J Pan

Summary

Affiliation: Kanazawa Medical University
Country: Japan

Publications

  1. pmc Paraquat toxicity induced by voltage-dependent anion channel 1 acts as an NADH-dependent oxidoreductase
    Hiroki Shimada
    Molecular and Cell Structural Science, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    J Biol Chem 284:28642-9. 2009
  2. ncbi request reprint Paraquat detoxicative system in the mouse liver postmitochondrial fraction
    Hiroki Shimada
    Department of Anatomy, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Arch Biochem Biophys 402:149-57. 2002
  3. ncbi request reprint Mitochondrial NADH-quinone oxidoreductase of the outer membrane is responsible for paraquat cytotoxicity in rat livers
    H Shimada
    Department of Anatomy, Kanazawa Medical University, Ishikawa, Japan
    Arch Biochem Biophys 351:75-81. 1998
  4. ncbi request reprint Cytochemical energy-filtering transmission electron microscopy of mitochondrial free radical formation in paraquat cytotoxicity
    K Hirai
    Department of Anatomy and High Technology Research Center, Kanazawa Medical University, Japan
    J Electron Microsc (Tokyo) 48:289-96. 1999
  5. ncbi request reprint Furanonaphthoquinone analogs possessing preferential antitumor activity compared to normal cells
    K I Hirai
    Department of Anatomy, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Cancer Detect Prev 23:539-50. 1999
  6. ncbi request reprint Use of a quantitative real-time reverse transcription-polymerase chain reaction method to study the induction of CYP1A, CYP2B and CYP4A forms in precision-cut rat liver slices
    J Pan
    Wyeth Ayerst Research, Drug Metabolism Division, CN8000, Princeton, NJ 08543 8000, USA
    Xenobiotica 32:739-47. 2002
  7. ncbi request reprint Effect of 8-isoprostaglandin F2alpha on the newborn rat pulmonary arterial muscle and endothelium
    J Belik
    Canadian Institutes of Health Research Group in Lung Development, Lung Biology and Integrative Biology Programmes, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    J Appl Physiol 95:1979-85. 2003
  8. ncbi request reprint A bronchial epithelium-derived factor reduces pulmonary vascular tone in the newborn rat
    J Belik
    Hospital for Sick Children, Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Toronto, Ontario, Canada M5G 1X8
    J Appl Physiol 96:1399-405. 2004
  9. ncbi request reprint Activation of fibronectin gene expression by hepatitis B virus x antigen
    P A Norton
    Department of Biochemistry and Molecular Pharmacology, Jefferson Center for Biomedical Research, Thomas Jefferson University, Philadelphia, PA 18901, USA
    J Viral Hepat 11:332-41. 2004
  10. ncbi request reprint The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region
    J Pan
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, 84 West Huai hai Road, Xuzhou 221002, Jiangsu, PR China
    Neuroscience 131:147-59. 2005

Collaborators

Detail Information

Publications22

  1. pmc Paraquat toxicity induced by voltage-dependent anion channel 1 acts as an NADH-dependent oxidoreductase
    Hiroki Shimada
    Molecular and Cell Structural Science, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    J Biol Chem 284:28642-9. 2009
    ..These insights into the mechanism of PQ poisoning not only demonstrated novel physiological functions of VDAC protein, but they may facilitate the development of new therapeutic approaches...
  2. ncbi request reprint Paraquat detoxicative system in the mouse liver postmitochondrial fraction
    Hiroki Shimada
    Department of Anatomy, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    Arch Biochem Biophys 402:149-57. 2002
    ....
  3. ncbi request reprint Mitochondrial NADH-quinone oxidoreductase of the outer membrane is responsible for paraquat cytotoxicity in rat livers
    H Shimada
    Department of Anatomy, Kanazawa Medical University, Ishikawa, Japan
    Arch Biochem Biophys 351:75-81. 1998
    ..This is in good agreement with our previous results showing that PQ selectively damaged Mt in vivo and in vitro, resulting in cell death (K.-I. Hirai et al., 1992, Toxicology 72, 1-16)...
  4. ncbi request reprint Cytochemical energy-filtering transmission electron microscopy of mitochondrial free radical formation in paraquat cytotoxicity
    K Hirai
    Department of Anatomy and High Technology Research Center, Kanazawa Medical University, Japan
    J Electron Microsc (Tokyo) 48:289-96. 1999
    ..These cytochemical energy-filtering transmission electron microscopic results indicated that paraquat generated free radicals from the outer membrane of mitochondria...
  5. ncbi request reprint Furanonaphthoquinone analogs possessing preferential antitumor activity compared to normal cells
    K I Hirai
    Department of Anatomy, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Cancer Detect Prev 23:539-50. 1999
    ..In nude mouse xenograft tests, FNQ3 demonstrated a significant antitumor activity with T/C% values of 16. 6 to 41.6 against several human carcinoma and osteosarcoma cells...
  6. ncbi request reprint Use of a quantitative real-time reverse transcription-polymerase chain reaction method to study the induction of CYP1A, CYP2B and CYP4A forms in precision-cut rat liver slices
    J Pan
    Wyeth Ayerst Research, Drug Metabolism Division, CN8000, Princeton, NJ 08543 8000, USA
    Xenobiotica 32:739-47. 2002
    ..Treatment with WY, but not ARO and NaPB, for 24h produced a 20.4-fold increase in levels of CYP4A1 mRNA. 7. These results demonstrate that cultured liver slices may be used to evaluate the effect of xenobiotics on CYP form mRNA levels...
  7. ncbi request reprint Effect of 8-isoprostaglandin F2alpha on the newborn rat pulmonary arterial muscle and endothelium
    J Belik
    Canadian Institutes of Health Research Group in Lung Development, Lung Biology and Integrative Biology Programmes, Hospital for Sick Children Research Institute, Toronto, Ontario, Canada
    J Appl Physiol 95:1979-85. 2003
    ..This phenomenon may contribute to the maintenance of a higher pulmonary vascular resistance in the early postnatal period...
  8. ncbi request reprint A bronchial epithelium-derived factor reduces pulmonary vascular tone in the newborn rat
    J Belik
    Hospital for Sick Children, Department of Pediatrics, Faculty of Medicine, University of Toronto, Toronto, Toronto, Ontario, Canada M5G 1X8
    J Appl Physiol 96:1399-405. 2004
    ..We speculate that such a mechanism may be operative in vivo and plays an important role in control of pulmonary vascular resistance in the early postnatal period...
  9. ncbi request reprint Activation of fibronectin gene expression by hepatitis B virus x antigen
    P A Norton
    Department of Biochemistry and Molecular Pharmacology, Jefferson Center for Biomedical Research, Thomas Jefferson University, Philadelphia, PA 18901, USA
    J Viral Hepat 11:332-41. 2004
    ....
  10. ncbi request reprint The neuroprotective effects of K252a through inhibiting MLK3/MKK7/JNK3 signaling pathway on ischemic brain injury in rat hippocampal CA1 region
    J Pan
    Research Center for Biochemistry and Molecular Biology, Xuzhou Medical College, 84 West Huai hai Road, Xuzhou 221002, Jiangsu, PR China
    Neuroscience 131:147-59. 2005
    ..Thus, JNK signaling may eventually emerge as a prime target for novel therapeutic approaches to treatment of ischemic stroke, and K252a may serve as a potential and important neuroprotectant in therapeutic aspect in ischemic stroke...
  11. ncbi request reprint The novel tyrosine kinase inhibitor EXEL-0862 induces apoptosis in human FIP1L1-PDGFR-alpha-expressing cells through caspase-3-mediated cleavage of Mcl-1
    J Pan
    Department of Leukemia, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA
    Leukemia 21:1395-404. 2007
    ..Our data establish EXEL-0862 as a solid candidate for the targeted treatment of patients with FIP1L1-PDGFR-alpha-positive HES...
  12. ncbi request reprint Cytochrome c release is upstream to activation of caspase-9, caspase-8, and caspase-3 in the enhanced apoptosis of anaplastic thyroid cancer cells induced by manumycin and paclitaxel
    J Pan
    Section of Endocrine Neoplasia and Hormonal Disorders, Department of Internal Medicine Specialties, University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA
    J Clin Endocrinol Metab 86:4731-40. 2001
    ....
  13. ncbi request reprint Neuroepithelial bodies in mammalian lung express functional serotonin type 3 receptor
    X W Fu
    Division of Pathology, Department of Pediatric Laboratory Medicine, The Research Institute, The Hospital for Sick Children and University of Toronto, Toronto, Ontario, Canada M5G 1X8
    Am J Physiol Lung Cell Mol Physiol 281:L931-40. 2001
    ..Our studies suggest that 5-HT(3)-R in NEB cells may function as an autoreceptor and may potentially be involved in modulation of hypoxia signaling...
  14. ncbi request reprint Role of counterion condensation in folding of the Tetrahymena ribozyme. II. Counterion-dependence of folding kinetics
    S L Heilman-Miller
    Department of Chemistry, University of Maryland, College Park 20742-2021, USA
    J Mol Biol 309:57-68. 2001
    ..This is attributed to competition among counterions for binding to the RNA. The counterion dependence of the folding kinetics is discussed in terms of the ability of condensed ions to stabilize compact structures in RNA...
  15. ncbi request reprint [Effects of yinchenhao decoction on normal animals and animal models of diabetes mellitus]
    J Pan
    Guangzhou Institute of Traditional Chinese Medicine and Materia Medica, Guangzhou 510130
    Zhong Yao Cai 24:128-31. 2001
    ..05-0.01), improve IGT and lower 2hBG (P < 0.01) after OGTT in DX-induced insulin-resistant rats. CONCLUSIONS: The results suggest that yinchenhao Decoction possesses similar hypoglycemic action to meftormin and gliclazied...
  16. ncbi request reprint Hepatitis B virus X protein protects against anti-Fas-mediated apoptosis in human liver cells by inducing NF-kappa B
    J Pan
    Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Room 222 Alumni Hall, 1020 Locust Street, Philadelphia, PA 19107-6799, USA
    J Gen Virol 82:171-82. 2001
    ..Hence, HBxAg stimulation of NF-kappa B promotes the survival of liver cells against Fas killing. This may contribute to the persistence of infected hepatocytes during chronic infection...
  17. ncbi request reprint Absence of spontaneous peroxisome proliferation in enoyl-CoA Hydratase/L-3-hydroxyacyl-CoA dehydrogenase-deficient mouse liver. Further support for the role of fatty acyl CoA oxidase in PPARalpha ligand metabolism
    C Qi
    Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
    J Biol Chem 274:15775-80. 1999
    ..This blunting of peroxisome proliferative response is attributed to the absence of L-PBE protein in L-PBE-/- mouse liver, because all other proteins are induced essentially to the same extent in both wild type and L-PBE-/- mice...
  18. pmc Mouse steroid receptor coactivator-1 is not essential for peroxisome proliferator-activated receptor alpha-regulated gene expression
    C Qi
    Department of Pathology, Northwestern University Medical School, Chicago, IL 60611, USA
    Proc Natl Acad Sci U S A 96:1585-90. 1999
    ..These results indicate that SRC-1 is not essential for PPARalpha-mediated transcriptional activation in vivo and suggest redundancy in nuclear receptor coactivators...
  19. ncbi request reprint Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase. Implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism
    C Y Fan
    Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611 3008, USA
    J Biol Chem 273:15639-45. 1998
    ..These observations implicate acyl-CoA and other putative substrates for AOX, as biological ligands for PPARalpha; thus, a normal AOX gene is indispensable for the physiological regulation of PPARalpha...
  20. ncbi request reprint Hepatocellular and hepatic peroxisomal alterations in mice with a disrupted peroxisomal fatty acyl-coenzyme A oxidase gene
    C Y Fan
    Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    J Biol Chem 271:24698-710. 1996
    ..These observations demonstrate links among peroxisomal beta-oxidation, development of severe microvesicular fatty liver, peroxisome assembly, cell death, and cell proliferation in liver...
  21. pmc Tyrosine phosphorylation of inducible nitric oxide synthase: implications for potential post-translational regulation
    J Pan
    Neuroscience Therapeutic Domain, Hoechst Roussel Pharmaceuticals Inc, Somerville, NJ 08876, USA
    Biochem J 314:889-94. 1996
    ....
  22. ncbi request reprint Post-transcriptional regulation of mouse renal cytochrome P450 2E1 by testosterone
    J Pan
    Laboratory for Cancer Research, College of Pharmacy, Rutgers University, Piscataway, New Jersey 08855 0789
    Arch Biochem Biophys 299:110-5. 1992
    ..This result suggests that the sex- and testosterone-related regulation of mouse renal P450 2E1 is predominantly at the post-transcriptional level...