Mikio Namiki

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. pmc Effectiveness and adverse effects of hormonal therapy for prostate cancer: Japanese experience and perspective
    Mikio Namiki
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Asian J Androl 14:451-7. 2012
  2. doi request reprint Prostate Cancer Working Group report
    Mikio Namiki
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Takara machi, Kanazawa City, Ishikawa 920 8640, Japan
    Jpn J Clin Oncol 40:i70-75. 2010
  3. ncbi request reprint Hormonal therapy
    Mikio Namiki
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa City, Ishikawa, Japan
    Int J Clin Oncol 12:427-32. 2007
  4. doi request reprint Primary combined androgen blockade in localized disease and its mechanism
    Mikio Namiki
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa City, Ishikawa, Japan
    Best Pract Res Clin Endocrinol Metab 22:303-15. 2008
  5. doi request reprint Prostate cancer stromal cells and LNCaP cells coordinately activate the androgen receptor through synthesis of testosterone and dihydrotestosterone from dehydroepiandrosterone
    Atsushi Mizokami
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, Takaramachi, Kanazawa City, Japan
    Endocr Relat Cancer 16:1139-55. 2009
  6. doi request reprint Tranilast inhibits hormone refractory prostate cancer cell proliferation and suppresses transforming growth factor beta1-associated osteoblastic changes
    Kouji Izumi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920 8641, Japan
    Prostate 69:1222-34. 2009
  7. pmc Liquid-based urine cytology as a tool for detection of human papillomavirus, Mycoplasma spp., and Ureaplasma spp. in men
    Shohei Kawaguchi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Clin Microbiol 50:401-6. 2012
  8. ncbi request reprint Preliminary results of tranilast treatment for patients with advanced castration-resistant prostate cancer
    Kouji Izumi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa, Ishikawa 920 8641, Japan
    Anticancer Res 30:3077-81. 2010
  9. ncbi request reprint Establishment and characterization of androgen-independent human prostate cancer cell lines, LN-REC4 and LNCaP-SF, from LNCaP
    Yoichi Iwasa
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, 13 1 Takara machi, Kanazawa city 929 8640, Japan
    Int J Urol 14:233-9. 2007
  10. doi request reprint Androgen replacement therapy contributes to improving lower urinary tract symptoms in patients with hypogonadism and benign prostate hypertrophy: a randomised controlled study
    Kazuyoshi Shigehara
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Aging Male 14:53-8. 2011

Collaborators

Detail Information

Publications95

  1. pmc Effectiveness and adverse effects of hormonal therapy for prostate cancer: Japanese experience and perspective
    Mikio Namiki
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Asian J Androl 14:451-7. 2012
    ..New hormonal compounds such as selective androgen receptor modulators capable of specifically targeting prostate cancer are expected to be developed...
  2. doi request reprint Prostate Cancer Working Group report
    Mikio Namiki
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Takara machi, Kanazawa City, Ishikawa 920 8640, Japan
    Jpn J Clin Oncol 40:i70-75. 2010
    ..At the same time, effort should be made to decrease the adverse effects of each treatment. Collaborative studies on the treatment of prostate cancer should be carried out among Asian countries...
  3. ncbi request reprint Hormonal therapy
    Mikio Namiki
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa City, Ishikawa, Japan
    Int J Clin Oncol 12:427-32. 2007
    ..Ideally, new hormonal compounds targeted only for prostate cancer will be developed...
  4. doi request reprint Primary combined androgen blockade in localized disease and its mechanism
    Mikio Namiki
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa City, Ishikawa, Japan
    Best Pract Res Clin Endocrinol Metab 22:303-15. 2008
    ..We propose algorithms for the treatment of localized prostate cancer not only in low- and intermediate-risk groups but also in the high-risk group...
  5. doi request reprint Prostate cancer stromal cells and LNCaP cells coordinately activate the androgen receptor through synthesis of testosterone and dihydrotestosterone from dehydroepiandrosterone
    Atsushi Mizokami
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, Takaramachi, Kanazawa City, Japan
    Endocr Relat Cancer 16:1139-55. 2009
    ....
  6. doi request reprint Tranilast inhibits hormone refractory prostate cancer cell proliferation and suppresses transforming growth factor beta1-associated osteoblastic changes
    Kouji Izumi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa 920 8641, Japan
    Prostate 69:1222-34. 2009
    ..To elucidate the effects of tranilast on prostate cancer, we investigated the mechanisms of its anti-tumor effect on prostate cancer...
  7. pmc Liquid-based urine cytology as a tool for detection of human papillomavirus, Mycoplasma spp., and Ureaplasma spp. in men
    Shohei Kawaguchi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Clin Microbiol 50:401-6. 2012
    ..05). LB-URC is applicable for detection of HPV, Mycoplasma, and Ureaplasma. HPV infection occurs in urothelial cells, especially in gonococcal urethritis...
  8. ncbi request reprint Preliminary results of tranilast treatment for patients with advanced castration-resistant prostate cancer
    Kouji Izumi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa, Ishikawa 920 8641, Japan
    Anticancer Res 30:3077-81. 2010
    ..It has been reported previously that tranilast has antitumour effects on prostate cancer cells. This study examined whether tranilast has clinical benefit for prostate cancer patients...
  9. ncbi request reprint Establishment and characterization of androgen-independent human prostate cancer cell lines, LN-REC4 and LNCaP-SF, from LNCaP
    Yoichi Iwasa
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, 13 1 Takara machi, Kanazawa city 929 8640, Japan
    Int J Urol 14:233-9. 2007
    ..To investigate the mechanisms of androgen-independent growth in prostate cancer (PCa), we established two PCa cell lines, LN-REC4 and LNCaP-SF, from the androgen-dependent PCa cell line, LNCaP...
  10. doi request reprint Androgen replacement therapy contributes to improving lower urinary tract symptoms in patients with hypogonadism and benign prostate hypertrophy: a randomised controlled study
    Kazuyoshi Shigehara
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Aging Male 14:53-8. 2011
    ..We performed a randomised controlled study regarding the effects of androgen replacement therapy (ART) on lower urinary tract symptoms (LUTS) in hypogonadal men with benign prostate hypertrophy (BPH)...
  11. doi request reprint The role of percutaneous needle biopsy in differentiation of renal tumors
    Kouji Izumi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Jpn J Clin Oncol 40:1081-6. 2010
    ..In this study, we examined the background, accuracy, adverse events and patient prognosis associated with such biopsies...
  12. ncbi request reprint Gene therapy for prostate cancer using the cytosine deaminase/uracil phosphoribosyltransferase suicide system
    Tohru Miyagi
    Department of Urology, Kanazawa University School of Medicine, Kanazawa, Japan
    J Gene Med 5:30-7. 2003
    ..This study demonstrates the effectiveness of transduction of the UPRT gene in addition to CD/5-FC cancer suicide gene therapy...
  13. doi request reprint Increases in bone turnover marker levels at an early phase after starting zoledronic acid predicts skeletal-related events in patients with prostate cancer with bone metastasis
    Kouji Izumi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Japan
    BJU Int 109:394-400. 2012
    ..To examine whether bone turnover markers could be predictive markers of the probability of newly arising skeletal-related events (SRE) after the start of zoledronic acid treatment in patients with prostate cancer with bone metastasis...
  14. doi request reprint Prevalence of genital Mycoplasma, Ureaplasma, Gardnerella, and human papillomavirus in Japanese men with urethritis, and risk factors for detection of urethral human papillomavirus infection
    Kazuyoshi Shigehara
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13 1, Takaramachi, Kanazawa, Ishikawa, 920 8641, Japan
    J Infect Chemother 17:487-92. 2011
    ..85 (95% CI 1.49-9.94) and 2.41 (95% CI 1.03-5.61), respectively. It is likely that urethral HPV detection is associated with current sexual activity and the presence of N. gonorrhoeae, C. trachomatis, and/or M. genitalium infections...
  15. ncbi request reprint Repression of cell proliferation and androgen receptor activity in prostate cancer cells by 2'-hydroxyflavanone
    Mitsuo Ofude
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, 13 1 Takaramachi, Kanazawa, Ishikawa, 920 8640, Japan
    Anticancer Res 33:4453-61. 2013
    ..We explored the effect of 2'-hydroxyflavanone on proliferation and androgen responsiveness using prostate cancer cell lines...
  16. ncbi request reprint Antitumor effect of reduction of 150-kDa oxygen-regulated protein expression on human prostate cancer cells
    Tohru Miyagi
    Department of Urology, Kanazawa University School of Medicine, Kanazawa, Japan
    Int J Urol 9:577-85. 2002
    ....
  17. doi request reprint Adrenal androgen levels as predictors of outcome in castration-resistant prostate cancer patients treated with combined androgen blockade using flutamide as a second-line anti-androgen
    Kazutaka Narimoto
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Int J Urol 17:337-45. 2010
    ..To analyze the clinical effects of flutamide as a second-line anti-androgen for combined androgen blockade in patients with castration-resistant prostate cancer (CRPC) initially treated with bicalutamide as a first-line anti-androgen...
  18. doi request reprint A novel Y chromosome microdeletion with the loss of an endogenous retrovirus related, testis specific transcript in AZFb region
    Ho Su Sin
    Department of Integrative Cancer Therapy, Andrology Unit, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Urol 186:1545-52. 2011
    ..We evaluated the relationship between endogenous retroviruses, and TTY expression patterns and function in spermatogenesis...
  19. doi request reprint Etiologic role of human papillomavirus infection in bladder carcinoma
    Kazuyoshi Shigehara
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Cancer 117:2067-76. 2011
    ..The authors elucidated an etiologic role of human papillomavirus (HPV) infection in carcinoma of the bladder...
  20. ncbi request reprint Retrospective analysis of the efficacy of two cycles of M-VAC neoadjuvant chemotherapy followed by radical cystectomy for muscle-invasive bladder cancer
    Yasuhide Kitagawa
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Takaramachi 13 1, Kanazawa, Ishikawa, Japan
    Anticancer Res 33:4497-503. 2013
    ..We determined the efficacy of two cycles of neoadjuvant chemotherapy with methotrexate, vinblastine, adriamycin, and cisplatin followed by radical cystectomy...
  21. ncbi request reprint The adrenal androgen androstenediol is present in prostate cancer tissue after androgen deprivation therapy and activates mutated androgen receptor
    Atsushi Mizokami
    Department of Urology, Kanazawa University, Kanazawa, Japan
    Cancer Res 64:765-71. 2004
    ..However, low concentration of adiol induced more AR nuclear translocation than DHT in LNCaP cells and not PC-3 cells transfected with AR. These results indicate that adiol may cause the progression of PCa even after hormone therapy...
  22. ncbi request reprint Study of azoospermia factor-a deletion caused by homologous recombination between the human endogenous retroviral elements and population-specific alleles in Japanese infertile males
    Jin Choi
    Department of Integrated Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Fertil Steril 89:1177-82. 2008
    ..To evaluate the relationship between the status of homologous recombination and population-specific alleles in infertile Japanese males with azoospermia factor (AZF)-a deletions and to characterize the clinical features of these patients...
  23. doi request reprint Clinicopathological outcomes of clinical T1a renal cell carcinoma by tumor size
    Yasuhide Kitagawa
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 920 8640 Takaramachi 13 1, Kanazawa, Ishikawa, Japan
    Jpn J Clin Oncol 41:637-41. 2011
    ..The clinicopathological findings and patients' prognoses were analyzed according to tumor size, and risk factors for tumor recurrence were elucidated...
  24. doi request reprint A case of bone, lung, pleural and liver metastases from renal cell carcinoma which responded remarkably well to zoledronic acid monotherapy
    Sotaro Miwa
    Department of Integrative Cancer Therapy and Urology, 13 1 Takara machi, Kanazawa City 920 8640, Japan
    Jpn J Clin Oncol 39:745-50. 2009
    ..We believe that the present report is the first of its kind announcing that ZA monotherapy has been effective for lung, pleural and liver metastases from RCC...
  25. doi request reprint CTEN/tensin 4 expression induces sensitivity to paclitaxel in prostate cancer
    Youqiang Li
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Japan
    Prostate 70:48-60. 2010
    ..Our results indicated that expression of the C-terminal tensin like protein (CTEN, tensin 4) gene was down-regulated by 10-fold in PC-3-TxR cells. We investigated the possibility that CTEN overexpression restores paclitaxel sensitivity...
  26. ncbi request reprint Global update on defining and treating high-risk localized prostate cancer with leuprorelin: an Asian perspective
    Atsushi Mizokami
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, Japan
    BJU Int 99:6-9; discussion 17-8. 2007
    ....
  27. doi request reprint Clinical results of iridium-192 high dose rate brachytherapy with external beam radiotherapy
    Takahiro Nohara
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Jpn J Clin Oncol 40:677-83. 2010
    ..Here, we report the clinical results of iridium-192 high dose rate brachytherapy at Kanazawa University Hospital...
  28. doi request reprint Features of constitutive gr/gr deletion in a Japanese population
    Ho Su Sin
    Department of Integrative Cancer Therapy, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa 920 8641, Japan
    Hum Reprod 25:2396-403. 2010
    ..The aim of this study was to investigate the association between gr/gr deletions and spermatogenic phenotype in fertile and infertile Japanese men...
  29. doi request reprint Exogenous SPARC suppresses proliferation and migration of prostate cancer by interacting with integrin β1
    Minkyoung Shin
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa, Japan
    Prostate 73:1159-70. 2013
    ..The matricellular protein secreted protein acidic and rich in cysteine (SPARC) plays an important role on tumor metastasis and progression in several cancers. However, the roles of SPARC in prostate cancer (PCa) remain unclear...
  30. ncbi request reprint Efficacy of androgen deprivation therapy for localized prostate cancer: analysis of pT0 evaluated by radical prostatectomy specimen
    Yoshifumi Kadono
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa, Ishikawa 920 8641, Japan
    Anticancer Res 33:1147-51. 2013
    ....
  31. doi request reprint Down-regulation of calcium/calmodulin-dependent protein kinase kinase 2 by androgen deprivation induces castration-resistant prostate cancer
    Takashi Shima
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, Ishikawa, Japan
    Prostate 72:1789-801. 2012
    ..It is important to identify differentially expressed genes between PCa and normal prostate tissues and to reveal the function of these genes that are involved in progression of PCa...
  32. ncbi request reprint Ethinylestradiol improves prostate-specific antigen levels in pretreated castration-resistant prostate cancer patients
    Kouji Izumi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Anticancer Res 30:5201-5. 2010
    ..However, its use has declined after the development of combined androgen blockade. In the present study, we analyzed the effects of ethinylestradiol on pretreated castration-resistant PCa patients...
  33. doi request reprint Risedronate recovers bone loss in patients with prostate cancer undergoing androgen-deprivation therapy
    Kouji Izumi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Urology 73:1342-6. 2009
    ..ADT for PCa has iatrogenic complications (eg, bone loss and fracture)...
  34. ncbi request reprint Single nucleotide polymorphism analysis of the follicle-stimulating hormone (FSH) receptor in Japanese with male infertility: identification of codon combination with heterozygous variations of the two discrete FSH receptor gene
    Chiharu Shimoda
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Endocr J 56:859-65. 2009
    ..Dysfunction of the FSH receptor (FSHR) may be involved in some form of male infertility with azoospermia or oligozoospermia. We assessed the discrete codon combination with homo/heterozygous variation of the exon 10 in the FSHR gene...
  35. ncbi request reprint Preserved renal function after percutaneous radiofrequency ablation for renal tumors: experience of a single institution
    Mitsuo Ofude
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa, Japan, 920 8640
    Anticancer Res 33:4669-73. 2013
    ..Percutaneous radiofrequency ablation (RFA) for small renal tumors has been reported to be effective in patients with poor surgical status. We retrospectively analyzed clinical outcomes, including renal function, after RFA...
  36. doi request reprint Role of surgical resection in adult urological soft tissue sarcoma: 25-year experience
    Kouji Izumi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Urol Int 84:309-14. 2010
    ..As adult urological soft tissue sarcomas (STS) are rare, there have been few recent large-scale studies of these tumors. This report describes a single institutional experience of adult urological STS over 25 years...
  37. ncbi request reprint Efficacy of primary hormonal therapy for patients with localized and locally advanced prostate cancer: a retrospective multicenter study
    Satoru Ueno
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Int J Urol 13:1494-500. 2006
    ..A retrospective review of patients with localized and locally advanced prostate cancer was performed to evaluate the efficacy of primary hormonal therapy and predict long-term prognosis in these patients...
  38. doi request reprint Myelodysplastic syndrome treated effectively with testosterone enanthate
    Masashi Iijima
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Int J Urol 18:469-71. 2011
    ....
  39. ncbi request reprint The effectiveness of interferon-alpha subtypes alternation for metastasis from renal cell carcinoma
    Yoshifumi Kadono
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa
    Biomed Res 33:323-8. 2012
    ..Among the three SD cases, one has continued SD for 14 months and the other for 12 months. Alternating IFN-α therapy for mRCC can be attempted even if other cytokines are not effective...
  40. ncbi request reprint Bisphosphonate induces apoptosis and inhibits pro-osteoclastic gene expression in prostate cancer cells
    Hideki Asahi
    Department of Urology, School of Medicine, Kanazawa University, Kanazawa, Japan
    Int J Urol 13:593-600. 2006
    ..To determine the direct effects of bisphosphonate on prostate cancer, we examined the effects of minodronate on prostatic cancer cell growth and the expression of apoptosis-related proteins and osteoclastogenic factors...
  41. doi request reprint Etiological role of human papillomavirus infection for inverted papilloma of the bladder
    Kazuyoshi Shigehara
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Med Virol 83:277-85. 2011
    ..High-risk HPV infection may be one of the causes of urothelial inverted papilloma, and inverted papilloma with atypia may have malignant potential...
  42. doi request reprint Current outcome of patients with ureteral stents for the management of malignant ureteral obstruction
    Kouji Izumi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Urol 185:556-61. 2011
    ..We analyzed the prognostic factors associated with overall survival and predictive factors of stent failure in patients treated with an indwelling retrograde ureteral stent for malignant ureteral obstruction...
  43. ncbi request reprint Comparison of two in vivo models for prostate cancer: orthotopic and intratesticular inoculation of LNCaP or PC-3 cells
    Kiyoshi Koshida
    Department of Urology, Graduate School of Medical Science, 13 1, Kanazawa University, Kanazawa City, Ishikawa 920 8641, Japan
    Int J Urol 11:1114-21. 2004
    ..In order to investigate the factors responsible for these events, we need appropriate in vivo models...
  44. doi request reprint Cranial nerve deficit caused by skull metastasis of prostate cancer: three Japanese castration-resistant prostate cancer cases
    Kouji Izumi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa, Ishikawa 920 8641, Japan
    Int J Clin Oncol 15:631-4. 2010
    ..EBRT with 40-50 Gy in 20-25 fractions in association with corticosteroid administration may be reasonable treatment of patients with metastatic PCa who develop cranial nerve dysfunction...
  45. doi request reprint Predictor of de novo stress urinary incontinence following TVM procedure: a further analysis of preoperative voiding function
    Masato Kuribayashi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University, Graduate School of Medical Science, 920 8640 Takaramachi 13 1, Kanazawa, Ishikawa, Japan
    Int Urogynecol J 24:407-11. 2013
    ..The purpose of this study was to evaluate the predictors of de novo stress urinary incontinence (SUI) in patients undergoing a tension-free vaginal mesh procedure (TVM) for pelvic organ prolapse (POP)...
  46. doi request reprint Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions
    Hiroshi Arakawa
    Department of Membrane Transport and Biopharmaceutics, Faculty of Pharmaceutical Science, Kanazawa University, Kakuma machi, Kanazawa, 920 1192, Japan
    Biochem Pharmacol 84:1070-7. 2012
    ..Our results suggest that enhanced OATP1A2 expression is associated with adaptive cell growth of prostate cancer cells under androgen-depleted conditions. Thus, OATP1A2 may be a pharmacological target for prostate cancer treatment...
  47. ncbi request reprint Retrospective study on stage B prostate cancer in the Hokuriku District, Japan
    Masayuki Egawa
    Department of Integrative Cancer Therapy and Urology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Int J Urol 11:304-9. 2004
    ..The present study was conducted to investigate how patients with clinically localized prostate cancer were treated in the Hokuriku District, Japan...
  48. ncbi request reprint Liquid chromatography-tandem mass spectrometry (LC-MS/MS) assay for simultaneous measurement of salivary testosterone and cortisol in healthy men for utilization in the diagnosis of late-onset hypogonadism in males
    Futoshi Matsui
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    Endocr J 56:1083-93. 2009
    ..05). LC-MS/MS allows rapid, simultaneous, sensitive, and accurate quantification of testosterone and cortisol in saliva for the diagnosis late-onset hypogonadism or other hormone related disease...
  49. doi request reprint Human endogenous retrovirus K14C drove genomic diversification of the Y chromosome during primate evolution
    Ho Su Sin
    Department of Integrative Cancer Therapy and Urology, Andrology Unit, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Hum Genet 55:717-25. 2010
    ..Taken together, our observation suggested that HERV-K14C-related sequences contributed to genomic diversification of Y chromosome during speciation of great ape lineage...
  50. ncbi request reprint Detection of sentinel node micrometastasis by step section and immunohistochemistry in patients with prostate cancer
    Mamoru Fukuda
    Department of Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Urol 177:1313-7; discussion 1317. 2007
    ..In patients administered neoadjuvant hormone therapy its influence on the sentinel node concept and metastasis diagnosis was also investigated...
  51. ncbi request reprint Efficacy of combined androgen blockade with zoledronic acid treatment in prostate cancer with bone metastasis: the ZABTON-PC (zoledronic acid/androgen blockade trial on prostate cancer) study
    Satoru Ueno
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8640, Japan
    Anticancer Res 33:3837-44. 2013
    ..Aim: Zoledronic acid (ZA) reduces the risk of skeletal-related events (SREs) in castration-resistant prostate cancer (CRPC) with bone metastasis and improves quality of life. It remains unclear when clinicians should initiate ZA treatment...
  52. ncbi request reprint Androgen-independent growth in LNCaP cell lines and steroid uridine diphosphate-glucuronosyltransferase expression
    Jiro Kanaya
    Department of Urology, Kanazawa University Graduate School of Medical Science, 15 1 Takarama machi, Kanazawa 920 8641, Japan
    Asian J Androl 5:9-13. 2003
    ..To investigate the mechanism of androgen-independent growth of prostate cancer after androgen ablation in LNCaP cells and the effect of glucuronidation activity...
  53. ncbi request reprint Cyclooxygenase-2 promotes prostate cancer progression
    Hiroshi Fujita
    Department of Urology, Kanazawa University, Kanazawa City, Japan
    Prostate 53:232-40. 2002
    ..Several studies have reported that COX-2 overexpression is associated with carcinogenesis, cell growth, angiogenesis, apoptosis, and invasiveness in a variety of tumor types...
  54. doi request reprint Japan Cancer of the Prostate Risk Assessment for combined androgen blockade including bicalutamide: clinical application and validation
    Yasuhide Kitagawa
    Department of Integrative Cancer Therapy and Urology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan
    Int J Urol 20:708-14. 2013
    ..We examined whether the clinical outcomes of patients treated with combined androgen blockade could be stratified using the Japan Cancer of the Prostate Risk Assessment...
  55. doi request reprint Cardiovascular and respiratory effects of the degree of head-down angle during robot-assisted laparoscopic radical prostatectomy
    Yoshifumi Kadono
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Japan
    Int J Med Robot 9:17-22. 2013
    ..The present study was performed to investigate the influence of each angle of Trendelenburg position during RALP on cardiovascular and respiratory homeostasis...
  56. ncbi request reprint In vitro chemosensitivity test for human genito-urinary tumors using collagen gel matrix
    Kiyoshi Koshida
    Department of Urology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Int J Urol 12:67-72. 2005
    ..Although the aim of chemosensitivity tests is to predict the efficacy of anticancer agents for individual patients, no generally accepted assay has been established...
  57. ncbi request reprint Novel HER2 selective tyrosine kinase inhibitor, TAK-165, inhibits bladder, kidney and androgen-independent prostate cancer in vitro and in vivo
    Joji Nagasawa
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medicine, Kanazawa, Ishikawa, Japan
    Int J Urol 13:587-92. 2006
    ..Several reports suggest HER2 expression in bladder cancer, renal cell carcinoma (RCC) and androgen-independent prostate cancer. We therefore investigated the antitumor effect of TAK-165 on these urological cancer cells...
  58. doi request reprint Postoperative voiding function in patients undergoing tension-free vaginal mesh procedure for pelvic organ prolapse
    Masato Kuribayashi
    Department of Integrative Cancer Therapy and Urology, Graduate School of Medical Science, Kanazawa University, 920 8640 Takaramachi 13 1, Kanazawa, Ishikawa, Japan
    Int Urogynecol J 22:1299-303. 2011
    ..We compared pre- and postoperative voiding function in patients with POP and assessed the efficacy of urodynamic studies in these cases...
  59. ncbi request reprint The establishment of two paclitaxel-resistant prostate cancer cell lines and the mechanisms of paclitaxel resistance with two cell lines
    Masashi Takeda
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Sciences, Kanazawa, Ishikawa, Japan
    Prostate 67:955-67. 2007
    ..Although paclitaxel is used for hormone-resistant prostate cancer, relapse definitely occurs later. Details of the molecular mechanism responsible for paclitaxel- resistance remain unclear...
  60. doi request reprint Tissue-specific differentially methylated regions of the human VASA gene are potentially associated with maturation arrest phenotype in the testis
    Kazuhiro Sugimoto
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    J Hum Genet 54:450-6. 2009
    ..This finding represents an important contribution to the molecular basis of meiotic arrest as one possible cause of idiopathic infertility...
  61. pmc Severe renal hemorrhage in a pregnant woman complicated with antiphospholipid syndrome: a case report
    Shohei Kawaguchi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa, Ishikawa 920 8641, Japan
    Adv Urol 2011:791094. 2011
    ..This is the first case report of serious renal hemorrhage in a pregnant woman with antiphospholipid syndrome receiving anticoagulation treatment and is an instructive case for urological and obstetrical practitioners...
  62. doi request reprint Measurement-specific bioavailable testosterone using concanavalin A precipitation: comparison of calculated and assayed bioavailable testosterone
    Kenrou Yamamoto
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Int J Urol 16:894-901. 2009
    ..To assess the value of calculated bioavailable testosterone (cBT) and assayed BT (aBT) for the diagnosis of late-onset hypogonadism (LOH) in middle-aged and elderly subjects...
  63. doi request reprint Successful treatment for metastases from renal cell carcinoma with alternation of interferon-alpha subtypes
    Sotaro Miwa
    Department of Urology, Kanazawa University Hospital, Kanazawa, Ishikawa, Japan
    Int J Clin Oncol 15:97-100. 2010
    ..Therefore, treatment was changed to Sumiferon, after which the pulmonary metastases and left hilar lymph node metastasis decreased in size. The metastases showed no progression for 16 months after switching from OIF to Sumiferon...
  64. ncbi request reprint Inverse correlation of microvessel density with metastasis and prognosis in renal cell carcinoma
    Tetsuya Imao
    Department of Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Int J Urol 11:948-53. 2004
    ..In order to clarify the significance of MVD, we investigated the relationships between MVD and tumor stage, grade, size, occurrence of metastasis and patient survival...
  65. ncbi request reprint Pathological effects of neoadjuvant hormonal therapy help predict progression of prostate cancer after radical prostatectomy
    Yasuhide Kitagawa
    Department of Urology, National Kanazawa Hospital, Kanazawa, Japan
    Int J Urol 10:377-82. 2003
    ..It is not clear whether pathological changes following neoadjuvant hormonal therapy (NHT) prior to radical prostatectomy have any value as predictors of progression in prostate cancer...
  66. doi request reprint A case study of human papillomavirus-associated bladder carcinoma developing after urethral condyloma acuminatum
    Shohei Kawaguchi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13 1, Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    Jpn J Clin Oncol 42:455-8. 2012
    ..Human papilloma virus-58 was continuously detected in the urethral brushing samples 8 years after treatment for urethral condyloma, and human papilloma virus-58 infection was still persistent in the urethra...
  67. ncbi request reprint Effects of opioid subtypes on detrusor overactivity in rats with cerebral infarction
    Yasuhiro Nagasaka
    Department of Urology, School of Medicine, Kanazawa University, Kanazawa, Japan
    Int J Urol 14:226-31; discussion 232. 2007
    ..In order to determine the influence of different opioid receptor subtypes on detrusor overactivity after left middle cerebral artery (MCA) occlusion, cystometric recordings were obtained in conscious rats...
  68. ncbi request reprint Alu sequence variants of the BPY2 gene in proven fertile and infertile men with Sertoli cell-only phenotype
    Jin Choi
    Department of Integrated Cancer Therapy and Urology, Kanazawa University Graduate School, Kanazawa, Japan
    Int J Urol 14:431-5. 2007
    ..Our objective was to screen the single nucleotide variation of BPY2 gene paralogously...
  69. ncbi request reprint Involvement of ABC transporters in chemosensitivity of human renal cell carcinoma, and regulation of MRP2 expression by conjugated bilirubin
    Masaaki Nomura
    Department of Pharmacy, Kanazawa University Hospital, Kanazawa, Japan
    Anticancer Res 25:2729-35. 2005
    ..Thus, the effectiveness of anticancer drugs selected on the basis of in vitro chemosensitivity testing of clinical cancers may be overestimated...
  70. doi request reprint Modified anatrophic partial nephrectomy with selective renal segmental artery clamping to preserve renal function: a preliminary report
    Takahiro Nohara
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Int J Urol 15:961-6. 2008
    ..We aimed to evaluate whether anatrophic partial nephrectomy (APNx) is useful in preserving renal function and to assess variations in renal artery anatomy to determine the feasibility of selective segmental artery clamping...
  71. doi request reprint Relationship between tumor-infiltrating T lymphocytes and clinical response after reduced-intensity allogeneic hematopoietic stem cell transplantation for advanced renal cell carcinoma: a single center prospective study
    Ken Ishiyama
    Division of Cancer Medicine, Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Jpn J Clin Oncol 39:807-12. 2009
    ..We performed an institutional clinical study of HSCT for refractory RCC patients...
  72. doi request reprint Free-to-total prostate-specific antigen (PSA) ratio contributes to an increased rate of prostate cancer detection in a Japanese population screened using a PSA level of 2.1-10.0 ng/ml as a criterion
    Yoshitomo Kobori
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, 13 1 Takaramachi, Kanazawa 920 8640, Japan
    Int J Clin Oncol 13:229-32. 2008
    ..We examined the clinical usefulness of the f/t ratio for screening in a Japanese population...
  73. doi request reprint [Bone and Men's Health. Hormonal therapy and bone loss in prostate cancer]
    Kouji Izumi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science
    Clin Calcium 20:175-81. 2010
    ..Bisphosphonates have been reported to prevent the bone loss caused by hormonal therapy. Therefore, oral bisphosphonates will play an important role in preventing bone loss in prostate cancer patients undergoing hormonal therapy...
  74. doi request reprint Clinical outcomes of prostate cancer patients detected by prostate-specific antigen-based population screening in Kanazawa City, Japan
    Yasuhide Kitagawa
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Int J Urol 18:592-6. 2011
    ..We analyzed the clinical characteristics and outcomes of prostate cancer patients detected in our prostate-specific antigen (PSA)-based population screen, and examined the efficiency of the system...
  75. ncbi request reprint Four year clinical statistics of iridium-192 high dose rate brachytherapy
    Kazuyoshi Shigehara
    Department of Urology, Kanazawa University Hospital, Kanazawa City, Japan
    Int J Urol 13:116-21. 2006
    ..We evaluated the efficacy and complications of high dose rate (HDR) brachytherapy using iridium-192 (192Ir) combined with external beam radiotherapy (EBRT) in patients with prostate cancer...
  76. doi request reprint Immediate effect on overactive bladder symptoms following administration of imidafenacin
    Yasuhide Kitagawa
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Takara machi 13 1, Kanazawa, Ichikawa, Japan
    Urol Int 86:330-3. 2011
    ..We investigated the immediate effect of imidafenacin on OAB symptoms...
  77. doi request reprint Fluoroscopic imaging of needle position in the tension-free vaginal mesh procedure for pelvic organ prolapse: two case reports
    Yasuhide Kitagawa
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    J Obstet Gynaecol Res 38:867-70. 2012
    ..Fluoroscopic imaging may be useful to understand the movement of surgical devices in the blind space, objectively evaluate the surgeon's skill, avoid injury to the pelvic organs, and detect any such injury immediately should it occur...
  78. ncbi request reprint [Total androgen blockade]
    Mikio Namiki
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science
    Nihon Rinsho 60:193-8. 2002
  79. ncbi request reprint Liquid chromatography-mass spectrometric assay of androstenediol in prostatic tissue: influence of androgen deprivation therapy on its level
    Tatsuya Higashi
    Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Steroids 71:1007-13. 2006
    ..83 +/- 0.28, 0.62 +/- 0.31 and 0.71 +/- 0.28 ng g(-1)tissue, respectively, and there was no significant difference between these groups...
  80. ncbi request reprint High-dose chemotherapy with peripheral blood stem cell transplantation for advanced testicular cancer
    Kiyoshi Koshida
    Department of Urology, Division of Transfusion Medicine, School of Medicine, Kanazawa University, 13 12 Takaramachi, Kanazawa 920 8640, Japan
    Int J Urol 9:146-53. 2002
    ..The aim of this study was to investigate the efficacy and safety of high-dose chemotherapy (HDCT) for the treatment of patients with advanced testicular cancer...
  81. ncbi request reprint Isolated hyperkalemia associated with cyclosporine administration in allogeneic stem cell transplantation for renal cell carcinoma
    Akiyoshi Takami
    Department of Cellular Transplantation Biology, Kanazawa University Graduate School of Medicine, Kanazawa, Japan
    Int J Hematol 81:159-61. 2005
    ..We propose that the presence of a single functional kidney may be a risk factor for isolated hyperkalemia due to CSP...
  82. ncbi request reprint Antitumor effect of radioimmunotherapy in a mouse model of testicular tumor with micrometastases defined by polymerase chain reaction
    Kiyoshi Koshida
    Department of Urology, School of Medicine, Kanazawa University, Kanazawa 920 8640, Japan
    Oncol Rep 9:1261-6. 2002
    ..These findings appear to have implications for the use of RIT in treatment for micrometastasis, especially when detectable only by PCR assay...
  83. ncbi request reprint Determination of prostatic androgens in 10 mg of tissue using liquid chromatography-tandem mass spectrometry with charged derivatization
    Tatsuya Higashi
    Division of Pharmaceutical Sciences, Graduate School of Natural Science and Technology, Kanazawa University, Kakuma machi, Kanazawa 920 1192, Japan
    Anal Bioanal Chem 382:1035-43. 2005
    ..0 ng g(-1) tissue. The developed method was used to determine DHT and T in the prostates of patients with benign prostatic hyperplasia and prostate cancer, and satisfactory results were obtained...
  84. doi request reprint Multiple noncoding exons 1 of nuclear receptors NR4A family (nerve growth factor-induced clone B, Nur-related factor 1 and neuron-derived orphan receptor 1) and NR5A1 (steroidogenic factor 1) in human cardiovascular and adrenal tissues
    Masashi Demura
    Division of Endocrinology and Hypertension, Department of Internal Medicine, Japan
    J Hypertens 29:1185-95. 2011
    ..The present study was undertaken to elucidate the mechanism of differential regulation of nuclear receptors between cardiovascular and adrenal tissues...
  85. ncbi request reprint Simultaneous determination of androstenediol 3-sulfate and dehydroepiandrosterone sulfate in human serum using isotope diluted liquid chromatography-electrospray ionization-mass spectrometry
    Kuniko Mitamura
    Faculty of Pharmaceutical Sciences, Kanazawa University, 13 1 Takara machi, Kanazawa 920 0934, Japan
    J Chromatogr B Analyt Technol Biomed Life Sci 796:121-30. 2003
    ..2-245.3 mg/ml (Adiol-3S) and 0.175-5.16 microg/ml (DHEA-S), and those of patients with prostate cancer (n=19) were 15.3-182.7 ng/ml (Adiol-3S; four samples, not detectable) and 0.110-2.421 microg/ml (DHEA-S)...
  86. doi request reprint Ureteral cancer first recognized by mechanical ileus due to intestinal metastasis
    Shigeyuki Takamatsu
    Department of Radiology, Kanazawa University Graduate School of Medical Science, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    Jpn J Radiol 27:48-52. 2009
    ..We believe this to be the first case of ureteral TCC that was first recognized because of mechanical ileus due to small intestinal metastasis...
  87. doi request reprint Prevalence of human papillomavirus infection in the urinary tract of men with urethritis
    Kazuyoshi Shigehara
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Ishikawa, Japan
    Int J Urol 17:563-8. 2010
    ..To investigate the prevalence of human papillomavirus (HPV) in the genital and urinary tract of men with urethritis...
  88. doi request reprint Putative transport mechanism and intracellular fate of trans-1-amino-3-18F-fluorocyclobutanecarboxylic acid in human prostate cancer
    Hiroyuki Okudaira
    Division of Health Sciences, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan
    J Nucl Med 52:822-9. 2011
    ..Therefore, we aimed to clarify the anti-(18)F-FACBC transport mechanism in prostate cancer cells. We also studied the fate of anti-(18)F-FACBC after it is transported into cells...
  89. ncbi request reprint Case of acute urinary retention as a result of non-steroidal anti-inflammatory drugs
    Hidero Minami
    Department of Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Int J Urol 14:368-9. 2007
    ..This patient was regularly followed up as an outpatient, and she could void smoothly in February 2006. This is the first report which acute urinary retention associated with non-steroidal anti-inflammatory drugs in Japan...
  90. ncbi request reprint Durability of working channel in flexible ureteroscopes when inserting ureteroscopic devices
    Chikashi Seto
    Department of Urology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    J Endourol 20:223-6. 2006
    ..We studied the physical damage to the working channel of flexible ureteroscopes caused by insertion of various accessories. A procedure was developed to avoid channel damage...
  91. ncbi request reprint Validity of sentinel lymph node concept for patients with prostate cancer
    Hiroshi Takashima
    Departments of Urology and Biotracer Medicine, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    J Urol 171:2268-71. 2004
    ..We investigated the feasibility and validity of the sentinel lymph node concept for patients with prostate cancer...
  92. pmc Late-onset hypogonadism syndrome and lower urinary tract symptoms
    Kazuyoshi Shigehara
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Ishikawa, Japan
    Korean J Urol 52:657-63. 2011
    ..However, only limited information is available regarding the effects of longer-term ART or the safety of ART in men with severe BPH and LUTS, and further studies are required to reach more definitive conclusions...
  93. ncbi request reprint Differential expression of 17beta-hydroxysteroid dehydrogenase isozyme genes in prostate cancer and noncancer tissues
    Eitetsu Koh
    Department of Urology, School of Medicine, Kanazawa University, Ishikawa, Japan
    Prostate 53:154-9. 2002
    ..This study presents the differential expression of 17betaHSD isozyme genes in cancerous and noncancerous prostate tissues of in vivo samples...
  94. ncbi request reprint Reevaluation of azoospermic factor c microdeletions using sequence-tagged site markers with confirmed physical positions from the GenBank database
    Masato Fukushima
    Department of Integrated Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Fertil Steril 85:965-71. 2006
    ....
  95. ncbi request reprint Incarcerated intestinal hernia in a hernia sac of reversed ileal conduit wall protruding through the stoma
    Kouji Izumi
    Department of Integrative Cancer Therapy and Urology, Kanazawa University Graduate School of Medical Science, Kanazawa, Japan
    Int J Urol 14:561-2. 2007
    ..This case was apparently caused by high abdominal pressure and thinning of the ileal conduit wall...