Hiroshi Sato

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. ncbi request reprint Coordinate action of membrane-type matrix metalloproteinase-1 (MT1-MMP) and MMP-2 enhances pericellular proteolysis and invasion
    Hiroshi Sato
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Cancer Sci 101:843-7. 2010
  2. ncbi request reprint Roles of membrane-type matrix metalloproteinase-1 in tumor invasion and metastasis
    Hiroshi Sato
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Cancer Sci 96:212-7. 2005
  3. ncbi request reprint Membrane-type 1 matrix metalloproteinase modulates focal adhesion stability and cell migration
    Takahisa Takino
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Exp Cell Res 312:1381-9. 2006
  4. ncbi request reprint Cleavage of syndecan-1 by membrane type matrix metalloproteinase-1 stimulates cell migration
    Kazuhira Endo
    Department of Molecular Virology and Oncology, Cancer Research Institute, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    J Biol Chem 278:40764-70. 2003
  5. ncbi request reprint JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration
    Takahisa Takino
    Department of Molecular Virology, Cancer Research Institute, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, Japan
    J Biol Chem 280:37772-81. 2005
  6. doi request reprint GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase
    Moustafa A Sakr
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Cancer Sci 101:2368-74. 2010
  7. ncbi request reprint Inhibition of membrane-type 1 matrix metalloproteinase at cell-matrix adhesions
    Takahisa Takino
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Cancer Res 67:11621-9. 2007
  8. ncbi request reprint Human glioblastomas overexpress ADAMTS-5 that degrades brevican
    Mitsutoshi Nakada
    Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan
    Acta Neuropathol 110:239-46. 2005
  9. ncbi request reprint Oncogenic role of Epstein-Barr virus-encoded small RNAs (EBERs) in nasopharyngeal carcinoma
    Tomokazu Yoshizaki
    Division of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    Auris Nasus Larynx 34:73-8. 2007
  10. pmc Ligand-dependent EphB1 signaling suppresses glioma invasion and correlates with patient survival
    Lei Teng
    Corresponding Authors Mitsutoshi Nakada, MD, PhD, Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 8641, Japan Shi Guang Zhao, MD, PhD, Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, People s Republic of China
    Neuro Oncol 15:1710-20. 2013

Collaborators

Detail Information

Publications80

  1. ncbi request reprint Coordinate action of membrane-type matrix metalloproteinase-1 (MT1-MMP) and MMP-2 enhances pericellular proteolysis and invasion
    Hiroshi Sato
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Cancer Sci 101:843-7. 2010
    ..Tetraspanins as binding proteins of MT1-MMP regulate MT1-MMP subcellular localization and compartmentalization, leading to efficient MMP-2 activation and proteolysis coupled with cellular function...
  2. ncbi request reprint Roles of membrane-type matrix metalloproteinase-1 in tumor invasion and metastasis
    Hiroshi Sato
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Cancer Sci 96:212-7. 2005
    ..An understanding of the functions of MT1-MMP could supply clues for developing novel therapeutic strategies targeting MT1-MMP...
  3. ncbi request reprint Membrane-type 1 matrix metalloproteinase modulates focal adhesion stability and cell migration
    Takahisa Takino
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Exp Cell Res 312:1381-9. 2006
    ..These results suggest that lysis of the extracellular matrix by MT1-MMP promotes focal adhesion turnover and subsequent ERK activation, which in turn stimulates cell migration...
  4. ncbi request reprint Cleavage of syndecan-1 by membrane type matrix metalloproteinase-1 stimulates cell migration
    Kazuhira Endo
    Department of Molecular Virology and Oncology, Cancer Research Institute, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    J Biol Chem 278:40764-70. 2003
    ..These results suggest that the shedding of syndecan-1 promoted by MT1-MMP through the preferential cleavage of Gly245-Leu246 peptide bond stimulates cell migration...
  5. ncbi request reprint JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration
    Takahisa Takino
    Department of Molecular Virology, Cancer Research Institute, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, Japan
    J Biol Chem 280:37772-81. 2005
    ..We propose that the JSAP1.FAK complex functions cooperatively as a scaffold for the JNK signaling pathway and regulator of cell migration on FN, and we suggest that JSAP1 is also associated with malignancy in brain tumors...
  6. doi request reprint GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase
    Moustafa A Sakr
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Cancer Sci 101:2368-74. 2010
    ..These results suggest that GI24 contributes to tumor-invasive growth in the collagen matrix by augmenting cell surface MT1-MMP...
  7. ncbi request reprint Inhibition of membrane-type 1 matrix metalloproteinase at cell-matrix adhesions
    Takahisa Takino
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Cancer Res 67:11621-9. 2007
    ..This model highlights the role of MT1-MMP at the leading edge of migrating cells...
  8. ncbi request reprint Human glioblastomas overexpress ADAMTS-5 that degrades brevican
    Mitsutoshi Nakada
    Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan
    Acta Neuropathol 110:239-46. 2005
    ..These results demonstrate for the first time that ADAMTS-5 is capable of degrading brevican and is overexpressed in glioblastoma cells, and suggest that ADAMTS-5 may play a role in glioma cell invasion through the cleavage of brevican...
  9. ncbi request reprint Oncogenic role of Epstein-Barr virus-encoded small RNAs (EBERs) in nasopharyngeal carcinoma
    Tomokazu Yoshizaki
    Division of Otolaryngology, Head and Neck Surgery, Graduate School of Medicine, Kanazawa University, 13 1 Takaramachi, Kanazawa 920 8641, Japan
    Auris Nasus Larynx 34:73-8. 2007
    ..However, the role of EBERs still remains unclear. This study was designed to investigate the relevance of EBERs to the oncogenesis of NPC...
  10. pmc Ligand-dependent EphB1 signaling suppresses glioma invasion and correlates with patient survival
    Lei Teng
    Corresponding Authors Mitsutoshi Nakada, MD, PhD, Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 8641, Japan Shi Guang Zhao, MD, PhD, Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, People s Republic of China
    Neuro Oncol 15:1710-20. 2013
    ..We sought to identify the Eph family members that correlate with patients' survival and to reveal the function of Eph in glioma invasion...
  11. ncbi request reprint Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins
    Mitsutoshi Nakada
    Department of Molecular Virology and Oncology, Kanazawa University, Ishikawa 920 0934, Japan
    Cancer Res 63:3364-9. 2003
    ..We propose that N-Tes-Delta 122, which is resistant to testican 2, may have therapeutic potential as a barrier against glioma invasion...
  12. ncbi request reprint Cleavage of metastasis suppressor gene product KiSS-1 protein/metastin by matrix metalloproteinases
    Takahisa Takino
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Kanazawa 920 0934, Japan
    Oncogene 22:4617-26. 2003
    ..We propose that metastin could be used as an antimetastatic agent in combination with MMP inhibitor, or MMP-resistant forms of metastin could be developed and may also be efficacious...
  13. doi request reprint Activation of matrix metalloproteinase-2 (MMP-2) by membrane type 1 matrix metalloproteinase through an artificial receptor for proMMP-2 generates active MMP-2
    Yuki Nishida
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Takara machi, Kanazawa, Japan
    Cancer Res 68:9096-104. 2008
    ..MSP-T2 is a unique tool to analyze physiologic and pathologic roles of MMP-2 and MT1-MMP in comparison with TIMP-2...
  14. ncbi request reprint Membrane type 1 matrix metalloproteinase regulates collagen-dependent mitogen-activated protein/extracellular signal-related kinase activation and cell migration
    Takahisa Takino
    Department of Molecular Virology and Oncology and Cell Cycle Regulation, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Cancer Res 64:1044-9. 2004
    ..Thus, adhesion of HT1080 cells to type I collagen induces MT1-MMP-dependent ERK activation, which in turn causes an increase in MT1-MMP levels and subsequent cell migration...
  15. ncbi request reprint Cleavage of lumican by membrane-type matrix metalloproteinase-1 abrogates this proteoglycan-mediated suppression of tumor cell colony formation in soft agar
    Yingyi Li
    Department of Molecular Virology and Oncology and Center for the Development of Molecular Target Drugs, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
    Cancer Res 64:7058-64. 2004
    ..These results suggest that MT1-MMP abrogates lumican-mediated suppression of tumor cell colony formation in soft agar by degrading this proteoglycan, which down-regulates it through the induction of p21...
  16. ncbi request reprint Substrate choice of membrane-type 1 matrix metalloproteinase is dictated by tissue inhibitor of metalloproteinase-2 levels
    Tomoya Kudo
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Cancer Sci 98:563-8. 2007
    ..These results suggest that TIMP-2 environment determines MT1-MMP substrate choice between direct cleavage of its own substrates and MMP-2 activation...
  17. ncbi request reprint MT1-MMP promotes cell growth and ERK activation through c-Src and paxillin in three-dimensional collagen matrix
    Takahisa Takino
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Biochem Biophys Res Commun 396:1042-7. 2010
    ..The results suggest that MT1-MMP contributes to proliferation of cancer cells in the extracellular matrix by activating ERK through c-Src and paxillin...
  18. ncbi request reprint MT1-MMP prevents growth inhibition by three dimensional fibronectin matrix
    Takahisa Takino
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Biochem Biophys Res Commun 436:503-8. 2013
    ..These results suggest that MT1-MMP prevents growth suppression by 3D fibronectin matrix, which is mediated through integrin β₁...
  19. ncbi request reprint Regulation of N-cadherin-based cell-cell interaction by JSAP1 scaffold in PC12h cells
    Munkhuu Bayarsaikhan
    Division of Molecular Cell Signaling, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920 0934, Japan
    Biochem Biophys Res Commun 353:357-62. 2007
    ..Taken together, these results suggest that JSAP1 regulates cell-cell interactions in PC12h cells specifically in the NGF-induced signaling pathway, and does so by modulating N-cadherin...
  20. ncbi request reprint The scaffold protein c-Jun NH2-terminal kinase-associated leucine zipper protein regulates cell migration through interaction with the G protein G(alpha 13)
    Davaakhuu Gantulga
    Department of Molecular and Cellular Biology, Cancer Research Institute, Kanazawa University, Kanazawa, 920 0934, Japan
    J Biochem 144:693-700. 2008
    ..Taken together, these results suggest that JLP regulates cell migration through an interaction with G(alpha13)...
  21. ncbi request reprint Shedding of kidney injury molecule-1 by membrane-type 1 matrix metalloproteinase
    Luyang Guo
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    J Biochem 152:425-32. 2012
    ..These results suggest that KIM-1 negatively regulates cellular function mediated through interaction with collagen, and MT1-MMP abrogates it through the cleavage and shedding of KIM-1...
  22. doi request reprint Cleavage of hepatocyte growth factor activator inhibitor-1 by membrane-type MMP-1 activates matriptase
    Takahiro Domoto
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Cancer Sci 103:448-54. 2012
    ....
  23. ncbi request reprint Cleavage of growth differentiation factor 15 (GDF15) by membrane type 1-matrix metalloproteinase abrogates GDF15-mediated suppression of tumor cell growth
    Shaban H Abd El-Aziz
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Cancer Sci 98:1330-5. 2007
    ..These results suggest that MT1-MMP contributes to tumor cell proliferation through the cleavage of GDF15, which down-regulates cell proliferation by inducing activation of p53 and p21 synthesis...
  24. doi request reprint Phosphorylation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase and nuclear translocation of nuclear factor-kappaB are involved in upregulation of matrix metalloproteinase-9 by tumour necrosis factor-alpha
    Keita Itatsu
    Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Liver Int 29:291-8. 2009
    ..In this study, we examined which signalling pathways are involved in TNF-alpha-induced MMP-9 upregulation in cholangiocarcinoma (CC)...
  25. ncbi request reprint Cleavage of amyloid-beta precursor protein (APP) by membrane-type matrix metalloproteinases
    Munirah Ahmad
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Takara machi, Ishikawa
    J Biochem 139:517-26. 2006
    ..These results suggest that MT1-MMP, MT3-MMP and MT5-MMP should play an important role in the regulation of APP functions in tissues including the central nervous system...
  26. pmc Aberrant glycogen synthase kinase 3β is involved in pancreatic cancer cell invasion and resistance to therapy
    Ayako Kitano
    Division of Translational and Clinical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    PLoS ONE 8:e55289. 2013
    ..Here we investigate a pathological role for GSK3β in the invasive and treatment resistant phenotype of pancreatic cancer...
  27. ncbi request reprint [Tumor metastasis and MMP inhibitor]
    Hiroshi Sato
    Kanazawa University, Cancer Research Institute
    Clin Calcium 16:621- 26. 2006
    ..Clinical trials of MMP inhibitor drugs have been carried out, however, they were not always as successful as expected...
  28. ncbi request reprint Cleavage of apolipoprotein E by membrane-type matrix metalloproteinase-1 abrogates suppression of cell proliferation
    Takanori Aoki
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    J Biochem 137:95-9. 2005
    ..These results suggest that cleavage of apoE protein by MT1-MMP abrogates apoE-mediated suppression of cell proliferation...
  29. ncbi request reprint Epstein-Barr virus (EBV) latent membrane protein 1 induces interleukin-8 through the nuclear factor-kappa B signaling pathway in EBV-infected nasopharyngeal carcinoma cell line
    Qingchun Ren
    Division of Otolaryngology, Graduate School of Medicine, and Department of Molecular Oncology and Virology, Cancer Research Institute, Kanazawa University, Takaramachi, Kanazawa, Japan
    Laryngoscope 114:855-9. 2004
    ..Our previous studies have indicated that interleukin (IL)-8 was over-expressed in many NPC tissues and was found to be significantly correlated with angiogenesis by immunohistochemistry...
  30. ncbi request reprint Modulation of cell growth and matrix metalloproteinase-2 activation of oral squamous cell carcinoma as a function of culture condition with type I collagen
    Hidenori Kinsenn
    Department of Otolaryngology, School of Medicine, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    Acta Otolaryngol 123:987-93. 2003
    ..This study was designed to analyze the effect of type I collagen on tumor growth and MMP-2 activation of OSCC cell lines as a function of culture conditions...
  31. doi request reprint Progressive adult primary glioblastoma in the medulla oblongata with an unmethylated MGMT promoter and without an IDH mutation
    Akifumi Yoshikawa
    Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 8641, Japan
    Brain Tumor Pathol 30:175-9. 2013
    ..We report an extremely short clinical course of adult GBM in medulla oblongata with genetic analysis and present a review of the literature...
  32. doi request reprint Membrane-type 1 matrix metalloproteinase regulates fibronectin assembly to promote cell motility
    Takahisa Takino
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    FEBS Lett 585:3378-84. 2011
    ..These results indicate that MT1-MMP stimulates cell migration and invasion by negatively regulating FN assembly...
  33. ncbi request reprint CrkI adapter protein modulates cell migration and invasion in glioblastoma
    Takahisa Takino
    Department of Molecular Virology and Oncology, Cancer Research Institute, Graduate School of Medical Science, Kanazawa University, Japan
    Cancer Res 63:2335-7. 2003
    ..These results suggest that CrkI contributes to malignancy of glioblastoma by inducing phosphorylation of p130 Crk-associated substrate...
  34. ncbi request reprint Recent advances in the regulation of matrix metalloproteinase 2 activation: from basic research to clinical implication (Review)
    Tomokazu Yoshizaki
    Department of Otolaryngology, Graduate School of Medicine, Kanazawa 920 8641, Japan
    Oncol Rep 9:607-11. 2002
    ..MMPs are especially important in the early stage of cancer progression, and thus strategies for future MMPI trials should be reconsidered...
  35. ncbi request reprint Membrane-type 1 matrix metalloproteinase regulates fibronectin assembly and N-cadherin adhesion
    Takahisa Takino
    Division of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan Electronic address
    Biochem Biophys Res Commun 450:1016-20. 2014
    ..These results demonstrate that fibronectin assembly initiated by MT1-MMP knockdown results in increase of N-cadherin adhesions, which are prerequisite for further fibronectin matrix formation. ..
  36. ncbi request reprint Increased matrix metalloproteinase-2 and membrane type 1 matrix metalloproteinase activity and expression in heterotopically transplanted murine tracheas
    Noriyuki Inaki
    Department of General and Cardiothoracic Surgery, School of Medicine, Kanazawa University, Kanazawa, Japan
    J Heart Lung Transplant 23:218-27. 2004
    ..In this study, we examine the expression of MMP-2, its activator MT1-MMP and MMP-9 in BOS using murine trachea transplantation models...
  37. ncbi request reprint Tetraspanin CD63 promotes targeting and lysosomal proteolysis of membrane-type 1 matrix metalloproteinase
    Takahisa Takino
    Department of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, 920 0934, Kanazawa, Japan
    Biochem Biophys Res Commun 304:160-6. 2003
    ..CD63 mutant lacking lysosomal targeting motif was unable to promote MT1-MMP degradation. These results suggest that CD63 regulates MT1-MMP by targeting to lysosomes...
  38. ncbi request reprint Diagnostic value of serum EBV-DNA quantification and antibody to viral capsid antigen in nasopharyngeal carcinoma patients
    Satoru Kondo
    Division of Otolaryngology, Graduate School of Medicine, Cancer Research Institute, Kanazawa University, Ishikawa, Kanazawa 920 8640, Japan
    Cancer Sci 95:508-13. 2004
    ..ROC analysis again revealed a higher diagnostic value of EBV-DNA than EBV-VCA. These results suggest EBV-DNA is a more reliable tumor marker than EBV-VCA in both high-incidence and low-incidence areas of NPC...
  39. ncbi request reprint Unexpected role of nucleoporins in coordination of cell cycle progression
    Hiroshi Nakano
    Frontier Science Organization, Kanazawa University, Kanazawa, Japan
    Cell Cycle 10:425-33. 2011
    ..An alteration in the concentration of Nups inside cells often causes aneuploidy. In this review, we discuss this sprouting area and the possible functions of Nups during mitosis...
  40. ncbi request reprint Raloxifene promotes adipocyte differentiation of 3T3-L1 cells
    Yuko Murase
    Department of Molecular Genetics of Cardiovascular Disorders, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 8640, Japan
    Eur J Pharmacol 538:1-4. 2006
    ..These findings suggest that raloxifene promotes adipocyte differentiation, providing a novel insight into the treatment of postmenopausal metabolic syndrome with hypoadiponectinemia...
  41. ncbi request reprint A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine-phosphorylated
    Takahisa Takino
    Division of Molecular Virology and Oncology, Cancer Research Institute, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    Oncogene 21:6488-97. 2002
    ..Taken together, these results suggest that JSAP1 is involved an integrin-mediated signaling pathway through FAK/Src by recruiting other signaling molecules, resulting in promotion of cell spreading onto FN...
  42. doi request reprint Combination therapy using Notch and Akt inhibitors is effective for suppressing invasion but not proliferation in glioma cells
    Rihua Jin
    Department of Neurosurgery, The First Bethune Clinical Hospital of Jilin University, 71 Xinmin Avenue, Changchun 130021, People s Republic of China
    Neurosci Lett 534:316-21. 2013
    ..Inhibition of invasion, further enhanced by combination therapy, correlated with increased Akt inactivation. In summary, combination therapy with MRK003 and MK-2206 may be effective for inhibiting invasion but not proliferation...
  43. ncbi request reprint The significance of membrane type 1 metalloproteinase in structural involution of human corpora lutea
    Kengo Manase
    Department of Obstetrics and Gynecology, Cancer Research Institute, Sapporo Medical University School of Medicine, South 1 West 16 Chuo Ku, Japan
    Mol Hum Reprod 8:742-9. 2002
    ..These results suggest that increased expression of MT1-MMP may be a major factor in remodelling of the human corpus luteum during structural luteolysis...
  44. ncbi request reprint Inhibition of cervical lymph node metastasis by marimastat (BB-2516) in an orthotopic oral squamous cell carcinoma implantation model
    Ken ichi Maekawa
    Department of Otolaryngology, School of Medicine, Kanazawa University, Japan
    Clin Exp Metastasis 19:513-8. 2002
    ..Improvement of survival in patients with OSCC could be expected using adjuvant therapy with marimastat...
  45. ncbi request reprint Crosstalk between neovessels and mural cells directs the site-specific expression of MT1-MMP to endothelial tip cells
    Ikuo Yana
    Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
    J Cell Sci 120:1607-14. 2007
    ....
  46. ncbi request reprint The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells
    Mitsutoshi Nakada
    Neuro Oncology Research, Barrow Neurological Institute, Phoenix, Arizona, USA
    Cancer Res 64:3179-85. 2004
    ..Dysregulation of EphB2 expression or function may underlie glioma invasion...
  47. pmc CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain
    Hidetoshi Mori
    Department of Cancer Cell Research, Institute of Medical Science, University of Tokyo, Minato ku, Tokyo 108 8639, Japan
    EMBO J 21:3949-59. 2002
    ..The PEX domain of MT1-MMP was indispensable in promoting cell migration and CD44H shedding...
  48. ncbi request reprint Expression of membrane-type-1-matrix metalloproteinase and metalloproteinase-2 in nonsmall cell lung carcinomas
    Tsuyoshi Yamamura
    Department of Pathology, National Defense Medical College, Tokorozawa 359 8513, Japan
    Lung Cancer 35:249-55. 2002
    ..However, an association was not demonstrated in the multivariate analysis. The detection of MT1-MMP and MMP2 is likely to be of limited value in informing the prognosis in NSCLC...
  49. ncbi request reprint Reg protein is overexpressed in gastric cancer cells, where it activates a signal transduction pathway that converges on ERK1/2 to stimulate growth
    Yasunori Kadowaki
    Second Department of Internal Medicine, Shimane Medical University, Izumo 693 8501, Japan
    FEBS Lett 530:59-64. 2002
    ..Taken together, these data suggest that gastric cancer cells have gained the ability to overexpress Reg protein, which confer upon themselves added proliferative capacities, resulting in a considerable growth advantage...
  50. ncbi request reprint Tyrosine phosphorylation of the CrkII adaptor protein modulates cell migration
    Takahisa Takino
    Craniofacial Developmental Biology and Regeneration Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4370, USA
    J Cell Sci 116:3145-55. 2003
    ....
  51. ncbi request reprint Six novel UDP-glucuronosyltransferase (UGT1A3) polymorphisms with varying activity
    Masaru Iwai
    Department of Pediatrics, Shiga University of Medical Science, Otsu, Shiga 520 2192, Japan
    J Hum Genet 49:123-8. 2004
    ..Several UGT 1A3 polymorphisms exist in the Japanese population, having different levels of activity. These polymorphisms are capable of affecting the steady state levels of estrogens, and may increase sensitivity to adverse drug effects...
  52. ncbi request reprint Membrane-type 1 matrix metalloproteinase cytoplasmic tail-binding protein-1 is a new member of the Cupin superfamily. A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors
    Takamasa Uekita
    Division of Cancer Cell Research, Institute of Medical Science, University of Tokyo, 4 6 1 Shirokane dai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 279:12734-43. 2004
    ..Thus, MTCBP-1 may have multiple functions other than the regulation of MT1-MMP, which presumably depends on the subcellular compartment...
  53. ncbi request reprint A novel mechanism for the inhibition of hyaluronan biosynthesis by 4-methylumbelliferone
    Ikuko Kakizaki
    Department of Biochemistry, Hirosaki University School of Medicine, 5 Zaifu cho, Hirosaki 036 8562, Japan
    J Biol Chem 279:33281-9. 2004
    ..We propose a novel mechanism for the MU-mediated inhibition of HA synthesis involving the glucuronidation of MU by endogenous UGT resulting in a depletion of UDP-GlcUA...
  54. ncbi request reprint Epstein-Barr virus latent membrane protein 1 induces the matrix metalloproteinase-1 promoter via an Ets binding site formed by a single nucleotide polymorphism: enhanced susceptibility to nasopharyngeal carcinoma
    Satoru Kondo
    Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Int J Cancer 115:368-76. 2005
    ..These results suggest that LMP1-induced MMP1 and MMP3 are closely linked and show that LMP1 activates MMP1 via an Ets binding site formed by 2G, which is a candidate marker for both risk and prognosis of NPC...
  55. ncbi request reprint Altered expression of NDST-1 messenger RNA in puromycin aminonucleoside nephrosis
    Kenji Nakayama
    Research Institute, International Medical Center of Japan, Tokyo, Japan
    J Lab Clin Med 143:106-14. 2004
    ..These data suggest an important role for this enzyme in heparan sulfate assembly in GBM and GEC and in the pathogenesis of proteinuria in PAN nephrosis...
  56. ncbi request reprint Regulation of IL-10 gene expression in Th2 cells by Jun proteins
    Zheng Yu Wang
    Department of Microbiology and Immunology and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 174:2098-105. 2005
    ..These data indicate that we have identified a novel regulatory element that can specifically activate transcription of the IL-10 gene in Th2 cells via the AP-1/Jun pathway...
  57. ncbi request reprint Inhibition of DNA-double strand break repair by antimony compounds
    Sentaro Takahashi
    Environmental and Toxicological Research Group, National Institute of Radiological Sciences, 4 9 1 Anagawa, Inage Ku, 263 8555, Chiba, Japan
    Toxicology 180:249-56. 2002
    ..This is the first report to indicate that antimony compounds may inhibit the repair of radiation-induced DNA DSB...
  58. ncbi request reprint Stimulation of transcriptional expression of human UDP-glucuronosyltransferase 1A1 by dexamethasone
    Masanobu Kanou
    Graduate School of Pharmaceutical Sciences, Nagoya City University, Nagoya 467 8603, Japan
    Mol Biol Rep 31:151-8. 2004
    ..Thus, we clarified that UGT1A1 was induced by dexamethasone and the key position was the region (-97/-53) in UGT1A1 promoter...
  59. ncbi request reprint Crigler-Najjar syndrome type II caused by a homozygous triple mutation [T-3279G, A(TA)7TAA, and H39D] of UGT1A1
    Yoshihiro Maruo
    Department of Pediatrics, Shiga University of Medical Science, Tsukinowa, Otsu, Shiga 530 2192, Japan
    J Pediatr Gastroenterol Nutr 42:236-9. 2006
  60. ncbi request reprint Localization of calcitonin gene-related peptide receptors in rat gastric mucosa
    Kousaku Kawashima
    Second Department of Internal Medicine, Shimane Medical University, 89 1 Enya cho, Izumo, Shimane, Japan
    Peptides 23:955-66. 2002
    ..Our results suggest that CGRP receptors are expressed in D cells in the rat gastric mucosa and control production and secretion of somatostatin...
  61. ncbi request reprint Genetic analysis of a Theiler-like virus isolated from rats
    Kazutaka Ohsawa
    Laboratory Animal Center for Biomedical Research, Nagasaki University School of Medicine 1 12 4 Sakamoto, Nagasaki, 855 858, Japan
    Comp Med 53:191-6. 2003
    ..As genetic distances between NGS910 and other TMEVs were greater than those between Mengo virus of EMCV and other EMCVs, we propose to designate the NGS910 isolate as a rat Theiler-like virus...
  62. ncbi request reprint Genetic polymorphisms of bilirubin uridine diphosphate-glucuronosyltransferase gene in Japanese patients with Crigler-Najjar syndrome or Gilbert's syndrome as well as in healthy Japanese subjects
    Keisuke Takeuchi
    Department of Internal Medicine, Division of Gastroenterology and Hepatology, Mie University School of Medicine, Tsu, Mie, Japan
    J Gastroenterol Hepatol 19:1023-8. 2004
    ....
  63. ncbi request reprint Novel vaccination protocol consisting of injecting MUC1 DNA and nonprimed dendritic cells at the same region greatly enhanced MUC1-specific antitumor immunity in a murine model
    Keiichi Kontani
    Second Department of Surgery, Shiga University of Medical Science, Otsu 520 2192, Japan
    Cancer Gene Ther 9:330-7. 2002
    ..This animal model is useful for developing DNA vaccine for anti-cancer immunotherapy...
  64. ncbi request reprint Use of herpesvirus papio 2 as an alternative antigen in immunoblotting assay for B virus diagnosis
    Seiichi Tanaka
    Division of Laboratory Animal Sciences, Department of Life Science, Institute of Scientific Research, Oita University, Hasama machi, Japan
    J Vet Med Sci 66:529-32. 2004
    ..No specific bands could be detected with BV-negative sera. These results show the usefulness of HVP2 antigen as an alternative and safer antigen than authentic BV antigen in detecting BV antibody in immunoblotting...
  65. ncbi request reprint Fatal Baylisascaris larva migrans in a colony of Japanese macaques kept by a safari-style zoo in Japan
    Hiroshi Sato
    Department of Parasitology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    J Parasitol 91:716-9. 2005
    ..This sporadic outbreak is the second record of Baylisascaris larva migrans in animals in Japan...
  66. doi request reprint Effect of D256N and Y483D on propofol glucuronidation by human uridine 5'-diphosphate glucuronosyltransferase (UGT1A9)
    Hiroko Takahashi
    Department of Pediatrics, Shiga University of Medical Science, Shiga, Japan
    Basic Clin Pharmacol Toxicol 103:131-6. 2008
    ..Carriers of D256N may be at risk of suffering adverse effects of propofol and other substrates that are primarily metabolized by UGT1A9...
  67. ncbi request reprint Radio-sensitivity of the cells from amyotrophic lateral sclerosis model mice transfected with human mutant SOD1
    Reika Wate
    Department of Neurology, Kansai Medical University, Moriguchi, Japan
    J Radiat Res 46:67-73. 2005
    ....
  68. ncbi request reprint Identification and characterization of the threadworm, Strongyloides procyonis, from feral raccoons (Procyon lotor) in Japan
    Hiroshi Sato
    Department of Parasitology, Hirosaki University School of Medicine, Hirosaki 036 8562, Japan
    J Parasitol 92:63-8. 2006
    ..Awareness of S. procyonis in raccoons in North America and other places worldwide where raccoons are introduced and naturalized is important to assess the epidemiological significance of this potentially zoonotic helminth species...
  69. ncbi request reprint Type I collagen abrogates the clathrin-mediated internalization of membrane type 1 matrix metalloproteinase (MT1-MMP) via the MT1-MMP hemopexin domain
    Marc A Lafleur
    VBCRC Invasion and Metastasis Group, St Vincent s Institute, Fitzroy, Victoria 3065, Australia
    J Biol Chem 281:6826-40. 2006
    ....
  70. ncbi request reprint Small adenocarcinoma of the lung: prognostic significance of central fibrosis chiefly because of its association with angiogenesis and lymphangiogenesis
    Koichi Okudera
    Hospital Pathology Center, Hirosaki University School of Medicine, Hirosaki, Japan
    Pathol Int 56:494-502. 2006
    ..Lymphatic vessels in some CF showed intravasation by carcinoma cells. In conclusion, CF could be an important histological prognostic factor in SA chiefly because of its association with angiogenesis and lymphangiogenesis...
  71. ncbi request reprint S100A4 regulates E-cadherin expression in oral squamous cell carcinoma
    Makiko Moriyama-Kita
    Department of Oral and Maxillofacial Surgery, Kanazawa University Graduate School of Medicine, 13 1 Takaramachi, Kanazawa 920 8640, Japan
    Cancer Lett 230:211-8. 2005
    ..Interestingly, vascular endothelial growth factor-C was up-regulated in OSC-19/S100A4 cells. In summary, S100A4-mediated regulation of E-cadherin expression may play an important mechanism in invasion and metastasis of oral SCC...
  72. ncbi request reprint Helicobacter pylori induces matrix metalloproteinase-9 through activation of nuclear factor kappaB
    Naoki Mori
    Department of Virology, Faculty of Medicine, University of the Ryukyus, Okinawa, Japan
    Gastroenterology 124:983-92. 2003
    ..The aim of this study was to analyze the molecular mechanism responsible for Helicobacter pylori-mediated MMP expression...
  73. ncbi request reprint Unique mutations in the filaggrin gene in Japanese patients with ichthyosis vulgaris and atopic dermatitis
    Toshifumi Nomura
    Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan
    J Allergy Clin Immunol 119:434-40. 2007
    ..Recently, mutations in the filaggrin gene, FLG, were identified in European families with ichthyosis vulgaris (IV) and shown to be an important predisposing factor for atopic dermatitis (AD)...
  74. ncbi request reprint Inhibition of Th2 differentiation and GATA-3 expression by BCL-6
    Saritha Kusam
    Department of Microbiology and Immunology and Walther Oncology Center, Indiana University School of Medicine, Indianapolis, IN 46202, USA
    J Immunol 170:2435-41. 2003
    ..These data also point to a novel regulatory mechanism for BCL-6 separate from transcriptional repression...
  75. ncbi request reprint Quantitative PCR to evaluate small amounts of BCL2 mRNA in human peripheral T cells: implication of equimolar target and competitor end products
    Hiroshi Sato
    Division of Bioscience, Shiga University of Medical Science, Seta, Otsu, Shiga 520 2192, Japan
    Clin Chim Acta 328:147-53. 2003
    ..It is difficult to reliably and reproducibly quantitate small amounts of mRNA by conventional PCR. The method we describe here enabled us to more accurately quantitate a small amount of BCL2 mRNA in human peripheral T cells...
  76. ncbi request reprint Detection of a unique genotype of monkey B virus (Cercopithecine herpesvirus 1) indigenous to native Japanese macaques (Macaca fuscata)
    Kazutaka Ohsawa
    Laboratory Animal Center for Biomedical Research, Nagasaki University School of Medicine, 1 12 4 Sakamoto, Nagasaki 852 8523, Japan
    Comp Med 52:555-9. 2002
    ..Phylogenetic analysis indicated that these monkeys harbor their own genotype of BV that is different from other known BV genotypes, and provided additional evidence supporting the co-evolution of BV and macaques...
  77. ncbi request reprint Arsenic enhances matrix metalloproteinase-14 expression in fibroblasts
    Masashi Kato
    Unit of Environmental Health Sciences, Department of Biomedical Sciences, College of Life and Health Sciences, Chubu University, Aichi, Japan
    J Toxicol Environ Health A 71:1053-5. 2008
    ..Evidence indicates that As appeared to be less effective than Hg in the conversion of pro-MMP-2 into its active form...
  78. ncbi request reprint Up-regulation of cell adhesion molecule genes in human endothelial cells stimulated by lymphotoxin alpha: DNA microarray analysis
    Shinichiro Suna
    Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan
    J Atheroscler Thromb 15:160-5. 2008
    ....
  79. ncbi request reprint Human T-cell leukemia virus type I Tax transactivates the matrix metalloproteinase-9 gene: potential role in mediating adult T-cell leukemia invasiveness
    Naoki Mori
    Departments of Preventive Medicine and AIDS Research, and Pathology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan
    Blood 99:1341-9. 2002
    ..In addition, plasma levels of MMP-9 correlated with organ involvement in ATL patients. Together these data suggest that overexpression of MMP-9 in HTLV-I- infected cells may be in part responsible for the invasiveness of ATL cells...
  80. ncbi request reprint Growth inhibition of esophageal squamous carcinoma cells by peroxisome proliferator-activated receptor-gamma ligands
    Mohammad Azharul Karim Rumi
    Second Department of Internal Medicine, Shimane Medical University, Izumo, Japan
    J Lab Clin Med 140:17-26. 2002
    ..These findings suggest that troglitazone and other PPAR-gamma ligands have adjuvant or neoadjuvant therapeutic potentials in esophageal cancer...