Hiroshi Sakurai

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. ncbi request reprint Artificial recruitment of certain Mediator components affects requirement of basal transcription factor IIE
    Hiroshi Sakurai
    School of Health Sciences, Faculty of Medicine, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    Genes Cells 8:41-50. 2003
  2. ncbi request reprint Interaction between heat shock transcription factors (HSFs) and divergent binding sequences: binding specificities of yeast HSFs and human HSF1
    Hiroshi Sakurai
    Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    J Biol Chem 282:13334-41. 2007
  3. ncbi request reprint Carboxy-terminal region of the yeast heat shock factor contains two domains that make transcription independent of the TFIIH protein kinase
    Hiroshi Sakurai
    School of Health Sciences, Faculty of Medicine, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    Genes Cells 8:951-61. 2003
  4. ncbi request reprint A novel domain of the yeast heat shock factor that regulates its activation function
    H Sakurai
    School of Health Sciences, Faculty of Medicine, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    Biochem Biophys Res Commun 285:696-701. 2001
  5. ncbi request reprint Functional connections between mediator components and general transcription factors of Saccharomyces cerevisiae
    H Sakurai
    School of Health Sciences, Faculty of Medicine, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    J Biol Chem 275:37251-6. 2000
  6. ncbi request reprint Novel aspects of heat shock factors: DNA recognition, chromatin modulation and gene expression
    Hiroshi Sakurai
    Department of Clinical Laboratory Science, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    FEBS J 277:4140-9. 2010
  7. doi request reprint Regulation of chaperone gene expression by heat shock transcription factor in Saccharomyces cerevisiae: importance in normal cell growth, stress resistance, and longevity
    Hiroshi Sakurai
    Division of Health Sciences, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    FEBS Lett 585:2744-8. 2011
  8. ncbi request reprint Stress-induced transcription of the endoplasmic reticulum oxidoreductin gene ERO1 in the yeast Saccharomyces cerevisiae
    Yukiko Takemori
    Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, 920 0942 Ishikawa, Japan
    Mol Genet Genomics 275:89-96. 2006
  9. pmc Regulation of thermotolerance by stress-induced transcription factors in Saccharomyces cerevisiae
    Noritaka Yamamoto
    Division of Health Sciences, Kanazawa University Graduate School of Medical Science, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    Eukaryot Cell 7:783-90. 2008
  10. ncbi request reprint Different mechanisms are involved in the transcriptional activation by yeast heat shock transcription factor through two different types of heat shock elements
    Naoya Hashikawa
    Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    J Biol Chem 282:10333-40. 2007

Collaborators

Detail Information

Publications34

  1. ncbi request reprint Artificial recruitment of certain Mediator components affects requirement of basal transcription factor IIE
    Hiroshi Sakurai
    School of Health Sciences, Faculty of Medicine, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    Genes Cells 8:41-50. 2003
    ....
  2. ncbi request reprint Interaction between heat shock transcription factors (HSFs) and divergent binding sequences: binding specificities of yeast HSFs and human HSF1
    Hiroshi Sakurai
    Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    J Biol Chem 282:13334-41. 2007
    ..These results show that human HSF1 recognizes HSEs in a slightly different way than yeast HSFs and suggest that the configuration of the unit is an important determinant for HSF-HSE interactions...
  3. ncbi request reprint Carboxy-terminal region of the yeast heat shock factor contains two domains that make transcription independent of the TFIIH protein kinase
    Hiroshi Sakurai
    School of Health Sciences, Faculty of Medicine, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    Genes Cells 8:951-61. 2003
    ..Although Kin28 is indispensable for transcription of many genes, its requirement is bypassed in certain genes such as SSA4 or CUP1, whose transcription is activated by the heat shock factor Hsf1...
  4. ncbi request reprint A novel domain of the yeast heat shock factor that regulates its activation function
    H Sakurai
    School of Health Sciences, Faculty of Medicine, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    Biochem Biophys Res Commun 285:696-701. 2001
    ..By contrast, it was dispensable for heat induction through the canonical HSE. We suggest that the basic region is a modulator involved in regulation of the Hsf1-mediated activation depending on the architecture of its binding site...
  5. ncbi request reprint Functional connections between mediator components and general transcription factors of Saccharomyces cerevisiae
    H Sakurai
    School of Health Sciences, Faculty of Medicine, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    J Biol Chem 275:37251-6. 2000
    ..We illustrate genetic interactions between Gal11 and other Mediator components such as Med2 and Pgd1/Hrs1/Med3...
  6. ncbi request reprint Novel aspects of heat shock factors: DNA recognition, chromatin modulation and gene expression
    Hiroshi Sakurai
    Department of Clinical Laboratory Science, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    FEBS J 277:4140-9. 2010
    ..This minireview focuses on the molecular mechanisms of DNA recognition, chromatin modulation and gene expression by yeast and mammalian HSFs...
  7. doi request reprint Regulation of chaperone gene expression by heat shock transcription factor in Saccharomyces cerevisiae: importance in normal cell growth, stress resistance, and longevity
    Hiroshi Sakurai
    Division of Health Sciences, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    FEBS Lett 585:2744-8. 2011
    ..Therefore, HSF-regulated changes in expression of these chaperone genes are necessary to maintain cell viability under various growth conditions...
  8. ncbi request reprint Stress-induced transcription of the endoplasmic reticulum oxidoreductin gene ERO1 in the yeast Saccharomyces cerevisiae
    Yukiko Takemori
    Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, 920 0942 Ishikawa, Japan
    Mol Genet Genomics 275:89-96. 2006
    ..Although mutations in the Hsf1-binding sequences do not affect the sensitivity of cells to heat, ethanol, or oxidative stresses, both the Hac1- and Hsf1-regulated pathways are critical for normal growth under complex stress conditions...
  9. pmc Regulation of thermotolerance by stress-induced transcription factors in Saccharomyces cerevisiae
    Noritaka Yamamoto
    Division of Health Sciences, Kanazawa University Graduate School of Medical Science, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    Eukaryot Cell 7:783-90. 2008
    ..These results show that Hsf1 and Msn2/4 act differentially before and after exposure to extreme temperatures to ensure cell survival and growth...
  10. ncbi request reprint Different mechanisms are involved in the transcriptional activation by yeast heat shock transcription factor through two different types of heat shock elements
    Naoya Hashikawa
    Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    J Biol Chem 282:10333-40. 2007
    ....
  11. ncbi request reprint Identification of a novel class of target genes and a novel type of binding sequence of heat shock transcription factor in Saccharomyces cerevisiae
    Ayako Yamamoto
    School of Health Sciences, Faculty of Medicine, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    J Biol Chem 280:11911-9. 2005
    ..In the yeast genome, the presence of the sequence is enriched in Hsf1-regulated genes, suggesting that it is generally used as an HSE in the Hsf1 regulon...
  12. ncbi request reprint The DNA-binding domain of yeast Hsf1 regulates both DNA-binding and transcriptional activities
    Ayako Yamamoto
    Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    Biochem Biophys Res Commun 346:1324-9. 2006
    ..These results indicate that the DNA-binding domain regulates both the DNA-binding and transcriptional activities of Hsf1, and suggest that these functions are located within discrete regions of the DNA-binding domain...
  13. pmc Role of heat shock transcription factor in Saccharomyces cerevisiae oxidative stress response
    Ayako Yamamoto
    Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    Eukaryot Cell 6:1373-9. 2007
    ..These results demonstrate that Hsf1 is a member of the oxidative stress-responsive activators and that PKA is a general negative regulator in the superoxide anion response...
  14. pmc Saccharomyces cerevisiae heat shock transcription factor regulates cell wall remodeling in response to heat shock
    Hiromi Imazu
    School of Health Sciences, Faculty of Medicine, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    Eukaryot Cell 4:1050-6. 2005
    ..Several of the other suppressors were found to encode proteins functioning in cell wall organization. These results suggest that Hsf1 in concert with Pkc1 regulates cell wall remodeling in response to heat shock...
  15. doi request reprint Heat shock transcription factor HSF1 regulates the expression of the Huntingtin-interacting protein HYPK
    Hiroshi Sakurai
    Division of Health Sciences, Kanazawa University Graduate School of Medical Science, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan Electronic address
    Biochim Biophys Acta 1840:1181-7. 2014
    ..The Huntingtin-interacting protein HYPK possesses chaperone-like activity. We hypothesized that the expression of HYPK could be regulated by heat shock factor HSF1, a transcriptional regulator of chaperone genes...
  16. doi request reprint Mutational analysis of human heat-shock transcription factor 1 reveals a regulatory role for oligomerization in DNA-binding specificity
    Yukiko Takemori
    Division of Health Sciences, Kanazawa University Graduate School of Medical Science, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    Biochem J 424:253-61. 2009
    ....
  17. ncbi request reprint Mutated yeast heat shock transcription factor activates transcription independently of hyperphosphorylation
    Naoya Hashikawa
    Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan
    J Biol Chem 281:3936-42. 2006
    ..These results demonstrate a functional link between hyperphosphorylation and the wing region and suggest that this modification is involved in a conformational change of a single Hsf1 trimer to an active form...
  18. ncbi request reprint DNA-binding and transcriptional activities of human HSF4 containing mutations that associate with congenital and age-related cataracts
    Yasuaki Enoki
    Division of Health Sciences, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920 0942, Japan
    Biochim Biophys Acta 1802:749-53. 2010
    ..However, two missense mutations that have been associated with age-related cataract did not or only slightly alter HSF4 activity, implying that other genetic and environmental factors affect the functions of these mutant proteins...
  19. pmc Phosphorylation of the yeast heat shock transcription factor is implicated in gene-specific activation dependent on the architecture of the heat shock element
    Naoya Hashikawa
    School of Health Sciences, Faculty of Medicine, Kanazawa University, Kanazawa, Ishikawa 920 0942, Japan
    Mol Cell Biol 24:3648-59. 2004
    ..Taken together, we suggest that CTM alleviates repression by CE2, which allows HSF to be heat-inducibly phosphorylated and presume that phosphorylation is a prerequisite for the activator function of HSF when it binds to an atypical HSE...
  20. doi request reprint Differential recognition of heat shock elements by members of the heat shock transcription factor family
    Noritaka Yamamoto
    Department of Clinical Laboratory Science, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    FEBS J 276:1962-74. 2009
    ..These results suggest that the HSE architecture is an important determinant of which HSF members regulate genes in diverse cellular processes...
  21. doi request reprint The proto-oncogene JUN is a target of the heat shock transcription factor HSF1
    Maki Sawai
    Department of Clinical Laboratory Science, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    FEBS J 280:6672-80. 2013
    ..Forced expression of active HSF1 in cells resulted in an increase in c-Jun expression and activation of c-Jun target genes. These results show that HSF1 regulates JUN expression, thereby modulating AP-1 activity. ..
  22. doi request reprint Evolutionarily conserved domain of heat shock transcription factor negatively regulates oligomerization and DNA binding
    Azumi Ota
    Division of Health Sciences, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Biochim Biophys Acta 1829:930-6. 2013
    ..This conserved domain plays an important role in maintaining HSF in an inactive monomeric form. ..
  23. doi request reprint Diversity in DNA recognition by heat shock transcription factors (HSFs) from model organisms
    Yasuaki Enoki
    Division of Health Sciences, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    FEBS Lett 585:1293-8. 2011
    ..Further analysis of alternatively spliced HSF isoforms showed the importance of the C-terminal region in HSF-HSE interaction...
  24. ncbi request reprint [Control of stress response by heat shock transcription factor]
    Hiroshi Sakurai
    School of Health Sciences, Faculty of Medicine, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    Seikagaku 77:347-50. 2005
  25. doi request reprint Stress-induced transcription of regulator of G protein signaling 2 (RGS2) by heat shock transcription factor HSF1
    Azumi Ota
    Division of Health Sciences, Kanazawa University Graduate School of Medical Science, 5 11 80 Kodatsuno, Kanazawa 920 0942, Ishikawa, Japan
    Biochimie 95:1432-6. 2013
    ..A single nucleotide change identified in the RGS2 promoter of hypertensive patients abolished HSF1-regulated expression of RGS2, suggesting that activated HSF1 is involved in blood pressure regulation via modulation of RGS2 expression...
  26. ncbi request reprint Functional correlation among Gal11, transcription factor (TF) IIE, and TFIIH in Saccharomyces cerevisiae. Gal11 and TFIIE cooperatively enhance TFIIH-mediated phosphorylation of RNA polymerase II carboxyl-terminal domain sequences
    H Sakurai
    School of Health Sciences, Faculty of Medicine, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920 0942, Japan
    J Biol Chem 273:9534-8. 1998
    ....
  27. ncbi request reprint Core promoter elements are essential as selective determinants for function of the yeast transcription factor GAL11
    H Sakurai
    School of Health Sciences, Faculty of Medicine, Kanazawa University, Japan
    FEBS Lett 398:113-9. 1996
    ..These results suggest that GAL11 is specifically involved in the transcription machinery formed on the TATA element...
  28. ncbi request reprint Promoter structure-dependent functioning of the general transcription factor IIE in Saccharomyces cerevisiae
    H Sakurai
    School of Health Sciences, Faculty of Medicine, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920, Japan
    J Biol Chem 272:15936-42. 1997
    ..These results strongly suggest that requirement for TFIIE varies in each gene depending on the promoter structures in vivo...
  29. ncbi request reprint Activator-specific requirement for the general transcription factor IIE in yeast
    H Sakurai
    Faculty of Medicine, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa, 920 0942, Japan
    Biochem Biophys Res Commun 261:734-9. 1999
    ....
  30. ncbi request reprint Yeast Gal11 and transcription factor IIE function through a common pathway in transcriptional regulation
    H Sakurai
    School of Health Sciences, Faculty of Medicine, Kanazawa University, 5 11 80 Kodatsuno, Kanazawa, Ishikawa 920, Japan
    J Biol Chem 272:32663-9. 1997
    ..In a reconstituted cell-free system, Gal11 protein stimulated basal transcription in the presence of wild-type TFIIE. Such a stimulation was not seen in the presence of TFIIE-DeltaC...
  31. pmc Dynamic regulation of extracellular signal-regulated kinase (ERK) by protein phosphatase 2A regulatory subunit B56γ1 in nuclei induces cell migration
    Ei Kawahara
    Department of Clinical Laboratory Science, Kanazawa University, Kanazawa, Japan
    PLoS ONE 8:e63729. 2013
    ....
  32. ncbi request reprint Changes of near-UV CD spectrum of human hemoglobin upon oxygen binding: a study of mutants at alpha 42, alpha 140, beta 145 tyrosine or beta 37 tryptophan
    Yayoi Jin
    School of Health Sciences, Kanazawa University Faculty of Medicine, Kanazawa 920 0942, Japan
    Biopolymers 74:60-3. 2004
    ..These results indicate that environmental alteration of the penultimate tyrosine residues caused by the formation of salt bridges upon the R-->T transition is primarily responsible for the negative CD band...
  33. pmc Hsf1 activation inhibits rapamycin resistance and TOR signaling in yeast revealed by combined proteomic and genetic analysis
    Sricharan Bandhakavi
    Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota, USA
    PLoS ONE 3:e1598. 2008
    ..cerevisiae. Additionally, these results highlight the value of comparative expression analyses between large-scale proteomic and transcriptomic datasets to reveal new regulatory connections...
  34. ncbi request reprint A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II
    Henri Marc Bourbon
    Mol Cell 14:553-7. 2004