotation on gene expression in human fibroblast cells
    Yoshiko Arase
    Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University, Chiba, 260 8670, Japan
    Cell Biol Int 26:225-33. 2002
    ..Our findings may be a basis for the biological study of 3-D culture systems...
  24. ncbi request reprint Increased expression of the Huntingtin interacting protein-1 gene in cells from Hutchinson Gilford Syndrome (Progeria) patients and aged donors
    Shinichi Chigira
    Department of Plastic Surgery, Graduate School of Medicine, Chiba University, Japan
    J Gerontol A Biol Sci Med Sci 58:B873-8. 2003
    ..Thus, HIP-1 might be a molecular assistant in the pathogenesis of the cellular senescent process in the human cells tested...
  25. doi request reprint Down-regulation of molecular chaperone 78-kd glucose-regulated protein/immunoglobulin-binding protein expression involved in enhancement of human RS cell mutability
    Junko Hirano
    Department of General Surgery, Graduate School of Medicine, Chiba University, Chiba, Japan
    Pancreas 36:e7-14. 2008
    ....
  26. ncbi request reprint Enhanced expression of the LDH-A gene after gravity-changing stress in human RSa cells
    Tetsuhiro Moriya
    Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University, Chiba City, Chiba, Japan
    Biol Sci Space 16:12-7. 2002
    ..Thus, LDH-A was found to be a candidate for the genes which play a role in the cellular response to gravity-changing stress, and mainly to microgravity...
  27. ncbi request reprint Down-regulation of SMT3A gene expression in association with DNA synthesis induction after X-ray irradiation in nevoid basal cell carcinoma syndrome (NBCCS) cells
    Shigeru Sugaya
    Department of Environmental Biochemistry, Graduate School of Medicine, Chiba University, 1 8 1 Inohana, Chiba 260 8670, Japan
    Mutat Res 578:327-32. 2005
    ..Thus, down-regulation of SMT3A gene expression may be involved in the DNA synthesis induction after X-ray irradiation in the NBCCS cells at least tested...
  28. ncbi request reprint Involvement of human heat shock protein 90 alpha in nicotine-induced apoptosis
    Yu ping Wu
    Department of Biochemistry, School of Medicine, Chiba University, Chiba City, Chiba, Japan
    Int J Cancer 100:37-42. 2002
    ..Thus, it was suggested that nicotine induces apoptosis, possibly via Hsp90 alpha expression, in human cells tested...
  29. ncbi request reprint Menaquinone-7 regulates the expressions of osteocalcin, OPG, RANKL and RANK in osteoblastic MC3T3E1 cells
    Hironobu Katsuyama
    Department of Public Health, Kawasaki Medical School, Kurashiki 701 0192, Japan
    Int J Mol Med 15:231-6. 2005
    ..This suppression was recovered when anti-RANK antibody and MK-7 were administered. These observations suggest that MK-7 may directly affect MC3T3E1 cells and stimulate osteoblastic differentiation, not proliferation...