Satoshi Ohno

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. ncbi Role of tumor-associated macrophages (TAM) in advanced gastric carcinoma: the impact on FasL-mediated counterattack
    Satoshi Ohno
    Department of Complementary and Alternative Medicine, Kanazawa University, Graduate School of Medical Science, Ishikawa, Japan
    Anticancer Res 25:463-70. 2005
  2. ncbi Cyclooxygenase-2 expression correlates with apoptosis and angiogenesis in endometrial cancer tissue
    Satoshi Ohno
    Departments of Complementary and Alternative Medicine, Clinical R and D, Ishikawa, Japan
    Anticancer Res 27:3765-70. 2007
  3. ncbi Expression of NLRP7 (PYPAF3, NALP7) protein in endometrial cancer tissues
    Satoshi Ohno
    Department of Complementary and Alternative Medicine Clinical R and D, Kanazawa University, Graduate School of Medical Science, Ishikawa, Japan
    Anticancer Res 28:2493-7. 2008
  4. ncbi Correlation of histological localization of tumor-associated macrophages with clinicopathological features in endometrial cancer
    Satoshi Ohno
    Department of Complementary and Alternative Medicine, Kanazawa University, Graduate School of Medical Science, Ishikawa, Japan
    Anticancer Res 24:3335-42. 2004
  5. ncbi Expression of Tn and sialyl-Tn antigens in endometrial cancer: its relationship with tumor-produced cyclooxygenase-2, tumor-infiltrated lymphocytes and patient prognosis
    Satoshi Ohno
    Department of Complementary and Alternative Medicine, Kanazawa University, Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa, 920 8640, Japan
    Anticancer Res 26:4047-53. 2006
  6. ncbi High-dose vitamin C (ascorbic acid) therapy in the treatment of patients with advanced cancer
    Satoshi Ohno
    Department of Complementary and Alternative Medicine Clinical R and D, Kanazawa University, Graduate School of Medical Science, Kanazawa, Ishikawa, 920 8640, Japan
    Anticancer Res 29:809-15. 2009
  7. ncbi The degree of macrophage infiltration into the cancer cell nest is a significant predictor of survival in gastric cancer patients
    Satoshi Ohno
    Department of Complementary and Alternative Medicine, Kanazawa University, Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8640, Japan
    Anticancer Res 23:5015-22. 2003
  8. ncbi Tumor-associated macrophages: foe or accomplice of tumors?
    Satoshi Ohno
    Department of Complementary and Alternative Medicine, Kanazawa University, Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8640, Japan
    Anticancer Res 23:4395-409. 2003
  9. ncbi Predictive factors and timing for liver recurrence after curative resection of gastric carcinoma
    Satoshi Ohno
    Department of Complementary and Alternative Medicine, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Ishikawa 920 8640, Japan
    Am J Surg 185:258-63. 2003
  10. ncbi Role of tumor-associated macrophage in malignant tumors: should the location of the infiltrated macrophages be taken into account during evaluation?
    Satoshi Ohno
    Department of Complementary and Alternative Medicine, Kanazawa University, Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8640, Japan
    Anticancer Res 22:4269-75. 2002

Collaborators

Detail Information

Publications38

  1. ncbi Role of tumor-associated macrophages (TAM) in advanced gastric carcinoma: the impact on FasL-mediated counterattack
    Satoshi Ohno
    Department of Complementary and Alternative Medicine, Kanazawa University, Graduate School of Medical Science, Ishikawa, Japan
    Anticancer Res 25:463-70. 2005
    ..We have evaluated the tumor FasL expression and TAM along the tumor margin and/or in cancer stroma, and their impact on the infiltration of immune-competent cells into the tumor nest...
  2. ncbi Cyclooxygenase-2 expression correlates with apoptosis and angiogenesis in endometrial cancer tissue
    Satoshi Ohno
    Departments of Complementary and Alternative Medicine, Clinical R and D, Ishikawa, Japan
    Anticancer Res 27:3765-70. 2007
    ..Recent experimental studies have indicated that cyclooxygenase-2 (COX-2) suppresses tumor-cell apoptosis and induces intratumoral angiogenesis. Patients and..
  3. ncbi Expression of NLRP7 (PYPAF3, NALP7) protein in endometrial cancer tissues
    Satoshi Ohno
    Department of Complementary and Alternative Medicine Clinical R and D, Kanazawa University, Graduate School of Medical Science, Ishikawa, Japan
    Anticancer Res 28:2493-7. 2008
    ..Although expression of NLRP7 in human seminoma tissues and several cancer cell lines has been demonstrated, the pathophysiological and prognostic importance in cancer tissues has not been defined...
  4. ncbi Correlation of histological localization of tumor-associated macrophages with clinicopathological features in endometrial cancer
    Satoshi Ohno
    Department of Complementary and Alternative Medicine, Kanazawa University, Graduate School of Medical Science, Ishikawa, Japan
    Anticancer Res 24:3335-42. 2004
    ..To clarify the pathophysiological role of tumor-associated macrophages (TAMs), we performed clinicopathological analysis of CD68+ cells in 70 cases of human endometrial cancer...
  5. ncbi Expression of Tn and sialyl-Tn antigens in endometrial cancer: its relationship with tumor-produced cyclooxygenase-2, tumor-infiltrated lymphocytes and patient prognosis
    Satoshi Ohno
    Department of Complementary and Alternative Medicine, Kanazawa University, Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa, 920 8640, Japan
    Anticancer Res 26:4047-53. 2006
    ..Moreover, the consequence of abnormal glycosylation and overexpression of mucins includes suppression of the host-immune function...
  6. ncbi High-dose vitamin C (ascorbic acid) therapy in the treatment of patients with advanced cancer
    Satoshi Ohno
    Department of Complementary and Alternative Medicine Clinical R and D, Kanazawa University, Graduate School of Medical Science, Kanazawa, Ishikawa, 920 8640, Japan
    Anticancer Res 29:809-15. 2009
    ..In this review, high-dose vitamin C therapy in cancer treatment is re-evaluated...
  7. ncbi The degree of macrophage infiltration into the cancer cell nest is a significant predictor of survival in gastric cancer patients
    Satoshi Ohno
    Department of Complementary and Alternative Medicine, Kanazawa University, Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8640, Japan
    Anticancer Res 23:5015-22. 2003
    ..Tumor-associated macrophages (TAMs) have varying functions depending on the microenvironment of tumor tissue. We studied the biological role of TAMs in gastric cancer on the basis of their spatial distribution in the cancer tissue...
  8. ncbi Tumor-associated macrophages: foe or accomplice of tumors?
    Satoshi Ohno
    Department of Complementary and Alternative Medicine, Kanazawa University, Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8640, Japan
    Anticancer Res 23:4395-409. 2003
    ..In this review, we focus on the range of pro- and anti-tumor functions performed by TAMs and outline a new class of cancer therapies that aims at controlling the complex functions of TAMs...
  9. ncbi Predictive factors and timing for liver recurrence after curative resection of gastric carcinoma
    Satoshi Ohno
    Department of Complementary and Alternative Medicine, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Ishikawa 920 8640, Japan
    Am J Surg 185:258-63. 2003
    ..Advanced and reliable diagnostic methods in order to identify the site of recurrence of gastric cancer in an early stage are needed...
  10. ncbi Role of tumor-associated macrophage in malignant tumors: should the location of the infiltrated macrophages be taken into account during evaluation?
    Satoshi Ohno
    Department of Complementary and Alternative Medicine, Kanazawa University, Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8640, Japan
    Anticancer Res 22:4269-75. 2002
    ..In this review, we discuss whether the recently published data can help to explain the apparent paradoxical effects of TAMs in cancers. We address this question on the basis of the histological location of TAMs in solid malignant tumors...
  11. ncbi Role of cyclooxygenase-2 in immunomodulation and prognosis of endometrial carcinoma
    Yumiko Ohno
    Department of Obstetrics and Gynecology, Kanazawa University, Graduate School of Medical Science, Ishikawa, Japan
    Int J Cancer 114:696-701. 2005
    ..Moreover, tumor-produced COX-2, which reduces the infiltration of CD8+ T cells into cancer cell nests, may allow tumors to avoid immune surveillance...
  12. ncbi WT1 expression correlates with angiogenesis in endometrial cancer tissue
    Satoshi Dohi
    Department of Obstetrics and Gynecology, Kanazawa University, Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa, 920 8640 Japan
    Anticancer Res 30:3187-92. 2010
    ..No direct comparison has been made of the relationship between the expression of Wilms' tumor gene WT1 within tumor cells and angiogenesis in vivo...
  13. ncbi Concomitant activation of AKT with extracellular-regulated kinase 1/2 occurs independently of PTEN or PIK3CA mutations in endometrial cancer and may be associated with favorable prognosiss
    Noriko Mori
    Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Cancer Sci 98:1881-8. 2007
    ....
  14. ncbi WT1 peptide vaccine stabilized intractable ovarian cancer patient for one year: a case report
    Satoshi Dohi
    Department of Obstetrics and Gynecology, Kanazawa University, Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa, 920 8640 Japan
    Anticancer Res 31:2441-5. 2011
    ..However, the immunotherapeutic mechanism of WT1 peptide and immunological escape mechanism for carcinoma cells remain to be elucidated...
  15. ncbi Activation of ERK1/2 occurs independently of KRAS or BRAF status in endometrial cancer and is associated with favorable prognosis
    Yasunari Mizumoto
    Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kanazawa University, 13 1, Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Cancer Sci 98:652-8. 2007
    ..047). These findings suggest that ERK activation occurs in a KRAS- and BRAF-independent manner in endometrial cancer, and is associated with favorable prognosis...
  16. doi Prognostic impact of CD133 expression as a tumor-initiating cell marker in endometrial cancer
    Mitsuhiro Nakamura
    Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920 8641, Japan
    Hum Pathol 41:1516-29. 2010
    ..045). Thus, the present study demonstrates that CD133 is not only a tumor-initiating cell marker but also a critical prognostic marker in endometrial cancer...
  17. ncbi Correlation between WT1 expression and cell proliferation in endometrial cancer
    Satoshi Dohi
    Department of Obstetrics and Gynecology, Kanazawa University, Graduate School of Medical Science, Kanazawa, Ishikawa, 920 8641 Japan
    Anticancer Res 29:4887-91. 2009
    ..The Wilms' tumor gene WT1 is overexpressed in endometrial cancer. Although recent studies have revealed that WT1 is a new prognostic factor, it remains unclear whether WT1 plays a pathophysiological role including cell proliferation...
  18. ncbi High Twist expression is involved in infiltrative endometrial cancer and affects patient survival
    Satoru Kyo
    Department of Obstetrics and Gynecology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    Hum Pathol 37:431-8. 2006
    ..Thus, our data implies that high Twist expression is a potential novel prognostic factor for disease survival of endometrial cancer. Furthermore, the present study implicates Twist as a potential therapeutic target for this tumor type...
  19. ncbi Immunohistochemical detection of WT1 protein in endometrial cancer
    Satoshi Ohno
    Department of Obstetrics and Gynecology, Kanazawa University, Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8640 Japan
    Anticancer Res 29:1691-5. 2009
    ..The Wilms' tumor gene WT1 is overexpressed in various kinds of solid tumors. However, it remains unclear whether WT1 plays a pathophysiological role in endometrial cancer...
  20. ncbi Quality of life improvements among cancer patients in remission following the consumption of Agaricus blazei Murill mushroom extract
    Satoshi Ohno
    Consolidated Research Institute for Advanced Science and Medical Care, Waseda University, Japan Department of Obstetrics and Gynecology, Graduate School of Medical Science, Kanazawa University, Japan Department of Clinical Research Medicine, Teikyo University School of Medicine, Japan Electronic address
    Complement Ther Med 21:460-7. 2013
    ..The aim of this preliminary clinical study was to assess if the daily intake of Agaricus blazei Murill (ABM) granulated powder (SSI Co., Ltd., Tokyo, Japan) for 6 months improved the quality of life (QOL) in cancer patients in remission...
  21. ncbi Efficacy of the herbal medicine Unkei-to as an adjunctive treatment to hormone replacement therapy for postmenopausal women with depressive symptoms
    Koji Koike
    Department of Obstetrics and Gynecology, School of Medicine, Graduate School of Medical Science, Knazawa University, Ishikawa, Japan
    Clin Neuropharmacol 27:157-62. 2004
    ..The aim of this study was to assess whether the herbal medicine Unkei-to has an impact on HRT-resistant menopausal depressive symptoms as an effective adjunctive therapy combined with HRT...
  22. ncbi [A case of long survival in Stage IV gastric carcinoma responding to combination treatment with paclitaxel and 5- fluorouracil followed by surgical resection]
    Kyoko Masumura
    Department of Surgery, Hiroshima City Hospital
    Gan To Kagaku Ryoho 35:1745-8. 2008
    ..FT therapy may be a useful method for a patient with StageIVgastric cancer...
  23. ncbi [The significance of low-dose CDDP intraperitoneal administration for cases of peritoneal dissemination of gastric cancer]
    Motoki Ninomiya
    Dept of Surgery, Hiroshima City Hospital
    Gan To Kagaku Ryoho 31:1717-9. 2004
    ..These results suggested that the low-dose CDDP intraperitoneal administration would contribute to improved prognosis of such gastric cancers as P1 or CY1...
  24. ncbi Expression and prognostic significance of PTEN product protein in patients with esophageal squamous cell carcinoma
    Mitsuo Tachibana
    Second Department of Surgery, Shimane Medical University, Enya cho 89 1, Izumo 693 8501, Shimane, Japan
    Cancer 94:1955-60. 2002
    ..The prognostic importance of PTEN product protein (PTEN) and its correlation with clinicopathologic characteristics have yet to be delineated in patients with esophageal carcinoma...
  25. ncbi Role of stromal collagen in immunomodulation and prognosis of advanced gastric carcinoma
    Satoshi Ohno
    Second Department of Surgery, Shimane Medical University, Shimane, Japan
    Int J Cancer 97:770-4. 2002
    ..Increased tumor stromal collagen worked as a barrier for CD8+ T-cell infiltration and might be one of the mechanisms of tumor escape from the host immune attack...
  26. ncbi [Evaluation of multimodality therapy for synchronous liver metastases of gastric cancer]
    Hiroshi Sasaki
    Dept of Surgery, Hiroshima City Hospital
    Gan To Kagaku Ryoho 31:1924-6. 2004
    ..These results suggested that HAI chemotherapy after hepatic resection for gastric cancer patients with synchronous liver metastasis would improve prognosis...
  27. ncbi Esophageal cancer patients surviving 6 years after esophagectomy
    Mitsuo Tachibana
    Second Department of Surgery, Shimane Medical University, Enya cho 89 1, Izumo 693 8501, Japan
    Langenbecks Arch Surg 387:77-83. 2002
    ..These patients need to be stratified according to prognostic variables for precise identification of high-risk group...
  28. ncbi Protein kinase Calpha-dependent increase in Ca2+-independent phospholipase A2 in membranes and arachidonic acid liberation in zymosan-stimulated macrophage-like P388D1 cells
    Satoshi Akiba
    Department of Pathological Biochemistry, Kyoto Pharmaceutical University, Misasagi, Yamashina ku, 607 8414, Kyoto, Japan
    Biochem Pharmacol 63:1969-77. 2002
    ..These results suggest that zymosan stimulates an increase in iPLA2 in the membranes of P388D1 cells probably through activation of PKCalpha in concert with cytochalasin D-sensitive events...
  29. ncbi Surgical treatment for locally advanced (T4) squamous cell carcinoma of the thoracic esophagus
    Mitsuo Tachibana
    Second Department of Surgery, Shimane Medical University, Enya cho 89 1, Izumo 693 8501, Shimane, Japan
    Dysphagia 17:255-61. 2002
    ..Esophageal carcinoma patients with T4 disease and distinct metastasis in the lymph nodes at a distant location (>3 cm) from the primary tumor may not benefit from an esophageal resection...
  30. ncbi [A case of cardiac cancer for which radiation therapy was effective in improving stenosis of the esophagogastric junction]
    Hiroshi Sasaki
    Dept of Surgery, Hiroshima City Hospital
    Gan To Kagaku Ryoho 29:2214-6. 2002
    ..Subjective complaints such as nausea and vomiting were also decreased, promoting her QOL. We conclude that radiation therapy treatment can be a treatment option for far advanced cardiac cancer...
  31. ncbi Effects of the traditional Japanese medicine Unkei-to on the corticotropin-releasing factor-induced increase in locomotor activity
    Kiyoshi Terawaki
    Tsumura Research Institute Medicinal Evaluation Laboratory, Tsumura and Co, Inashiki Gun, Ibaraki, Japan
    Pharmacol Biochem Behav 78:799-803. 2004
    ..These results suggest that Unkei-to has an alleviative effect on the action induced by brain CRF and the mechanism of this effect may partly involve CINC...
  32. ncbi Immunogenic variation between multiple HLA-A*0201-restricted, Hepatitis C Virus-derived epitopes for cytotoxic T lymphocytes
    Satoshi Ohno
    Department of Microbiology, Saitama Medical School, Saitama, Japan
    Viral Immunol 19:458-67. 2006
    ..Analyses of the immunogenicity of CTL epitopes such as in the current study should provide important information about the design of an efficient HCV vaccine that induces vigorous, sustained, and broad HCV-specific CTL responses...
  33. ncbi [Effects of repeated intraperitoneal CDDP chemotherapy for the prevention of T3 and T4 gastric cancer]
    Shuya Yano
    Dept of Surgery, Hiroshima City Hospital
    Gan To Kagaku Ryoho 31:1720-2. 2004
    ..Group A was superior to Group B in comparing the analyzed data. These results suggested that repeated intraperitoneal CDDP chemotherapy for the prevention of T3 and T4 advanced gastric cancer would improve survival rate...
  34. doi Phase II clinical trial of Wilms tumor 1 peptide vaccination for patients with recurrent glioblastoma multiforme
    Shuichi Izumoto
    Department of Neurosurgery, Nagoya University, Nagoya, Japan
    J Neurosurg 108:963-71. 2008
    ..The object of this study was to investigate the safety and clinical responses of immunotherapy targeting the WT1 (Wilms tumor 1) gene product in patients with recurrent glioblastoma multiforme (GBM)...
  35. ncbi Wilms tumor gene WT1 peptide-based immunotherapy induced a minimal response in a patient with advanced therapy-resistant multiple myeloma
    Akihiro Tsuboi
    Department of Cancer Immunotherapy, Osaka University Graduate School of Medicine, 1 7 Yamada oka, Suita City, Osaka, Japan
    Int J Hematol 86:414-7. 2007
    ....
  36. ncbi Aromatase expression in stromal cells of endometrioid endometrial cancer correlates with poor survival
    Tomoya Segawa
    Department of Obstetrics and Gynecology, Kanazawa University School of Medicine, Kanazawa 920 0934, Japan
    Clin Cancer Res 11:2188-94. 2005
    ....
  37. ncbi [A clinical study of endoscopic local coagulation therapy for hepatocellular carcinoma (HCC)]
    Shigehiro Shiozaki
    Dept of Surgery, Hiroshima City Hospital
    Gan To Kagaku Ryoho 32:1603-5. 2005
    ..However, it is well indicated when the scope is evident with observation being feasible from the liver surface...
  38. ncbi Multiple roles of cyclooxygenase-2 in endometrial cancer
    Satoshi Ohno
    Department of Cancer Immunotherapy, Osaka University Graduate School of Medicine, Osaka, Japan
    Anticancer Res 25:3679-87. 2005
    ..It also outlines the clinicopathological and prognostic significance of COX-2 in endometrial cancer...