K Osanai

Summary

Affiliation: Kanazawa Medical University
Country: Japan

Publications

  1. pmc Expression and localization of a novel Rab small G protein (Rab38) in the rat lung
    K Osanai
    Department of Internal Medicine, Division of Respiratory Disease, Kanazawa Medical University, Ishikawa, Japan
    Am J Pathol 158:1665-75. 2001
  2. ncbi request reprint Melanocyte differentiation antigen RAB38/NY-MEL-1 induces frequent antibody responses exclusively in melanoma patients
    Alfred Zippelius
    Klinik und Poliklinik für Onkologie, Departement fur Innere Medizin, Universitatsspital Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
    Cancer Immunol Immunother 56:249-58. 2007
  3. doi request reprint Altered lung surfactant system in a Rab38-deficient rat model of Hermansky-Pudlak syndrome
    Kazuhiro Osanai
    Dept of Respiratory Medicine, Kanazawa Medical Univ, 1 1 Uchinada Daigaku, Kahokugun, Ishikawa 920 0293, Japan
    Am J Physiol Lung Cell Mol Physiol 298:L243-51. 2010
  4. pmc A mutation in Rab38 small GTPase causes abnormal lung surfactant homeostasis and aberrant alveolar structure in mice
    Kazuhiro Osanai
    Department of Respiratory Medicine, Kanazawa Medical University, Kahokugun, Ishikawa 920 0293, Japan
    Am J Pathol 173:1265-74. 2008
  5. ncbi request reprint Pulmonary surfactant transport in alveolar type II cells
    Kazuhiro Osanai
    Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan
    Respirology 11:S70-3. 2006
  6. ncbi request reprint Expression and characterization of Rab38, a new member of the Rab small G protein family
    Kazuhiro Osanai
    Department of Respiratory Medicine, Kanazawa Medical University, 1 1 Daigaku Uchinada, Kahokugun, Ishikawa 920 0293, Japan
    Biol Chem 386:143-53. 2005
  7. ncbi request reprint Denopamine, a beta(1)-adrenergic agonist, increases alveolar fluid clearance in ex vivo rat and guinea pig lungs
    T Sakuma
    Department of Pulmonary Medicine, Kanazawa Medical University, Uchinade, Ishikawa 920 0293, Japan
    J Appl Physiol (1985) 90:10-6. 2001
  8. ncbi request reprint Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs
    T Sakuma
    Department of Thoracic Surgery, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Jpn J Pharmacol 85:161-6. 2001
  9. ncbi request reprint Beta1-adrenoceptor stimulation by high-dose terbutaline downregulates terbutaline-stimulated alveolar fluid clearance in ex vivo rat lung
    T Sakuma
    Department of Thoracic Surgery, Kanazawa Medical University, Uchinade, Ishikawa, Japan
    Exp Lung Res 27:453-68. 2001
  10. ncbi request reprint Effects of hypoxia on alveolar fluid transport capacity in rat lungs
    T Sakuma
    Thoracic Surgery, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    J Appl Physiol (1985) 91:1766-74. 2001

Collaborators

Detail Information

Publications16

  1. pmc Expression and localization of a novel Rab small G protein (Rab38) in the rat lung
    K Osanai
    Department of Internal Medicine, Division of Respiratory Disease, Kanazawa Medical University, Ishikawa, Japan
    Am J Pathol 158:1665-75. 2001
    ..These results suggest that this novel rab small G protein (Rab38) mediates vesicular transport in terminal airway epithelium...
  2. ncbi request reprint Melanocyte differentiation antigen RAB38/NY-MEL-1 induces frequent antibody responses exclusively in melanoma patients
    Alfred Zippelius
    Klinik und Poliklinik für Onkologie, Departement fur Innere Medizin, Universitatsspital Zurich, Ramistrasse 100, 8091 Zurich, Switzerland
    Cancer Immunol Immunother 56:249-58. 2007
    ..Implications for the understanding of spontaneous humoral immune responses are discussed...
  3. doi request reprint Altered lung surfactant system in a Rab38-deficient rat model of Hermansky-Pudlak syndrome
    Kazuhiro Osanai
    Dept of Respiratory Medicine, Kanazawa Medical Univ, 1 1 Uchinada Daigaku, Kahokugun, Ishikawa 920 0293, Japan
    Am J Physiol Lung Cell Mol Physiol 298:L243-51. 2010
    ..These results suggest that aberrant lung surfactant secretion may be involved in the pathogenesis of interstitial pneumonia in HPS...
  4. pmc A mutation in Rab38 small GTPase causes abnormal lung surfactant homeostasis and aberrant alveolar structure in mice
    Kazuhiro Osanai
    Department of Respiratory Medicine, Kanazawa Medical University, Kahokugun, Ishikawa 920 0293, Japan
    Am J Pathol 173:1265-74. 2008
    ..These results suggest that the genetic abnormality of Rab38 affects multiple lysosome-related organelles, resulting in lung disease in addition to oculocutaneous albinism...
  5. ncbi request reprint Pulmonary surfactant transport in alveolar type II cells
    Kazuhiro Osanai
    Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa, Japan
    Respirology 11:S70-3. 2006
    ..These different pathways may reflect the different nature and role of each surfactant component such as surface tension-lowering activity and innate host defense...
  6. ncbi request reprint Expression and characterization of Rab38, a new member of the Rab small G protein family
    Kazuhiro Osanai
    Department of Respiratory Medicine, Kanazawa Medical University, 1 1 Daigaku Uchinada, Kahokugun, Ishikawa 920 0293, Japan
    Biol Chem 386:143-53. 2005
    ....
  7. ncbi request reprint Denopamine, a beta(1)-adrenergic agonist, increases alveolar fluid clearance in ex vivo rat and guinea pig lungs
    T Sakuma
    Department of Pulmonary Medicine, Kanazawa Medical University, Uchinade, Ishikawa 920 0293, Japan
    J Appl Physiol (1985) 90:10-6. 2001
    ..In summary, denopamine, a selective beta(1)-adrenergic agonist, stimulates alveolar fluid clearance in both ex vivo rat and guinea pig lungs...
  8. ncbi request reprint Beta1-adrenergic agonist is a potent stimulator of alveolar fluid clearance in hyperoxic rat lungs
    T Sakuma
    Department of Thoracic Surgery, Medical Research Institute, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Jpn J Pharmacol 85:161-6. 2001
    ..In summary, denopamine is a potent stimulator of alveolar fluid clearance in rats exposed to hyperoxia...
  9. ncbi request reprint Beta1-adrenoceptor stimulation by high-dose terbutaline downregulates terbutaline-stimulated alveolar fluid clearance in ex vivo rat lung
    T Sakuma
    Department of Thoracic Surgery, Kanazawa Medical University, Uchinade, Ishikawa, Japan
    Exp Lung Res 27:453-68. 2001
    ....
  10. ncbi request reprint Effects of hypoxia on alveolar fluid transport capacity in rat lungs
    T Sakuma
    Thoracic Surgery, Kanazawa Medical University, Uchinada, Ishikawa 920 0293, Japan
    J Appl Physiol (1985) 91:1766-74. 2001
    ..It is likely that a combination of endogenous norepinephrine and nutritional impairment regulates alveolar fluid clearance under hypoxic conditions...
  11. ncbi request reprint Inducible nitric oxide synthase expression and nuclear factor-kappaB activation in alveolar type II cells in lung injury
    H Toga
    Department of Internal Medicine, Kanazawa Medical University, Ishikawa, Japan
    Exp Lung Res 27:485-504. 2001
    ..These findings suggest that type II cells can be a source of NO production in lung injury,and that the effects of corticosteroids may be in part through inhibition of both iNOS expression and NF-kappaB activation...
  12. pmc Stimulation of alveolar epithelial fluid clearance in human lungs by exogenous epinephrine
    Tsutomu Sakuma
    Thoracic Surgery, Kanazawa Medical University, Uchinada, Ishikawa, Japan
    Crit Care Med 34:676-81. 2006
    ....
  13. ncbi request reprint Time-dependent effect of pneumonectomy on alveolar epithelial fluid clearance in rat lungs
    Tsutomu Sakuma
    Department of Thoracic Surgery, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Ishikawa 920 0293, Japan
    J Thorac Cardiovasc Surg 124:668-74. 2002
    ..Because pneumonectomy initiates compensatory growth of the remaining lung, we determined the time-dependent effects of pneumonectomy on alveolar fluid clearance capacity...
  14. doi request reprint Analysis and expression of Rab38 in oculocutaneous lung disease
    Kazuhiro Osanai
    Department of Respiratory Medicine, Kanazawa Medical University, Kahokugun, Ishikawa, Japan
    Methods Enzymol 438:203-15. 2008
    ..Rab38 is a new strong candidate gene for human Hermansky-Pudlak syndrome (HPS) that is characterized by OCA, bleeding diathesis, and lung disease...
  15. ncbi request reprint [Function of lung surfactant and its deterioration]
    Kazuhiro Osanai
    Department of Respiratory Medicine, Kanazawa Medical University, Ishikawa pref 920 0293
    Rinsho Byori 50:365-9. 2002
    ..Recently, growing evidences are accumulating that LS plays a role in innate host defense in the lung against large species of bacteria, mycoplasma, and viruses...
  16. ncbi request reprint [An intra-pulmonary lymphnode resembling typical pulmonary primary adenocarcinoma on high-resolution computed tomographic (HR-CT) chest images]
    Rieko Hatta
    Department of Respiratory Medicine, Kanazawa Medical University, 1 1 Daigaku, Uchinada, Kahoku gun, Ishikawa, Japan
    Nihon Kokyuki Gakkai Zasshi 40:980-3. 2002
    ..In cases with such radiographic findings, careful attention should be paid in the differential diagnosis to distinguish intrapulmonary lymph nodes from primary pulmonary adenocarcinoma...