Mitsutoshi Nakada

Summary

Affiliation: Kanazawa University
Country: Japan

Publications

  1. pmc The phosphorylation of ephrin-B2 ligand promotes glioma cell migration and invasion
    Mitsutoshi Nakada
    Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix, AZ, USA
    Int J Cancer 126:1155-65. 2010
  2. pmc Role of Eph/ephrin tyrosine kinase in malignant glioma
    Mitsutoshi Nakada
    Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    Neuro Oncol 13:1163-70. 2011
  3. doi request reprint Glycogen synthase kinase 3β inhibition sensitizes human glioblastoma cells to temozolomide by affecting O6-methylguanine DNA methyltransferase promoter methylation via c-Myc signaling
    Ilya V Pyko
    Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, 920 8641, Kanazawa, Ishikawa, Japan
    Carcinogenesis 34:2206-17. 2013
  4. ncbi request reprint MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival
    Tim Demuth
    Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Mol Cancer Ther 6:1212-22. 2007
  5. ncbi request reprint Ephrin-B3 ligand promotes glioma invasion through activation of Rac1
    Mitsutoshi Nakada
    The Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Cancer Res 66:8492-500. 2006
  6. pmc Glioma cells on the run - the migratory transcriptome of 10 human glioma cell lines
    Tim Demuth
    Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    BMC Genomics 9:54. 2008
  7. ncbi request reprint Human glioblastomas overexpress ADAMTS-5 that degrades brevican
    Mitsutoshi Nakada
    Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan
    Acta Neuropathol 110:239-46. 2005
  8. doi request reprint Epithelioid glioblastoma changed to typical glioblastoma: the methylation status of MGMT promoter and 5-ALA fluorescence
    Shingo Tanaka
    Division of Neuroscience, Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 8641, Japan
    Brain Tumor Pathol 28:59-64. 2011
  9. ncbi request reprint Autotaxin: a secreted autocrine/paracrine factor that promotes glioma invasion
    Dominique B Hoelzinger
    Cancer and Cell Biology Division, Translational Genomics Research Institute, 445 North 5th Street, 5th Floor, Phoenix, AZ 85004, USA
    J Neurooncol 86:297-309. 2008
  10. ncbi request reprint Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome
    Nhan L Tran
    Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Cancer Res 66:9535-42. 2006

Collaborators

Detail Information

Publications57

  1. pmc The phosphorylation of ephrin-B2 ligand promotes glioma cell migration and invasion
    Mitsutoshi Nakada
    Cancer and Cell Biology Division, The Translational Genomics Research Institute, Phoenix, AZ, USA
    Int J Cancer 126:1155-65. 2010
    ..These results demonstrate that high expression of ephrin-B2 is a strong predictor of short-term survival and that ephrin-B2 plays a critical role in glioma invasion rendering this signaling pathway as a potential therapeutic target...
  2. pmc Role of Eph/ephrin tyrosine kinase in malignant glioma
    Mitsutoshi Nakada
    Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    Neuro Oncol 13:1163-70. 2011
    ..Here, we review recent advances in research on the role of Eph/ephrin signaling in glioma and suggest that the Eph/ephrin system could be a potential target of glioma therapy...
  3. doi request reprint Glycogen synthase kinase 3β inhibition sensitizes human glioblastoma cells to temozolomide by affecting O6-methylguanine DNA methyltransferase promoter methylation via c-Myc signaling
    Ilya V Pyko
    Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, 920 8641, Kanazawa, Ishikawa, Japan
    Carcinogenesis 34:2206-17. 2013
    ..The results of this study suggest that GSK3β inhibition enhances temozolomide effect by silencing MGMT expression via c-Myc-mediated promoter methylation. ..
  4. ncbi request reprint MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival
    Tim Demuth
    Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Mol Cancer Ther 6:1212-22. 2007
    ..Our findings therefore argue that interference with MKK3 signaling through a novel treatment combination of p38 inhibitor plus temozolomide heightens the vulnerability of glioma to chemotherapy...
  5. ncbi request reprint Ephrin-B3 ligand promotes glioma invasion through activation of Rac1
    Mitsutoshi Nakada
    The Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Cancer Res 66:8492-500. 2006
    ..Immunohistochemistry revealed robust staining for phosphorylated ephrin-B and ephrin-B3 in invading glioblastoma cells. These data show that ephrin-B3 expression and signaling through Rac1 are critically important to glioma invasion...
  6. pmc Glioma cells on the run - the migratory transcriptome of 10 human glioma cell lines
    Tim Demuth
    Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    BMC Genomics 9:54. 2008
    ..Using a monolayer radial migration assay, motile and stationary cell populations from seven human long term glioma cell lines and three primary GBM cultures were isolated and prepared for expression analysis...
  7. ncbi request reprint Human glioblastomas overexpress ADAMTS-5 that degrades brevican
    Mitsutoshi Nakada
    Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan
    Acta Neuropathol 110:239-46. 2005
    ..These results demonstrate for the first time that ADAMTS-5 is capable of degrading brevican and is overexpressed in glioblastoma cells, and suggest that ADAMTS-5 may play a role in glioma cell invasion through the cleavage of brevican...
  8. doi request reprint Epithelioid glioblastoma changed to typical glioblastoma: the methylation status of MGMT promoter and 5-ALA fluorescence
    Shingo Tanaka
    Division of Neuroscience, Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 8641, Japan
    Brain Tumor Pathol 28:59-64. 2011
    ..The methylation status of the MGMT promoter was found to have changed from methylated to unmethylated and 5-ALA fluorescence became positive along with the histological change...
  9. ncbi request reprint Autotaxin: a secreted autocrine/paracrine factor that promotes glioma invasion
    Dominique B Hoelzinger
    Cancer and Cell Biology Division, Translational Genomics Research Institute, 445 North 5th Street, 5th Floor, Phoenix, AZ 85004, USA
    J Neurooncol 86:297-309. 2008
    ..Secreted factors that drive GBM invasion can have autocrine and paracrine roles; one stimulates GBM motility and the other results in ODC dis-adhesion...
  10. ncbi request reprint Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome
    Nhan L Tran
    Cancer and Cell Biology Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA
    Cancer Res 66:9535-42. 2006
    ..Such a feedback loop argues for aggressive targeting of the Fn14 axis as a unique and specific driver of glioma malignant behavior...
  11. doi request reprint Sphingosine-1-phosphate receptor type 1 regulates glioma cell proliferation and correlates with patient survival
    Yuya Yoshida
    Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Int J Cancer 126:2341-52. 2010
    ..05). These data indicate that the downregulation of S1P(1) expression enhances the malignancy of glioblastoma by increasing cell proliferation and correlates with the shorter survival of patients with glioblastoma...
  12. doi request reprint The expression level of sphingosine-1-phosphate receptor type 1 is related to MIB-1 labeling index and predicts survival of glioblastoma patients
    Yuya Yoshida
    Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, 920 8641, Japan
    J Neurooncol 98:41-7. 2010
    ..Furthermore, downregulation of S1P(1) expression increases proliferative activity, and thus enhances the malignancy of glioblastomas, resulting in a poor survival...
  13. pmc EphB2/R-Ras signaling regulates glioma cell adhesion, growth, and invasion
    Mitsutoshi Nakada
    Neuro Oncology Research, Barrow Neurological Institute, Phoenix, AZ, USA
    Am J Pathol 167:565-76. 2005
    ..These results demonstrate that R-Ras plays an important role in glioma pathology, further suggesting the EphB2/R-Ras signaling pathway as a potential therapeutic target...
  14. doi request reprint A reevaluation of the primary diagnosis of hemangiopericytoma and the clinical importance of differential diagnosis from solitary fibrous tumor of the central nervous system
    Yutaka Hayashi
    Department of Neurosurgery, Kanazawa University Hospital, Kanazawa, Japan
    Clin Neurol Neurosurg 111:34-8. 2009
    ..We also compared the clinical features of these cases...
  15. doi request reprint What bone part is important to remove in accessing the suprachiasmatic region with less frontal lobe retraction in frontotemporal craniotomies
    Masashi Kinoshita
    Department of Neurosurgery, Kanazawa University, Kanazawa, Japan
    World Neurosurg 77:342-8. 2012
    ....
  16. doi request reprint NKX2.2 suppresses self-renewal of glioma-initiating cells
    Teruyuki Muraguchi
    Division of Molecular Genetics, Cancer and Stem Cell Research Program, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa, Japan
    Cancer Res 71:1135-45. 2011
    ..Thus, our mouse models offer pathobiologically significant advantages to investigate the nature of brain tumors, with improved opportunities to develop novel mechanism-based therapeutic approaches...
  17. ncbi request reprint JSAP1/JIP3 cooperates with focal adhesion kinase to regulate c-Jun N-terminal kinase and cell migration
    Takahisa Takino
    Department of Molecular Virology, Cancer Research Institute, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, Japan
    J Biol Chem 280:37772-81. 2005
    ..We propose that the JSAP1.FAK complex functions cooperatively as a scaffold for the JNK signaling pathway and regulator of cell migration on FN, and we suggest that JSAP1 is also associated with malignancy in brain tumors...
  18. ncbi request reprint Anaplastic meningioma with extremely rapid recurrence
    Yosuke Kawahara
    Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, Ishikawa
    Neurol Med Chir (Tokyo) 51:386-8. 2011
    ..Although meningiomas rarely show malignant behavior, corresponding to World Health Organization grade III, it is necessary to consider malignant behavior when treating meningiomas...
  19. ncbi request reprint Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins
    Mitsutoshi Nakada
    Department of Molecular Virology and Oncology, Kanazawa University, Ishikawa 920 0934, Japan
    Cancer Res 63:3364-9. 2003
    ..We propose that N-Tes-Delta 122, which is resistant to testican 2, may have therapeutic potential as a barrier against glioma invasion...
  20. pmc Aberrant glycogen synthase kinase 3β is involved in pancreatic cancer cell invasion and resistance to therapy
    Ayako Kitano
    Division of Translational and Clinical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
    PLoS ONE 8:e55289. 2013
    ..Here we investigate a pathological role for GSK3β in the invasive and treatment resistant phenotype of pancreatic cancer...
  21. doi request reprint Prediction of high-grade meningioma by preoperative MRI assessment
    Yosuke Kawahara
    Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa, 920 8641, Japan
    J Neurooncol 108:147-52. 2012
    ..Our data suggest that this combination of factors obtained from conventional sequences on MR imaging may be useful to predict high-grade meningioma...
  22. doi request reprint The correlation between promoter methylation status and the expression level of O6-methylguanine-DNA methyltransferase in recurrent glioma
    Tomohide Suzuki
    Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa 920 8641 Japan
    Jpn J Clin Oncol 41:190-6. 2011
    ..Thereby, there were many reports on O(6)-methylguanine-DNA methyltransferase promoter methylation and mRNA expression in primary glioma, in contrast, there were only a few studies in recurrent glioma...
  23. doi request reprint Radiation-induced cerebellar high-grade glioma accompanied by meningioma and cavernoma 29 years after the treatment of medulloblastoma: a case report
    Tomoya Kamide
    Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, Kanazawa, Ishikawa, Japan
    J Neurooncol 100:299-303. 2010
    ..To our knowledge, this is the first case of radiation-induced double intracranial tumors accompanied by symptomatic cavernoma...
  24. doi request reprint Implication of 5-aminolevulinic acid fluorescence of the ventricular wall for postoperative communicating hydrocephalus associated with cerebrospinal fluid dissemination in patients with glioblastoma multiforme: a report of 7 cases
    Yutaka Hayashi
    Department of Neurosurgery, Kanazawa University Hospital, Kanazawa, Japan
    J Neurosurg 112:1015-9. 2010
    ..To evaluate the clinical significance of the 5-ALA fluorescence, the authors resected ventricle wall tissue together with the adjacent tumors for pathological examination and then followed up the clinical courses of the patients...
  25. ncbi request reprint The phosphorylation of EphB2 receptor regulates migration and invasion of human glioma cells
    Mitsutoshi Nakada
    Neuro Oncology Research, Barrow Neurological Institute, Phoenix, Arizona, USA
    Cancer Res 64:3179-85. 2004
    ..Dysregulation of EphB2 expression or function may underlie glioma invasion...
  26. doi request reprint Association between carotid plaque composition assessed by multidetector computed tomography and cerebral embolism after carotid stenting
    Naoyuki Uchiyama
    Department of Neurosurgery and Radiology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Neuroradiology 54:487-93. 2012
    ....
  27. doi request reprint BCL10 single nucleotide polymorphism and its association with CSF dissemination of primary intracranial germ cell tumors
    Yutaka Hayashi
    Department of Neurosurgery, Kanazawa University Hospital, Kanazawa, Japan
    Pediatr Neurosurg 45:291-5. 2009
    ..The BCL10 gene, a proapoptotic signaling molecule involved in the Apaf-1/caspase-9 cell death pathway, may act as a tumor suppressor gene in multiple types of tumors including testicular GCTs...
  28. doi request reprint Ossified peripheral middle cerebral artery aneurysm in a 30-year-old man
    Yasuhiko Hayashi
    Department of Neurosurgery, Kanazawa University, Takara machi, Kanazawa, Japan
    J Clin Neurosci 16:1075-7. 2009
    ..The ossified aneurysm that we report developed over a prolonged period and may have arisen during childhood...
  29. pmc Ligand-dependent EphB1 signaling suppresses glioma invasion and correlates with patient survival
    Lei Teng
    Corresponding Authors Mitsutoshi Nakada, MD, PhD, Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 8641, Japan Shi Guang Zhao, MD, PhD, Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, People s Republic of China
    Neuro Oncol 15:1710-20. 2013
    ..We sought to identify the Eph family members that correlate with patients' survival and to reveal the function of Eph in glioma invasion...
  30. ncbi request reprint [Awake surgery with line bisection task for two cases of parietal glioma in the non-dominant hemisphere]
    Tomohiro Kitabayashi
    Department of Neurosurgery, Kanazawa University, Kanazawa City, Japan
    No Shinkei Geka 40:1087-93. 2012
    ..The tumor was successfully removed without any neurological deficit in both the cases. The line bisection test is simple and useful for preserving spatial recognition during an awake surgery...
  31. doi request reprint Receptor tyrosine kinases: principles and functions in glioma invasion
    Mitsutoshi Nakada
    Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa, 920 8640, Japan
    Adv Exp Med Biol 986:143-70. 2013
    ..Herein, we summarize recent advances in understanding the role of RTKs in glioma pathobiology, especially the invasive phenotype, and present the perspective that RTKs are a potential target of glioma therapy...
  32. doi request reprint MGMT promoter methylation and temozolomide response in choroid plexus carcinoma
    Kouichi Misaki
    Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 8641, Japan
    Brain Tumor Pathol 28:259-63. 2011
    ..We discuss the ineffectiveness of adjuvant temozolomide therapy for CPC in connection with O(6)-methylguanine-DNA methyltransferase promoter methylation...
  33. doi request reprint Potential therapeutic effect of glycogen synthase kinase 3beta inhibition against human glioblastoma
    Katsuyoshi Miyashita
    Division of Translational and Clinical Oncology, Cancer Research Institute, Kanazawa, Japan
    Clin Cancer Res 15:887-97. 2009
    ..We investigated the expression, activity, and putative pathologic role of glycogen synthase kinase 3beta (GSK3beta), an emerging therapeutic target for neurodegenerative diseases, in human glioblastoma...
  34. doi request reprint Skull osteohypertrophy as a complication of bone wax
    Tomoya Kamide
    Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    J Clin Neurosci 16:1658-60. 2009
    ..Pathological examination revealed granulation and osteogenesis due to a foreign body. To our knowledge, this is the first report of bone wax-induced hyperostosis leading to exophthalmos...
  35. ncbi request reprint An emerging strategy for cancer treatment targeting aberrant glycogen synthase kinase 3 beta
    Katsuyoshi Miyashita
    Division of Translational and Clinical Oncology, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan
    Anticancer Agents Med Chem 9:1114-22. 2009
    ..This will allow exploration of novel therapeutic strategies for cancer that target aberrant GSK3beta...
  36. doi request reprint Combination therapy using Notch and Akt inhibitors is effective for suppressing invasion but not proliferation in glioma cells
    Rihua Jin
    Department of Neurosurgery, The First Bethune Clinical Hospital of Jilin University, 71 Xinmin Avenue, Changchun 130021, People s Republic of China
    Neurosci Lett 534:316-21. 2013
    ..Inhibition of invasion, further enhanced by combination therapy, correlated with increased Akt inactivation. In summary, combination therapy with MRK003 and MK-2206 may be effective for inhibiting invasion but not proliferation...
  37. doi request reprint Retro-odontoid pseudotumor without atlantoaxial subluxation
    Shingo Tanaka
    Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    J Clin Neurosci 17:649-52. 2010
    ..MRI performed 6 months after the operation revealed that the pseudotumor was markedly reduced. To the best of our knowledge, patients with ROP without AAS are uncommon...
  38. ncbi request reprint [Role of extracellular matrix degradation enzyme for glioma invasion]
    Mitsutoshi Nakada
    Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University
    Nihon Rinsho 63:55-60. 2005
  39. doi request reprint Transcrusal approach to the retrochiasmatic region with special reference to temporal lobe retraction: an anatomical study
    Masashi Kinoshita
    Department of Neurosurgery, Kanazawa University, 13 1 Takaramachi, Kanazawa, 920 8641, Japan
    Acta Neurochir (Wien) 153:659-65. 2011
    ....
  40. doi request reprint Gonadotropin-releasing hormone (GnRH) and its receptor in human meningiomas
    Yuichi Hirota
    Department of Neurosurgery, Kanazawa University Hospital, 13 1 Takaramachi, Kanazawa, Japan
    Clin Neurol Neurosurg 111:127-33. 2009
    ..This study aims to determine the status of GnRH and GnRH-R and to elucidate the correlations of GnRH and GnRH-R with PR, ER, and clinical features in meningiomas...
  41. doi request reprint Intraparenchymal pneumocephalus caused by ethmoid sinus osteoma
    Tomoya Kamide
    Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, 13 1 Takaramachi, Kanazawa, Ishikawa 920 8641, Japan
    J Clin Neurosci 16:1487-9. 2009
    ..To our knowledge, this is the first report of a patient with intraparenchymal pneumocephalus caused by an ethmoid sinus osteoma...
  42. doi request reprint Predictive value of fractional anisotropy of the arcuate fasciculus for the functional recovery of language after brain tumor resection: A preliminary study
    Masashi Kinoshita
    Department of Neurosurgery, Kanazawa University, Kanazawa, Japan
    Clin Neurol Neurosurg 117:45-50. 2014
    ..The aim of this study is to analyze the preoperative state of the arcuate fasciculus in the patients with brain tumor from the perspective of its usefulness as a predictive factor for postoperative recovery of language functions...
  43. doi request reprint Molecular analysis of a recurrent glioblastoma treated with bevacizumab
    Takuya Furuta
    Division of Neuroscience, Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa, 920 8641, Japan
    Brain Tumor Pathol 31:32-9. 2014
    ..Consequently, bevacizumab might inhibit the VEGF autocrine loop, which then causes a change in molecular expression related not only to enhancement of tumor invasion but also maintenance of tumor proliferation. ..
  44. doi request reprint Progressive adult primary glioblastoma in the medulla oblongata with an unmethylated MGMT promoter and without an IDH mutation
    Akifumi Yoshikawa
    Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 8641, Japan
    Brain Tumor Pathol 30:175-9. 2013
    ..We report an extremely short clinical course of adult GBM in medulla oblongata with genetic analysis and present a review of the literature...
  45. doi request reprint Correlation between language function and the left arcuate fasciculus detected by diffusion tensor imaging tractography after brain tumor surgery
    Yutaka Hayashi
    Department of Neurosurgery, Kanazawa University, Kanazawa, Japan
    J Neurosurg 117:839-43. 2012
    ....
  46. pmc The strategy for enhancing temozolomide against malignant glioma
    Mitsutoshi Nakada
    Department of Neurosurgery, Kanazawa University Kanazawa, Ishikawa, Japan
    Front Oncol 2:98. 2012
    ..Thus, administration of these drugs as an adjunct to TMZ chemotherapy may have clinical applications in patients with malignant gliomas to improve the outcome...
  47. doi request reprint Ganglioglioma of the thoracolumbar spinal cord in a patient with neurofibromatosis type 1: a case report and literature review
    Yutaka Hayashi
    Department of Neurosurgery, Kanazawa University Hospital, Kanazawa, Japan
    Pediatr Neurosurg 47:210-3. 2011
    ....
  48. doi request reprint Ependymoma and choroid plexus papilloma as synchronous multiple neuroepithelial tumors in the same patient: a case report and review of literature
    Yutaka Hayashi
    Department of Neurosurgery, Kanazawa University Hospital, Kanazawa, Japan
    Neurosurgery 68:E1144-7; discussion E1147. 2011
    ..In this patient, synchronous appearance of tumors of the central nervous system, ie, cervical ependymoma and a fourth ventricle choroid plexus papilloma, was noted...
  49. pmc Progressive tentorial cavernous malformation
    Takuya Furuta
    Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, Japan
    Surg Neurol Int 3:18. 2012
    ..Because extra-axial cavernous malformations (CMs) are rare, the common clinical course remains unclear. We report the case of a patient with progressive CM originating from the cerebellar tentorium...
  50. doi request reprint Association fibers connecting the Broca center and the lateral superior frontal gyrus: a microsurgical and tractographic anatomy
    Masashi Kinoshita
    Departments of Neurosurgery, Kanazawa University, Kanazawa, Japan
    J Neurosurg 116:323-30. 2012
    ..To show the existence of the structural connection, white matter association fibers between the inferior frontal gyrus (IFG) and the LSFG were examined using fiber dissection (FD) and diffusion tensor (DT) imaging-based tractography...
  51. ncbi request reprint CrkI adapter protein modulates cell migration and invasion in glioblastoma
    Takahisa Takino
    Department of Molecular Virology and Oncology, Cancer Research Institute, Graduate School of Medical Science, Kanazawa University, Japan
    Cancer Res 63:2335-7. 2003
    ..These results suggest that CrkI contributes to malignancy of glioblastoma by inducing phosphorylation of p130 Crk-associated substrate...
  52. ncbi request reprint Surgical strategies for nonenhancing slow-growing gliomas with special reference to functional reorganization: review with own experience
    Yutaka Hayashi
    Department of Neurosurgery, Kanazawa University, Kanazama, Ishikawa, Japan
    Neurol Med Chir (Tokyo) 53:438-46. 2013
    ..Therefore, awake surgery could increase the extent of the resection of the tumor without deficits, resulting in the delay of malignant transformation and increase in overall survival. ..
  53. pmc Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin
    Akira Tamase
    Division of Molecular Genetics, Center for Cancer and Stem Cell Research, Cancer Research Institute, Kanazawa University, Kanazawa, Ishikawa 920 0934, Japan
    Proc Natl Acad Sci U S A 106:17163-8. 2009
    ..Thus, the NS-GFP system provides a powerful tool to elucidate stem cell biology in normal and malignant tissues...
  54. doi request reprint Force-detecting gripper and force feedback system for neurosurgery applications
    Takeshi Yoneyama
    School of Mechanical Engineering, Kanazawa University, Kakuma machi, Kanazawa, 920 1192, Japan
    Int J Comput Assist Radiol Surg 8:819-29. 2013
    ..For the application of less invasive robotic neurosurgery to the resection of deep-seated tumors, a prototype system of a force-detecting gripper with a flexible micromanipulator and force feedback to the operating unit will be developed...
  55. ncbi request reprint Simulation of clipping position for cerebral aneurysms using three-dimensional computed tomography angiography
    Kazuya Futami
    Department of Neurosurgery, Toyama City Hospital, Toyama, Japan
    Neurol Med Chir (Tokyo) 44:6-12; discussion 13. 2004
    ..5% and specificity of 60%. The present simulation method can predict aneurysm remnants and improve the likelihood of complete obliteration by clipping...
  56. ncbi request reprint Unusual angiographic changes in an internal carotid artery pseudoaneurysm after infection in the deep neck space
    Yasuhiko Hayashi
    Department of Neurosurgery, Graduate School of Medical Science, Kanazawa University, Ishikawa, Japan
    Neurol Med Chir (Tokyo) 48:216-9. 2008
    ..ICA occlusion caused by spread of infection in the deep neck space may cause accelerated coagulopathy due to ICA wall inflammation...
  57. ncbi request reprint The role of matrix metalloproteinases in glioma invasion
    Mitsutoshi Nakada
    Department of Neurosurgery, Division of Neuroscience, Graduate School of Medical Science, Kanazawa University, 13 1 Takara machi, Kanazawa, Ishikawa 920 0934, Japan
    Front Biosci 8:e261-9. 2003
    ..We discuss here the biological significance of these MMPs in the glioblastoma invasion processes. A better understanding of cell-ECM interactions will help in developing therapeutic strategies to decrease the invasion of gliomas...